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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DNTTIP2
Full Name:
Deoxynucleotidyltransferase terminal-interacting protein 2
Alias:
Acidic 82 kDa protein mRNA (HSU15552); ERBP; Estrogen receptor binding protein; LPTS-interacting protein 2; TDIF2; Terminal deoxynucleotidyltransferase-interacting factor 2
Type:
Transcription, coactivator/corepressor, Nuclear receptor co-regulator
Mass (Da):
84469
Number AA:
756
UniProt ID:
Q5QJE6
International Prot ID:
IPI00290410
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
R
S
A
R
A
K
A
S
I
Q
A
A
S
A
E
Site 2
S17
K
A
S
I
Q
A
A
S
A
E
S
S
G
Q
K
Site 3
S21
Q
A
A
S
A
E
S
S
G
Q
K
S
F
A
A
Site 4
S25
A
E
S
S
G
Q
K
S
F
A
A
N
G
I
Q
Site 5
S37
G
I
Q
A
H
P
E
S
S
T
G
S
D
A
R
Site 6
T39
Q
A
H
P
E
S
S
T
G
S
D
A
R
T
T
Site 7
S41
H
P
E
S
S
T
G
S
D
A
R
T
T
A
E
Site 8
T45
S
T
G
S
D
A
R
T
T
A
E
S
Q
T
T
Site 9
T46
T
G
S
D
A
R
T
T
A
E
S
Q
T
T
G
Site 10
S49
D
A
R
T
T
A
E
S
Q
T
T
G
K
Q
S
Site 11
T52
T
T
A
E
S
Q
T
T
G
K
Q
S
L
I
P
Site 12
S56
S
Q
T
T
G
K
Q
S
L
I
P
R
T
P
K
Site 13
T61
K
Q
S
L
I
P
R
T
P
K
A
R
K
R
K
Site 14
S69
P
K
A
R
K
R
K
S
R
T
T
G
S
L
P
Site 15
T72
R
K
R
K
S
R
T
T
G
S
L
P
K
G
T
Site 16
S74
R
K
S
R
T
T
G
S
L
P
K
G
T
E
P
Site 17
T79
T
G
S
L
P
K
G
T
E
P
S
T
D
G
E
Site 18
S82
L
P
K
G
T
E
P
S
T
D
G
E
T
S
E
Site 19
T83
P
K
G
T
E
P
S
T
D
G
E
T
S
E
A
Site 20
T87
E
P
S
T
D
G
E
T
S
E
A
E
S
N
Y
Site 21
S88
P
S
T
D
G
E
T
S
E
A
E
S
N
Y
S
Site 22
S92
G
E
T
S
E
A
E
S
N
Y
S
V
S
E
H
Site 23
Y94
T
S
E
A
E
S
N
Y
S
V
S
E
H
H
D
Site 24
S95
S
E
A
E
S
N
Y
S
V
S
E
H
H
D
T
Site 25
S97
A
E
S
N
Y
S
V
S
E
H
H
D
T
I
L
Site 26
T102
S
V
S
E
H
H
D
T
I
L
R
V
T
R
R
Site 27
T107
H
D
T
I
L
R
V
T
R
R
R
Q
I
L
I
Site 28
S117
R
Q
I
L
I
A
C
S
P
V
S
S
V
R
K
Site 29
S120
L
I
A
C
S
P
V
S
S
V
R
K
K
P
K
Site 30
S121
I
A
C
S
P
V
S
S
V
R
K
K
P
K
V
Site 31
T129
V
R
K
K
P
K
V
T
P
T
K
E
S
Y
T
Site 32
T131
K
K
P
K
V
T
P
T
K
E
S
Y
T
E
E
Site 33
S134
K
V
T
P
T
K
E
S
Y
T
E
E
I
V
S
Site 34
Y135
V
T
P
T
K
E
S
Y
T
E
E
I
V
S
E
Site 35
T136
T
P
T
K
E
S
Y
T
E
E
I
V
S
E
A
Site 36
S141
S
Y
T
E
E
I
V
S
E
A
E
S
H
V
S
Site 37
S145
E
I
V
S
E
A
E
S
H
V
S
G
I
S
R
Site 38
S148
S
E
A
E
S
H
V
S
G
I
S
R
I
V
L
Site 39
S151
E
S
H
V
S
G
I
S
R
I
V
L
P
T
E
Site 40
S166
K
T
T
G
A
R
R
S
K
A
K
S
L
T
D
Site 41
S170
A
R
R
S
K
A
K
S
L
T
D
P
S
Q
E
Site 42
T172
R
S
K
A
K
S
L
T
D
P
S
Q
E
S
H
Site 43
S175
A
K
S
L
T
D
P
S
Q
E
S
H
T
E
A
Site 44
S184
E
S
H
T
E
A
I
S
D
A
E
T
S
S
S
Site 45
T188
E
A
I
S
D
A
E
T
S
S
S
D
I
S
F
Site 46
S189
A
I
S
D
A
E
T
S
S
S
D
I
S
F
S
Site 47
S190
I
S
D
A
E
T
S
S
S
D
I
S
F
S
G
Site 48
S191
S
D
A
E
T
S
S
S
D
I
S
F
S
G
I
Site 49
S194
E
T
S
S
S
D
I
S
F
S
G
I
A
T
R
Site 50
S196
S
S
S
D
I
S
F
S
G
I
A
T
R
R
T
Site 51
T200
I
S
F
S
G
I
A
T
R
R
T
R
S
M
Q
Site 52
T203
S
G
I
A
T
R
R
T
R
S
M
Q
R
K
L
Site 53
S205
I
A
T
R
R
T
R
S
M
Q
R
K
L
K
A
Site 54
S219
A
Q
T
E
K
K
D
S
K
I
V
P
G
N
E
Site 55
T232
N
E
K
Q
I
V
G
T
P
V
N
S
E
D
S
Site 56
S236
I
V
G
T
P
V
N
S
E
D
S
D
T
R
Q
Site 57
S239
T
P
V
N
S
E
D
S
D
T
R
Q
T
S
H
Site 58
T241
V
N
S
E
D
S
D
T
R
Q
T
S
H
L
Q
Site 59
T244
E
D
S
D
T
R
Q
T
S
H
L
Q
A
R
S
Site 60
S245
D
S
D
T
R
Q
T
S
H
L
Q
A
R
S
L
Site 61
S251
T
S
H
L
Q
A
R
S
L
S
E
I
N
K
P
Site 62
S253
H
L
Q
A
R
S
L
S
E
I
N
K
P
N
F
Site 63
Y261
E
I
N
K
P
N
F
Y
N
N
D
F
D
D
D
Site 64
S270
N
D
F
D
D
D
F
S
H
R
S
S
E
N
I
Site 65
S274
D
D
F
S
H
R
S
S
E
N
I
L
T
V
H
Site 66
T279
R
S
S
E
N
I
L
T
V
H
E
Q
A
N
V
Site 67
S317
G
K
E
I
N
E
K
S
S
Q
L
K
N
L
S
Site 68
S318
K
E
I
N
E
K
S
S
Q
L
K
N
L
S
E
Site 69
S324
S
S
Q
L
K
N
L
S
E
L
Q
D
T
S
L
Site 70
T329
N
L
S
E
L
Q
D
T
S
L
Q
Q
L
V
S
Site 71
S330
L
S
E
L
Q
D
T
S
L
Q
Q
L
V
S
Q
Site 72
S336
T
S
L
Q
Q
L
V
S
Q
R
H
S
T
P
Q
Site 73
S340
Q
L
V
S
Q
R
H
S
T
P
Q
N
K
N
A
Site 74
T341
L
V
S
Q
R
H
S
T
P
Q
N
K
N
A
V
Site 75
S349
P
Q
N
K
N
A
V
S
V
H
S
N
L
N
S
Site 76
S352
K
N
A
V
S
V
H
S
N
L
N
S
E
A
V
Site 77
S356
S
V
H
S
N
L
N
S
E
A
V
M
K
S
L
Site 78
S362
N
S
E
A
V
M
K
S
L
T
Q
T
F
A
T
Site 79
T364
E
A
V
M
K
S
L
T
Q
T
F
A
T
V
E
Site 80
T369
S
L
T
Q
T
F
A
T
V
E
V
G
R
W
N
Site 81
S381
R
W
N
N
N
K
K
S
P
I
K
A
S
D
L
Site 82
T389
P
I
K
A
S
D
L
T
K
F
G
D
C
G
G
Site 83
S397
K
F
G
D
C
G
G
S
D
D
E
E
E
S
T
Site 84
S403
G
S
D
D
E
E
E
S
T
V
I
S
V
S
E
Site 85
T404
S
D
D
E
E
E
S
T
V
I
S
V
S
E
D
Site 86
S407
E
E
E
S
T
V
I
S
V
S
E
D
M
N
S
Site 87
S409
E
S
T
V
I
S
V
S
E
D
M
N
S
E
G
Site 88
S414
S
V
S
E
D
M
N
S
E
G
N
V
D
F
E
Site 89
T424
N
V
D
F
E
C
D
T
K
L
Y
T
S
A
P
Site 90
T428
E
C
D
T
K
L
Y
T
S
A
P
N
T
S
Q
Site 91
S429
C
D
T
K
L
Y
T
S
A
P
N
T
S
Q
G
Site 92
T433
L
Y
T
S
A
P
N
T
S
Q
G
K
D
N
S
Site 93
S434
Y
T
S
A
P
N
T
S
Q
G
K
D
N
S
V
Site 94
S440
T
S
Q
G
K
D
N
S
V
L
L
V
L
S
S
Site 95
S446
N
S
V
L
L
V
L
S
S
D
E
S
Q
Q
S
Site 96
S447
S
V
L
L
V
L
S
S
D
E
S
Q
Q
S
E
Site 97
S450
L
V
L
S
S
D
E
S
Q
Q
S
E
N
S
E
Site 98
S453
S
S
D
E
S
Q
Q
S
E
N
S
E
N
E
E
Site 99
T462
N
S
E
N
E
E
D
T
L
C
F
V
E
N
S
Site 100
S469
T
L
C
F
V
E
N
S
G
Q
R
E
S
L
S
Site 101
S474
E
N
S
G
Q
R
E
S
L
S
G
D
T
G
S
Site 102
S476
S
G
Q
R
E
S
L
S
G
D
T
G
S
L
S
Site 103
T479
R
E
S
L
S
G
D
T
G
S
L
S
C
D
N
Site 104
S481
S
L
S
G
D
T
G
S
L
S
C
D
N
A
L
Site 105
S512
L
E
E
E
D
K
A
S
E
V
A
I
E
E
E
Site 106
S528
E
E
E
E
D
E
K
S
E
E
D
S
S
D
H
Site 107
S532
D
E
K
S
E
E
D
S
S
D
H
D
E
N
E
Site 108
S533
E
K
S
E
E
D
S
S
D
H
D
E
N
E
D
Site 109
S543
D
E
N
E
D
E
F
S
D
E
E
D
F
L
N
Site 110
S562
K
L
L
K
L
T
S
S
S
I
D
P
G
L
S
Site 111
S587
F
N
A
D
K
L
Q
S
N
K
R
T
L
T
Q
Site 112
T591
K
L
Q
S
N
K
R
T
L
T
Q
I
K
E
K
Site 113
T593
Q
S
N
K
R
T
L
T
Q
I
K
E
K
K
K
Site 114
T610
L
L
Q
K
A
V
I
T
P
D
F
E
K
N
H
Site 115
Y622
K
N
H
C
V
P
P
Y
S
E
S
K
Y
Q
L
Site 116
S623
N
H
C
V
P
P
Y
S
E
S
K
Y
Q
L
Q
Site 117
Y627
P
P
Y
S
E
S
K
Y
Q
L
Q
K
K
R
R
Site 118
T640
R
R
K
E
R
Q
K
T
A
G
D
G
W
F
G
Site 119
S669
K
A
L
K
M
R
A
S
M
D
P
K
R
F
Y
Site 120
Y676
S
M
D
P
K
R
F
Y
K
K
N
D
R
D
G
Site 121
Y687
D
R
D
G
F
P
K
Y
F
Q
I
G
T
I
V
Site 122
Y701
V
D
N
P
A
D
F
Y
H
S
R
I
P
K
K
Site 123
T713
P
K
K
Q
R
K
R
T
I
V
E
E
L
L
A
Site 124
S722
V
E
E
L
L
A
D
S
E
F
R
R
Y
N
R
Site 125
Y727
A
D
S
E
F
R
R
Y
N
R
R
K
Y
S
E
Site 126
Y732
R
R
Y
N
R
R
K
Y
S
E
I
M
A
E
K
Site 127
S733
R
Y
N
R
R
K
Y
S
E
I
M
A
E
K
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation