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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM67
Full Name:
Meckelin
Alias:
Meckel syndrome type 3 protein;Transmembrane protein 67
Type:
Mass (Da):
111731
Number AA:
995
UniProt ID:
Q5HYA8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T38
P
R
F
L
Q
A
Q
T
F
S
F
P
F
Q
Q
Site 2
S40
F
L
Q
A
Q
T
F
S
F
P
F
Q
Q
P
E
Site 3
Y54
E
K
C
D
N
N
Q
Y
F
D
I
S
A
L
S
Site 4
T76
Q
R
Q
D
A
R
G
T
S
C
V
C
L
P
G
Site 5
S77
R
Q
D
A
R
G
T
S
C
V
C
L
P
G
F
Site 6
T122
I
S
C
P
S
D
L
T
A
E
G
K
C
H
C
Site 7
T143
V
E
R
D
I
N
G
T
L
L
S
Q
A
T
C
Site 8
T176
R
C
V
R
C
E
P
T
F
V
N
T
S
R
S
Site 9
S183
T
F
V
N
T
S
R
S
C
A
C
S
E
P
N
Site 10
S187
T
S
R
S
C
A
C
S
E
P
N
I
L
T
G
Site 11
S200
T
G
G
L
C
F
S
S
T
G
N
F
P
L
R
Site 12
T201
G
G
L
C
F
S
S
T
G
N
F
P
L
R
R
Site 13
S210
N
F
P
L
R
R
I
S
A
A
R
Y
G
E
V
Site 14
Y214
R
R
I
S
A
A
R
Y
G
E
V
G
M
S
L
Site 15
S220
R
Y
G
E
V
G
M
S
L
T
S
E
W
F
A
Site 16
Y229
T
S
E
W
F
A
K
Y
L
Q
S
S
A
A
A
Site 17
T283
E
N
T
A
G
L
S
T
V
H
S
I
S
F
W
Site 18
S286
A
G
L
S
T
V
H
S
I
S
F
W
R
Q
N
Site 19
S288
L
S
T
V
H
S
I
S
F
W
R
Q
N
L
P
Site 20
S314
P
Q
V
L
S
S
T
S
L
P
T
N
F
S
F
Site 21
S320
T
S
L
P
T
N
F
S
F
K
G
E
N
Q
N
Site 22
T328
F
K
G
E
N
Q
N
T
K
L
K
F
V
A
A
Site 23
T360
V
L
Q
L
C
P
D
T
E
T
R
L
N
A
A
Site 24
Y368
E
T
R
L
N
A
A
Y
S
F
G
T
T
Y
Q
Site 25
S369
T
R
L
N
A
A
Y
S
F
G
T
T
Y
Q
Q
Site 26
Y374
A
Y
S
F
G
T
T
Y
Q
Q
N
C
E
I
P
Site 27
Y395
D
F
P
T
P
I
F
Y
D
V
Y
L
E
Y
T
Site 28
Y398
T
P
I
F
Y
D
V
Y
L
E
Y
T
D
E
N
Site 29
Y401
F
Y
D
V
Y
L
E
Y
T
D
E
N
Q
H
Q
Site 30
S431
K
I
F
V
N
Q
D
S
N
S
G
K
W
L
L
Site 31
S433
F
V
N
Q
D
S
N
S
G
K
W
L
L
T
R
Site 32
T439
N
S
G
K
W
L
L
T
R
R
I
F
L
V
D
Site 33
S449
I
F
L
V
D
A
V
S
G
R
E
N
D
L
G
Site 34
T457
G
R
E
N
D
L
G
T
Q
P
R
V
I
R
V
Site 35
T478
S
V
H
L
V
P
N
T
I
N
G
N
I
Y
P
Site 36
S502
I
D
I
K
D
A
N
S
Q
S
V
K
V
S
F
Site 37
S504
I
K
D
A
N
S
Q
S
V
K
V
S
F
S
V
Site 38
S508
N
S
Q
S
V
K
V
S
F
S
V
T
Y
E
M
Site 39
S510
Q
S
V
K
V
S
F
S
V
T
Y
E
M
D
H
Site 40
T512
V
K
V
S
F
S
V
T
Y
E
M
D
H
G
E
Site 41
S552
G
W
K
R
R
I
G
S
P
M
I
D
L
Q
T
Site 42
T662
E
G
G
V
R
S
A
T
V
P
V
S
I
W
R
Site 43
T682
N
E
W
N
E
I
Q
T
V
R
K
I
N
S
L
Site 44
S712
K
N
L
A
L
M
D
S
S
S
S
L
S
R
N
Site 45
S713
N
L
A
L
M
D
S
S
S
S
L
S
R
N
P
Site 46
S714
L
A
L
M
D
S
S
S
S
L
S
R
N
P
P
Site 47
S715
A
L
M
D
S
S
S
S
L
S
R
N
P
P
S
Site 48
S717
M
D
S
S
S
S
L
S
R
N
P
P
S
Y
I
Site 49
S722
S
L
S
R
N
P
P
S
Y
I
A
P
Y
S
C
Site 50
Y723
L
S
R
N
P
P
S
Y
I
A
P
Y
S
C
I
Site 51
Y787
L
S
H
K
C
F
G
Y
Y
I
H
G
R
S
V
Site 52
Y788
S
H
K
C
F
G
Y
Y
I
H
G
R
S
V
H
Site 53
S818
R
E
A
E
N
L
C
S
Q
R
G
L
V
P
N
Site 54
T830
V
P
N
T
D
G
Q
T
F
E
I
A
I
S
N
Site 55
Y843
S
N
Q
M
R
Q
H
Y
D
R
I
H
E
T
L
Site 56
S861
N
G
P
A
R
L
L
S
S
S
A
S
T
F
E
Site 57
S863
P
A
R
L
L
S
S
S
A
S
T
F
E
Q
S
Site 58
S865
R
L
L
S
S
S
A
S
T
F
E
Q
S
I
K
Site 59
T866
L
L
S
S
S
A
S
T
F
E
Q
S
I
K
A
Site 60
Y874
F
E
Q
S
I
K
A
Y
H
M
M
N
K
F
L
Site 61
Y894
H
V
H
K
E
M
D
Y
F
I
K
D
K
L
L
Site 62
Y920
P
M
E
K
S
I
F
Y
N
D
E
G
Y
S
F
Site 63
Y925
I
F
Y
N
D
E
G
Y
S
F
S
S
V
L
Y
Site 64
S929
D
E
G
Y
S
F
S
S
V
L
Y
Y
G
N
E
Site 65
Y932
Y
S
F
S
S
V
L
Y
Y
G
N
E
A
T
L
Site 66
Y973
L
Q
Q
E
I
F
R
Y
I
R
N
T
V
G
Q
Site 67
T977
I
F
R
Y
I
R
N
T
V
G
Q
K
N
L
A
Site 68
T987
Q
K
N
L
A
S
K
T
L
V
D
Q
R
F
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation