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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HERC4
Full Name:
Probable E3 ubiquitin-protein ligase HERC4
Alias:
DKFZP564G092; EC 6.3.2.-; Hect domain and RLD 4; KIAA1593; Probable E3 ubiquitin-protein ligase HERC4
Type:
EC 6.3.2.-; Ubiquitin ligase; Ligase; Ubiquitin conjugating system
Mass (Da):
118563
Number AA:
1057
UniProt ID:
Q5GLZ8
International Prot ID:
IPI00333067
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0016881
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
I
V
L
E
P
R
K
S
D
F
F
I
N
K
R
Site 2
S71
G
Q
L
G
H
E
K
S
R
K
K
P
E
Q
V
Site 3
Y106
L
N
D
K
G
Q
V
Y
A
W
G
L
D
S
D
Site 4
S133
R
V
P
R
N
I
K
S
L
S
D
I
Q
I
V
Site 5
S135
P
R
N
I
K
S
L
S
D
I
Q
I
V
Q
V
Site 6
Y166
F
C
W
G
Q
N
K
Y
G
Q
L
G
L
G
T
Site 7
T173
Y
G
Q
L
G
L
G
T
D
C
K
K
Q
T
S
Site 8
S180
T
D
C
K
K
Q
T
S
P
Q
L
L
K
S
L
Site 9
Y231
L
N
D
E
N
D
R
Y
V
P
N
L
L
K
S
Site 10
S238
Y
V
P
N
L
L
K
S
L
R
S
Q
K
I
V
Site 11
Y246
L
R
S
Q
K
I
V
Y
I
C
C
G
E
D
H
Site 12
T265
T
K
E
G
G
V
F
T
F
G
A
G
G
Y
G
Site 13
T306
I
A
C
G
R
Q
H
T
S
A
F
V
P
S
S
Site 14
S307
A
C
G
R
Q
H
T
S
A
F
V
P
S
S
G
Site 15
Y317
V
P
S
S
G
R
I
Y
S
F
G
L
G
G
N
Site 16
S318
P
S
S
G
R
I
Y
S
F
G
L
G
G
N
G
Site 17
T329
G
G
N
G
Q
L
G
T
G
S
T
S
N
R
K
Site 18
S331
N
G
Q
L
G
T
G
S
T
S
N
R
K
S
P
Site 19
T332
G
Q
L
G
T
G
S
T
S
N
R
K
S
P
F
Site 20
S333
Q
L
G
T
G
S
T
S
N
R
K
S
P
F
T
Site 21
S337
G
S
T
S
N
R
K
S
P
F
T
V
K
G
N
Site 22
T340
S
N
R
K
S
P
F
T
V
K
G
N
W
Y
P
Site 23
Y348
V
K
G
N
W
Y
P
Y
N
G
Q
C
L
P
D
Site 24
Y361
P
D
I
D
S
E
E
Y
F
C
V
K
R
I
F
Site 25
S369
F
C
V
K
R
I
F
S
G
G
D
Q
S
F
S
Site 26
S374
I
F
S
G
G
D
Q
S
F
S
H
Y
S
S
P
Site 27
S376
S
G
G
D
Q
S
F
S
H
Y
S
S
P
Q
N
Site 28
Y378
G
D
Q
S
F
S
H
Y
S
S
P
Q
N
C
G
Site 29
S380
Q
S
F
S
H
Y
S
S
P
Q
N
C
G
P
P
Site 30
T401
N
P
T
K
Q
I
W
T
V
N
E
A
L
I
Q
Site 31
S412
A
L
I
Q
K
W
L
S
Y
P
S
G
R
F
P
Site 32
Y413
L
I
Q
K
W
L
S
Y
P
S
G
R
F
P
V
Site 33
S415
Q
K
W
L
S
Y
P
S
G
R
F
P
V
E
I
Site 34
S431
N
E
I
D
G
T
F
S
S
S
G
C
L
N
G
Site 35
S432
E
I
D
G
T
F
S
S
S
G
C
L
N
G
S
Site 36
Y449
A
V
S
N
D
D
H
Y
R
T
G
T
R
F
S
Site 37
T451
S
N
D
D
H
Y
R
T
G
T
R
F
S
G
V
Site 38
T453
D
D
H
Y
R
T
G
T
R
F
S
G
V
D
M
Site 39
S456
Y
R
T
G
T
R
F
S
G
V
D
M
N
A
A
Site 40
S479
Q
P
D
H
P
Q
I
S
Q
Q
V
A
A
S
L
Site 41
S517
L
P
E
C
P
L
M
S
D
S
N
N
F
T
T
Site 42
S519
E
C
P
L
M
S
D
S
N
N
F
T
T
I
A
Site 43
S581
Y
K
I
G
I
P
P
S
E
R
R
I
F
N
S
Site 44
S588
S
E
R
R
I
F
N
S
F
L
H
T
A
L
K
Site 45
Y613
K
M
G
Q
I
I
Q
Y
D
K
F
Y
I
H
E
Site 46
Y617
I
I
Q
Y
D
K
F
Y
I
H
E
V
Q
E
L
Site 47
Y631
L
I
D
I
R
N
D
Y
I
N
W
V
Q
Q
Q
Site 48
T729
A
M
E
V
L
R
K
T
K
N
I
D
Y
K
K
Site 49
Y734
R
K
T
K
N
I
D
Y
K
K
P
L
K
V
I
Site 50
Y770
R
E
L
L
D
P
K
Y
G
M
F
R
Y
Y
E
Site 51
Y775
P
K
Y
G
M
F
R
Y
Y
E
D
S
R
L
I
Site 52
Y776
K
Y
G
M
F
R
Y
Y
E
D
S
R
L
I
W
Site 53
S785
D
S
R
L
I
W
F
S
D
K
T
F
E
D
S
Site 54
T788
L
I
W
F
S
D
K
T
F
E
D
S
D
L
F
Site 55
S792
S
D
K
T
F
E
D
S
D
L
F
H
L
I
G
Site 56
Y821
L
H
F
P
L
A
L
Y
K
K
L
L
K
K
K
Site 57
S830
K
L
L
K
K
K
P
S
L
D
D
L
K
E
L
Site 58
Y851
S
M
Q
Q
L
L
D
Y
P
E
D
D
I
E
E
Site 59
T886
L
V
L
N
G
A
D
T
A
V
N
K
Q
N
R
Site 60
Y900
R
Q
E
F
V
D
A
Y
V
D
Y
I
F
N
K
Site 61
Y947
M
V
I
G
N
T
N
Y
D
W
K
E
L
E
K
Site 62
S1011
S
L
K
L
V
I
Q
S
T
G
G
G
E
E
Y
Site 63
Y1018
S
T
G
G
G
E
E
Y
L
P
V
S
H
T
C
Site 64
Y1034
N
L
L
D
L
P
K
Y
T
E
K
E
T
L
R
Site 65
T1039
P
K
Y
T
E
K
E
T
L
R
S
K
L
I
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation