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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FGD3
Full Name:
FYVE, RhoGEF and PH domain-containing protein 3
Alias:
FLJ00004; FYVE, RhoGEF and PH domain containing 3; ZFYVE5; zinc finger FYVE domain-containing protein 5
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
79400
Number AA:
UniProt ID:
Q5JSP0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005856
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0031267
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0006915
GO:0046847
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
S
G
R
G
S
S
T
P
P
G
P
I
Site 2
S8
M
E
S
G
R
G
S
S
T
P
P
G
P
I
A
Site 3
T9
E
S
G
R
G
S
S
T
P
P
G
P
I
A
A
Site 4
T22
A
A
L
G
M
P
D
T
G
P
G
S
S
S
L
Site 5
S26
M
P
D
T
G
P
G
S
S
S
L
G
K
L
Q
Site 6
S27
P
D
T
G
P
G
S
S
S
L
G
K
L
Q
A
Site 7
S28
D
T
G
P
G
S
S
S
L
G
K
L
Q
A
L
Site 8
S56
L
A
A
A
G
D
G
S
P
D
I
G
P
T
G
Site 9
T62
G
S
P
D
I
G
P
T
G
E
L
S
G
S
L
Site 10
S66
I
G
P
T
G
E
L
S
G
S
L
K
I
P
N
Site 11
S68
P
T
G
E
L
S
G
S
L
K
I
P
N
R
D
Site 12
S76
L
K
I
P
N
R
D
S
G
I
D
S
P
S
S
Site 13
S80
N
R
D
S
G
I
D
S
P
S
S
S
V
A
G
Site 14
S82
D
S
G
I
D
S
P
S
S
S
V
A
G
E
N
Site 15
S83
S
G
I
D
S
P
S
S
S
V
A
G
E
N
F
Site 16
S84
G
I
D
S
P
S
S
S
V
A
G
E
N
F
P
Site 17
S101
E
G
L
E
A
G
P
S
P
T
V
L
G
A
H
Site 18
S115
H
A
E
M
A
L
D
S
Q
V
P
K
V
T
P
Site 19
T121
D
S
Q
V
P
K
V
T
P
Q
E
E
A
D
S
Site 20
S128
T
P
Q
E
E
A
D
S
D
V
G
E
E
P
D
Site 21
S136
D
V
G
E
E
P
D
S
E
N
T
P
Q
K
A
Site 22
T139
E
E
P
D
S
E
N
T
P
Q
K
A
D
K
D
Site 23
T168
I
A
Q
E
L
L
H
T
E
E
T
Y
V
K
R
Site 24
T171
E
L
L
H
T
E
E
T
Y
V
K
R
L
H
L
Site 25
Y172
L
L
H
T
E
E
T
Y
V
K
R
L
H
L
L
Site 26
T188
Q
V
F
C
T
R
L
T
D
A
G
I
P
P
E
Site 27
T224
P
E
L
K
T
R
I
T
E
E
W
D
T
N
P
Site 28
T229
R
I
T
E
E
W
D
T
N
P
R
L
G
D
I
Site 29
Y250
F
L
K
M
Y
G
E
Y
V
K
N
F
D
R
A
Site 30
T265
V
G
L
V
S
T
W
T
Q
R
S
P
L
F
K
Site 31
S268
V
S
T
W
T
Q
R
S
P
L
F
K
D
V
V
Site 32
Y303
P
V
Q
R
V
P
R
Y
E
L
L
L
K
D
Y
Site 33
Y310
Y
E
L
L
L
K
D
Y
L
K
R
L
P
Q
D
Site 34
S327
D
R
K
D
A
E
R
S
L
E
L
I
S
T
A
Site 35
T333
R
S
L
E
L
I
S
T
A
A
N
H
S
N
A
Site 36
Y355
M
H
K
L
L
E
V
Y
E
Q
L
G
G
E
E
Site 37
S381
E
G
Q
I
Q
K
L
S
A
K
N
G
T
P
Q
Site 38
T386
K
L
S
A
K
N
G
T
P
Q
D
R
H
L
F
Site 39
S397
R
H
L
F
L
F
N
S
M
I
L
Y
C
V
P
Site 40
Y401
L
F
N
S
M
I
L
Y
C
V
P
K
L
R
L
Site 41
S414
R
L
M
G
Q
K
F
S
V
R
E
K
M
D
I
Site 42
T437
V
K
P
N
T
A
H
T
F
I
I
T
G
R
K
Site 43
T441
T
A
H
T
F
I
I
T
G
R
K
R
S
L
E
Site 44
S446
I
I
T
G
R
K
R
S
L
E
L
Q
T
R
T
Site 45
T477
K
H
K
Q
N
S
E
T
F
K
A
F
G
G
A
Site 46
S486
K
A
F
G
G
A
F
S
Q
D
E
D
P
S
L
Site 47
S492
F
S
Q
D
E
D
P
S
L
S
P
D
M
P
I
Site 48
S494
Q
D
E
D
P
S
L
S
P
D
M
P
I
T
S
Site 49
T500
L
S
P
D
M
P
I
T
S
T
S
P
V
E
P
Site 50
S501
S
P
D
M
P
I
T
S
T
S
P
V
E
P
V
Site 51
T510
S
P
V
E
P
V
V
T
T
E
G
S
S
G
A
Site 52
S526
G
L
E
P
R
K
L
S
S
K
T
R
R
D
K
Site 53
S527
L
E
P
R
K
L
S
S
K
T
R
R
D
K
E
Site 54
T529
P
R
K
L
S
S
K
T
R
R
D
K
E
K
Q
Site 55
S540
K
E
K
Q
S
C
K
S
C
G
E
T
F
N
S
Site 56
T544
S
C
K
S
C
G
E
T
F
N
S
I
T
K
R
Site 57
S547
S
C
G
E
T
F
N
S
I
T
K
R
R
H
H
Site 58
T549
G
E
T
F
N
S
I
T
K
R
R
H
H
C
K
Site 59
S577
K
A
E
N
S
R
Q
S
R
V
C
R
D
C
F
Site 60
S593
T
Q
P
V
A
P
E
S
T
E
K
T
P
T
A
Site 61
T597
A
P
E
S
T
E
K
T
P
T
A
D
P
Q
P
Site 62
T599
E
S
T
E
K
T
P
T
A
D
P
Q
P
S
L
Site 63
S605
P
T
A
D
P
Q
P
S
L
L
C
G
P
L
R
Site 64
S614
L
C
G
P
L
R
L
S
E
S
G
E
T
W
S
Site 65
S616
G
P
L
R
L
S
E
S
G
E
T
W
S
E
V
Site 66
T619
R
L
S
E
S
G
E
T
W
S
E
V
W
A
A
Site 67
S621
S
E
S
G
E
T
W
S
E
V
W
A
A
I
P
Site 68
S641
V
L
H
L
Q
G
G
S
Q
D
G
R
L
P
R
Site 69
T649
Q
D
G
R
L
P
R
T
I
P
L
P
S
C
K
Site 70
S654
P
R
T
I
P
L
P
S
C
K
L
S
V
P
D
Site 71
S658
P
L
P
S
C
K
L
S
V
P
D
P
E
E
R
Site 72
S668
D
P
E
E
R
L
D
S
G
H
V
W
K
L
Q
Site 73
S680
K
L
Q
W
A
K
Q
S
W
Y
L
S
A
S
S
Site 74
Y682
Q
W
A
K
Q
S
W
Y
L
S
A
S
S
A
E
Site 75
S684
A
K
Q
S
W
Y
L
S
A
S
S
A
E
L
Q
Site 76
S686
Q
S
W
Y
L
S
A
S
S
A
E
L
Q
Q
Q
Site 77
T700
Q
W
L
E
T
L
S
T
A
A
H
G
D
T
A
Site 78
T706
S
T
A
A
H
G
D
T
A
Q
D
S
P
G
A
Site 79
S710
H
G
D
T
A
Q
D
S
P
G
A
L
Q
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation