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Updated November 2019
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Protein Info
Short Name:
Ankyrin repeat domain-containing protein 36C
Full Name:
Ankyrin repeat domain-containing protein 36C
Alias:
Protein immuno-reactive with anti-PTH polyclonal antibodies
Type:
Mass (Da):
136200
Number AA:
1211
UniProt ID:
Q5JPF3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
R
R
K
D
S
P
P
P
G
K
V
S
Site 2
S13
S
P
P
P
G
K
V
S
S
Q
K
Q
P
A
E
Site 3
S14
P
P
P
G
K
V
S
S
Q
K
Q
P
A
E
K
Site 4
S24
Q
P
A
E
K
A
T
S
D
D
K
D
S
V
S
Site 5
S29
A
T
S
D
D
K
D
S
V
S
N
I
A
T
E
Site 6
S31
S
D
D
K
D
S
V
S
N
I
A
T
E
I
K
Site 7
T35
D
S
V
S
N
I
A
T
E
I
K
E
G
P
I
Site 8
S43
E
I
K
E
G
P
I
S
G
T
V
S
S
Q
K
Site 9
T45
K
E
G
P
I
S
G
T
V
S
S
Q
K
Q
P
Site 10
S47
G
P
I
S
G
T
V
S
S
Q
K
Q
P
A
E
Site 11
S48
P
I
S
G
T
V
S
S
Q
K
Q
P
A
E
K
Site 12
S58
Q
P
A
E
K
A
T
S
D
E
K
D
S
V
S
Site 13
S63
A
T
S
D
E
K
D
S
V
S
N
I
A
T
E
Site 14
S65
S
D
E
K
D
S
V
S
N
I
A
T
E
I
K
Site 15
T69
D
S
V
S
N
I
A
T
E
I
K
E
G
Q
Q
Site 16
S77
E
I
K
E
G
Q
Q
S
G
T
V
S
P
Q
K
Site 17
T79
K
E
G
Q
Q
S
G
T
V
S
P
Q
K
Q
S
Site 18
S81
G
Q
Q
S
G
T
V
S
P
Q
K
Q
S
A
W
Site 19
S86
T
V
S
P
Q
K
Q
S
A
W
K
V
I
F
K
Site 20
T106
L
N
I
A
T
R
I
T
G
G
G
K
S
G
T
Site 21
S111
R
I
T
G
G
G
K
S
G
T
V
S
S
Q
K
Site 22
T113
T
G
G
G
K
S
G
T
V
S
S
Q
K
Q
P
Site 23
S115
G
G
K
S
G
T
V
S
S
Q
K
Q
P
P
S
Site 24
S116
G
K
S
G
T
V
S
S
Q
K
Q
P
P
S
K
Site 25
S122
S
S
Q
K
Q
P
P
S
K
A
T
S
D
K
T
Site 26
S126
Q
P
P
S
K
A
T
S
D
K
T
D
S
A
L
Site 27
T129
S
K
A
T
S
D
K
T
D
S
A
L
N
I
A
Site 28
T147
K
D
G
L
Q
C
G
T
V
S
S
Q
K
Q
P
Site 29
S149
G
L
Q
C
G
T
V
S
S
Q
K
Q
P
A
L
Site 30
S165
A
T
T
D
E
E
D
S
V
S
N
I
A
T
E
Site 31
S167
T
D
E
E
D
S
V
S
N
I
A
T
E
I
K
Site 32
T171
D
S
V
S
N
I
A
T
E
I
K
D
G
E
K
Site 33
S179
E
I
K
D
G
E
K
S
G
T
V
S
S
Q
K
Site 34
T181
K
D
G
E
K
S
G
T
V
S
S
Q
K
Q
P
Site 35
S183
G
E
K
S
G
T
V
S
S
Q
K
Q
P
A
L
Site 36
S184
E
K
S
G
T
V
S
S
Q
K
Q
P
A
L
K
Site 37
S199
A
T
T
D
E
E
D
S
V
S
I
I
A
T
E
Site 38
S201
T
D
E
E
D
S
V
S
I
I
A
T
E
I
K
Site 39
T205
D
S
V
S
I
I
A
T
E
I
K
D
G
E
K
Site 40
S213
E
I
K
D
G
E
K
S
G
T
V
S
S
R
K
Site 41
T215
K
D
G
E
K
S
G
T
V
S
S
R
K
K
P
Site 42
S217
G
E
K
S
G
T
V
S
S
R
K
K
P
A
L
Site 43
S228
K
P
A
L
K
A
T
S
D
E
K
D
S
F
S
Site 44
S233
A
T
S
D
E
K
D
S
F
S
N
I
T
R
E
Site 45
S235
S
D
E
K
D
S
F
S
N
I
T
R
E
K
K
Site 46
S247
E
K
K
D
G
E
I
S
R
T
V
T
S
E
K
Site 47
T249
K
D
G
E
I
S
R
T
V
T
S
E
K
P
A
Site 48
T251
G
E
I
S
R
T
V
T
S
E
K
P
A
G
L
Site 49
S262
P
A
G
L
K
A
T
S
D
E
E
D
S
V
L
Site 50
S267
A
T
S
D
E
E
D
S
V
L
N
I
A
R
G
Site 51
T281
G
K
E
D
G
E
K
T
R
R
V
S
S
R
K
Site 52
S285
G
E
K
T
R
R
V
S
S
R
K
K
P
A
L
Site 53
S286
E
K
T
R
R
V
S
S
R
K
K
P
A
L
K
Site 54
T314
R
E
K
K
D
G
E
T
S
R
T
V
S
S
Q
Site 55
S315
E
K
K
D
G
E
T
S
R
T
V
S
S
Q
K
Site 56
T317
K
D
G
E
T
S
R
T
V
S
S
Q
K
P
P
Site 57
S319
G
E
T
S
R
T
V
S
S
Q
K
P
P
A
L
Site 58
S320
E
T
S
R
T
V
S
S
Q
K
P
P
A
L
K
Site 59
S330
P
P
A
L
K
A
T
S
D
E
E
D
S
V
L
Site 60
S349
E
K
K
D
G
E
K
S
R
T
V
S
S
E
K
Site 61
T351
K
D
G
E
K
S
R
T
V
S
S
E
K
P
S
Site 62
S353
G
E
K
S
R
T
V
S
S
E
K
P
S
G
L
Site 63
S354
E
K
S
R
T
V
S
S
E
K
P
S
G
L
K
Site 64
S358
T
V
S
S
E
K
P
S
G
L
K
A
T
S
D
Site 65
S364
P
S
G
L
K
A
T
S
D
E
K
D
S
V
L
Site 66
T383
G
K
K
H
G
E
K
T
R
R
V
S
S
H
K
Site 67
S387
G
E
K
T
R
R
V
S
S
H
K
Q
P
A
L
Site 68
S388
E
K
T
R
R
V
S
S
H
K
Q
P
A
L
K
Site 69
S417
E
T
K
D
E
Q
I
S
G
T
V
S
S
Q
K
Site 70
T419
K
D
E
Q
I
S
G
T
V
S
S
Q
K
Q
P
Site 71
S421
E
Q
I
S
G
T
V
S
S
Q
K
Q
P
A
L
Site 72
S437
A
T
S
D
K
K
D
S
V
S
N
I
P
T
E
Site 73
S439
S
D
K
K
D
S
V
S
N
I
P
T
E
I
K
Site 74
T443
D
S
V
S
N
I
P
T
E
I
K
D
G
Q
Q
Site 75
S451
E
I
K
D
G
Q
Q
S
G
T
V
S
S
Q
K
Site 76
T453
K
D
G
Q
Q
S
G
T
V
S
S
Q
K
Q
P
Site 77
S455
G
Q
Q
S
G
T
V
S
S
Q
K
Q
P
A
W
Site 78
S471
A
T
S
V
K
K
D
S
V
S
N
I
A
T
E
Site 79
S473
S
V
K
K
D
S
V
S
N
I
A
T
E
I
K
Site 80
T477
D
S
V
S
N
I
A
T
E
I
K
D
G
Q
I
Site 81
T487
K
D
G
Q
I
R
G
T
V
S
S
Q
R
Q
P
Site 82
S489
G
Q
I
R
G
T
V
S
S
Q
R
Q
P
A
L
Site 83
S490
Q
I
R
G
T
V
S
S
Q
R
Q
P
A
L
K
Site 84
S505
A
T
G
D
E
K
D
S
V
S
N
I
A
R
E
Site 85
S507
G
D
E
K
D
S
V
S
N
I
A
R
E
I
K
Site 86
S519
E
I
K
D
G
E
K
S
G
T
V
S
P
Q
K
Site 87
T521
K
D
G
E
K
S
G
T
V
S
P
Q
K
Q
S
Site 88
S523
G
E
K
S
G
T
V
S
P
Q
K
Q
S
A
Q
Site 89
T548
L
N
I
A
T
R
I
T
G
S
W
K
S
G
T
Site 90
S550
I
A
T
R
I
T
G
S
W
K
S
G
T
E
Y
Site 91
S553
R
I
T
G
S
W
K
S
G
T
E
Y
P
E
N
Site 92
T555
T
G
S
W
K
S
G
T
E
Y
P
E
N
L
P
Site 93
Y557
S
W
K
S
G
T
E
Y
P
E
N
L
P
T
L
Site 94
T563
E
Y
P
E
N
L
P
T
L
K
A
T
I
E
N
Site 95
S573
A
T
I
E
N
K
N
S
V
L
N
T
A
T
K
Site 96
T586
T
K
M
K
D
V
Q
T
S
T
P
E
Q
D
L
Site 97
T588
M
K
D
V
Q
T
S
T
P
E
Q
D
L
E
M
Site 98
Y607
E
Q
K
R
L
E
E
Y
E
N
N
Q
P
Q
V
Site 99
S631
L
D
D
I
I
Q
S
S
Q
T
V
S
E
D
G
Site 100
S635
I
Q
S
S
Q
T
V
S
E
D
G
D
S
L
C
Site 101
T679
F
C
L
C
K
R
L
T
E
L
K
D
N
H
C
Site 102
S701
R
K
L
K
N
K
A
S
V
L
Q
K
R
L
S
Site 103
S708
S
V
L
Q
K
R
L
S
E
K
E
E
I
K
S
Site 104
S715
S
E
K
E
E
I
K
S
Q
L
K
H
E
T
L
Site 105
S730
E
L
E
K
E
L
C
S
L
R
F
A
I
Q
Q
Site 106
T759
V
R
E
K
L
R
I
T
E
E
Q
Y
R
I
E
Site 107
T770
Y
R
I
E
A
D
V
T
K
P
I
K
P
A
L
Site 108
S779
P
I
K
P
A
L
K
S
A
E
V
E
L
K
T
Site 109
T786
S
A
E
V
E
L
K
T
G
G
N
N
S
N
Q
Site 110
S791
L
K
T
G
G
N
N
S
N
Q
V
S
E
T
D
Site 111
S795
G
N
N
S
N
Q
V
S
E
T
D
E
K
E
D
Site 112
T823
R
L
R
L
E
K
D
T
I
K
N
Q
N
L
E
Site 113
Y833
N
Q
N
L
E
K
K
Y
L
K
D
F
E
I
V
Site 114
T873
S
G
Q
L
A
A
L
T
D
E
N
T
T
L
R
Site 115
T877
A
A
L
T
D
E
N
T
T
L
R
S
K
L
E
Site 116
T878
A
L
T
D
E
N
T
T
L
R
S
K
L
E
K
Site 117
S889
K
L
E
K
Q
R
E
S
G
Q
R
L
E
T
E
Site 118
T895
E
S
G
Q
R
L
E
T
E
M
Q
S
Y
R
C
Site 119
S899
R
L
E
T
E
M
Q
S
Y
R
C
R
L
N
A
Site 120
Y900
L
E
T
E
M
Q
S
Y
R
C
R
L
N
A
A
Site 121
S914
A
L
C
D
H
D
Q
S
H
S
S
K
R
D
Q
Site 122
S917
D
H
D
Q
S
H
S
S
K
R
D
Q
E
L
A
Site 123
T928
Q
E
L
A
F
Q
G
T
V
D
K
C
C
H
L
Site 124
S951
L
I
L
S
L
Q
L
S
K
A
E
S
K
F
R
Site 125
S955
L
Q
L
S
K
A
E
S
K
F
R
V
L
E
T
Site 126
T967
L
E
T
E
L
H
Y
T
G
E
A
L
K
E
K
Site 127
S990
S
E
L
K
Q
K
Q
S
Q
M
K
D
I
E
K
Site 128
Y1003
E
K
M
Y
K
S
G
Y
N
T
M
E
K
C
I
Site 129
T1005
M
Y
K
S
G
Y
N
T
M
E
K
C
I
E
K
Site 130
S1083
L
V
N
E
L
N
H
S
K
E
K
K
C
Q
Y
Site 131
S1116
D
D
V
L
N
K
R
S
A
T
K
A
L
L
D
Site 132
T1118
V
L
N
K
R
S
A
T
K
A
L
L
D
A
S
Site 133
S1126
K
A
L
L
D
A
S
S
R
H
C
I
Y
L
E
Site 134
Y1131
A
S
S
R
H
C
I
Y
L
E
N
G
M
Q
D
Site 135
S1139
L
E
N
G
M
Q
D
S
R
K
K
L
D
Q
M
Site 136
S1148
K
K
L
D
Q
M
R
S
Q
F
Q
E
I
Q
D
Site 137
T1158
Q
E
I
Q
D
Q
L
T
A
T
I
R
C
T
K
Site 138
T1160
I
Q
D
Q
L
T
A
T
I
R
C
T
K
E
M
Site 139
T1164
L
T
A
T
I
R
C
T
K
E
M
E
G
D
A
Site 140
S1203
E
K
I
L
Q
H
S
S
L
M
L
Q
V
F
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation