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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DGKK
Full Name:
Diacylglycerol kinase kappa
Alias:
Diacylglycerol kinase, kappa; Diglyceride kinase kappa
Type:
EC 2.7.1.107; Kinase, lipid
Mass (Da):
141829
Number AA:
1271
UniProt ID:
Q5KSL6
International Prot ID:
IPI00046309
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004143
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006629
GO:0006638
GO:0006639
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
D
G
E
Q
P
A
E
S
P
E
P
P
P
P
W
Site 2
S47
P
P
A
P
P
L
L
S
E
A
S
P
E
P
I
Site 3
S50
P
P
L
L
S
E
A
S
P
E
P
I
P
E
P
Site 4
S71
G
P
C
P
E
A
T
S
E
S
A
T
E
L
Y
Site 5
Y78
S
E
S
A
T
E
L
Y
T
E
P
T
P
E
P
Site 6
T82
T
E
L
Y
T
E
P
T
P
E
P
A
T
E
P
Site 7
T87
E
P
T
P
E
P
A
T
E
P
A
S
E
P
A
Site 8
S91
E
P
A
T
E
P
A
S
E
P
A
P
E
P
A
Site 9
T126
T
E
S
A
P
E
P
T
P
E
P
A
L
E
S
Site 10
S133
T
P
E
P
A
L
E
S
V
P
E
P
A
P
E
Site 11
T142
P
E
P
A
P
E
L
T
P
E
V
A
P
E
L
Site 12
T154
P
E
L
A
P
E
P
T
P
E
P
V
T
E
L
Site 13
S176
A
A
P
E
F
R
P
S
P
A
P
C
L
L
Q
Site 14
T195
T
R
E
R
G
L
K
T
S
P
S
P
S
P
S
Site 15
S196
R
E
R
G
L
K
T
S
P
S
P
S
P
S
P
Site 16
S198
R
G
L
K
T
S
P
S
P
S
P
S
P
S
P
Site 17
S200
L
K
T
S
P
S
P
S
P
S
P
S
P
R
T
Site 18
S202
T
S
P
S
P
S
P
S
P
S
P
R
T
P
M
Site 19
S204
P
S
P
S
P
S
P
S
P
R
T
P
M
S
W
Site 20
T207
S
P
S
P
S
P
R
T
P
M
S
W
S
R
I
Site 21
S210
P
S
P
R
T
P
M
S
W
S
R
I
K
K
I
Site 22
S212
P
R
T
P
M
S
W
S
R
I
K
K
I
L
K
Site 23
S229
P
M
L
K
N
C
N
S
F
K
R
W
K
L
R
Site 24
Y237
F
K
R
W
K
L
R
Y
F
L
V
Q
G
Q
K
Site 25
Y246
L
V
Q
G
Q
K
L
Y
F
A
H
H
P
A
F
Site 26
S262
H
F
E
T
I
D
L
S
Q
A
T
V
A
E
S
Site 27
T265
T
I
D
L
S
Q
A
T
V
A
E
S
S
C
R
Site 28
S270
Q
A
T
V
A
E
S
S
C
R
N
L
C
H
S
Site 29
T288
I
T
P
Q
R
K
I
T
L
A
A
P
N
R
K
Site 30
Y313
T
I
Q
Q
G
E
I
Y
K
I
P
A
A
E
N
Site 31
S347
H
C
N
V
C
R
E
S
I
P
A
L
S
R
D
Site 32
S352
R
E
S
I
P
A
L
S
R
D
A
I
I
C
E
Site 33
T381
S
K
D
C
K
W
N
T
L
S
I
T
D
D
L
Site 34
S383
D
C
K
W
N
T
L
S
I
T
D
D
L
L
L
Site 35
Y422
C
H
E
S
C
G
S
Y
Q
R
L
Q
D
F
R
Site 36
S453
S
K
E
C
C
F
R
S
H
R
S
S
V
I
P
Site 37
S457
C
F
R
S
H
R
S
S
V
I
P
P
T
A
L
Site 38
T462
R
S
S
V
I
P
P
T
A
L
S
D
P
K
G
Site 39
S465
V
I
P
P
T
A
L
S
D
P
K
G
D
G
Q
Site 40
S498
P
L
L
I
F
I
N
S
K
S
G
D
H
Q
G
Site 41
Y515
F
L
R
K
F
K
Q
Y
L
N
P
S
Q
V
F
Site 42
S519
F
K
Q
Y
L
N
P
S
Q
V
F
D
L
L
K
Site 43
S534
G
G
P
E
A
G
L
S
M
F
K
N
F
A
R
Site 44
S597
A
F
W
N
K
S
K
S
P
L
D
I
L
N
R
Site 45
S609
L
N
R
V
E
Q
A
S
V
R
I
L
D
R
W
Site 46
S617
V
R
I
L
D
R
W
S
V
M
I
R
E
T
P
Site 47
T623
W
S
V
M
I
R
E
T
P
R
Q
T
P
L
L
Site 48
T627
I
R
E
T
P
R
Q
T
P
L
L
K
G
Q
V
Site 49
T654
Q
H
L
E
S
A
A
T
E
L
N
K
I
L
K
Site 50
Y664
N
K
I
L
K
A
K
Y
P
T
E
M
I
I
A
Site 51
T728
L
A
E
E
A
A
A
T
S
A
E
K
S
A
T
Site 52
S733
A
A
T
S
A
E
K
S
A
T
E
Y
A
D
S
Site 53
T735
T
S
A
E
K
S
A
T
E
Y
A
D
S
S
K
Site 54
Y737
A
E
K
S
A
T
E
Y
A
D
S
S
K
A
D
Site 55
S740
S
A
T
E
Y
A
D
S
S
K
A
D
R
K
P
Site 56
S768
E
L
A
T
K
A
Q
S
L
Q
K
S
L
K
L
Site 57
S772
K
A
Q
S
L
Q
K
S
L
K
L
I
I
F
Q
Site 58
S788
E
Q
A
L
D
E
E
S
R
Q
T
I
S
V
K
Site 59
T791
L
D
E
E
S
R
Q
T
I
S
V
K
N
F
S
Site 60
S793
E
E
S
R
Q
T
I
S
V
K
N
F
S
S
T
Site 61
S798
T
I
S
V
K
N
F
S
S
T
F
F
L
E
D
Site 62
T800
S
V
K
N
F
S
S
T
F
F
L
E
D
D
P
Site 63
T813
D
P
E
D
I
N
Q
T
S
P
R
R
R
S
R
Site 64
S814
P
E
D
I
N
Q
T
S
P
R
R
R
S
R
R
Site 65
S819
Q
T
S
P
R
R
R
S
R
R
G
T
L
S
S
Site 66
T823
R
R
R
S
R
R
G
T
L
S
S
I
S
S
L
Site 67
S825
R
S
R
R
G
T
L
S
S
I
S
S
L
K
S
Site 68
S826
S
R
R
G
T
L
S
S
I
S
S
L
K
S
E
Site 69
S828
R
G
T
L
S
S
I
S
S
L
K
S
E
D
L
Site 70
S829
G
T
L
S
S
I
S
S
L
K
S
E
D
L
D
Site 71
S832
S
S
I
S
S
L
K
S
E
D
L
D
N
L
N
Site 72
T846
N
L
D
H
L
H
F
T
P
E
S
I
R
F
K
Site 73
Y861
E
K
C
V
M
N
N
Y
F
G
I
G
L
D
A
Site 74
S871
I
G
L
D
A
K
I
S
L
D
F
N
T
R
R
Site 75
T876
K
I
S
L
D
F
N
T
R
R
D
E
H
P
G
Site 76
Y885
R
D
E
H
P
G
Q
Y
N
S
R
L
K
N
K
Site 77
S907
T
K
E
L
L
Q
R
S
Y
R
K
L
E
E
R
Site 78
Y908
K
E
L
L
Q
R
S
Y
R
K
L
E
E
R
V
Site 79
S925
E
C
D
G
E
T
I
S
L
P
N
L
Q
G
I
Site 80
T953
F
W
G
S
N
T
A
T
T
E
Y
E
A
P
A
Site 81
Y956
S
N
T
A
T
T
E
Y
E
A
P
A
I
D
D
Site 82
T999
Q
C
H
E
V
M
I
T
I
D
G
E
E
G
I
Site 83
Y1026
P
G
L
I
K
I
R
Y
K
N
A
A
Q
M
L
Site 84
S1066
P
Q
L
D
F
Q
D
S
Q
E
S
L
S
D
E
Site 85
S1069
D
F
Q
D
S
Q
E
S
L
S
D
E
E
Y
A
Site 86
S1071
Q
D
S
Q
E
S
L
S
D
E
E
Y
A
Q
M
Site 87
Y1075
E
S
L
S
D
E
E
Y
A
Q
M
Q
H
L
A
Site 88
S1090
R
L
A
E
N
L
I
S
K
L
N
D
L
S
K
Site 89
S1096
I
S
K
L
N
D
L
S
K
I
H
Q
H
V
S
Site 90
S1103
S
K
I
H
Q
H
V
S
V
L
M
G
S
V
N
Site 91
Y1121
N
I
L
N
D
I
F
Y
G
Q
D
S
G
N
E
Site 92
S1125
D
I
F
Y
G
Q
D
S
G
N
E
M
G
A
A
Site 93
T1149
R
N
D
A
V
D
V
T
F
S
L
K
G
L
Y
Site 94
T1159
L
K
G
L
Y
D
D
T
T
A
F
L
D
E
K
Site 95
T1160
K
G
L
Y
D
D
T
T
A
F
L
D
E
K
L
Site 96
S1207
I
F
V
P
E
E
K
S
S
D
T
D
S
R
S
Site 97
S1208
F
V
P
E
E
K
S
S
D
T
D
S
R
S
L
Site 98
T1210
P
E
E
K
S
S
D
T
D
S
R
S
L
R
L
Site 99
S1212
E
K
S
S
D
T
D
S
R
S
L
R
L
K
I
Site 100
S1214
S
S
D
T
D
S
R
S
L
R
L
K
I
K
F
Site 101
S1237
E
E
E
R
K
P
K
S
G
Q
S
V
Q
S
F
Site 102
S1240
R
K
P
K
S
G
Q
S
V
Q
S
F
I
G
N
Site 103
S1243
K
S
G
Q
S
V
Q
S
F
I
G
N
L
W
H
Site 104
T1265
A
E
G
D
D
P
L
T
P
S
R
S
Q
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation