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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZRANB3
Full Name:
Zinc finger Ran-binding domain-containing protein 3
Alias:
DKFZP434B1727; zinc finger, RAN-binding domain containing 3; ZRAB3
Type:
EC 3.6.1.-; Helicase
Mass (Da):
123230
Number AA:
1079
UniProt ID:
Q5FWF4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0004519
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
R
V
H
N
I
K
K
S
L
T
P
H
I
S
C
Site 2
T12
H
N
I
K
K
S
L
T
P
H
I
S
C
V
T
Site 3
S16
K
S
L
T
P
H
I
S
C
V
T
N
E
S
D
Site 4
Y74
I
Q
A
I
G
I
T
Y
F
Y
K
E
E
W
P
Site 5
Y92
V
V
P
S
S
L
R
Y
P
W
T
E
E
I
E
Site 6
T95
S
S
L
R
Y
P
W
T
E
E
I
E
K
W
I
Site 7
S106
E
K
W
I
P
E
L
S
P
E
E
I
N
V
I
Site 8
T117
I
N
V
I
Q
N
K
T
D
V
R
R
M
S
T
Site 9
S123
K
T
D
V
R
R
M
S
T
S
K
V
T
V
L
Site 10
T124
T
D
V
R
R
M
S
T
S
K
V
T
V
L
G
Site 11
S125
D
V
R
R
M
S
T
S
K
V
T
V
L
G
Y
Site 12
S164
D
E
S
H
Y
M
K
S
R
N
A
T
R
S
R
Site 13
T168
Y
M
K
S
R
N
A
T
R
S
R
I
L
L
P
Site 14
S170
K
S
R
N
A
T
R
S
R
I
L
L
P
I
V
Site 15
Y216
K
F
G
R
W
T
D
Y
A
K
R
Y
C
N
A
Site 16
S250
N
E
L
H
Q
L
L
S
D
I
M
I
R
R
L
Site 17
T263
R
L
K
T
E
V
L
T
Q
L
P
P
K
V
R
Site 18
S279
R
I
P
F
D
L
P
S
A
A
A
K
E
L
N
Site 19
S288
A
A
K
E
L
N
T
S
F
E
E
W
E
K
I
Site 20
T298
E
W
E
K
I
M
R
T
P
N
S
G
A
M
E
Site 21
S301
K
I
M
R
T
P
N
S
G
A
M
E
T
V
M
Site 22
Y329
K
A
G
A
V
K
D
Y
I
K
M
M
L
Q
N
Site 23
Y365
V
I
E
N
K
T
R
Y
I
R
I
D
G
S
V
Site 24
S371
R
Y
I
R
I
D
G
S
V
S
S
S
E
R
I
Site 25
S373
I
R
I
D
G
S
V
S
S
S
E
R
I
H
L
Site 26
S374
R
I
D
G
S
V
S
S
S
E
R
I
H
L
V
Site 27
S375
I
D
G
S
V
S
S
S
E
R
I
H
L
V
N
Site 28
T390
Q
F
Q
K
D
P
D
T
R
V
A
I
L
S
I
Site 29
Y418
H
V
V
F
A
E
L
Y
W
D
P
G
H
I
K
Site 30
T466
L
N
R
K
A
Q
V
T
G
S
T
L
N
G
R
Site 31
T497
L
Q
F
A
E
A
W
T
P
N
D
S
S
E
E
Site 32
S501
E
A
W
T
P
N
D
S
S
E
E
L
R
K
E
Site 33
S502
A
W
T
P
N
D
S
S
E
E
L
R
K
E
A
Site 34
T512
L
R
K
E
A
L
F
T
H
F
E
K
E
K
Q
Site 35
S524
E
K
Q
H
D
I
R
S
F
F
V
P
Q
P
K
Site 36
T537
P
K
K
R
Q
L
M
T
S
C
D
E
S
K
R
Site 37
S538
K
K
R
Q
L
M
T
S
C
D
E
S
K
R
F
Site 38
S542
L
M
T
S
C
D
E
S
K
R
F
R
E
E
N
Site 39
T550
K
R
F
R
E
E
N
T
V
V
S
S
D
P
T
Site 40
S554
E
E
N
T
V
V
S
S
D
P
T
K
T
A
A
Site 41
T557
T
V
V
S
S
D
P
T
K
T
A
A
R
D
I
Site 42
T559
V
S
S
D
P
T
K
T
A
A
R
D
I
I
D
Site 43
Y567
A
A
R
D
I
I
D
Y
E
S
D
V
E
P
E
Site 44
S569
R
D
I
I
D
Y
E
S
D
V
E
P
E
T
K
Site 45
T575
E
S
D
V
E
P
E
T
K
R
L
K
L
A
A
Site 46
S583
K
R
L
K
L
A
A
S
E
D
H
C
S
P
S
Site 47
S588
A
A
S
E
D
H
C
S
P
S
E
E
T
P
S
Site 48
S590
S
E
D
H
C
S
P
S
E
E
T
P
S
Q
S
Site 49
T593
H
C
S
P
S
E
E
T
P
S
Q
S
K
Q
I
Site 50
S595
S
P
S
E
E
T
P
S
Q
S
K
Q
I
R
T
Site 51
S597
S
E
E
T
P
S
Q
S
K
Q
I
R
T
P
L
Site 52
T602
S
Q
S
K
Q
I
R
T
P
L
V
E
S
V
Q
Site 53
T617
E
A
K
A
Q
L
T
T
P
A
F
P
V
E
G
Site 54
Y632
W
Q
C
S
L
C
T
Y
I
N
N
S
E
L
P
Site 55
Y640
I
N
N
S
E
L
P
Y
C
E
M
C
E
T
P
Site 56
S657
S
A
V
M
Q
I
D
S
L
N
H
I
Q
D
K
Site 57
S670
D
K
N
E
K
D
D
S
Q
K
D
T
S
K
K
Site 58
T674
K
D
D
S
Q
K
D
T
S
K
K
V
Q
T
I
Site 59
S675
D
D
S
Q
K
D
T
S
K
K
V
Q
T
I
S
Site 60
S682
S
K
K
V
Q
T
I
S
D
C
E
K
Q
A
L
Site 61
S692
E
K
Q
A
L
A
Q
S
E
P
G
Q
L
A
D
Site 62
S700
E
P
G
Q
L
A
D
S
K
E
E
T
P
K
I
Site 63
T704
L
A
D
S
K
E
E
T
P
K
I
E
K
E
D
Site 64
T714
I
E
K
E
D
G
L
T
S
Q
P
G
N
E
Q
Site 65
S715
E
K
E
D
G
L
T
S
Q
P
G
N
E
Q
W
Site 66
S724
P
G
N
E
Q
W
K
S
S
D
T
L
P
V
Y
Site 67
T727
E
Q
W
K
S
S
D
T
L
P
V
Y
D
T
L
Site 68
Y748
N
T
D
R
I
H
I
Y
T
K
D
G
K
Q
M
Site 69
T749
T
D
R
I
H
I
Y
T
K
D
G
K
Q
M
S
Site 70
S775
L
W
E
D
L
P
A
S
F
Q
L
K
Q
Y
R
Site 71
Y781
A
S
F
Q
L
K
Q
Y
R
S
L
I
L
R
F
Site 72
S783
F
Q
L
K
Q
Y
R
S
L
I
L
R
F
V
R
Site 73
S793
L
R
F
V
R
E
W
S
S
L
T
A
M
K
Q
Site 74
S794
R
F
V
R
E
W
S
S
L
T
A
M
K
Q
R
Site 75
S806
K
Q
R
I
I
R
K
S
G
Q
L
F
C
S
P
Site 76
T835
N
C
T
K
R
Y
I
T
K
E
D
V
A
V
A
Site 77
T858
G
G
H
V
R
L
I
T
K
E
S
R
P
R
D
Site 78
S861
V
R
L
I
T
K
E
S
R
P
R
D
P
F
T
Site 79
T868
S
R
P
R
D
P
F
T
K
K
L
L
E
D
G
Site 80
Y884
C
V
P
F
L
N
P
Y
T
V
Q
A
D
L
T
Site 81
T885
V
P
F
L
N
P
Y
T
V
Q
A
D
L
T
V
Site 82
T891
Y
T
V
Q
A
D
L
T
V
K
P
S
T
S
K
Site 83
S895
A
D
L
T
V
K
P
S
T
S
K
G
Y
L
Q
Site 84
Y952
W
I
R
S
N
N
S
Y
L
R
A
K
V
F
E
Site 85
S985
R
L
R
D
A
P
K
S
Q
R
K
N
L
L
Y
Site 86
Y992
S
Q
R
K
N
L
L
Y
A
T
W
T
S
K
L
Site 87
Y1026
V
D
H
I
K
P
V
Y
G
G
G
G
Q
C
S
Site 88
S1033
Y
G
G
G
G
Q
C
S
L
D
N
L
Q
T
L
Site 89
T1042
D
N
L
Q
T
L
C
T
V
C
H
K
E
R
T
Site 90
S1057
A
R
Q
A
K
E
R
S
Q
V
R
R
Q
S
L
Site 91
S1063
R
S
Q
V
R
R
Q
S
L
A
S
K
H
G
S
Site 92
S1066
V
R
R
Q
S
L
A
S
K
H
G
S
D
I
T
Site 93
S1070
S
L
A
S
K
H
G
S
D
I
T
R
F
L
V
Site 94
T1073
S
K
H
G
S
D
I
T
R
F
L
V
K
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation