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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FREM1
Full Name:
FRAS1-related extracellular matrix protein 1
Alias:
Protein QBRICK
Type:
Mass (Da):
244154
Number AA:
2179
UniProt ID:
Q5H8C1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S43
K
G
H
S
A
F
L
S
G
D
D
L
K
F
A
Site 2
T69
V
V
M
N
E
P
I
T
Q
R
V
G
K
L
T
Site 3
T76
T
Q
R
V
G
K
L
T
P
Q
V
F
D
C
H
Site 4
Y91
F
L
P
N
E
V
K
Y
V
H
N
G
C
P
I
Site 5
T103
C
P
I
L
D
E
D
T
V
K
L
R
L
Y
R
Site 6
Y109
D
T
V
K
L
R
L
Y
R
F
T
E
R
D
T
Site 7
T112
K
L
R
L
Y
R
F
T
E
R
D
T
F
I
E
Site 8
T116
Y
R
F
T
E
R
D
T
F
I
E
T
F
I
L
Site 9
S151
V
P
E
F
N
G
L
S
Q
A
I
D
K
N
L
Site 10
Y163
K
N
L
L
R
F
D
Y
D
R
M
A
S
L
E
Site 11
T172
R
M
A
S
L
E
C
T
V
S
L
D
T
A
R
Site 12
S174
A
S
L
E
C
T
V
S
L
D
T
A
R
T
R
Site 13
T177
E
C
T
V
S
L
D
T
A
R
T
R
L
P
A
Site 14
S205
P
R
G
D
Q
P
H
S
F
F
P
E
S
Q
L
Site 15
S210
P
H
S
F
F
P
E
S
Q
L
R
A
K
L
K
Site 16
S222
K
L
K
C
P
G
G
S
C
T
P
G
L
K
K
Site 17
T224
K
C
P
G
G
S
C
T
P
G
L
K
K
I
G
Site 18
S232
P
G
L
K
K
I
G
S
L
K
V
S
C
E
E
Site 19
Y247
F
L
L
M
G
L
R
Y
Q
H
L
D
P
P
S
Site 20
S254
Y
Q
H
L
D
P
P
S
P
N
I
D
Y
I
S
Site 21
Y259
P
P
S
P
N
I
D
Y
I
S
I
Q
L
D
L
Site 22
S261
S
P
N
I
D
Y
I
S
I
Q
L
D
L
T
D
Site 23
T269
I
Q
L
D
L
T
D
T
R
S
K
I
V
Y
K
Site 24
S271
L
D
L
T
D
T
R
S
K
I
V
Y
K
S
E
Site 25
Y275
D
T
R
S
K
I
V
Y
K
S
E
S
A
W
L
Site 26
S277
R
S
K
I
V
Y
K
S
E
S
A
W
L
P
V
Site 27
T327
L
D
C
E
E
D
E
T
P
K
P
L
L
V
F
Site 28
Y344
T
K
A
P
L
Q
G
Y
V
T
H
L
L
D
H
Site 29
T352
V
T
H
L
L
D
H
T
R
P
I
S
S
F
T
Site 30
S356
L
D
H
T
R
P
I
S
S
F
T
W
K
D
L
Site 31
S357
D
H
T
R
P
I
S
S
F
T
W
K
D
L
S
Site 32
Y370
L
S
D
M
Q
I
A
Y
Q
P
P
N
S
S
H
Site 33
S375
I
A
Y
Q
P
P
N
S
S
H
S
E
R
R
H
Site 34
S376
A
Y
Q
P
P
N
S
S
H
S
E
R
R
H
D
Site 35
S378
Q
P
P
N
S
S
H
S
E
R
R
H
D
E
V
Site 36
Y390
D
E
V
E
L
E
V
Y
D
F
F
F
E
R
S
Site 37
T401
F
E
R
S
A
P
M
T
V
H
I
S
I
R
T
Site 38
S405
A
P
M
T
V
H
I
S
I
R
T
A
D
T
N
Site 39
T411
I
S
I
R
T
A
D
T
N
A
P
R
V
S
W
Site 40
S417
D
T
N
A
P
R
V
S
W
N
T
G
L
S
L
Site 41
T420
A
P
R
V
S
W
N
T
G
L
S
L
L
E
G
Site 42
S423
V
S
W
N
T
G
L
S
L
L
E
G
Q
S
R
Site 43
S429
L
S
L
L
E
G
Q
S
R
A
I
T
W
E
Q
Site 44
T433
E
G
Q
S
R
A
I
T
W
E
Q
F
Q
V
V
Site 45
T462
G
L
Q
H
G
W
L
T
L
R
G
G
K
G
F
Site 46
S488
V
R
Y
H
H
D
D
S
D
S
T
K
D
F
V
Site 47
S520
N
V
L
P
K
D
D
S
P
P
F
L
I
T
N
Site 48
S548
Q
G
S
M
L
R
A
S
D
V
D
A
S
D
D
Site 49
S553
R
A
S
D
V
D
A
S
D
D
Y
I
F
F
N
Site 50
Y556
D
V
D
A
S
D
D
Y
I
F
F
N
I
T
K
Site 51
Y597
D
L
F
N
G
I
I
Y
Y
R
H
F
G
G
E
Site 52
S617
F
Q
F
V
L
W
D
S
H
E
P
P
N
L
S
Site 53
S624
S
H
E
P
P
N
L
S
V
P
Q
V
A
T
I
Site 54
S671
K
Q
L
H
F
I
D
S
E
S
Y
D
R
E
L
Site 55
S673
L
H
F
I
D
S
E
S
Y
D
R
E
L
V
Y
Site 56
Y674
H
F
I
D
S
E
S
Y
D
R
E
L
V
Y
T
Site 57
Y680
S
Y
D
R
E
L
V
Y
T
I
T
T
P
P
F
Site 58
T681
Y
D
R
E
L
V
Y
T
I
T
T
P
P
F
F
Site 59
S689
I
T
T
P
P
F
F
S
F
S
H
R
H
L
D
Site 60
S691
T
P
P
F
F
S
F
S
H
R
H
L
D
A
G
Site 61
S720
P
T
A
L
E
L
R
S
F
T
Q
H
A
V
N
Site 62
T722
A
L
E
L
R
S
F
T
Q
H
A
V
N
Y
M
Site 63
Y733
V
N
Y
M
K
V
A
Y
M
P
P
M
Q
D
I
Site 64
S752
R
D
V
Q
F
T
F
S
V
S
N
Q
H
G
G
Site 65
S754
V
Q
F
T
F
S
V
S
N
Q
H
G
G
T
L
Site 66
S793
K
V
T
E
G
G
Q
S
I
I
S
T
E
H
I
Site 67
S803
S
T
E
H
I
L
I
S
D
A
D
T
K
L
D
Site 68
S815
K
L
D
N
I
D
L
S
L
R
E
L
P
L
H
Site 69
S834
L
N
G
F
P
L
N
S
G
G
T
F
S
W
G
Site 70
T837
F
P
L
N
S
G
G
T
F
S
W
G
D
L
H
Site 71
S839
L
N
S
G
G
T
F
S
W
G
D
L
H
T
L
Site 72
T845
F
S
W
G
D
L
H
T
L
K
V
R
Y
Q
H
Site 73
T855
V
R
Y
Q
H
D
G
T
E
V
L
Q
D
D
L
Site 74
T917
T
S
E
Y
I
F
A
T
D
V
D
S
D
N
L
Site 75
T945
V
V
R
R
A
G
V
T
V
D
Q
F
S
Q
R
Site 76
S950
G
V
T
V
D
Q
F
S
Q
R
D
V
I
S
E
Site 77
S956
F
S
Q
R
D
V
I
S
E
A
V
T
Y
K
H
Site 78
T960
D
V
I
S
E
A
V
T
Y
K
H
T
G
G
E
Site 79
Y961
V
I
S
E
A
V
T
Y
K
H
T
G
G
E
I
Site 80
Y995
P
F
V
N
G
C
C
Y
N
G
P
N
P
S
V
Site 81
S1001
C
Y
N
G
P
N
P
S
V
P
L
H
A
S
F
Site 82
T1016
P
V
Y
D
L
N
I
T
V
Y
P
V
D
N
Q
Site 83
Y1018
Y
D
L
N
I
T
V
Y
P
V
D
N
Q
P
P
Site 84
T1055
L
S
A
T
D
P
D
T
A
A
D
D
L
E
F
Site 85
Y1072
V
S
P
P
Q
F
G
Y
L
E
N
I
L
P
S
Site 86
S1085
P
S
V
G
F
E
K
S
N
I
G
I
S
I
D
Site 87
Y1106
M
N
A
F
H
I
N
Y
V
Q
S
R
H
L
R
Site 88
T1117
R
H
L
R
I
E
P
T
A
D
Q
F
T
V
Y
Site 89
T1122
E
P
T
A
D
Q
F
T
V
Y
V
T
D
G
K
Site 90
Y1124
T
A
D
Q
F
T
V
Y
V
T
D
G
K
H
H
Site 91
S1132
V
T
D
G
K
H
H
S
L
E
I
P
F
S
I
Site 92
S1168
G
Q
M
K
E
L
D
S
S
I
I
S
A
V
D
Site 93
S1186
P
Q
D
A
L
L
F
S
I
T
Q
K
P
R
H
Site 94
T1188
D
A
L
L
F
S
I
T
Q
K
P
R
H
G
L
Site 95
S1202
L
L
I
D
R
G
F
S
K
D
F
S
E
N
K
Site 96
S1206
R
G
F
S
K
D
F
S
E
N
K
Q
P
A
N
Site 97
S1223
Q
K
H
A
P
V
H
S
F
S
M
E
L
L
K
Site 98
T1236
L
K
T
G
M
R
L
T
Y
M
H
D
D
S
E
Site 99
Y1237
K
T
G
M
R
L
T
Y
M
H
D
D
S
E
S
Site 100
S1242
L
T
Y
M
H
D
D
S
E
S
L
A
D
D
F
Site 101
S1244
Y
M
H
D
D
S
E
S
L
A
D
D
F
T
I
Site 102
T1250
E
S
L
A
D
D
F
T
I
Q
L
S
D
G
K
Site 103
S1254
D
D
F
T
I
Q
L
S
D
G
K
H
K
I
L
Site 104
S1279
N
D
E
K
P
M
L
S
K
K
A
E
I
A
M
Site 105
S1306
L
S
A
I
D
E
D
S
P
R
E
K
I
Y
Y
Site 106
Y1312
D
S
P
R
E
K
I
Y
Y
V
F
E
R
L
P
Site 107
Y1313
S
P
R
E
K
I
Y
Y
V
F
E
R
L
P
Q
Site 108
S1336
G
R
D
W
V
P
L
S
P
G
M
K
C
T
Q
Site 109
Y1353
V
D
L
N
L
L
R
Y
T
H
T
G
A
M
D
Site 110
T1354
D
L
N
L
L
R
Y
T
H
T
G
A
M
D
S
Site 111
S1361
T
H
T
G
A
M
D
S
Q
N
Q
D
S
F
T
Site 112
Y1370
N
Q
D
S
F
T
F
Y
L
W
D
G
N
N
R
Site 113
S1378
L
W
D
G
N
N
R
S
P
A
L
D
C
Q
I
Site 114
T1423
T
L
L
A
V
D
G
T
D
K
P
E
E
L
L
Site 115
Y1431
D
K
P
E
E
L
L
Y
V
I
T
S
P
P
R
Site 116
T1434
E
E
L
L
Y
V
I
T
S
P
P
R
Y
G
Q
Site 117
Y1439
V
I
T
S
P
P
R
Y
G
Q
I
E
Y
V
H
Site 118
Y1444
P
R
Y
G
Q
I
E
Y
V
H
Y
P
G
V
P
Site 119
Y1447
G
Q
I
E
Y
V
H
Y
P
G
V
P
I
T
N
Site 120
S1471
T
V
C
Y
V
H
K
S
K
V
T
V
S
S
D
Site 121
S1476
H
K
S
K
V
T
V
S
S
D
R
F
R
F
I
Site 122
S1477
K
S
K
V
T
V
S
S
D
R
F
R
F
I
I
Site 123
T1533
S
P
D
L
L
Q
L
T
D
P
D
T
P
A
E
Site 124
T1537
L
Q
L
T
D
P
D
T
P
A
E
N
L
T
F
Site 125
T1568
G
L
L
Q
H
N
F
T
Q
Q
D
V
D
S
K
Site 126
S1582
K
N
V
A
Y
R
H
S
G
G
D
S
Q
T
D
Site 127
S1586
Y
R
H
S
G
G
D
S
Q
T
D
C
F
T
F
Site 128
T1626
Q
V
D
Q
L
D
K
T
A
P
R
I
T
L
L
Site 129
T1631
D
K
T
A
P
R
I
T
L
L
H
S
P
S
Q
Site 130
Y1650
K
N
G
C
Y
G
I
Y
I
T
S
R
V
L
K
Site 131
S1659
T
S
R
V
L
K
A
S
D
P
D
T
E
D
D
Site 132
T1663
L
K
A
S
D
P
D
T
E
D
D
Q
I
I
F
Site 133
T1686
G
H
L
E
N
T
T
T
G
E
F
I
H
E
K
Site 134
S1695
E
F
I
H
E
K
F
S
Q
K
D
L
N
S
K
Site 135
S1701
F
S
Q
K
D
L
N
S
K
T
I
L
Y
I
I
Site 136
T1703
Q
K
D
L
N
S
K
T
I
L
Y
I
I
N
P
Site 137
T1718
S
L
E
V
N
S
D
T
V
E
F
Q
I
M
D
Site 138
T1727
E
F
Q
I
M
D
P
T
G
N
S
A
T
P
Q
Site 139
T1732
D
P
T
G
N
S
A
T
P
Q
I
L
E
L
K
Site 140
Y1750
I
E
W
S
Q
T
E
Y
E
V
C
E
N
V
G
Site 141
S1769
E
I
I
R
R
G
Y
S
M
D
S
A
F
V
G
Site 142
S1850
A
A
V
K
I
L
D
S
K
G
G
Q
C
H
P
Site 143
S1858
K
G
G
Q
C
H
P
S
Y
S
S
N
Q
S
K
Site 144
Y1859
G
G
Q
C
H
P
S
Y
S
S
N
Q
S
K
H
Site 145
S1860
G
Q
C
H
P
S
Y
S
S
N
Q
S
K
H
S
Site 146
S1861
Q
C
H
P
S
Y
S
S
N
Q
S
K
H
S
T
Site 147
S1864
P
S
Y
S
S
N
Q
S
K
H
S
T
W
E
K
Site 148
S1867
S
S
N
Q
S
K
H
S
T
W
E
K
G
I
W
Site 149
S1881
W
H
L
L
P
P
G
S
S
S
S
T
T
S
G
Site 150
S1882
H
L
L
P
P
G
S
S
S
S
T
T
S
G
S
Site 151
S1883
L
L
P
P
G
S
S
S
S
T
T
S
G
S
F
Site 152
S1884
L
P
P
G
S
S
S
S
T
T
S
G
S
F
H
Site 153
T1885
P
P
G
S
S
S
S
T
T
S
G
S
F
H
L
Site 154
T1886
P
G
S
S
S
S
T
T
S
G
S
F
H
L
E
Site 155
S1887
G
S
S
S
S
T
T
S
G
S
F
H
L
E
R
Site 156
S1889
S
S
S
T
T
S
G
S
F
H
L
E
R
R
P
Site 157
S1900
E
R
R
P
L
P
S
S
M
Q
L
A
V
I
R
Site 158
T1910
L
A
V
I
R
G
D
T
L
R
G
F
D
S
T
Site 159
S1916
D
T
L
R
G
F
D
S
T
D
L
S
Q
R
K
Site 160
T1917
T
L
R
G
F
D
S
T
D
L
S
Q
R
K
L
Site 161
S1920
G
F
D
S
T
D
L
S
Q
R
K
L
R
T
R
Site 162
T1932
R
T
R
G
N
G
K
T
V
R
P
S
S
V
Y
Site 163
S1936
N
G
K
T
V
R
P
S
S
V
Y
R
N
G
T
Site 164
S1937
G
K
T
V
R
P
S
S
V
Y
R
N
G
T
D
Site 165
Y1939
T
V
R
P
S
S
V
Y
R
N
G
T
D
I
I
Site 166
T1943
S
S
V
Y
R
N
G
T
D
I
I
Y
N
Y
H
Site 167
Y1947
R
N
G
T
D
I
I
Y
N
Y
H
G
I
V
S
Site 168
S1954
Y
N
Y
H
G
I
V
S
L
K
L
E
D
D
S
Site 169
S1961
S
L
K
L
E
D
D
S
F
P
T
H
K
R
K
Site 170
T1964
L
E
D
D
S
F
P
T
H
K
R
K
A
K
V
Site 171
S1972
H
K
R
K
A
K
V
S
I
I
S
Q
P
Q
K
Site 172
S1975
K
A
K
V
S
I
I
S
Q
P
Q
K
T
I
K
Site 173
S1994
P
Q
A
D
K
V
E
S
T
T
D
S
H
F
P
Site 174
T1996
A
D
K
V
E
S
T
T
D
S
H
F
P
R
Q
Site 175
S1998
K
V
E
S
T
T
D
S
H
F
P
R
Q
D
Q
Site 176
S2008
P
R
Q
D
Q
L
P
S
F
P
K
N
C
T
L
Site 177
T2014
P
S
F
P
K
N
C
T
L
E
L
K
G
L
F
Site 178
Y2031
E
E
G
I
Q
K
L
Y
Q
C
N
G
I
A
W
Site 179
S2042
G
I
A
W
K
A
W
S
P
Q
T
K
D
V
E
Site 180
T2092
Q
Y
L
G
N
L
V
T
V
F
S
R
Q
H
M
Site 181
T2135
G
G
E
P
V
A
F
T
N
G
R
R
G
P
S
Site 182
S2142
T
N
G
R
R
G
P
S
Q
R
S
K
L
G
K
Site 183
S2150
Q
R
S
K
L
G
K
S
C
V
L
V
Q
R
Q
Site 184
Y2173
R
R
A
K
P
H
N
Y
V
C
S
R
K
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation