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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NHSL2
Full Name:
NHS-like protein 2
Alias:
Type:
Mass (Da):
76301
Number AA:
709
UniProt ID:
Q5HYW2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
E
S
M
G
M
V
Y
S
V
P
S
S
C
N
Site 2
S9
E
S
M
G
M
V
Y
S
V
P
S
S
C
N
G
Site 3
S13
M
V
Y
S
V
P
S
S
C
N
G
P
T
E
S
Site 4
T18
P
S
S
C
N
G
P
T
E
S
T
F
S
T
S
Site 5
S20
S
C
N
G
P
T
E
S
T
F
S
T
S
W
K
Site 6
T21
C
N
G
P
T
E
S
T
F
S
T
S
W
K
G
Site 7
S23
G
P
T
E
S
T
F
S
T
S
W
K
G
D
A
Site 8
T24
P
T
E
S
T
F
S
T
S
W
K
G
D
A
F
Site 9
T32
S
W
K
G
D
A
F
T
Y
M
T
P
S
A
T
Site 10
Y33
W
K
G
D
A
F
T
Y
M
T
P
S
A
T
S
Site 11
T35
G
D
A
F
T
Y
M
T
P
S
A
T
S
Q
S
Site 12
S37
A
F
T
Y
M
T
P
S
A
T
S
Q
S
N
Q
Site 13
S53
N
E
N
G
K
N
P
S
C
G
N
S
W
V
S
Site 14
S57
K
N
P
S
C
G
N
S
W
V
S
L
N
K
V
Site 15
S60
S
C
G
N
S
W
V
S
L
N
K
V
P
P
L
Site 16
Y91
G
C
S
G
S
A
G
Y
P
E
R
L
I
Q
Q
Site 17
S106
R
H
M
P
E
R
P
S
K
I
G
L
L
T
S
Site 18
T112
P
S
K
I
G
L
L
T
S
G
T
S
R
L
E
Site 19
S113
S
K
I
G
L
L
T
S
G
T
S
R
L
E
T
Site 20
T115
I
G
L
L
T
S
G
T
S
R
L
E
T
G
P
Site 21
T120
S
G
T
S
R
L
E
T
G
P
G
G
A
S
R
Site 22
S126
E
T
G
P
G
G
A
S
R
F
R
E
R
S
L
Site 23
S132
A
S
R
F
R
E
R
S
L
S
V
P
T
D
S
Site 24
S134
R
F
R
E
R
S
L
S
V
P
T
D
S
G
T
Site 25
S139
S
L
S
V
P
T
D
S
G
T
T
D
V
D
Y
Site 26
Y146
S
G
T
T
D
V
D
Y
D
E
E
Q
K
A
N
Site 27
S162
A
C
A
L
P
F
A
S
T
S
S
E
G
S
N
Site 28
S164
A
L
P
F
A
S
T
S
S
E
G
S
N
S
A
Site 29
S165
L
P
F
A
S
T
S
S
E
G
S
N
S
A
D
Site 30
S168
A
S
T
S
S
E
G
S
N
S
A
D
N
I
A
Site 31
S170
T
S
S
E
G
S
N
S
A
D
N
I
A
S
L
Site 32
S176
N
S
A
D
N
I
A
S
L
S
A
Q
Q
E
A
Site 33
S190
A
Q
H
R
R
Q
R
S
K
S
I
S
L
R
K
Site 34
S192
H
R
R
Q
R
S
K
S
I
S
L
R
K
A
K
Site 35
S194
R
Q
R
S
K
S
I
S
L
R
K
A
K
K
K
Site 36
S203
R
K
A
K
K
K
P
S
P
P
T
R
S
V
S
Site 37
T206
K
K
K
P
S
P
P
T
R
S
V
S
L
V
K
Site 38
S208
K
P
S
P
P
T
R
S
V
S
L
V
K
D
E
Site 39
S210
S
P
P
T
R
S
V
S
L
V
K
D
E
P
G
Site 40
S224
G
L
L
P
E
G
G
S
A
L
P
K
D
Q
R
Site 41
S234
P
K
D
Q
R
P
K
S
L
C
L
S
L
E
H
Site 42
S238
R
P
K
S
L
C
L
S
L
E
H
Q
G
H
H
Site 43
S247
E
H
Q
G
H
H
S
S
H
P
D
A
Q
G
H
Site 44
T282
T
D
W
K
S
G
D
T
Y
Q
S
L
S
S
S
Site 45
Y283
D
W
K
S
G
D
T
Y
Q
S
L
S
S
S
S
Site 46
S285
K
S
G
D
T
Y
Q
S
L
S
S
S
S
T
A
Site 47
S287
G
D
T
Y
Q
S
L
S
S
S
S
T
A
T
G
Site 48
S289
T
Y
Q
S
L
S
S
S
S
T
A
T
G
T
T
Site 49
T291
Q
S
L
S
S
S
S
T
A
T
G
T
T
V
I
Site 50
T301
G
T
T
V
I
E
C
T
Q
V
Q
G
S
S
E
Site 51
S306
E
C
T
Q
V
Q
G
S
S
E
S
L
A
S
P
Site 52
S309
Q
V
Q
G
S
S
E
S
L
A
S
P
S
T
S
Site 53
S312
G
S
S
E
S
L
A
S
P
S
T
S
R
A
T
Site 54
S314
S
E
S
L
A
S
P
S
T
S
R
A
T
T
P
Site 55
T315
E
S
L
A
S
P
S
T
S
R
A
T
T
P
S
Site 56
S316
S
L
A
S
P
S
T
S
R
A
T
T
P
S
Q
Site 57
T319
S
P
S
T
S
R
A
T
T
P
S
Q
L
S
I
Site 58
T320
P
S
T
S
R
A
T
T
P
S
Q
L
S
I
E
Site 59
S322
T
S
R
A
T
T
P
S
Q
L
S
I
E
V
E
Site 60
S334
E
V
E
A
R
E
I
S
S
P
G
R
P
P
G
Site 61
S335
V
E
A
R
E
I
S
S
P
G
R
P
P
G
L
Site 62
S344
G
R
P
P
G
L
M
S
P
S
S
G
Y
S
S
Site 63
S346
P
P
G
L
M
S
P
S
S
G
Y
S
S
Q
S
Site 64
S347
P
G
L
M
S
P
S
S
G
Y
S
S
Q
S
E
Site 65
S350
M
S
P
S
S
G
Y
S
S
Q
S
E
T
P
T
Site 66
S351
S
P
S
S
G
Y
S
S
Q
S
E
T
P
T
P
Site 67
S353
S
S
G
Y
S
S
Q
S
E
T
P
T
P
T
V
Site 68
T355
G
Y
S
S
Q
S
E
T
P
T
P
T
V
S
M
Site 69
T357
S
S
Q
S
E
T
P
T
P
T
V
S
M
S
L
Site 70
T359
Q
S
E
T
P
T
P
T
V
S
M
S
L
T
L
Site 71
S361
E
T
P
T
P
T
V
S
M
S
L
T
L
G
H
Site 72
S373
L
G
H
L
P
P
P
S
S
S
V
R
V
R
P
Site 73
S374
G
H
L
P
P
P
S
S
S
V
R
V
R
P
V
Site 74
S375
H
L
P
P
P
S
S
S
V
R
V
R
P
V
V
Site 75
S387
P
V
V
P
E
R
K
S
S
L
P
P
T
S
P
Site 76
S388
V
V
P
E
R
K
S
S
L
P
P
T
S
P
M
Site 77
T392
R
K
S
S
L
P
P
T
S
P
M
E
K
F
P
Site 78
S393
K
S
S
L
P
P
T
S
P
M
E
K
F
P
K
Site 79
S401
P
M
E
K
F
P
K
S
R
L
S
F
D
L
P
Site 80
S404
K
F
P
K
S
R
L
S
F
D
L
P
L
T
S
Site 81
S411
S
F
D
L
P
L
T
S
S
P
N
L
D
L
S
Site 82
S412
F
D
L
P
L
T
S
S
P
N
L
D
L
S
G
Site 83
S418
S
S
P
N
L
D
L
S
G
M
S
I
S
I
R
Site 84
S423
D
L
S
G
M
S
I
S
I
R
S
K
T
K
V
Site 85
S426
G
M
S
I
S
I
R
S
K
T
K
V
S
R
H
Site 86
T428
S
I
S
I
R
S
K
T
K
V
S
R
H
H
S
Site 87
S431
I
R
S
K
T
K
V
S
R
H
H
S
E
T
N
Site 88
S435
T
K
V
S
R
H
H
S
E
T
N
F
G
V
K
Site 89
T437
V
S
R
H
H
S
E
T
N
F
G
V
K
L
A
Site 90
T447
G
V
K
L
A
Q
K
T
N
P
N
Q
P
I
M
Site 91
S464
V
T
Q
S
D
L
R
S
V
R
L
R
S
V
S
Site 92
S469
L
R
S
V
R
L
R
S
V
S
K
S
E
P
E
Site 93
S471
S
V
R
L
R
S
V
S
K
S
E
P
E
D
D
Site 94
S473
R
L
R
S
V
S
K
S
E
P
E
D
D
I
E
Site 95
S481
E
P
E
D
D
I
E
S
P
E
Y
A
E
E
P
Site 96
Y484
D
D
I
E
S
P
E
Y
A
E
E
P
R
A
E
Site 97
T495
P
R
A
E
E
V
F
T
L
P
E
R
K
T
K
Site 98
T501
F
T
L
P
E
R
K
T
K
P
P
V
A
E
K
Site 99
S517
P
V
A
R
R
P
P
S
L
V
H
K
P
P
S
Site 100
S524
S
L
V
H
K
P
P
S
V
P
E
E
Y
A
L
Site 101
Y529
P
P
S
V
P
E
E
Y
A
L
T
S
P
T
L
Site 102
S533
P
E
E
Y
A
L
T
S
P
T
L
A
M
P
P
Site 103
T535
E
Y
A
L
T
S
P
T
L
A
M
P
P
R
S
Site 104
S542
T
L
A
M
P
P
R
S
S
I
Q
H
A
R
P
Site 105
S543
L
A
M
P
P
R
S
S
I
Q
H
A
R
P
L
Site 106
S554
A
R
P
L
P
Q
D
S
Y
T
V
V
R
K
P
Site 107
Y555
R
P
L
P
Q
D
S
Y
T
V
V
R
K
P
K
Site 108
T556
P
L
P
Q
D
S
Y
T
V
V
R
K
P
K
P
Site 109
S564
V
V
R
K
P
K
P
S
S
F
P
D
G
R
S
Site 110
S565
V
R
K
P
K
P
S
S
F
P
D
G
R
S
P
Site 111
S571
S
S
F
P
D
G
R
S
P
G
E
S
T
A
P
Site 112
S575
D
G
R
S
P
G
E
S
T
A
P
S
S
L
V
Site 113
T576
G
R
S
P
G
E
S
T
A
P
S
S
L
V
F
Site 114
S579
P
G
E
S
T
A
P
S
S
L
V
F
T
P
F
Site 115
S595
S
S
S
D
A
F
F
S
G
T
Q
Q
P
P
Q
Site 116
T597
S
D
A
F
F
S
G
T
Q
Q
P
P
Q
G
S
Site 117
S604
T
Q
Q
P
P
Q
G
S
V
E
D
E
G
P
K
Site 118
S620
R
V
L
P
E
R
I
S
L
Q
S
Q
E
E
A
Site 119
S623
P
E
R
I
S
L
Q
S
Q
E
E
A
E
K
K
Site 120
S643
P
P
V
P
K
K
P
S
V
L
Y
L
P
L
T
Site 121
Y646
P
K
K
P
S
V
L
Y
L
P
L
T
S
P
T
Site 122
Y659
P
T
A
Q
M
E
A
Y
V
A
E
P
R
L
P
Site 123
S668
A
E
P
R
L
P
L
S
P
I
I
T
L
E
E
Site 124
T677
I
I
T
L
E
E
D
T
K
C
P
A
T
G
D
Site 125
S688
A
T
G
D
D
L
Q
S
L
G
Q
R
V
T
S
Site 126
T694
Q
S
L
G
Q
R
V
T
S
T
P
Q
A
D
S
Site 127
S695
S
L
G
Q
R
V
T
S
T
P
Q
A
D
S
E
Site 128
T696
L
G
Q
R
V
T
S
T
P
Q
A
D
S
E
R
Site 129
S701
T
S
T
P
Q
A
D
S
E
R
E
A
S
P
L
Site 130
S706
A
D
S
E
R
E
A
S
P
L
G
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation