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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SH3D19
Full Name:
SH3 domain-containing protein 19
Alias:
ADAM binding protein Eve-1; DKFZp434D0215; EBP; EEN binding protein; EEN-binding protein; EVE1; Kryn; SH3 domain containing 19; SH3 domain protein D19; SH319; SH3P19
Type:
Mass (Da):
86525
Number AA:
790
UniProt ID:
Q5HYK7
International Prot ID:
IPI00885212
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0070064
PhosphoSite+
KinaseNET
Biological Process:
GO:0016044
GO:0051044
GO:0006892
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
N
I
M
N
T
E
Q
S
Q
N
S
I
V
S
R
Site 2
S12
N
T
E
Q
S
Q
N
S
I
V
S
R
I
K
V
Site 3
T38
L
P
K
K
P
E
I
T
P
R
S
L
P
P
K
Site 4
S41
K
P
E
I
T
P
R
S
L
P
P
K
P
T
V
Site 5
T47
R
S
L
P
P
K
P
T
V
S
S
G
K
P
S
Site 6
S49
L
P
P
K
P
T
V
S
S
G
K
P
S
V
A
Site 7
S50
P
P
K
P
T
V
S
S
G
K
P
S
V
A
P
Site 8
S54
T
V
S
S
G
K
P
S
V
A
P
K
P
A
A
Site 9
S65
K
P
A
A
N
R
A
S
G
E
W
D
S
G
T
Site 10
S70
R
A
S
G
E
W
D
S
G
T
E
N
R
L
K
Site 11
T72
S
G
E
W
D
S
G
T
E
N
R
L
K
V
T
Site 12
S80
E
N
R
L
K
V
T
S
K
E
G
L
T
P
Y
Site 13
T85
V
T
S
K
E
G
L
T
P
Y
P
P
L
Q
E
Site 14
Y87
S
K
E
G
L
T
P
Y
P
P
L
Q
E
A
G
Site 15
S95
P
P
L
Q
E
A
G
S
I
P
V
T
K
P
E
Site 16
T99
E
A
G
S
I
P
V
T
K
P
E
L
P
K
K
Site 17
S114
P
N
P
G
L
I
R
S
V
N
P
E
I
P
G
Site 18
S129
R
G
P
L
A
E
S
S
D
S
G
K
K
V
P
Site 19
S131
P
L
A
E
S
S
D
S
G
K
K
V
P
T
P
Site 20
T137
D
S
G
K
K
V
P
T
P
A
P
R
P
L
L
Site 21
S148
R
P
L
L
L
K
K
S
V
S
S
E
N
P
T
Site 22
S150
L
L
L
K
K
S
V
S
S
E
N
P
T
Y
P
Site 23
T155
S
V
S
S
E
N
P
T
Y
P
S
A
P
L
K
Site 24
Y156
V
S
S
E
N
P
T
Y
P
S
A
P
L
K
P
Site 25
S158
S
E
N
P
T
Y
P
S
A
P
L
K
P
V
T
Site 26
T165
S
A
P
L
K
P
V
T
V
P
P
R
L
A
G
Site 27
S174
P
P
R
L
A
G
A
S
Q
A
K
A
Y
K
S
Site 28
S181
S
Q
A
K
A
Y
K
S
L
G
E
G
P
P
A
Site 29
T215
F
D
D
D
V
L
P
T
P
S
G
N
L
A
E
Site 30
S224
S
G
N
L
A
E
E
S
V
G
S
E
M
V
L
Site 31
T253
R
A
V
Q
P
A
P
T
R
K
P
T
V
I
R
Site 32
T257
P
A
P
T
R
K
P
T
V
I
R
I
P
A
K
Site 33
S275
C
L
H
E
D
P
Q
S
P
P
P
L
P
A
E
Site 34
T288
A
E
K
P
I
G
N
T
F
S
T
V
S
G
K
Site 35
S290
K
P
I
G
N
T
F
S
T
V
S
G
K
L
S
Site 36
T291
P
I
G
N
T
F
S
T
V
S
G
K
L
S
N
Site 37
S293
G
N
T
F
S
T
V
S
G
K
L
S
N
V
E
Site 38
S297
S
T
V
S
G
K
L
S
N
V
E
R
T
R
N
Site 39
S307
E
R
T
R
N
L
E
S
N
H
P
G
Q
T
G
Site 40
T332
P
R
P
V
N
G
K
T
I
P
T
Q
Q
P
P
Site 41
T335
V
N
G
K
T
I
P
T
Q
Q
P
P
T
K
V
Site 42
T340
I
P
T
Q
Q
P
P
T
K
V
P
P
E
R
P
Site 43
S353
R
P
P
P
P
K
L
S
A
T
R
R
S
N
K
Site 44
T355
P
P
P
K
L
S
A
T
R
R
S
N
K
K
L
Site 45
S358
K
L
S
A
T
R
R
S
N
K
K
L
P
F
N
Site 46
S367
K
K
L
P
F
N
R
S
S
S
D
M
D
L
Q
Site 47
S368
K
L
P
F
N
R
S
S
S
D
M
D
L
Q
K
Site 48
S369
L
P
F
N
R
S
S
S
D
M
D
L
Q
K
K
Site 49
S378
M
D
L
Q
K
K
Q
S
N
L
A
T
G
L
S
Site 50
T382
K
K
Q
S
N
L
A
T
G
L
S
K
A
K
S
Site 51
S385
S
N
L
A
T
G
L
S
K
A
K
S
Q
V
F
Site 52
S389
T
G
L
S
K
A
K
S
Q
V
F
K
N
Q
D
Site 53
Y410
P
K
P
G
H
P
L
Y
S
K
Y
M
L
S
V
Site 54
Y413
G
H
P
L
Y
S
K
Y
M
L
S
V
P
H
G
Site 55
S428
I
A
N
E
D
I
V
S
Q
N
P
G
E
L
S
Site 56
S435
S
Q
N
P
G
E
L
S
C
K
R
G
D
V
L
Site 57
Y452
L
K
Q
T
E
N
N
Y
L
E
C
Q
K
G
E
Site 58
T461
E
C
Q
K
G
E
D
T
G
R
V
H
L
S
Q
Site 59
S467
D
T
G
R
V
H
L
S
Q
M
K
I
I
T
P
Site 60
T473
L
S
Q
M
K
I
I
T
P
L
D
E
H
L
R
Site 61
S481
P
L
D
E
H
L
R
S
R
P
N
D
P
S
H
Site 62
S487
R
S
R
P
N
D
P
S
H
A
Q
K
P
V
D
Site 63
Y533
E
K
I
D
T
D
W
Y
R
G
N
C
R
N
Q
Site 64
S567
N
G
K
R
E
C
V
S
S
H
C
V
K
G
S
Site 65
S568
G
K
R
E
C
V
S
S
H
C
V
K
G
S
R
Site 66
Y582
R
C
V
A
R
F
E
Y
I
G
E
Q
K
D
E
Site 67
S591
G
E
Q
K
D
E
L
S
F
S
E
G
E
I
I
Site 68
S593
Q
K
D
E
L
S
F
S
E
G
E
I
I
I
L
Site 69
Y603
E
I
I
I
L
K
E
Y
V
N
E
E
W
A
R
Site 70
T617
R
G
E
V
R
G
R
T
G
I
F
P
L
N
F
Site 71
Y631
F
V
E
P
V
E
D
Y
P
T
S
G
A
N
V
Site 72
T633
E
P
V
E
D
Y
P
T
S
G
A
N
V
L
S
Site 73
S634
P
V
E
D
Y
P
T
S
G
A
N
V
L
S
T
Site 74
S640
T
S
G
A
N
V
L
S
T
K
V
P
L
K
T
Site 75
T641
S
G
A
N
V
L
S
T
K
V
P
L
K
T
K
Site 76
T647
S
T
K
V
P
L
K
T
K
K
E
D
S
G
S
Site 77
S652
L
K
T
K
K
E
D
S
G
S
N
S
Q
V
N
Site 78
S654
T
K
K
E
D
S
G
S
N
S
Q
V
N
S
L
Site 79
S656
K
E
D
S
G
S
N
S
Q
V
N
S
L
P
A
Site 80
S660
G
S
N
S
Q
V
N
S
L
P
A
E
W
C
E
Site 81
S671
E
W
C
E
A
L
H
S
F
T
A
E
T
S
D
Site 82
S677
H
S
F
T
A
E
T
S
D
D
L
S
F
K
R
Site 83
S681
A
E
T
S
D
D
L
S
F
K
R
G
D
R
I
Site 84
S696
Q
I
L
E
R
L
D
S
D
W
C
R
G
R
L
Site 85
Y739
G
R
K
A
K
A
L
Y
D
F
R
G
E
N
E
Site 86
S750
G
E
N
E
D
E
L
S
F
K
A
G
D
I
I
Site 87
T758
F
K
A
G
D
I
I
T
E
L
E
S
V
D
D
Site 88
S762
D
I
I
T
E
L
E
S
V
D
D
D
W
M
S
Site 89
S769
S
V
D
D
D
W
M
S
G
E
L
M
G
K
S
Site 90
S776
S
G
E
L
M
G
K
S
G
I
F
P
K
N
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation