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Updated November 2019
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Protein Info
Short Name:
GPRASP1
Full Name:
G-protein coupled receptor-associated sorting protein 1
Alias:
G protein-coupled receptor associated sorting protein 1; GASP; GASP1; GASP-1
Type:
Vesicle protein
Mass (Da):
156865
Number AA:
1395
UniProt ID:
Q5JY77
International Prot ID:
IPI00060549
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T42
V
V
R
P
K
V
R
T
Q
A
Q
I
M
P
G
Site 2
S56
G
A
R
P
K
N
K
S
K
V
M
P
G
A
S
Site 3
S63
S
K
V
M
P
G
A
S
T
K
V
E
T
S
A
Site 4
T68
G
A
S
T
K
V
E
T
S
A
V
G
G
A
R
Site 5
S78
V
G
G
A
R
P
K
S
K
A
K
A
I
P
V
Site 6
S86
K
A
K
A
I
P
V
S
R
F
K
E
E
A
Q
Site 7
S106
R
F
G
A
E
R
L
S
K
T
E
R
N
S
Q
Site 8
T108
G
A
E
R
L
S
K
T
E
R
N
S
Q
T
N
Site 9
S112
L
S
K
T
E
R
N
S
Q
T
N
I
I
A
S
Site 10
S119
S
Q
T
N
I
I
A
S
P
L
V
S
T
D
S
Site 11
T132
D
S
V
L
V
A
K
T
K
Y
L
S
E
D
R
Site 12
Y134
V
L
V
A
K
T
K
Y
L
S
E
D
R
E
L
Site 13
S136
V
A
K
T
K
Y
L
S
E
D
R
E
L
V
N
Site 14
T144
E
D
R
E
L
V
N
T
D
T
E
S
F
P
R
Site 15
T146
R
E
L
V
N
T
D
T
E
S
F
P
R
R
K
Site 16
S148
L
V
N
T
D
T
E
S
F
P
R
R
K
A
H
Site 17
Y156
F
P
R
R
K
A
H
Y
Q
A
G
F
Q
P
S
Site 18
S163
Y
Q
A
G
F
Q
P
S
F
R
S
K
E
E
T
Site 19
S166
G
F
Q
P
S
F
R
S
K
E
E
T
N
M
G
Site 20
T170
S
F
R
S
K
E
E
T
N
M
G
S
W
C
C
Site 21
T181
S
W
C
C
P
R
P
T
S
K
Q
E
A
S
P
Site 22
S182
W
C
C
P
R
P
T
S
K
Q
E
A
S
P
N
Site 23
S187
P
T
S
K
Q
E
A
S
P
N
S
D
F
K
W
Site 24
S190
K
Q
E
A
S
P
N
S
D
F
K
W
V
D
K
Site 25
S198
D
F
K
W
V
D
K
S
V
S
S
L
F
W
S
Site 26
S200
K
W
V
D
K
S
V
S
S
L
F
W
S
G
D
Site 27
S201
W
V
D
K
S
V
S
S
L
F
W
S
G
D
E
Site 28
S205
S
V
S
S
L
F
W
S
G
D
E
V
T
A
K
Site 29
S222
P
G
N
R
V
K
D
S
N
R
S
M
H
M
A
Site 30
T235
M
A
N
Q
E
A
N
T
M
S
R
S
Q
T
N
Site 31
S239
E
A
N
T
M
S
R
S
Q
T
N
Q
E
L
Y
Site 32
T241
N
T
M
S
R
S
Q
T
N
Q
E
L
Y
I
A
Site 33
Y246
S
Q
T
N
Q
E
L
Y
I
A
S
S
S
G
S
Site 34
S249
N
Q
E
L
Y
I
A
S
S
S
G
S
E
D
E
Site 35
S250
Q
E
L
Y
I
A
S
S
S
G
S
E
D
E
S
Site 36
S251
E
L
Y
I
A
S
S
S
G
S
E
D
E
S
V
Site 37
S253
Y
I
A
S
S
S
G
S
E
D
E
S
V
K
T
Site 38
S257
S
S
G
S
E
D
E
S
V
K
T
P
W
F
W
Site 39
T260
S
E
D
E
S
V
K
T
P
W
F
W
A
R
D
Site 40
T271
W
A
R
D
K
T
N
T
W
S
G
P
R
E
D
Site 41
S273
R
D
K
T
N
T
W
S
G
P
R
E
D
P
N
Site 42
S281
G
P
R
E
D
P
N
S
R
S
R
F
R
S
K
Site 43
S283
R
E
D
P
N
S
R
S
R
F
R
S
K
K
E
Site 44
S287
N
S
R
S
R
F
R
S
K
K
E
V
Y
V
E
Site 45
Y292
F
R
S
K
K
E
V
Y
V
E
S
S
S
G
S
Site 46
S295
K
K
E
V
Y
V
E
S
S
S
G
S
E
H
E
Site 47
S297
E
V
Y
V
E
S
S
S
G
S
E
H
E
D
H
Site 48
S299
Y
V
E
S
S
S
G
S
E
H
E
D
H
L
E
Site 49
S319
G
K
E
A
K
F
R
S
K
M
R
A
G
K
E
Site 50
T365
W
P
E
E
N
A
N
T
F
S
R
P
M
I
K
Site 51
T381
E
A
R
A
R
A
M
T
K
E
E
A
K
T
K
Site 52
T387
M
T
K
E
E
A
K
T
K
A
R
A
R
A
K
Site 53
S399
R
A
K
Q
E
A
R
S
E
E
E
A
L
I
G
Site 54
S422
S
S
M
A
D
E
A
S
I
E
S
S
L
Q
V
Site 55
S426
D
E
A
S
I
E
S
S
L
Q
V
E
D
E
S
Site 56
S446
F
W
T
E
E
E
A
S
M
G
T
G
A
S
S
Site 57
S453
S
M
G
T
G
A
S
S
K
S
R
P
R
T
D
Site 58
S455
G
T
G
A
S
S
K
S
R
P
R
T
D
G
E
Site 59
T459
S
S
K
S
R
P
R
T
D
G
E
R
I
G
D
Site 60
S467
D
G
E
R
I
G
D
S
L
F
G
A
R
E
K
Site 61
T475
L
F
G
A
R
E
K
T
S
M
K
T
G
A
E
Site 62
S537
V
E
S
G
V
G
V
S
C
E
S
R
T
R
S
Site 63
S540
G
V
G
V
S
C
E
S
R
T
R
S
E
E
E
Site 64
S544
S
C
E
S
R
T
R
S
E
E
E
E
V
I
G
Site 65
S631
C
V
E
G
D
V
N
S
K
S
S
L
E
D
K
Site 66
S633
E
G
D
V
N
S
K
S
S
L
E
D
K
E
E
Site 67
S634
G
D
V
N
S
K
S
S
L
E
D
K
E
E
A
Site 68
S653
F
G
A
K
E
E
V
S
M
K
H
G
T
G
V
Site 69
Y686
A
E
K
E
P
C
M
Y
P
A
G
G
G
S
W
Site 70
S695
A
G
G
G
S
W
K
S
R
P
E
E
E
E
D
Site 71
Y713
S
W
F
W
S
R
K
Y
T
K
P
E
A
I
I
Site 72
S769
E
A
T
D
R
E
E
S
R
P
E
A
E
E
G
Site 73
S813
E
K
E
G
I
V
G
S
W
F
G
A
R
E
E
Site 74
T821
W
F
G
A
R
E
E
T
I
R
R
E
A
G
S
Site 75
S828
T
I
R
R
E
A
G
S
C
S
K
S
S
P
K
Site 76
S830
R
R
E
A
G
S
C
S
K
S
S
P
K
A
E
Site 77
S832
E
A
G
S
C
S
K
S
S
P
K
A
E
E
E
Site 78
S833
A
G
S
C
S
K
S
S
P
K
A
E
E
E
E
Site 79
S853
W
F
W
E
E
E
A
S
P
E
A
V
A
G
V
Site 80
T868
G
F
E
S
K
P
G
T
E
E
E
E
I
T
V
Site 81
S886
F
W
P
E
E
E
A
S
I
Q
A
G
S
Q
A
Site 82
S891
E
A
S
I
Q
A
G
S
Q
A
V
E
E
M
E
Site 83
S899
Q
A
V
E
E
M
E
S
E
T
E
E
E
T
I
Site 84
T953
K
A
I
K
E
T
G
T
V
A
T
C
E
S
K
Site 85
T983
E
D
E
V
D
N
R
T
D
N
G
S
N
C
G
Site 86
S987
D
N
R
T
D
N
G
S
N
C
G
S
R
T
L
Site 87
S991
D
N
G
S
N
C
G
S
R
T
L
A
D
E
D
Site 88
T993
G
S
N
C
G
S
R
T
L
A
D
E
D
E
A
Site 89
S1016
G
D
E
A
H
F
E
S
N
P
S
P
V
F
R
Site 90
S1019
A
H
F
E
S
N
P
S
P
V
F
R
A
I
C
Site 91
S1028
V
F
R
A
I
C
R
S
T
C
S
V
E
Q
E
Site 92
T1029
F
R
A
I
C
R
S
T
C
S
V
E
Q
E
P
Site 93
S1031
A
I
C
R
S
T
C
S
V
E
Q
E
P
D
P
Site 94
S1039
V
E
Q
E
P
D
P
S
R
R
P
Q
S
W
E
Site 95
S1044
D
P
S
R
R
P
Q
S
W
E
E
V
T
V
Q
Site 96
T1049
P
Q
S
W
E
E
V
T
V
Q
F
K
P
G
P
Site 97
S1064
W
G
R
V
G
F
P
S
I
S
P
F
R
F
P
Site 98
S1066
R
V
G
F
P
S
I
S
P
F
R
F
P
K
E
Site 99
S1092
K
P
R
N
M
V
L
S
P
E
G
E
D
Q
E
Site 100
S1100
P
E
G
E
D
Q
E
S
L
L
Q
P
D
Q
P
Site 101
S1108
L
L
Q
P
D
Q
P
S
P
E
F
P
F
Q
Y
Site 102
Y1115
S
P
E
F
P
F
Q
Y
D
P
S
Y
R
S
V
Site 103
S1118
F
P
F
Q
Y
D
P
S
Y
R
S
V
Q
E
I
Site 104
Y1119
P
F
Q
Y
D
P
S
Y
R
S
V
Q
E
I
R
Site 105
S1121
Q
Y
D
P
S
Y
R
S
V
Q
E
I
R
E
H
Site 106
S1134
E
H
L
R
A
K
E
S
T
E
P
E
S
S
S
Site 107
T1135
H
L
R
A
K
E
S
T
E
P
E
S
S
S
C
Site 108
S1139
K
E
S
T
E
P
E
S
S
S
C
N
C
I
Q
Site 109
S1140
E
S
T
E
P
E
S
S
S
C
N
C
I
Q
C
Site 110
S1141
S
T
E
P
E
S
S
S
C
N
C
I
Q
C
E
Site 111
S1183
K
I
A
M
G
M
R
S
A
S
Q
F
T
R
D
Site 112
S1185
A
M
G
M
R
S
A
S
Q
F
T
R
D
F
I
Site 113
S1195
T
R
D
F
I
R
D
S
G
V
V
S
L
I
E
Site 114
Y1207
L
I
E
T
L
L
N
Y
P
S
S
R
V
R
T
Site 115
S1209
E
T
L
L
N
Y
P
S
S
R
V
R
T
S
F
Site 116
S1210
T
L
L
N
Y
P
S
S
R
V
R
T
S
F
L
Site 117
T1214
Y
P
S
S
R
V
R
T
S
F
L
E
N
M
I
Site 118
S1215
P
S
S
R
V
R
T
S
F
L
E
N
M
I
R
Site 119
Y1247
V
C
E
E
T
L
A
Y
S
V
D
S
P
E
Q
Site 120
S1248
C
E
E
T
L
A
Y
S
V
D
S
P
E
Q
L
Site 121
S1251
T
L
A
Y
S
V
D
S
P
E
Q
L
S
G
I
Site 122
S1256
V
D
S
P
E
Q
L
S
G
I
R
M
I
R
H
Site 123
T1265
I
R
M
I
R
H
L
T
T
T
T
D
Y
H
T
Site 124
T1267
M
I
R
H
L
T
T
T
T
D
Y
H
T
L
V
Site 125
Y1270
H
L
T
T
T
T
D
Y
H
T
L
V
A
N
Y
Site 126
T1272
T
T
T
T
D
Y
H
T
L
V
A
N
Y
M
S
Site 127
S1320
L
L
S
A
E
A
V
S
E
F
I
G
L
F
N
Site 128
T1331
G
L
F
N
R
E
E
T
N
D
N
I
Q
I
V
Site 129
S1356
I
K
K
E
T
V
F
S
D
D
D
F
N
I
E
Site 130
S1367
F
N
I
E
P
L
I
S
A
F
H
K
V
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation