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Updated November 2019
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Protein Info
Short Name:
FLG2
Full Name:
Filaggrin-2
Alias:
Fila2; Filaggrin 2; Filaggrin family member 2; Flg2; Ifps; Intermediate filament-associated and psoriasis-susceptibility protein
Type:
Mass (Da):
248073
Number AA:
2391
UniProt ID:
Q5D862
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
V
T
V
I
D
V
F
Y
K
Y
T
K
Q
D
G
Site 2
Y18
V
I
D
V
F
Y
K
Y
T
K
Q
D
G
E
C
Site 3
T27
K
Q
D
G
E
C
G
T
L
S
K
G
E
L
K
Site 4
S29
D
G
E
C
G
T
L
S
K
G
E
L
K
E
L
Site 5
Y93
N
K
V
L
S
K
E
Y
C
K
A
S
G
S
K
Site 6
S97
S
K
E
Y
C
K
A
S
G
S
K
K
H
R
R
Site 7
S113
H
R
H
Q
E
E
E
S
E
T
E
E
D
E
E
Site 8
T115
H
Q
E
E
E
S
E
T
E
E
D
E
E
D
T
Site 9
T122
T
E
E
D
E
E
D
T
P
G
H
K
S
G
Y
Site 10
S127
E
D
T
P
G
H
K
S
G
Y
R
H
S
S
W
Site 11
Y129
T
P
G
H
K
S
G
Y
R
H
S
S
W
S
E
Site 12
S132
H
K
S
G
Y
R
H
S
S
W
S
E
G
E
E
Site 13
S133
K
S
G
Y
R
H
S
S
W
S
E
G
E
E
H
Site 14
S135
G
Y
R
H
S
S
W
S
E
G
E
E
H
G
Y
Site 15
Y142
S
E
G
E
E
H
G
Y
S
S
G
H
S
R
G
Site 16
S143
E
G
E
E
H
G
Y
S
S
G
H
S
R
G
T
Site 17
S144
G
E
E
H
G
Y
S
S
G
H
S
R
G
T
V
Site 18
S147
H
G
Y
S
S
G
H
S
R
G
T
V
K
C
R
Site 19
T150
S
S
G
H
S
R
G
T
V
K
C
R
H
G
S
Site 20
S157
T
V
K
C
R
H
G
S
N
S
R
R
L
G
R
Site 21
S159
K
C
R
H
G
S
N
S
R
R
L
G
R
Q
G
Site 22
S169
L
G
R
Q
G
N
L
S
S
S
G
N
Q
E
G
Site 23
S170
G
R
Q
G
N
L
S
S
S
G
N
Q
E
G
S
Site 24
S171
R
Q
G
N
L
S
S
S
G
N
Q
E
G
S
Q
Site 25
S177
S
S
G
N
Q
E
G
S
Q
K
R
Y
H
R
S
Site 26
Y181
Q
E
G
S
Q
K
R
Y
H
R
S
S
C
G
H
Site 27
S184
S
Q
K
R
Y
H
R
S
S
C
G
H
S
W
S
Site 28
S185
Q
K
R
Y
H
R
S
S
C
G
H
S
W
S
G
Site 29
S189
H
R
S
S
C
G
H
S
W
S
G
G
K
D
R
Site 30
S191
S
S
C
G
H
S
W
S
G
G
K
D
R
H
G
Site 31
S199
G
G
K
D
R
H
G
S
S
S
V
E
L
R
E
Site 32
S200
G
K
D
R
H
G
S
S
S
V
E
L
R
E
R
Site 33
S201
K
D
R
H
G
S
S
S
V
E
L
R
E
R
I
Site 34
S211
L
R
E
R
I
N
K
S
H
I
S
P
S
R
E
Site 35
S214
R
I
N
K
S
H
I
S
P
S
R
E
S
G
E
Site 36
S216
N
K
S
H
I
S
P
S
R
E
S
G
E
E
Y
Site 37
S219
H
I
S
P
S
R
E
S
G
E
E
Y
E
S
G
Site 38
Y223
S
R
E
S
G
E
E
Y
E
S
G
S
G
S
N
Site 39
S225
E
S
G
E
E
Y
E
S
G
S
G
S
N
S
W
Site 40
S227
G
E
E
Y
E
S
G
S
G
S
N
S
W
E
R
Site 41
S229
E
Y
E
S
G
S
G
S
N
S
W
E
R
K
G
Site 42
S231
E
S
G
S
G
S
N
S
W
E
R
K
G
H
G
Site 43
S241
R
K
G
H
G
G
L
S
C
G
L
E
T
S
G
Site 44
T246
G
L
S
C
G
L
E
T
S
G
H
E
S
N
S
Site 45
S247
L
S
C
G
L
E
T
S
G
H
E
S
N
S
T
Site 46
S251
L
E
T
S
G
H
E
S
N
S
T
Q
S
R
I
Site 47
S253
T
S
G
H
E
S
N
S
T
Q
S
R
I
R
E
Site 48
T254
S
G
H
E
S
N
S
T
Q
S
R
I
R
E
Q
Site 49
S265
I
R
E
Q
K
L
G
S
S
C
S
G
S
G
D
Site 50
S266
R
E
Q
K
L
G
S
S
C
S
G
S
G
D
S
Site 51
S268
Q
K
L
G
S
S
C
S
G
S
G
D
S
G
R
Site 52
S270
L
G
S
S
C
S
G
S
G
D
S
G
R
R
S
Site 53
S273
S
C
S
G
S
G
D
S
G
R
R
S
H
A
C
Site 54
S277
S
G
D
S
G
R
R
S
H
A
C
G
Y
S
N
Site 55
Y282
R
R
S
H
A
C
G
Y
S
N
S
S
G
C
G
Site 56
S283
R
S
H
A
C
G
Y
S
N
S
S
G
C
G
R
Site 57
S286
A
C
G
Y
S
N
S
S
G
C
G
R
P
Q
N
Site 58
S295
C
G
R
P
Q
N
A
S
S
S
C
Q
S
H
R
Site 59
S296
G
R
P
Q
N
A
S
S
S
C
Q
S
H
R
F
Site 60
S297
R
P
Q
N
A
S
S
S
C
Q
S
H
R
F
G
Site 61
S300
N
A
S
S
S
C
Q
S
H
R
F
G
G
Q
G
Site 62
Y312
G
Q
G
N
Q
F
S
Y
I
Q
S
G
C
Q
S
Site 63
S319
Y
I
Q
S
G
C
Q
S
G
I
K
G
G
Q
G
Site 64
S331
G
Q
G
H
G
C
V
S
G
G
Q
P
S
G
C
Site 65
S336
C
V
S
G
G
Q
P
S
G
C
G
Q
P
E
S
Site 66
S343
S
G
C
G
Q
P
E
S
N
P
C
S
Q
S
Y
Site 67
S347
Q
P
E
S
N
P
C
S
Q
S
Y
S
Q
R
G
Site 68
S349
E
S
N
P
C
S
Q
S
Y
S
Q
R
G
Y
G
Site 69
Y350
S
N
P
C
S
Q
S
Y
S
Q
R
G
Y
G
A
Site 70
S351
N
P
C
S
Q
S
Y
S
Q
R
G
Y
G
A
R
Site 71
Y355
Q
S
Y
S
Q
R
G
Y
G
A
R
E
N
G
Q
Site 72
T372
N
C
G
G
Q
W
R
T
G
S
S
Q
S
S
C
Site 73
S374
G
G
Q
W
R
T
G
S
S
Q
S
S
C
C
G
Site 74
S375
G
Q
W
R
T
G
S
S
Q
S
S
C
C
G
Q
Site 75
S378
R
T
G
S
S
Q
S
S
C
C
G
Q
Y
G
S
Site 76
Y383
Q
S
S
C
C
G
Q
Y
G
S
G
G
S
Q
S
Site 77
S385
S
C
C
G
Q
Y
G
S
G
G
S
Q
S
C
S
Site 78
S388
G
Q
Y
G
S
G
G
S
Q
S
C
S
N
G
Q
Site 79
S390
Y
G
S
G
G
S
Q
S
C
S
N
G
Q
H
E
Site 80
S392
S
G
G
S
Q
S
C
S
N
G
Q
H
E
Y
G
Site 81
Y398
C
S
N
G
Q
H
E
Y
G
S
C
G
R
F
S
Site 82
S400
N
G
Q
H
E
Y
G
S
C
G
R
F
S
N
S
Site 83
S405
Y
G
S
C
G
R
F
S
N
S
S
S
S
N
E
Site 84
S407
S
C
G
R
F
S
N
S
S
S
S
N
E
F
S
Site 85
S408
C
G
R
F
S
N
S
S
S
S
N
E
F
S
K
Site 86
S409
G
R
F
S
N
S
S
S
S
N
E
F
S
K
C
Site 87
S410
R
F
S
N
S
S
S
S
N
E
F
S
K
C
D
Site 88
S414
S
S
S
S
N
E
F
S
K
C
D
Q
Y
G
S
Site 89
Y419
E
F
S
K
C
D
Q
Y
G
S
G
S
S
Q
S
Site 90
S421
S
K
C
D
Q
Y
G
S
G
S
S
Q
S
T
S
Site 91
S423
C
D
Q
Y
G
S
G
S
S
Q
S
T
S
F
E
Site 92
S424
D
Q
Y
G
S
G
S
S
Q
S
T
S
F
E
Q
Site 93
S426
Y
G
S
G
S
S
Q
S
T
S
F
E
Q
H
G
Site 94
T427
G
S
G
S
S
Q
S
T
S
F
E
Q
H
G
T
Site 95
S428
S
G
S
S
Q
S
T
S
F
E
Q
H
G
T
G
Site 96
T434
T
S
F
E
Q
H
G
T
G
L
S
Q
S
S
G
Site 97
S437
E
Q
H
G
T
G
L
S
Q
S
S
G
F
E
Q
Site 98
S439
H
G
T
G
L
S
Q
S
S
G
F
E
Q
H
V
Site 99
S458
Q
T
C
G
Q
H
E
S
T
S
S
Q
S
L
G
Site 100
T459
T
C
G
Q
H
E
S
T
S
S
Q
S
L
G
Y
Site 101
S460
C
G
Q
H
E
S
T
S
S
Q
S
L
G
Y
D
Site 102
S461
G
Q
H
E
S
T
S
S
Q
S
L
G
Y
D
Q
Site 103
S463
H
E
S
T
S
S
Q
S
L
G
Y
D
Q
H
G
Site 104
Y466
T
S
S
Q
S
L
G
Y
D
Q
H
G
S
S
S
Site 105
S471
L
G
Y
D
Q
H
G
S
S
S
G
K
T
S
G
Site 106
S472
G
Y
D
Q
H
G
S
S
S
G
K
T
S
G
F
Site 107
S473
Y
D
Q
H
G
S
S
S
G
K
T
S
G
F
G
Site 108
T476
H
G
S
S
S
G
K
T
S
G
F
G
Q
H
G
Site 109
S477
G
S
S
S
G
K
T
S
G
F
G
Q
H
G
S
Site 110
S484
S
G
F
G
Q
H
G
S
G
S
G
Q
S
S
G
Site 111
S486
F
G
Q
H
G
S
G
S
G
Q
S
S
G
F
G
Site 112
S490
G
S
G
S
G
Q
S
S
G
F
G
Q
C
G
S
Site 113
S497
S
G
F
G
Q
C
G
S
G
S
G
Q
S
S
G
Site 114
S499
F
G
Q
C
G
S
G
S
G
Q
S
S
G
F
G
Site 115
S502
C
G
S
G
S
G
Q
S
S
G
F
G
Q
H
G
Site 116
S503
G
S
G
S
G
Q
S
S
G
F
G
Q
H
G
S
Site 117
S510
S
G
F
G
Q
H
G
S
V
S
G
Q
S
S
G
Site 118
S512
F
G
Q
H
G
S
V
S
G
Q
S
S
G
F
G
Site 119
S515
H
G
S
V
S
G
Q
S
S
G
F
G
Q
H
G
Site 120
S516
G
S
V
S
G
Q
S
S
G
F
G
Q
H
G
S
Site 121
S529
G
S
V
S
G
Q
S
S
G
F
G
Q
H
E
S
Site 122
S536
S
G
F
G
Q
H
E
S
R
S
R
Q
S
S
Y
Site 123
S538
F
G
Q
H
E
S
R
S
R
Q
S
S
Y
G
Q
Site 124
S541
H
E
S
R
S
R
Q
S
S
Y
G
Q
H
G
S
Site 125
S542
E
S
R
S
R
Q
S
S
Y
G
Q
H
G
S
G
Site 126
Y543
S
R
S
R
Q
S
S
Y
G
Q
H
G
S
G
S
Site 127
S548
S
S
Y
G
Q
H
G
S
G
S
S
Q
S
S
G
Site 128
S550
Y
G
Q
H
G
S
G
S
S
Q
S
S
G
Y
G
Site 129
S551
G
Q
H
G
S
G
S
S
Q
S
S
G
Y
G
Q
Site 130
S553
H
G
S
G
S
S
Q
S
S
G
Y
G
Q
Y
G
Site 131
S554
G
S
G
S
S
Q
S
S
G
Y
G
Q
Y
G
S
Site 132
Y559
Q
S
S
G
Y
G
Q
Y
G
S
R
E
T
S
G
Site 133
S561
S
G
Y
G
Q
Y
G
S
R
E
T
S
G
F
G
Site 134
T564
G
Q
Y
G
S
R
E
T
S
G
F
G
Q
H
G
Site 135
S565
Q
Y
G
S
R
E
T
S
G
F
G
Q
H
G
L
Site 136
S574
F
G
Q
H
G
L
G
S
G
Q
S
T
G
F
G
Site 137
S577
H
G
L
G
S
G
Q
S
T
G
F
G
Q
Y
G
Site 138
T578
G
L
G
S
G
Q
S
T
G
F
G
Q
Y
G
S
Site 139
Y583
Q
S
T
G
F
G
Q
Y
G
S
G
S
G
Q
S
Site 140
S585
T
G
F
G
Q
Y
G
S
G
S
G
Q
S
S
G
Site 141
S587
F
G
Q
Y
G
S
G
S
G
Q
S
S
G
F
G
Site 142
S590
Y
G
S
G
S
G
Q
S
S
G
F
G
Q
H
G
Site 143
S604
G
S
G
S
G
Q
S
S
G
F
G
Q
H
E
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G
H
S
E
S
S
D
S
E
V
H
S
Site 449
S1884
R
S
G
H
S
E
S
S
D
S
E
V
H
S
G
Site 450
T1895
V
H
S
G
G
S
H
T
H
S
G
H
T
H
S
Site 451
S1897
S
G
G
S
H
T
H
S
G
H
T
H
S
Q
A
Site 452
S1902
T
H
S
G
H
T
H
S
Q
A
R
S
Q
H
G
Site 453
S1906
H
T
H
S
Q
A
R
S
Q
H
G
E
S
E
S
Site 454
S1913
S
Q
H
G
E
S
E
S
T
V
H
K
R
H
Q
Site 455
T1914
Q
H
G
E
S
E
S
T
V
H
K
R
H
Q
T
Site 456
T1921
T
V
H
K
R
H
Q
T
T
H
G
Q
T
G
D
Site 457
T1929
T
H
G
Q
T
G
D
T
T
E
H
G
H
P
S
Site 458
T1930
H
G
Q
T
G
D
T
T
E
H
G
H
P
S
H
Site 459
T1940
G
H
P
S
H
G
Q
T
I
Q
T
G
S
R
T
Site 460
T1943
S
H
G
Q
T
I
Q
T
G
S
R
T
T
G
R
Site 461
T1947
T
I
Q
T
G
S
R
T
T
G
R
R
G
S
G
Site 462
T1948
I
Q
T
G
S
R
T
T
G
R
R
G
S
G
H
Site 463
Y1958
R
G
S
G
H
S
E
Y
S
D
S
E
G
P
S
Site 464
S1959
G
S
G
H
S
E
Y
S
D
S
E
G
P
S
G
Site 465
S1961
G
H
S
E
Y
S
D
S
E
G
P
S
G
V
S
Site 466
S1965
Y
S
D
S
E
G
P
S
G
V
S
H
T
H
S
Site 467
S1968
S
E
G
P
S
G
V
S
H
T
H
S
G
H
T
Site 468
T1970
G
P
S
G
V
S
H
T
H
S
G
H
T
H
G
Site 469
S1981
H
T
H
G
Q
A
G
S
H
Y
P
E
S
G
S
Site 470
Y1983
H
G
Q
A
G
S
H
Y
P
E
S
G
S
S
V
Site 471
S1986
A
G
S
H
Y
P
E
S
G
S
S
V
H
E
R
Site 472
S1988
S
H
Y
P
E
S
G
S
S
V
H
E
R
H
G
Site 473
S1989
H
Y
P
E
S
G
S
S
V
H
E
R
H
G
T
Site 474
T1996
S
V
H
E
R
H
G
T
T
H
G
Q
T
A
D
Site 475
T1997
V
H
E
R
H
G
T
T
H
G
Q
T
A
D
T
Site 476
T2004
T
H
G
Q
T
A
D
T
T
R
H
G
H
S
G
Site 477
S2020
G
Q
S
T
Q
R
G
S
R
T
T
G
R
R
A
Site 478
T2022
S
T
Q
R
G
S
R
T
T
G
R
R
A
S
G
Site 479
T2023
T
Q
R
G
S
R
T
T
G
R
R
A
S
G
H
Site 480
S2028
R
T
T
G
R
R
A
S
G
H
S
E
Y
S
D
Site 481
S2031
G
R
R
A
S
G
H
S
E
Y
S
D
S
E
G
Site 482
Y2033
R
A
S
G
H
S
E
Y
S
D
S
E
G
H
S
Site 483
S2034
A
S
G
H
S
E
Y
S
D
S
E
G
H
S
G
Site 484
S2036
G
H
S
E
Y
S
D
S
E
G
H
S
G
V
S
Site 485
S2040
Y
S
D
S
E
G
H
S
G
V
S
H
T
H
S
Site 486
S2043
S
E
G
H
S
G
V
S
H
T
H
S
G
H
A
Site 487
T2045
G
H
S
G
V
S
H
T
H
S
G
H
A
H
G
Site 488
S2047
S
G
V
S
H
T
H
S
G
H
A
H
G
Q
A
Site 489
S2056
H
A
H
G
Q
A
G
S
Q
H
G
E
S
G
S
Site 490
S2061
A
G
S
Q
H
G
E
S
G
S
S
V
H
E
R
Site 491
S2063
S
Q
H
G
E
S
G
S
S
V
H
E
R
H
G
Site 492
S2064
Q
H
G
E
S
G
S
S
V
H
E
R
H
G
T
Site 493
T2071
S
V
H
E
R
H
G
T
T
H
G
Q
T
G
D
Site 494
T2079
T
H
G
Q
T
G
D
T
T
R
H
A
H
S
G
Site 495
S2090
A
H
S
G
H
G
Q
S
T
Q
R
G
S
R
T
Site 496
T2091
H
S
G
H
G
Q
S
T
Q
R
G
S
R
T
A
Site 497
S2095
G
Q
S
T
Q
R
G
S
R
T
A
G
R
R
G
Site 498
T2097
S
T
Q
R
G
S
R
T
A
G
R
R
G
S
G
Site 499
S2103
R
T
A
G
R
R
G
S
G
H
S
E
S
S
D
Site 500
S2111
G
H
S
E
S
S
D
S
E
V
H
S
G
V
S
Site 501
S2115
S
S
D
S
E
V
H
S
G
V
S
H
T
H
S
Site 502
S2118
S
E
V
H
S
G
V
S
H
T
H
S
G
H
T
Site 503
T2120
V
H
S
G
V
S
H
T
H
S
G
H
T
Y
G
Site 504
S2122
S
G
V
S
H
T
H
S
G
H
T
Y
G
Q
A
Site 505
Y2126
H
T
H
S
G
H
T
Y
G
Q
A
R
S
Q
H
Site 506
S2131
H
T
Y
G
Q
A
R
S
Q
H
G
E
S
G
S
Site 507
S2138
S
Q
H
G
E
S
G
S
A
I
H
G
R
Q
G
Site 508
T2146
A
I
H
G
R
Q
G
T
I
H
G
Q
T
G
D
Site 509
T2154
I
H
G
Q
T
G
D
T
T
R
H
G
Q
S
G
Site 510
T2155
H
G
Q
T
G
D
T
T
R
H
G
Q
S
G
H
Site 511
S2165
G
Q
S
G
H
G
Q
S
T
Q
T
G
S
R
T
Site 512
T2166
Q
S
G
H
G
Q
S
T
Q
T
G
S
R
T
T
Site 513
T2172
S
T
Q
T
G
S
R
T
T
G
R
Q
R
S
S
Site 514
T2173
T
Q
T
G
S
R
T
T
G
R
Q
R
S
S
H
Site 515
S2184
R
S
S
H
S
E
S
S
D
S
E
V
H
S
E
Site 516
S2186
S
H
S
E
S
S
D
S
E
V
H
S
E
A
S
Site 517
S2190
S
S
D
S
E
V
H
S
E
A
S
P
T
H
S
Site 518
S2193
S
E
V
H
S
E
A
S
P
T
H
S
G
H
T
Site 519
T2195
V
H
S
E
A
S
P
T
H
S
G
H
T
H
S
Site 520
S2197
S
E
A
S
P
T
H
S
G
H
T
H
S
Q
A
Site 521
S2202
T
H
S
G
H
T
H
S
Q
A
G
S
R
H
G
Site 522
S2206
H
T
H
S
Q
A
G
S
R
H
G
Q
S
G
S
Site 523
S2211
A
G
S
R
H
G
Q
S
G
S
S
G
H
G
R
Site 524
S2213
S
R
H
G
Q
S
G
S
S
G
H
G
R
Q
G
Site 525
S2214
R
H
G
Q
S
G
S
S
G
H
G
R
Q
G
T
Site 526
T2221
S
G
H
G
R
Q
G
T
T
H
G
Q
T
G
D
Site 527
S2240
A
H
Y
G
Y
G
Q
S
T
Q
R
G
S
R
T
Site 528
T2241
H
Y
G
Y
G
Q
S
T
Q
R
G
S
R
T
T
Site 529
S2259
G
S
G
H
S
E
S
S
D
S
E
V
H
S
W
Site 530
S2261
G
H
S
E
S
S
D
S
E
V
H
S
W
G
S
Site 531
S2265
S
S
D
S
E
V
H
S
W
G
S
H
T
H
S
Site 532
S2268
S
E
V
H
S
W
G
S
H
T
H
S
G
H
I
Site 533
S2281
H
I
Q
G
Q
A
G
S
Q
Q
R
Q
P
G
S
Site 534
S2288
S
Q
Q
R
Q
P
G
S
T
V
H
G
R
L
E
Site 535
T2289
Q
Q
R
Q
P
G
S
T
V
H
G
R
L
E
T
Site 536
T2296
T
V
H
G
R
L
E
T
T
H
G
Q
T
G
D
Site 537
T2304
T
H
G
Q
T
G
D
T
T
R
H
G
H
S
G
Site 538
T2305
H
G
Q
T
G
D
T
T
R
H
G
H
S
G
Y
Site 539
S2310
D
T
T
R
H
G
H
S
G
Y
G
Q
S
T
Q
Site 540
Y2312
T
R
H
G
H
S
G
Y
G
Q
S
T
Q
T
G
Site 541
S2315
G
H
S
G
Y
G
Q
S
T
Q
T
G
S
R
S
Site 542
T2316
H
S
G
Y
G
Q
S
T
Q
T
G
S
R
S
S
Site 543
T2318
G
Y
G
Q
S
T
Q
T
G
S
R
S
S
R
A
Site 544
S2320
G
Q
S
T
Q
T
G
S
R
S
S
R
A
S
H
Site 545
S2322
S
T
Q
T
G
S
R
S
S
R
A
S
H
F
Q
Site 546
S2323
T
Q
T
G
S
R
S
S
R
A
S
H
F
Q
S
Site 547
S2326
G
S
R
S
S
R
A
S
H
F
Q
S
H
S
S
Site 548
S2330
S
R
A
S
H
F
Q
S
H
S
S
E
R
Q
R
Site 549
S2332
A
S
H
F
Q
S
H
S
S
E
R
Q
R
H
G
Site 550
S2333
S
H
F
Q
S
H
S
S
E
R
Q
R
H
G
S
Site 551
S2340
S
E
R
Q
R
H
G
S
S
Q
V
W
K
H
G
Site 552
S2341
E
R
Q
R
H
G
S
S
Q
V
W
K
H
G
S
Site 553
Y2354
G
S
Y
G
P
A
E
Y
D
Y
G
H
T
G
Y
Site 554
Y2356
Y
G
P
A
E
Y
D
Y
G
H
T
G
Y
G
P
Site 555
Y2361
Y
D
Y
G
H
T
G
Y
G
P
S
G
G
S
R
Site 556
S2364
G
H
T
G
Y
G
P
S
G
G
S
R
K
S
I
Site 557
S2367
G
Y
G
P
S
G
G
S
R
K
S
I
S
N
S
Site 558
S2370
P
S
G
G
S
R
K
S
I
S
N
S
H
L
S
Site 559
S2372
G
G
S
R
K
S
I
S
N
S
H
L
S
W
S
Site 560
S2374
S
R
K
S
I
S
N
S
H
L
S
W
S
T
D
Site 561
S2377
S
I
S
N
S
H
L
S
W
S
T
D
S
T
A
Site 562
T2383
L
S
W
S
T
D
S
T
A
N
K
Q
L
S
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation