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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MIA3
Full Name:
Melanoma inhibitory activity protein 3
Alias:
ARNT; C219 reactive peptide; C219-reactive peptide; D320; FLJ39207; KIAA0268; Melanoma inhibitory activity family, member 3; TANGO; Transport and Golgi organization protein 1; UNQ6077
Type:
Mass (Da):
213702
Number AA:
1907
UniProt ID:
Q5JRA6
International Prot ID:
IPI00455473
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006887
GO:0007162
GO:0030336
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
V
P
G
Q
L
D
P
S
T
G
R
R
F
S
E
Site 2
T28
P
G
Q
L
D
P
S
T
G
R
R
F
S
E
H
Site 3
S33
P
S
T
G
R
R
F
S
E
H
K
L
C
A
D
Site 4
Y73
F
K
K
G
D
P
V
Y
V
Y
Y
K
L
A
R
Site 5
Y75
K
G
D
P
V
Y
V
Y
Y
K
L
A
R
G
W
Site 6
Y76
G
D
P
V
Y
V
Y
Y
K
L
A
R
G
W
P
Site 7
T93
W
A
G
S
V
G
R
T
F
G
Y
F
P
K
D
Site 8
Y96
S
V
G
R
T
F
G
Y
F
P
K
D
L
I
Q
Site 9
T120
L
Q
V
P
T
D
E
T
D
F
V
C
F
D
G
Site 10
Y135
G
R
D
D
F
H
N
Y
N
V
E
E
L
L
G
Site 11
S149
G
F
L
E
L
Y
N
S
A
A
T
D
S
E
K
Site 12
S154
Y
N
S
A
A
T
D
S
E
K
A
V
E
K
T
Site 13
S172
M
E
K
N
P
E
L
S
K
E
R
E
P
E
P
Site 14
S186
P
E
P
V
E
A
N
S
E
E
S
D
S
V
F
Site 15
S189
V
E
A
N
S
E
E
S
D
S
V
F
S
E
N
Site 16
S191
A
N
S
E
E
S
D
S
V
F
S
E
N
T
E
Site 17
T206
D
L
Q
E
Q
F
T
T
Q
K
H
H
S
H
A
Site 18
S215
K
H
H
S
H
A
N
S
Q
A
N
H
A
Q
G
Site 19
S226
H
A
Q
G
E
Q
A
S
F
E
S
F
E
E
M
Site 20
S229
G
E
Q
A
S
F
E
S
F
E
E
M
L
Q
D
Site 21
S243
D
K
L
K
V
P
E
S
E
N
N
K
T
S
N
Site 22
T248
P
E
S
E
N
N
K
T
S
N
S
S
Q
V
S
Site 23
S249
E
S
E
N
N
K
T
S
N
S
S
Q
V
S
N
Site 24
S251
E
N
N
K
T
S
N
S
S
Q
V
S
N
E
Q
Site 25
S255
T
S
N
S
S
Q
V
S
N
E
Q
D
K
I
D
Site 26
Y264
E
Q
D
K
I
D
A
Y
K
L
L
K
K
E
M
Site 27
T272
K
L
L
K
K
E
M
T
L
D
L
K
T
K
F
Site 28
T277
E
M
T
L
D
L
K
T
K
F
G
S
T
A
D
Site 29
S281
D
L
K
T
K
F
G
S
T
A
D
A
L
V
S
Site 30
T282
L
K
T
K
F
G
S
T
A
D
A
L
V
S
D
Site 31
S288
D
L
K
T
K
F
G
S
T
A
D
A
L
V
S
Site 32
T293
L
V
S
D
D
E
T
T
R
L
V
T
S
L
E
Site 33
T297
D
E
T
T
R
L
V
T
S
L
E
D
D
F
D
Site 34
T309
D
F
D
E
E
L
D
T
E
Y
Y
A
V
G
K
Site 35
Y311
D
E
E
L
D
T
E
Y
Y
A
V
G
K
E
D
Site 36
Y312
E
E
L
D
T
E
Y
Y
A
V
G
K
E
D
E
Site 37
T332
F
D
E
L
P
L
L
T
F
T
D
G
E
D
M
Site 38
T341
T
D
G
E
D
M
K
T
P
A
K
S
G
V
E
Site 39
S345
D
M
K
T
P
A
K
S
G
V
E
K
Y
P
T
Site 40
Y350
A
K
S
G
V
E
K
Y
P
T
D
K
E
Q
N
Site 41
T352
S
G
V
E
K
Y
P
T
D
K
E
Q
N
S
N
Site 42
S358
P
T
D
K
E
Q
N
S
N
E
E
D
K
V
Q
Site 43
T367
E
E
D
K
V
Q
L
T
V
P
P
G
I
K
N
Site 44
T382
D
D
K
N
I
L
T
T
W
G
D
T
I
F
S
Site 45
S389
T
W
G
D
T
I
F
S
I
V
T
G
G
E
E
Site 46
T400
G
G
E
E
T
R
D
T
M
D
L
E
S
S
S
Site 47
S405
R
D
T
M
D
L
E
S
S
S
S
E
E
E
K
Site 48
S407
T
M
D
L
E
S
S
S
S
E
E
E
K
E
D
Site 49
S408
M
D
L
E
S
S
S
S
E
E
E
K
E
D
D
Site 50
S423
D
D
A
L
V
P
D
S
K
Q
G
K
P
Q
S
Site 51
S430
S
K
Q
G
K
P
Q
S
A
T
D
Y
S
D
P
Site 52
Y434
K
P
Q
S
A
T
D
Y
S
D
P
D
N
V
D
Site 53
S435
P
Q
S
A
T
D
Y
S
D
P
D
N
V
D
D
Site 54
T452
F
I
V
D
I
P
K
T
N
N
D
K
E
V
N
Site 55
S474
K
G
R
G
V
Q
E
S
K
R
G
L
V
Q
D
Site 56
T483
R
G
L
V
Q
D
K
T
E
L
E
D
E
N
Q
Site 57
T494
D
E
N
Q
E
G
M
T
V
H
S
S
V
H
S
Site 58
S498
E
G
M
T
V
H
S
S
V
H
S
N
N
L
N
Site 59
S501
T
V
H
S
S
V
H
S
N
N
L
N
S
M
P
Site 60
T516
A
A
E
K
G
K
D
T
L
K
S
A
Y
D
D
Site 61
S519
K
G
K
D
T
L
K
S
A
Y
D
D
T
E
N
Site 62
T524
L
K
S
A
Y
D
D
T
E
N
D
L
K
G
A
Site 63
S554
E
Q
I
L
E
G
G
S
E
S
E
S
A
Q
K
Site 64
S558
E
G
G
S
E
S
E
S
A
Q
K
A
A
G
N
Site 65
S576
D
R
K
I
Q
Q
E
S
L
G
S
A
P
L
M
Site 66
S579
I
Q
Q
E
S
L
G
S
A
P
L
M
G
D
D
Site 67
S591
G
D
D
H
P
N
A
S
R
D
S
V
E
G
D
Site 68
S594
H
P
N
A
S
R
D
S
V
E
G
D
A
L
V
Site 69
T608
V
N
G
A
K
L
H
T
L
S
V
E
H
Q
R
Site 70
S610
G
A
K
L
H
T
L
S
V
E
H
Q
R
E
E
Site 71
S633
T
Q
N
Q
P
R
F
S
S
P
D
E
I
D
L
Site 72
S634
Q
N
Q
P
R
F
S
S
P
D
E
I
D
L
P
Site 73
T666
Q
E
R
D
V
A
A
T
A
S
K
Q
M
S
E
Site 74
S668
R
D
V
A
A
T
A
S
K
Q
M
S
E
K
I
Site 75
S672
A
T
A
S
K
Q
M
S
E
K
I
R
L
S
E
Site 76
S678
M
S
E
K
I
R
L
S
E
G
E
A
K
E
D
Site 77
S686
E
G
E
A
K
E
D
S
L
D
E
E
F
F
H
Site 78
T705
Q
G
T
E
V
G
Q
T
D
Q
T
D
S
T
G
Site 79
T708
E
V
G
Q
T
D
Q
T
D
S
T
G
G
P
A
Site 80
S710
G
Q
T
D
Q
T
D
S
T
G
G
P
A
F
L
Site 81
T711
Q
T
D
Q
T
D
S
T
G
G
P
A
F
L
S
Site 82
S718
T
G
G
P
A
F
L
S
K
V
E
E
D
D
Y
Site 83
Y725
S
K
V
E
E
D
D
Y
P
S
E
E
L
L
E
Site 84
S727
V
E
E
D
D
Y
P
S
E
E
L
L
E
D
E
Site 85
S742
N
A
I
N
A
K
R
S
K
E
K
N
P
G
N
Site 86
T768
P
D
R
A
V
L
G
T
I
H
P
D
P
E
I
Site 87
S778
P
D
P
E
I
E
E
S
K
Q
E
T
S
M
I
Site 88
S788
E
T
S
M
I
L
D
S
E
K
T
S
E
T
A
Site 89
S792
I
L
D
S
E
K
T
S
E
T
A
A
K
G
V
Site 90
T808
T
G
G
R
E
P
N
T
M
V
E
K
E
R
P
Site 91
S828
A
Q
R
P
F
E
R
S
D
F
S
D
S
I
K
Site 92
S831
P
F
E
R
S
D
F
S
D
S
I
K
I
Q
T
Site 93
S833
E
R
S
D
F
S
D
S
I
K
I
Q
T
P
E
Site 94
T838
S
D
S
I
K
I
Q
T
P
E
L
G
E
V
F
Site 95
S850
E
V
F
Q
N
K
D
S
D
Y
L
K
N
D
N
Site 96
Y852
F
Q
N
K
D
S
D
Y
L
K
N
D
N
P
E
Site 97
T864
N
P
E
E
H
L
K
T
S
G
L
A
G
E
P
Site 98
S876
G
E
P
E
G
E
L
S
K
E
D
H
E
N
T
Site 99
Y886
D
H
E
N
T
E
K
Y
M
G
T
E
S
Q
G
Site 100
S891
E
K
Y
M
G
T
E
S
Q
G
S
A
A
A
E
Site 101
S894
M
G
T
E
S
Q
G
S
A
A
A
E
P
E
D
Site 102
S903
A
A
E
P
E
D
D
S
F
H
W
T
P
H
T
Site 103
T907
E
D
D
S
F
H
W
T
P
H
T
S
V
E
P
Site 104
T910
S
F
H
W
T
P
H
T
S
V
E
P
G
H
S
Site 105
S917
T
S
V
E
P
G
H
S
D
K
R
E
D
L
L
Site 106
S928
E
D
L
L
I
I
S
S
F
F
K
E
Q
Q
S
Site 107
S935
S
F
F
K
E
Q
Q
S
L
Q
R
F
Q
K
Y
Site 108
Y942
S
L
Q
R
F
Q
K
Y
F
N
V
H
E
L
E
Site 109
S956
E
A
L
L
Q
E
M
S
S
K
L
K
S
A
Q
Site 110
S957
A
L
L
Q
E
M
S
S
K
L
K
S
A
Q
Q
Site 111
S961
E
M
S
S
K
L
K
S
A
Q
Q
E
S
L
P
Site 112
Y969
A
Q
Q
E
S
L
P
Y
N
M
E
K
V
L
D
Site 113
S984
K
V
F
R
A
S
E
S
Q
I
L
S
I
A
E
Site 114
S988
A
S
E
S
Q
I
L
S
I
A
E
K
M
L
D
Site 115
Y1026
D
D
I
Q
D
L
I
Y
F
V
R
Y
K
H
S
Site 116
T1034
F
V
R
Y
K
H
S
T
A
E
E
T
A
T
L
Site 117
S1067
P
L
H
E
D
N
F
S
R
E
K
T
A
E
L
Site 118
T1071
D
N
F
S
R
E
K
T
A
E
L
N
V
Q
V
Site 119
T1093
D
Q
R
V
I
G
D
T
H
A
S
E
V
S
Q
Site 120
S1099
D
T
H
A
S
E
V
S
Q
K
P
N
T
E
K
Site 121
T1114
D
L
D
P
G
P
V
T
T
E
D
T
P
M
D
Site 122
T1118
G
P
V
T
T
E
D
T
P
M
D
A
I
D
A
Site 123
S1138
T
A
A
E
E
P
A
S
V
T
P
L
E
N
A
Site 124
S1159
F
M
F
Y
L
T
K
S
L
V
A
T
L
P
D
Site 125
T1163
L
T
K
S
L
V
A
T
L
P
D
D
V
Q
P
Site 126
Y1175
V
Q
P
G
P
D
F
Y
G
L
P
W
K
P
V
Site 127
Y1209
L
V
V
K
D
R
V
Y
Q
V
T
E
Q
Q
I
Site 128
T1212
K
D
R
V
Y
Q
V
T
E
Q
Q
I
S
E
K
Site 129
T1222
Q
I
S
E
K
L
K
T
I
M
K
E
N
T
E
Site 130
S1235
T
E
L
V
Q
K
L
S
N
Y
E
Q
K
I
K
Site 131
S1259
R
K
Q
N
M
I
L
S
D
E
A
I
K
Y
K
Site 132
Y1265
L
S
D
E
A
I
K
Y
K
D
K
I
K
T
L
Site 133
T1271
K
Y
K
D
K
I
K
T
L
E
K
N
Q
E
I
Site 134
T1282
N
Q
E
I
L
D
D
T
A
K
N
L
R
V
M
Site 135
S1292
N
L
R
V
M
L
E
S
E
R
E
Q
N
V
K
Site 136
S1305
V
K
N
Q
D
L
I
S
E
N
K
K
S
I
E
Site 137
S1310
L
I
S
E
N
K
K
S
I
E
K
L
K
D
V
Site 138
S1319
E
K
L
K
D
V
I
S
M
N
A
S
E
F
S
Site 139
S1338
A
L
N
E
A
K
L
S
E
E
K
V
K
S
E
Site 140
S1344
L
S
E
E
K
V
K
S
E
C
H
R
V
Q
E
Site 141
S1371
Q
Q
E
I
E
D
W
S
K
L
H
A
E
L
S
Site 142
S1378
S
K
L
H
A
E
L
S
E
Q
I
K
S
F
E
Site 143
S1383
E
L
S
E
Q
I
K
S
F
E
K
S
Q
K
D
Site 144
S1387
Q
I
K
S
F
E
K
S
Q
K
D
L
E
V
A
Site 145
T1396
K
D
L
E
V
A
L
T
H
K
D
D
N
I
N
Site 146
S1419
L
N
L
L
E
C
E
S
E
S
E
G
Q
N
K
Site 147
S1431
Q
N
K
G
G
N
D
S
D
E
L
A
N
G
E
Site 148
S1458
I
K
Q
M
M
D
V
S
R
T
Q
T
A
I
S
Site 149
T1462
M
D
V
S
R
T
Q
T
A
I
S
V
V
E
E
Site 150
S1465
S
R
T
Q
T
A
I
S
V
V
E
E
D
L
K
Site 151
S1481
L
Q
L
K
L
R
A
S
V
S
T
K
C
N
L
Site 152
S1483
L
K
L
R
A
S
V
S
T
K
C
N
L
E
D
Site 153
S1501
K
L
E
D
D
R
N
S
L
Q
A
A
K
A
G
Site 154
T1515
G
L
E
D
E
C
K
T
L
R
Q
K
V
E
I
Site 155
Y1527
V
E
I
L
N
E
L
Y
Q
Q
K
E
M
A
L
Site 156
S1539
M
A
L
Q
K
K
L
S
Q
E
E
Y
E
R
Q
Site 157
Y1543
K
K
L
S
Q
E
E
Y
E
R
Q
E
R
E
H
Site 158
S1553
Q
E
R
E
H
R
L
S
A
A
D
E
K
A
V
Site 159
S1561
A
A
D
E
K
A
V
S
A
A
E
E
V
K
T
Site 160
T1568
S
A
A
E
E
V
K
T
Y
K
R
R
I
E
E
Site 161
Y1569
A
A
E
E
V
K
T
Y
K
R
R
I
E
E
M
Site 162
T1583
M
E
D
E
L
Q
K
T
E
R
S
F
K
N
Q
Site 163
S1586
E
L
Q
K
T
E
R
S
F
K
N
Q
I
A
T
Site 164
T1652
P
M
P
G
K
P
N
T
Q
N
P
P
R
R
G
Site 165
S1662
P
P
R
R
G
P
L
S
Q
N
G
S
F
G
P
Site 166
S1666
G
P
L
S
Q
N
G
S
F
G
P
S
P
V
S
Site 167
S1670
Q
N
G
S
F
G
P
S
P
V
S
G
G
E
C
Site 168
S1673
S
F
G
P
S
P
V
S
G
G
E
C
S
P
P
Site 169
S1678
P
V
S
G
G
E
C
S
P
P
L
T
V
E
P
Site 170
T1682
G
E
C
S
P
P
L
T
V
E
P
P
V
R
P
Site 171
S1691
E
P
P
V
R
P
L
S
A
T
L
N
R
R
D
Site 172
T1693
P
V
R
P
L
S
A
T
L
N
R
R
D
M
P
Site 173
S1702
N
R
R
D
M
P
R
S
E
F
G
S
V
D
G
Site 174
S1706
M
P
R
S
E
F
G
S
V
D
G
P
L
P
H
Site 175
S1717
P
L
P
H
P
R
W
S
A
E
A
S
G
K
P
Site 176
S1721
P
R
W
S
A
E
A
S
G
K
P
S
P
S
D
Site 177
S1725
A
E
A
S
G
K
P
S
P
S
D
P
G
S
G
Site 178
S1727
A
S
G
K
P
S
P
S
D
P
G
S
G
T
A
Site 179
S1731
P
S
P
S
D
P
G
S
G
T
A
T
M
M
N
Site 180
T1733
P
S
D
P
G
S
G
T
A
T
M
M
N
S
S
Site 181
T1735
D
P
G
S
G
T
A
T
M
M
N
S
S
S
R
Site 182
S1739
G
T
A
T
M
M
N
S
S
S
R
G
S
S
P
Site 183
S1740
T
A
T
M
M
N
S
S
S
R
G
S
S
P
T
Site 184
S1741
A
T
M
M
N
S
S
S
R
G
S
S
P
T
R
Site 185
S1744
M
N
S
S
S
R
G
S
S
P
T
R
V
L
D
Site 186
S1745
N
S
S
S
R
G
S
S
P
T
R
V
L
D
E
Site 187
T1747
S
S
R
G
S
S
P
T
R
V
L
D
E
G
K
Site 188
Y1785
P
V
P
P
P
I
R
Y
G
P
P
P
Q
L
C
Site 189
S1847
A
P
F
R
P
L
G
S
L
G
P
R
E
Y
F
Site 190
Y1853
G
S
L
G
P
R
E
Y
F
I
P
G
T
R
L
Site 191
T1858
R
E
Y
F
I
P
G
T
R
L
P
P
P
T
H
Site 192
T1864
G
T
R
L
P
P
P
T
H
G
P
Q
E
Y
P
Site 193
Y1870
P
T
H
G
P
Q
E
Y
P
P
P
P
A
V
R
Site 194
S1882
A
V
R
D
L
L
P
S
G
S
R
D
E
P
P
Site 195
S1884
R
D
L
L
P
S
G
S
R
D
E
P
P
P
A
Site 196
S1892
R
D
E
P
P
P
A
S
Q
S
T
S
Q
D
C
Site 197
S1894
E
P
P
P
A
S
Q
S
T
S
Q
D
C
S
Q
Site 198
T1895
P
P
P
A
S
Q
S
T
S
Q
D
C
S
Q
A
Site 199
S1896
P
P
A
S
Q
S
T
S
Q
D
C
S
Q
A
L
Site 200
S1900
Q
S
T
S
Q
D
C
S
Q
A
L
K
Q
S
P
Site 201
S1906
C
S
Q
A
L
K
Q
S
P
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation