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Updated November 2019
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Protein Info
Short Name:
CCDC158
Full Name:
Coiled-coil domain-containing protein 158
Alias:
Type:
Mass (Da):
127140
Number AA:
1113
UniProt ID:
Q5M9N0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
S
N
N
E
D
L
L
S
S
S
G
V
T
S
N
Site 2
S17
N
E
D
L
L
S
S
S
G
V
T
S
N
G
G
Site 3
T20
L
L
S
S
S
G
V
T
S
N
G
G
S
S
S
Site 4
S21
L
S
S
S
G
V
T
S
N
G
G
S
S
S
S
Site 5
S25
G
V
T
S
N
G
G
S
S
S
S
F
F
V
S
Site 6
S26
V
T
S
N
G
G
S
S
S
S
F
F
V
S
S
Site 7
S27
T
S
N
G
G
S
S
S
S
F
F
V
S
S
I
Site 8
S28
S
N
G
G
S
S
S
S
F
F
V
S
S
I
R
Site 9
T47
E
N
T
S
S
A
G
T
L
T
Q
V
P
F
F
Site 10
T49
T
S
S
A
G
T
L
T
Q
V
P
F
F
P
K
Site 11
Y57
Q
V
P
F
F
P
K
Y
E
V
E
L
D
S
P
Site 12
S63
K
Y
E
V
E
L
D
S
P
R
K
I
I
P
S
Site 13
S70
S
P
R
K
I
I
P
S
P
G
K
E
H
F
E
Site 14
Y83
F
E
R
V
L
E
E
Y
S
H
Q
V
K
D
L
Site 15
S97
L
Q
R
R
L
N
E
S
N
E
L
H
E
K
Q
Site 16
Y107
L
H
E
K
Q
K
F
Y
L
R
Q
S
V
I
D
Site 17
S111
Q
K
F
Y
L
R
Q
S
V
I
D
L
Q
T
K
Site 18
S137
A
D
I
R
R
R
E
S
Q
S
Q
E
D
L
R
Site 19
S139
I
R
R
R
E
S
Q
S
Q
E
D
L
R
N
Q
Site 20
T150
L
R
N
Q
L
Q
N
T
V
H
E
L
E
A
A
Site 21
S168
K
E
D
M
L
K
D
S
N
T
Q
I
E
Q
L
Site 22
T170
D
M
L
K
D
S
N
T
Q
I
E
Q
L
R
K
Site 23
S181
Q
L
R
K
M
M
L
S
H
E
G
V
L
Q
E
Site 24
S211
I
C
E
H
D
S
M
S
T
L
H
F
R
S
L
Site 25
S217
M
S
T
L
H
F
R
S
L
G
S
A
I
S
K
Site 26
S223
R
S
L
G
S
A
I
S
K
I
L
R
E
L
D
Site 27
T231
K
I
L
R
E
L
D
T
E
I
S
Y
L
K
G
Site 28
S234
R
E
L
D
T
E
I
S
Y
L
K
G
R
I
F
Site 29
Y235
E
L
D
T
E
I
S
Y
L
K
G
R
I
F
P
Site 30
S252
D
Q
L
E
A
L
K
S
E
S
Q
N
K
I
E
Site 31
S254
L
E
A
L
K
S
E
S
Q
N
K
I
E
L
L
Site 32
S274
D
R
I
E
Q
L
I
S
E
H
E
V
E
I
T
Site 33
T281
S
E
H
E
V
E
I
T
G
L
T
E
K
A
S
Site 34
T284
E
V
E
I
T
G
L
T
E
K
A
S
S
A
R
Site 35
S288
T
G
L
T
E
K
A
S
S
A
R
S
Q
A
N
Site 36
S289
G
L
T
E
K
A
S
S
A
R
S
Q
A
N
S
Site 37
S292
E
K
A
S
S
A
R
S
Q
A
N
S
I
Q
S
Site 38
S296
S
A
R
S
Q
A
N
S
I
Q
S
Q
M
E
I
Site 39
Y315
A
R
N
Q
N
S
M
Y
M
R
Q
L
S
D
L
Site 40
S320
S
M
Y
M
R
Q
L
S
D
L
E
S
T
V
S
Site 41
S324
R
Q
L
S
D
L
E
S
T
V
S
Q
L
R
S
Site 42
T325
Q
L
S
D
L
E
S
T
V
S
Q
L
R
S
E
Site 43
S327
S
D
L
E
S
T
V
S
Q
L
R
S
E
L
R
Site 44
S331
S
T
V
S
Q
L
R
S
E
L
R
E
A
K
R
Site 45
Y340
L
R
E
A
K
R
M
Y
E
D
K
T
E
E
L
Site 46
T344
K
R
M
Y
E
D
K
T
E
E
L
E
K
Q
L
Site 47
S356
K
Q
L
V
L
A
N
S
E
L
T
E
A
R
T
Site 48
T363
S
E
L
T
E
A
R
T
E
R
D
Q
F
S
Q
Site 49
S369
R
T
E
R
D
Q
F
S
Q
E
S
G
N
L
D
Site 50
S394
H
K
R
E
K
E
L
S
L
E
K
E
Q
N
K
Site 51
T408
K
R
L
W
D
R
D
T
G
N
S
I
T
I
D
Site 52
S440
A
L
L
K
A
L
K
S
E
C
Q
G
Q
M
E
Site 53
S459
A
I
Q
G
K
N
E
S
L
E
K
V
S
S
L
Site 54
S465
E
S
L
E
K
V
S
S
L
T
A
Q
L
E
S
Site 55
S472
S
L
T
A
Q
L
E
S
T
K
E
M
L
R
K
Site 56
T473
L
T
A
Q
L
E
S
T
K
E
M
L
R
K
V
Site 57
T490
E
L
T
A
K
K
M
T
L
E
S
S
E
R
T
Site 58
S493
A
K
K
M
T
L
E
S
S
E
R
T
I
S
D
Site 59
S494
K
K
M
T
L
E
S
S
E
R
T
I
S
D
L
Site 60
T497
T
L
E
S
S
E
R
T
I
S
D
L
T
T
S
Site 61
S499
E
S
S
E
R
T
I
S
D
L
T
T
S
L
Q
Site 62
T502
E
R
T
I
S
D
L
T
T
S
L
Q
E
K
E
Site 63
T503
R
T
I
S
D
L
T
T
S
L
Q
E
K
E
R
Site 64
S504
T
I
S
D
L
T
T
S
L
Q
E
K
E
R
A
Site 65
T515
K
E
R
A
I
E
A
T
N
A
E
I
T
K
L
Site 66
T548
D
H
L
R
N
V
Q
T
E
C
E
A
L
K
L
Site 67
T575
R
Q
Q
I
E
N
M
T
Q
L
V
G
Q
H
G
Site 68
S628
R
E
L
E
A
R
V
S
D
L
E
L
E
K
V
Site 69
S642
V
K
L
V
N
A
G
S
E
R
L
R
A
V
K
Site 70
T664
Q
L
L
N
E
V
K
T
S
R
S
E
L
N
N
Site 71
S667
N
E
V
K
T
S
R
S
E
L
N
N
L
S
E
Site 72
S673
R
S
E
L
N
N
L
S
E
E
Y
E
V
L
K
Site 73
S687
K
R
N
F
R
N
K
S
E
E
M
E
M
T
T
Site 74
T693
K
S
E
E
M
E
M
T
T
N
K
L
K
M
Q
Site 75
S703
K
L
K
M
Q
L
K
S
A
Q
S
E
L
E
Q
Site 76
T711
A
Q
S
E
L
E
Q
T
R
N
T
L
K
S
M
Site 77
T714
E
L
E
Q
T
R
N
T
L
K
S
M
E
G
S
Site 78
S717
Q
T
R
N
T
L
K
S
M
E
G
S
D
G
H
Site 79
S721
T
L
K
S
M
E
G
S
D
G
H
A
M
K
V
Site 80
T737
M
G
M
Q
K
Q
I
T
A
K
R
G
Q
I
D
Site 81
S748
G
Q
I
D
A
L
Q
S
K
I
Q
F
L
E
E
Site 82
T758
Q
F
L
E
E
A
M
T
N
A
N
K
E
K
H
Site 83
S772
H
F
L
K
E
E
K
S
K
L
S
Q
E
L
S
Site 84
S775
K
E
E
K
S
K
L
S
Q
E
L
S
T
V
A
Site 85
S779
S
K
L
S
Q
E
L
S
T
V
A
T
E
K
N
Site 86
T783
Q
E
L
S
T
V
A
T
E
K
N
K
M
A
G
Site 87
S797
G
E
L
E
V
L
R
S
Q
E
R
R
L
K
E
Site 88
S834
I
Q
R
Q
E
Q
E
S
V
R
L
K
L
Q
H
Site 89
T842
V
R
L
K
L
Q
H
T
L
D
I
K
E
L
Q
Site 90
Y853
K
E
L
Q
G
P
G
Y
T
S
N
S
S
L
K
Site 91
S855
L
Q
G
P
G
Y
T
S
N
S
S
L
K
P
R
Site 92
S858
P
G
Y
T
S
N
S
S
L
K
P
R
L
L
Q
Site 93
S868
P
R
L
L
Q
P
A
S
V
T
R
S
H
S
N
Site 94
S872
Q
P
A
S
V
T
R
S
H
S
N
V
P
S
S
Site 95
S874
A
S
V
T
R
S
H
S
N
V
P
S
S
Q
S
Site 96
S878
R
S
H
S
N
V
P
S
S
Q
S
T
A
S
F
Site 97
S879
S
H
S
N
V
P
S
S
Q
S
T
A
S
F
L
Site 98
S881
S
N
V
P
S
S
Q
S
T
A
S
F
L
S
H
Site 99
T882
N
V
P
S
S
Q
S
T
A
S
F
L
S
H
H
Site 100
S884
P
S
S
Q
S
T
A
S
F
L
S
H
H
S
T
Site 101
S887
Q
S
T
A
S
F
L
S
H
H
S
T
K
A
N
Site 102
T891
S
F
L
S
H
H
S
T
K
A
N
T
L
K
E
Site 103
S913
Q
L
L
Q
E
L
R
S
V
I
N
E
E
P
A
Site 104
S922
I
N
E
E
P
A
V
S
L
S
K
T
E
E
D
Site 105
S924
E
E
P
A
V
S
L
S
K
T
E
E
D
G
R
Site 106
T926
P
A
V
S
L
S
K
T
E
E
D
G
R
T
S
Site 107
T932
K
T
E
E
D
G
R
T
S
L
G
A
L
E
D
Site 108
S933
T
E
E
D
G
R
T
S
L
G
A
L
E
D
R
Site 109
T946
D
R
V
R
D
C
I
T
E
S
S
L
R
S
D
Site 110
S948
V
R
D
C
I
T
E
S
S
L
R
S
D
M
C
Site 111
S949
R
D
C
I
T
E
S
S
L
R
S
D
M
C
H
Site 112
S952
I
T
E
S
S
L
R
S
D
M
C
H
R
S
N
Site 113
S958
R
S
D
M
C
H
R
S
N
N
S
L
R
D
S
Site 114
S961
M
C
H
R
S
N
N
S
L
R
D
S
T
E
G
Site 115
S965
S
N
N
S
L
R
D
S
T
E
G
S
K
S
S
Site 116
T966
N
N
S
L
R
D
S
T
E
G
S
K
S
S
E
Site 117
S969
L
R
D
S
T
E
G
S
K
S
S
E
T
L
S
Site 118
S971
D
S
T
E
G
S
K
S
S
E
T
L
S
R
E
Site 119
S972
S
T
E
G
S
K
S
S
E
T
L
S
R
E
P
Site 120
T974
E
G
S
K
S
S
E
T
L
S
R
E
P
V
T
Site 121
S976
S
K
S
S
E
T
L
S
R
E
P
V
T
L
H
Site 122
S991
A
G
D
R
E
D
P
S
G
C
F
T
F
T
S
Site 123
T995
E
D
P
S
G
C
F
T
F
T
S
A
A
S
P
Site 124
S1001
F
T
F
T
S
A
A
S
P
S
V
K
N
S
A
Site 125
S1003
F
T
S
A
A
S
P
S
V
K
N
S
A
S
R
Site 126
S1007
A
S
P
S
V
K
N
S
A
S
R
S
F
N
S
Site 127
S1009
P
S
V
K
N
S
A
S
R
S
F
N
S
S
P
Site 128
S1011
V
K
N
S
A
S
R
S
F
N
S
S
P
K
K
Site 129
S1014
S
A
S
R
S
F
N
S
S
P
K
K
S
P
V
Site 130
S1015
A
S
R
S
F
N
S
S
P
K
K
S
P
V
H
Site 131
S1019
F
N
S
S
P
K
K
S
P
V
H
S
L
L
T
Site 132
S1023
P
K
K
S
P
V
H
S
L
L
T
S
S
V
E
Site 133
S1032
L
T
S
S
V
E
G
S
I
G
S
T
S
Q
Y
Site 134
S1035
S
V
E
G
S
I
G
S
T
S
Q
Y
R
S
A
Site 135
T1036
V
E
G
S
I
G
S
T
S
Q
Y
R
S
A
K
Site 136
S1037
E
G
S
I
G
S
T
S
Q
Y
R
S
A
K
P
Site 137
Y1039
S
I
G
S
T
S
Q
Y
R
S
A
K
P
I
H
Site 138
S1041
G
S
T
S
Q
Y
R
S
A
K
P
I
H
S
S
Site 139
S1047
R
S
A
K
P
I
H
S
S
D
S
V
K
D
S
Site 140
S1048
S
A
K
P
I
H
S
S
D
S
V
K
D
S
Q
Site 141
S1050
K
P
I
H
S
S
D
S
V
K
D
S
Q
S
P
Site 142
S1054
S
S
D
S
V
K
D
S
Q
S
P
P
I
E
T
Site 143
S1056
D
S
V
K
D
S
Q
S
P
P
I
E
T
T
G
Site 144
T1065
P
I
E
T
T
G
K
T
C
R
K
L
Q
N
R
Site 145
S1075
K
L
Q
N
R
L
E
S
L
Q
T
L
V
E
D
Site 146
T1078
N
R
L
E
S
L
Q
T
L
V
E
D
L
Q
L
Site 147
S1091
Q
L
K
N
Q
A
M
S
S
M
I
R
N
Q
E
Site 148
S1092
L
K
N
Q
A
M
S
S
M
I
R
N
Q
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation