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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKAP4
Full Name:
A-kinase anchor protein 4
Alias:
Protein kinase A-anchoring protein 4
Type:
Adapter/scaffold protein
Mass (Da):
94477
Number AA:
854
UniProt ID:
Q5JQC9
International Prot ID:
IPI00157860
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0005929
GO:0005952
Uniprot
OncoNet
Molecular Function:
GO:0005198
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000902
GO:0006928
GO:0007154
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
M
A
Y
S
D
T
T
M
M
S
D
Site 2
T7
_
M
M
A
Y
S
D
T
T
M
M
S
D
D
I
Site 3
T8
M
M
A
Y
S
D
T
T
M
M
S
D
D
I
D
Site 4
S11
Y
S
D
T
T
M
M
S
D
D
I
D
W
L
R
Site 5
S19
D
D
I
D
W
L
R
S
H
R
G
V
C
K
V
Site 6
Y29
G
V
C
K
V
D
L
Y
N
P
E
G
Q
Q
D
Site 7
Y57
L
N
V
E
D
K
D
Y
K
D
A
A
S
S
S
Site 8
S62
K
D
Y
K
D
A
A
S
S
S
S
E
G
N
L
Site 9
S63
D
Y
K
D
A
A
S
S
S
S
E
G
N
L
N
Site 10
S64
Y
K
D
A
A
S
S
S
S
E
G
N
L
N
L
Site 11
S65
K
D
A
A
S
S
S
S
E
G
N
L
N
L
G
Site 12
S73
E
G
N
L
N
L
G
S
L
E
E
K
E
I
I
Site 13
T93
E
K
K
D
Q
S
K
T
E
G
S
V
C
L
F
Site 14
S96
D
Q
S
K
T
E
G
S
V
C
L
F
K
Q
A
Site 15
S130
L
G
F
Q
H
A
L
S
P
S
T
S
T
C
K
Site 16
S134
H
A
L
S
P
S
T
S
T
C
K
H
K
V
G
Site 17
Y147
V
G
D
T
E
G
E
Y
H
R
A
S
S
E
N
Site 18
S151
E
G
E
Y
H
R
A
S
S
E
N
C
Y
S
V
Site 19
S152
G
E
Y
H
R
A
S
S
E
N
C
Y
S
V
Y
Site 20
Y156
R
A
S
S
E
N
C
Y
S
V
Y
A
D
Q
V
Site 21
S157
A
S
S
E
N
C
Y
S
V
Y
A
D
Q
V
N
Site 22
Y159
S
E
N
C
Y
S
V
Y
A
D
Q
V
N
I
D
Site 23
Y167
A
D
Q
V
N
I
D
Y
L
M
N
R
P
Q
N
Site 24
S190
K
N
T
N
N
N
Q
S
P
S
A
P
P
A
K
Site 25
S192
T
N
N
N
Q
S
P
S
A
P
P
A
K
P
P
Site 26
S200
A
P
P
A
K
P
P
S
T
Q
R
A
V
I
S
Site 27
T201
P
P
A
K
P
P
S
T
Q
R
A
V
I
S
P
Site 28
S207
S
T
Q
R
A
V
I
S
P
D
G
E
C
S
I
Site 29
S213
I
S
P
D
G
E
C
S
I
D
D
L
S
F
Y
Site 30
S218
E
C
S
I
D
D
L
S
F
Y
V
N
R
L
S
Site 31
Y220
S
I
D
D
L
S
F
Y
V
N
R
L
S
S
L
Site 32
S226
F
Y
V
N
R
L
S
S
L
V
I
Q
M
A
H
Site 33
S250
K
S
K
C
L
H
H
S
I
C
P
S
P
G
N
Site 34
S254
L
H
H
S
I
C
P
S
P
G
N
K
E
R
I
Site 35
S262
P
G
N
K
E
R
I
S
P
R
T
P
A
S
K
Site 36
T265
K
E
R
I
S
P
R
T
P
A
S
K
I
A
S
Site 37
S268
I
S
P
R
T
P
A
S
K
I
A
S
E
M
A
Site 38
S272
T
P
A
S
K
I
A
S
E
M
A
Y
E
A
V
Site 39
T289
T
A
A
E
M
R
G
T
G
E
E
S
R
E
G
Site 40
S293
M
R
G
T
G
E
E
S
R
E
G
G
Q
K
S
Site 41
S300
S
R
E
G
G
Q
K
S
F
L
Y
S
E
L
S
Site 42
Y303
G
G
Q
K
S
F
L
Y
S
E
L
S
N
K
S
Site 43
S304
G
Q
K
S
F
L
Y
S
E
L
S
N
K
S
K
Site 44
S307
S
F
L
Y
S
E
L
S
N
K
S
K
S
G
D
Site 45
S310
Y
S
E
L
S
N
K
S
K
S
G
D
K
Q
M
Site 46
S312
E
L
S
N
K
S
K
S
G
D
K
Q
M
S
Q
Site 47
S318
K
S
G
D
K
Q
M
S
Q
R
E
S
K
E
F
Site 48
S322
K
Q
M
S
Q
R
E
S
K
E
F
A
D
S
I
Site 49
S328
E
S
K
E
F
A
D
S
I
S
K
G
L
M
V
Site 50
Y336
I
S
K
G
L
M
V
Y
A
N
Q
V
A
S
D
Site 51
S357
K
T
L
K
V
H
S
S
G
K
P
I
P
A
S
Site 52
S364
S
G
K
P
I
P
A
S
V
V
L
K
R
V
L
Site 53
T375
K
R
V
L
L
R
H
T
K
E
I
V
S
D
L
Site 54
S380
R
H
T
K
E
I
V
S
D
L
I
D
S
C
M
Site 55
S405
M
T
D
S
D
F
V
S
A
V
K
R
N
L
F
Site 56
T420
N
Q
W
K
Q
N
A
T
D
I
M
E
A
M
L
Site 57
S432
A
M
L
K
R
L
V
S
A
L
I
G
E
E
K
Site 58
T441
L
I
G
E
E
K
E
T
K
S
Q
S
L
S
Y
Site 59
S443
G
E
E
K
E
T
K
S
Q
S
L
S
Y
A
S
Site 60
S445
E
K
E
T
K
S
Q
S
L
S
Y
A
S
L
K
Site 61
S447
E
T
K
S
Q
S
L
S
Y
A
S
L
K
A
G
Site 62
Y448
T
K
S
Q
S
L
S
Y
A
S
L
K
A
G
S
Site 63
S450
S
Q
S
L
S
Y
A
S
L
K
A
G
S
H
D
Site 64
S455
Y
A
S
L
K
A
G
S
H
D
P
K
C
R
N
Site 65
S464
D
P
K
C
R
N
Q
S
L
E
F
S
T
M
K
Site 66
S468
R
N
Q
S
L
E
F
S
T
M
K
A
E
M
K
Site 67
S484
R
D
K
G
K
M
K
S
D
P
C
K
S
L
T
Site 68
S489
M
K
S
D
P
C
K
S
L
T
S
A
E
K
V
Site 69
T491
S
D
P
C
K
S
L
T
S
A
E
K
V
G
E
Site 70
S492
D
P
C
K
S
L
T
S
A
E
K
V
G
E
H
Site 71
S536
K
G
E
K
I
N
A
S
T
D
S
L
A
K
D
Site 72
S539
K
I
N
A
S
T
D
S
L
A
K
D
L
I
V
Site 73
Y554
S
A
L
K
L
I
Q
Y
H
L
T
Q
Q
T
K
Site 74
T557
K
L
I
Q
Y
H
L
T
Q
Q
T
K
G
K
D
Site 75
Y577
C
P
G
S
T
M
G
Y
M
A
Q
S
T
Q
Y
Site 76
Y584
Y
M
A
Q
S
T
Q
Y
E
K
C
G
G
G
Q
Site 77
S592
E
K
C
G
G
G
Q
S
A
K
A
L
S
V
K
Site 78
S597
G
Q
S
A
K
A
L
S
V
K
Q
L
E
S
H
Site 79
S603
L
S
V
K
Q
L
E
S
H
R
A
P
G
P
S
Site 80
S610
S
H
R
A
P
G
P
S
T
C
Q
K
E
N
Q
Site 81
S621
K
E
N
Q
H
L
D
S
Q
K
M
D
M
S
N
Site 82
S656
C
E
G
E
N
K
C
S
E
P
R
A
S
K
A
Site 83
S661
K
C
S
E
P
R
A
S
K
A
A
S
M
S
N
Site 84
S665
P
R
A
S
K
A
A
S
M
S
N
R
S
D
K
Site 85
S667
A
S
K
A
A
S
M
S
N
R
S
D
K
A
E
Site 86
T686
E
H
Q
E
L
D
C
T
S
G
M
K
Q
A
N
Site 87
Y714
L
C
L
I
M
A
K
Y
S
N
D
G
A
A
L
Site 88
S730
E
L
E
E
Q
A
A
S
A
N
K
P
N
F
R
Site 89
T739
N
K
P
N
F
R
G
T
R
C
I
H
S
G
A
Site 90
Y751
S
G
A
M
P
Q
N
Y
Q
D
S
L
G
H
E
Site 91
S769
N
N
Q
C
S
T
N
S
L
Q
K
Q
L
Q
A
Site 92
Y792
Q
F
N
V
P
M
L
Y
F
M
G
D
K
D
G
Site 93
S817
K
A
A
E
K
G
Y
S
V
G
G
L
L
Q
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation