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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EARS2
Full Name:
Probable glutamyl-tRNA synthetase, mitochondrial
Alias:
Glutamate--tRNA ligase
Type:
Mass (Da):
58689
Number AA:
523
UniProt ID:
Q5JPH6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
L
L
Q
R
E
R
P
S
A
A
S
G
R
P
V
Site 2
S18
R
E
R
P
S
A
A
S
G
R
P
V
G
R
R
Site 3
T46
V
R
F
A
P
S
P
T
G
F
L
H
L
G
G
Site 4
Y59
G
G
L
R
T
A
L
Y
N
Y
I
F
A
K
K
Site 5
Y67
N
Y
I
F
A
K
K
Y
Q
G
S
F
I
L
R
Site 6
S70
F
A
K
K
Y
Q
G
S
F
I
L
R
L
E
D
Site 7
T78
F
I
L
R
L
E
D
T
D
Q
T
R
V
V
P
Site 8
T81
R
L
E
D
T
D
Q
T
R
V
V
P
G
A
A
Site 9
S105
A
G
I
P
P
D
E
S
P
R
R
G
G
P
A
Site 10
Y115
R
G
G
P
A
G
P
Y
Q
Q
S
Q
R
L
E
Site 11
S118
P
A
G
P
Y
Q
Q
S
Q
R
L
E
L
Y
A
Site 12
Y124
Q
S
Q
R
L
E
L
Y
A
Q
A
T
E
A
L
Site 13
T160
E
A
L
R
N
H
Q
T
P
R
Y
D
N
R
C
Site 14
Y163
R
N
H
Q
T
P
R
Y
D
N
R
C
R
N
M
Site 15
S171
D
N
R
C
R
N
M
S
Q
E
Q
V
A
Q
K
Site 16
Y203
P
A
F
Q
D
L
V
Y
G
W
N
R
H
E
V
Site 17
S212
W
N
R
H
E
V
A
S
V
E
G
D
P
V
I
Site 18
Y228
K
S
D
G
F
P
T
Y
H
L
A
C
V
V
D
Site 19
Y261
T
A
K
H
L
L
L
Y
Q
A
L
G
W
Q
P
Site 20
S283
L
L
L
N
R
D
G
S
K
L
S
K
R
Q
G
Site 21
S286
N
R
D
G
S
K
L
S
K
R
Q
G
D
V
F
Site 22
S364
L
H
L
Q
R
L
V
S
N
E
S
Q
R
R
Q
Site 23
S367
Q
R
L
V
S
N
E
S
Q
R
R
Q
L
V
G
Site 24
Y421
Q
D
L
V
S
P
V
Y
S
Y
L
W
T
R
P
Site 25
S422
D
L
V
S
P
V
Y
S
Y
L
W
T
R
P
A
Site 26
T426
P
V
Y
S
Y
L
W
T
R
P
A
V
G
R
A
Site 27
S456
V
L
G
L
L
E
R
S
S
M
S
L
T
Q
D
Site 28
S457
L
G
L
L
E
R
S
S
M
S
L
T
Q
D
M
Site 29
S459
L
L
E
R
S
S
M
S
L
T
Q
D
M
L
N
Site 30
T461
E
R
S
S
M
S
L
T
Q
D
M
L
N
G
E
Site 31
S473
N
G
E
L
K
K
L
S
E
G
L
E
G
T
K
Site 32
Y481
E
G
L
E
G
T
K
Y
S
N
V
M
K
L
L
Site 33
S482
G
L
E
G
T
K
Y
S
N
V
M
K
L
L
R
Site 34
S493
K
L
L
R
M
A
L
S
G
Q
Q
Q
G
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation