KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LRRC35
Full Name:
Tubulin-specific chaperone cofactor E-like protein
Alias:
Leucine-rich repeat-containing protein 35
Type:
Mass (Da):
48205
Number AA:
424
UniProt ID:
Q5QJ74
International Prot ID:
IPI00166956
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
D
Q
P
S
G
R
S
F
M
Q
V
L
C
E
Site 2
S18
Q
V
L
C
E
K
Y
S
P
E
N
F
P
Y
R
Site 3
Y24
Y
S
P
E
N
F
P
Y
R
R
G
P
G
M
G
Site 4
T37
M
G
V
H
V
P
A
T
P
Q
G
S
P
M
K
Site 5
S41
V
P
A
T
P
Q
G
S
P
M
K
D
R
L
N
Site 6
S82
H
V
S
E
L
D
L
S
D
N
K
L
E
D
W
Site 7
S93
L
E
D
W
H
E
V
S
K
I
V
S
N
V
P
Site 8
S97
H
E
V
S
K
I
V
S
N
V
P
Q
L
E
F
Site 9
S108
Q
L
E
F
L
N
L
S
S
N
P
L
N
L
S
Site 10
S115
S
S
N
P
L
N
L
S
V
L
E
R
T
C
A
Site 11
S124
L
E
R
T
C
A
G
S
F
S
G
V
R
K
L
Site 12
S136
R
K
L
V
L
N
N
S
K
A
S
W
E
T
V
Site 13
T190
D
N
N
L
Q
D
W
T
E
I
R
K
L
G
V
Site 14
S221
A
I
E
E
P
D
D
S
L
A
R
L
F
P
N
Site 15
S231
R
L
F
P
N
L
R
S
I
S
L
H
K
S
G
Site 16
S233
F
P
N
L
R
S
I
S
L
H
K
S
G
L
Q
Site 17
S237
R
S
I
S
L
H
K
S
G
L
Q
S
W
E
D
Site 18
S241
L
H
K
S
G
L
Q
S
W
E
D
I
D
K
L
Site 19
S250
E
D
I
D
K
L
N
S
F
P
K
L
E
E
V
Site 20
T270
P
L
L
Q
P
Y
T
T
E
E
R
R
K
L
V
Site 21
S290
S
V
S
K
L
N
G
S
V
V
T
D
G
E
R
Site 22
S300
T
D
G
E
R
E
D
S
E
R
F
F
I
R
Y
Site 23
Y307
S
E
R
F
F
I
R
Y
Y
V
D
V
P
Q
E
Site 24
Y308
E
R
F
F
I
R
Y
Y
V
D
V
P
Q
E
E
Site 25
Y327
Y
H
E
L
I
T
K
Y
G
K
L
E
P
L
A
Site 26
S342
E
V
D
L
R
P
Q
S
S
A
K
V
E
V
H
Site 27
S343
V
D
L
R
P
Q
S
S
A
K
V
E
V
H
F
Site 28
S358
N
D
Q
V
E
E
M
S
I
R
L
D
Q
T
V
Site 29
T364
M
S
I
R
L
D
Q
T
V
A
E
L
K
K
Q
Site 30
T374
E
L
K
K
Q
L
K
T
L
V
Q
L
P
T
S
Site 31
Y386
P
T
S
N
M
L
L
Y
Y
F
D
H
E
A
P
Site 32
Y387
T
S
N
M
L
L
Y
Y
F
D
H
E
A
P
F
Site 33
Y401
F
G
P
E
E
M
K
Y
S
S
R
A
L
H
S
Site 34
S402
G
P
E
E
M
K
Y
S
S
R
A
L
H
S
F
Site 35
S403
P
E
E
M
K
Y
S
S
R
A
L
H
S
F
G
Site 36
S408
Y
S
S
R
A
L
H
S
F
G
I
R
D
G
D
Site 37
Y418
I
R
D
G
D
K
I
Y
V
E
S
K
T
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation