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Updated November 2019
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Protein Info
Short Name:
IQSEC2
Full Name:
IQ motif and SEC7 domain-containing protein 2
Alias:
IQ motif and Sec7 domain 2; IQ motif and Sec7 domain-containing protein 2; IQEC2; KIAA0522
Type:
Intracellular, Cytoplasm, Intracellular membrane-bound organelle protein
Mass (Da):
161736
Number AA:
1478
UniProt ID:
Q5JU85
International Prot ID:
IPI00759479
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0043231
Uniprot
OncoNet
Molecular Function:
GO:0005086
PhosphoSite+
KinaseNET
Biological Process:
GO:0032012
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
E
A
G
S
G
P
P
G
G
P
G
Site 2
S13
G
P
P
G
G
P
G
S
E
S
P
N
R
A
V
Site 3
S15
P
G
G
P
G
S
E
S
P
N
R
A
V
E
Y
Site 4
S32
E
L
N
N
I
I
E
S
Q
Q
Q
L
L
E
T
Site 5
T39
S
Q
Q
Q
L
L
E
T
Q
R
R
R
I
E
E
Site 6
T55
E
G
Q
L
D
Q
L
T
Q
E
N
R
D
L
R
Site 7
S65
N
R
D
L
R
E
E
S
Q
L
H
R
G
E
L
Site 8
S82
D
P
H
G
A
R
D
S
P
G
R
E
S
Q
Y
Site 9
S87
R
D
S
P
G
R
E
S
Q
Y
Q
N
L
R
E
Site 10
Y89
S
P
G
R
E
S
Q
Y
Q
N
L
R
E
T
Q
Site 11
S105
H
H
R
E
L
R
E
S
Q
F
H
Q
A
A
R
Site 12
Y116
Q
A
A
R
D
V
G
Y
P
N
R
E
G
A
Y
Site 13
S138
R
D
K
E
R
D
A
S
Y
P
L
Q
D
T
T
Site 14
Y139
D
K
E
R
D
A
S
Y
P
L
Q
D
T
T
G
Site 15
Y188
G
R
E
K
E
A
G
Y
S
A
A
V
G
V
G
Site 16
S189
R
E
K
E
A
G
Y
S
A
A
V
G
V
G
P
Site 17
S206
P
R
E
R
G
Q
L
S
R
G
A
S
R
S
S
Site 18
S210
G
Q
L
S
R
G
A
S
R
S
S
S
P
G
A
Site 19
S212
L
S
R
G
A
S
R
S
S
S
P
G
A
G
G
Site 20
S213
S
R
G
A
S
R
S
S
S
P
G
A
G
G
G
Site 21
S214
R
G
A
S
R
S
S
S
P
G
A
G
G
G
H
Site 22
S222
P
G
A
G
G
G
H
S
T
S
T
S
T
S
P
Site 23
S224
A
G
G
G
H
S
T
S
T
S
T
S
P
A
T
Site 24
S226
G
G
H
S
T
S
T
S
T
S
P
A
T
T
L
Site 25
S228
H
S
T
S
T
S
T
S
P
A
T
T
L
Q
R
Site 26
T232
T
S
T
S
P
A
T
T
L
Q
R
N
V
E
G
Site 27
S244
V
E
G
D
A
P
G
S
D
L
S
T
A
V
D
Site 28
S247
D
A
P
G
S
D
L
S
T
A
V
D
S
P
G
Site 29
T248
A
P
G
S
D
L
S
T
A
V
D
S
P
G
S
Site 30
S252
D
L
S
T
A
V
D
S
P
G
S
Q
P
P
Y
Site 31
S255
T
A
V
D
S
P
G
S
Q
P
P
Y
R
L
S
Site 32
Y259
S
P
G
S
Q
P
P
Y
R
L
S
Q
L
P
P
Site 33
S262
S
Q
P
P
Y
R
L
S
Q
L
P
P
S
S
S
Site 34
S267
R
L
S
Q
L
P
P
S
S
S
H
M
G
G
P
Site 35
S268
L
S
Q
L
P
P
S
S
S
H
M
G
G
P
P
Site 36
S269
S
Q
L
P
P
S
S
S
H
M
G
G
P
P
A
Site 37
S292
R
A
R
L
Q
P
A
S
V
A
L
R
K
Q
E
Site 38
S306
E
E
E
E
I
K
R
S
K
A
L
S
D
S
Y
Site 39
S310
I
K
R
S
K
A
L
S
D
S
Y
E
L
S
T
Site 40
S312
R
S
K
A
L
S
D
S
Y
E
L
S
T
D
L
Site 41
Y313
S
K
A
L
S
D
S
Y
E
L
S
T
D
L
Q
Site 42
S316
L
S
D
S
Y
E
L
S
T
D
L
Q
D
K
K
Site 43
T317
S
D
S
Y
E
L
S
T
D
L
Q
D
K
K
V
Site 44
Y331
V
E
M
L
E
R
K
Y
G
G
S
F
L
S
R
Site 45
S334
L
E
R
K
Y
G
G
S
F
L
S
R
R
A
A
Site 46
S337
K
Y
G
G
S
F
L
S
R
R
A
A
R
T
I
Site 47
T343
L
S
R
R
A
A
R
T
I
Q
T
A
F
R
Q
Site 48
Y351
I
Q
T
A
F
R
Q
Y
R
M
N
K
N
F
E
Site 49
S362
K
N
F
E
R
L
R
S
S
A
S
E
S
R
M
Site 50
S363
N
F
E
R
L
R
S
S
A
S
E
S
R
M
S
Site 51
S365
E
R
L
R
S
S
A
S
E
S
R
M
S
R
R
Site 52
S367
L
R
S
S
A
S
E
S
R
M
S
R
R
I
I
Site 53
S370
S
A
S
E
S
R
M
S
R
R
I
I
L
S
N
Site 54
S383
S
N
M
R
M
Q
F
S
F
E
E
Y
E
K
A
Site 55
Y387
M
Q
F
S
F
E
E
Y
E
K
A
Q
N
P
A
Site 56
Y395
E
K
A
Q
N
P
A
Y
F
E
G
K
P
A
S
Site 57
S402
Y
F
E
G
K
P
A
S
L
D
E
G
A
M
A
Site 58
S413
G
A
M
A
G
A
R
S
H
R
L
E
R
G
L
Site 59
Y422
R
L
E
R
G
L
P
Y
G
G
S
C
G
G
G
Site 60
S425
R
G
L
P
Y
G
G
S
C
G
G
G
I
D
G
Site 61
S435
G
G
I
D
G
G
G
S
S
V
T
T
S
G
E
Site 62
S436
G
I
D
G
G
G
S
S
V
T
T
S
G
E
F
Site 63
T438
D
G
G
G
S
S
V
T
T
S
G
E
F
S
N
Site 64
T439
G
G
G
S
S
V
T
T
S
G
E
F
S
N
D
Site 65
S440
G
G
S
S
V
T
T
S
G
E
F
S
N
D
I
Site 66
S444
V
T
T
S
G
E
F
S
N
D
I
T
E
L
E
Site 67
T448
G
E
F
S
N
D
I
T
E
L
E
D
S
F
S
Site 68
S453
D
I
T
E
L
E
D
S
F
S
K
Q
V
K
S
Site 69
S455
T
E
L
E
D
S
F
S
K
Q
V
K
S
L
A
Site 70
S460
S
F
S
K
Q
V
K
S
L
A
E
S
I
D
E
Site 71
S464
Q
V
K
S
L
A
E
S
I
D
E
A
L
N
C
Site 72
S474
E
A
L
N
C
H
P
S
G
P
M
S
E
E
P
Site 73
S478
C
H
P
S
G
P
M
S
E
E
P
G
S
A
Q
Site 74
S483
P
M
S
E
E
P
G
S
A
Q
L
E
K
R
E
Site 75
S491
A
Q
L
E
K
R
E
S
K
E
Q
Q
E
D
S
Site 76
S498
S
K
E
Q
Q
E
D
S
S
A
T
S
F
S
D
Site 77
S499
K
E
Q
Q
E
D
S
S
A
T
S
F
S
D
L
Site 78
S502
Q
E
D
S
S
A
T
S
F
S
D
L
P
L
Y
Site 79
S504
D
S
S
A
T
S
F
S
D
L
P
L
Y
L
D
Site 80
Y509
S
F
S
D
L
P
L
Y
L
D
D
T
V
P
Q
Site 81
T513
L
P
L
Y
L
D
D
T
V
P
Q
Q
S
P
E
Site 82
S518
D
D
T
V
P
Q
Q
S
P
E
R
L
P
S
T
Site 83
S524
Q
S
P
E
R
L
P
S
T
E
P
P
P
Q
G
Site 84
T525
S
P
E
R
L
P
S
T
E
P
P
P
Q
G
R
Site 85
S550
P
V
P
P
P
V
P
S
G
T
R
E
D
G
S
Site 86
S557
S
G
T
R
E
D
G
S
R
E
E
G
T
R
R
Site 87
T562
D
G
S
R
E
E
G
T
R
R
G
P
G
C
L
Site 88
T585
A
A
H
L
P
L
L
T
I
E
P
P
S
D
S
Site 89
S590
L
L
T
I
E
P
P
S
D
S
S
V
D
L
S
Site 90
S592
T
I
E
P
P
S
D
S
S
V
D
L
S
D
R
Site 91
S593
I
E
P
P
S
D
S
S
V
D
L
S
D
R
S
Site 92
S597
S
D
S
S
V
D
L
S
D
R
S
D
R
G
S
Site 93
S600
S
V
D
L
S
D
R
S
D
R
G
S
V
H
R
Site 94
S604
S
D
R
S
D
R
G
S
V
H
R
Q
L
V
Y
Site 95
Y611
S
V
H
R
Q
L
V
Y
E
A
D
G
C
S
P
Site 96
S617
V
Y
E
A
D
G
C
S
P
H
G
T
L
K
H
Site 97
T621
D
G
C
S
P
H
G
T
L
K
H
K
G
P
P
Site 98
Y638
A
P
I
P
H
R
H
Y
P
A
P
E
G
P
A
Site 99
S658
P
L
P
P
A
P
N
S
G
T
G
P
S
G
V
Site 100
S663
P
N
S
G
T
G
P
S
G
V
A
G
G
R
R
Site 101
S688
S
D
G
G
D
N
E
S
L
E
S
S
S
N
S
Site 102
S691
G
D
N
E
S
L
E
S
S
S
N
S
N
E
T
Site 103
S692
D
N
E
S
L
E
S
S
S
N
S
N
E
T
I
Site 104
S693
N
E
S
L
E
S
S
S
N
S
N
E
T
I
N
Site 105
S695
S
L
E
S
S
S
N
S
N
E
T
I
N
C
S
Site 106
T698
S
S
S
N
S
N
E
T
I
N
C
S
S
G
S
Site 107
S702
S
N
E
T
I
N
C
S
S
G
S
S
S
R
D
Site 108
S703
N
E
T
I
N
C
S
S
G
S
S
S
R
D
S
Site 109
S705
T
I
N
C
S
S
G
S
S
S
R
D
S
L
R
Site 110
S706
I
N
C
S
S
G
S
S
S
R
D
S
L
R
E
Site 111
S707
N
C
S
S
G
S
S
S
R
D
S
L
R
E
P
Site 112
S710
S
G
S
S
S
R
D
S
L
R
E
P
P
A
T
Site 113
T717
S
L
R
E
P
P
A
T
G
L
C
K
Q
T
Y
Site 114
Y724
T
G
L
C
K
Q
T
Y
Q
R
E
T
R
H
S
Site 115
T728
K
Q
T
Y
Q
R
E
T
R
H
S
W
D
S
P
Site 116
S731
Y
Q
R
E
T
R
H
S
W
D
S
P
A
F
N
Site 117
S734
E
T
R
H
S
W
D
S
P
A
F
N
N
D
V
Site 118
Y747
D
V
V
Q
R
R
H
Y
R
I
G
L
N
L
F
Site 119
Y764
K
P
E
K
G
I
Q
Y
L
I
E
R
G
F
L
Site 120
T774
E
R
G
F
L
S
D
T
P
V
G
V
A
H
F
Site 121
S819
V
V
D
E
M
D
F
S
S
M
D
L
D
D
A
Site 122
S820
V
D
E
M
D
F
S
S
M
D
L
D
D
A
L
Site 123
S832
D
A
L
R
K
F
Q
S
H
I
R
V
Q
G
E
Site 124
Y886
I
L
L
N
T
D
M
Y
S
P
S
V
K
A
E
Site 125
S887
L
L
N
T
D
M
Y
S
P
S
V
K
A
E
R
Site 126
S889
N
T
D
M
Y
S
P
S
V
K
A
E
R
K
M
Site 127
Y923
R
D
L
L
V
G
I
Y
Q
R
I
Q
G
R
E
Site 128
S939
R
T
N
D
D
H
V
S
Q
V
Q
A
V
E
R
Site 129
S956
V
G
K
K
P
V
L
S
L
P
H
R
R
L
V
Site 130
Y969
L
V
C
C
C
Q
L
Y
E
V
P
D
P
N
R
Site 131
T1008
Q
K
K
K
I
L
V
T
Y
S
F
R
Q
S
F
Site 132
Y1009
K
K
K
I
L
V
T
Y
S
F
R
Q
S
F
P
Site 133
S1010
K
K
I
L
V
T
Y
S
F
R
Q
S
F
P
L
Site 134
S1014
V
T
Y
S
F
R
Q
S
F
P
L
V
E
M
H
Site 135
Y1029
M
Q
L
F
Q
N
S
Y
Y
Q
F
G
I
K
L
Site 136
Y1030
Q
L
F
Q
N
S
Y
Y
Q
F
G
I
K
L
L
Site 137
T1063
L
Q
D
R
L
R
F
T
S
D
L
R
E
S
I
Site 138
S1064
Q
D
R
L
R
F
T
S
D
L
R
E
S
I
A
Site 139
S1069
F
T
S
D
L
R
E
S
I
A
E
V
Q
E
M
Site 140
Y1079
E
V
Q
E
M
E
K
Y
R
V
E
S
E
L
E
Site 141
S1083
M
E
K
Y
R
V
E
S
E
L
E
K
Q
K
G
Site 142
S1097
G
M
M
R
P
N
A
S
Q
P
G
G
A
K
D
Site 143
S1105
Q
P
G
G
A
K
D
S
V
N
G
T
M
A
R
Site 144
T1109
A
K
D
S
V
N
G
T
M
A
R
S
S
L
E
Site 145
S1113
V
N
G
T
M
A
R
S
S
L
E
D
T
Y
G
Site 146
S1114
N
G
T
M
A
R
S
S
L
E
D
T
Y
G
A
Site 147
T1118
A
R
S
S
L
E
D
T
Y
G
A
G
D
G
L
Site 148
Y1119
R
S
S
L
E
D
T
Y
G
A
G
D
G
L
K
Site 149
S1131
G
L
K
R
G
A
L
S
S
S
L
R
D
L
S
Site 150
S1132
L
K
R
G
A
L
S
S
S
L
R
D
L
S
D
Site 151
S1133
K
R
G
A
L
S
S
S
L
R
D
L
S
D
A
Site 152
S1138
S
S
S
L
R
D
L
S
D
A
G
K
R
G
R
Site 153
S1148
G
K
R
G
R
R
N
S
V
G
S
L
D
S
T
Site 154
S1151
G
R
R
N
S
V
G
S
L
D
S
T
I
E
G
Site 155
S1154
N
S
V
G
S
L
D
S
T
I
E
G
S
V
I
Site 156
T1155
S
V
G
S
L
D
S
T
I
E
G
S
V
I
S
Site 157
S1159
L
D
S
T
I
E
G
S
V
I
S
S
P
R
P
Site 158
S1162
T
I
E
G
S
V
I
S
S
P
R
P
H
Q
R
Site 159
S1163
I
E
G
S
V
I
S
S
P
R
P
H
Q
R
M
Site 160
Y1182
P
P
P
P
P
E
E
Y
K
S
Q
R
P
V
S
Site 161
S1184
P
P
P
E
E
Y
K
S
Q
R
P
V
S
N
S
Site 162
S1189
Y
K
S
Q
R
P
V
S
N
S
S
S
F
L
G
Site 163
S1191
S
Q
R
P
V
S
N
S
S
S
F
L
G
S
L
Site 164
S1193
R
P
V
S
N
S
S
S
F
L
G
S
L
F
G
Site 165
S1197
N
S
S
S
F
L
G
S
L
F
G
S
K
R
G
Site 166
S1201
F
L
G
S
L
F
G
S
K
R
G
K
G
P
F
Site 167
T1215
F
Q
M
P
P
P
P
T
G
Q
A
S
A
S
S
Site 168
S1219
P
P
P
T
G
Q
A
S
A
S
S
S
S
A
S
Site 169
S1221
P
T
G
Q
A
S
A
S
S
S
S
A
S
S
T
Site 170
S1222
T
G
Q
A
S
A
S
S
S
S
A
S
S
T
H
Site 171
S1223
G
Q
A
S
A
S
S
S
S
A
S
S
T
H
H
Site 172
S1224
Q
A
S
A
S
S
S
S
A
S
S
T
H
H
H
Site 173
S1226
S
A
S
S
S
S
A
S
S
T
H
H
H
H
H
Site 174
S1227
A
S
S
S
S
A
S
S
T
H
H
H
H
H
H
Site 175
T1228
S
S
S
S
A
S
S
T
H
H
H
H
H
H
H
Site 176
S1252
G
V
L
P
D
G
Q
S
K
L
Q
A
L
H
A
Site 177
Y1272
P
G
P
A
P
P
P
Y
L
P
P
Q
Q
P
S
Site 178
S1279
Y
L
P
P
Q
Q
P
S
L
P
P
P
P
Q
Q
Site 179
S1295
P
P
L
P
Q
L
G
S
I
P
P
P
P
A
S
Site 180
S1302
S
I
P
P
P
P
A
S
A
P
P
V
G
P
H
Site 181
Y1324
P
V
P
G
P
Q
H
Y
T
L
G
R
P
G
R
Site 182
T1325
V
P
G
P
Q
H
Y
T
L
G
R
P
G
R
A
Site 183
S1356
H
P
L
H
Q
P
T
S
P
L
P
L
Y
S
P
Site 184
Y1361
P
T
S
P
L
P
L
Y
S
P
A
P
Q
H
P
Site 185
S1362
T
S
P
L
P
L
Y
S
P
A
P
Q
H
P
P
Site 186
S1398
G
A
A
G
G
P
G
S
R
P
P
G
G
S
Y
Site 187
S1404
G
S
R
P
P
G
G
S
Y
S
H
P
H
H
P
Site 188
Y1405
S
R
P
P
G
G
S
Y
S
H
P
H
H
P
Q
Site 189
S1406
R
P
P
G
G
S
Y
S
H
P
H
H
P
Q
S
Site 190
S1413
S
H
P
H
H
P
Q
S
P
L
S
P
H
S
P
Site 191
S1416
H
H
P
Q
S
P
L
S
P
H
S
P
I
P
P
Site 192
S1419
Q
S
P
L
S
P
H
S
P
I
P
P
H
P
S
Site 193
S1426
S
P
I
P
P
H
P
S
Y
P
P
L
P
P
P
Site 194
Y1427
P
I
P
P
H
P
S
Y
P
P
L
P
P
P
S
Site 195
S1434
Y
P
P
L
P
P
P
S
P
H
T
P
H
S
P
Site 196
T1437
L
P
P
P
S
P
H
T
P
H
S
P
L
P
P
Site 197
S1440
P
S
P
H
T
P
H
S
P
L
P
P
T
S
P
Site 198
T1445
P
H
S
P
L
P
P
T
S
P
H
G
P
L
H
Site 199
S1446
H
S
P
L
P
P
T
S
P
H
G
P
L
H
A
Site 200
S1454
P
H
G
P
L
H
A
S
G
P
P
G
T
A
N
Site 201
T1459
H
A
S
G
P
P
G
T
A
N
P
P
S
A
N
Site 202
S1464
P
G
T
A
N
P
P
S
A
N
P
K
A
K
P
Site 203
S1472
A
N
P
K
A
K
P
S
R
I
S
T
V
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation