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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRK2
Full Name:
Leucine-rich repeat serine/threonine-protein kinase 2
Alias:
Dardarin; DKFZp434H2111; EC 2.7.11.1; FLJ45829; Leucine-rich repeat kinase 2; PARK8; RIPK7; ROCO2
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
TKL
group; LRRK family
Mass (Da):
286058
Number AA:
2527
UniProt ID:
Q5S007
International Prot ID:
IPI00175649
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032473
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005525
GO:0034211
PhosphoSite+
KinaseNET
Biological Process:
GO:0000165
GO:0008219
GO:0008340
Phosida
TranscriptoNet
STRING
Kinexus Products
Leucine-rich repeat serine/threonine-protein kinase 2 pan-specific antibody AB-NK303-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK303-1#Leucine-rich repeat serine/threonine-protein kinase 2 pan-specific antibody AB-NK303-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK303-2#LRRKtide KinSub - LRRKtide peptide substrate - Powder PE-01ADD95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADD95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
G
S
C
Q
G
C
E
Site 2
S5
_
_
_
M
A
S
G
S
C
Q
G
C
E
E
D
Site 3
T15
G
C
E
E
D
E
E
T
L
K
K
L
I
V
R
Site 4
Y47
E
D
L
L
V
F
T
Y
S
E
H
A
S
K
L
Site 5
S52
F
T
Y
S
E
H
A
S
K
L
F
Q
G
K
N
Site 6
S76
D
S
Y
M
R
V
A
S
V
Q
Q
V
G
W
S
Site 7
S192
H
V
L
F
E
R
V
S
E
E
Q
L
T
E
F
Site 8
T197
R
V
S
E
E
Q
L
T
E
F
V
E
N
K
D
Site 9
Y205
E
F
V
E
N
K
D
Y
M
I
L
L
S
A
S
Site 10
S210
K
D
Y
M
I
L
L
S
A
S
T
N
F
K
D
Site 11
S263
A
M
K
A
F
P
M
S
E
R
I
Q
E
V
S
Site 12
S270
S
E
R
I
Q
E
V
S
C
C
L
L
H
R
L
Site 13
Y380
A
L
N
N
L
L
M
Y
Q
N
S
L
H
E
K
Site 14
S383
N
L
L
M
Y
Q
N
S
L
H
E
K
I
G
D
Site 15
S404
A
H
R
E
V
M
L
S
M
L
M
H
S
S
S
Site 16
S409
M
L
S
M
L
M
H
S
S
S
K
E
V
F
Q
Site 17
S411
S
M
L
M
H
S
S
S
K
E
V
F
Q
A
S
Site 18
S418
S
K
E
V
F
Q
A
S
A
N
A
L
S
T
L
Site 19
T424
A
S
A
N
A
L
S
T
L
L
E
Q
N
V
N
Site 20
S455
L
M
Q
K
H
I
H
S
P
E
V
A
E
S
G
Site 21
S461
H
S
P
E
V
A
E
S
G
C
K
M
L
N
H
Site 22
T489
A
V
V
P
K
I
L
T
V
M
K
R
H
E
T
Site 23
T496
T
V
M
K
R
H
E
T
S
L
P
V
Q
L
E
Site 24
T524
P
E
E
S
R
E
D
T
E
F
H
H
K
L
N
Site 25
S581
P
D
A
L
E
M
L
S
L
E
G
A
M
D
S
Site 26
T592
A
M
D
S
V
L
H
T
L
Q
M
Y
P
D
D
Site 27
Y596
V
L
H
T
L
Q
M
Y
P
D
D
Q
E
I
Q
Site 28
S633
L
L
A
K
I
L
V
S
S
L
Y
R
F
K
D
Site 29
S634
L
A
K
I
L
V
S
S
L
Y
R
F
K
D
V
Site 30
Y636
K
I
L
V
S
S
L
Y
R
F
K
D
V
A
E
Site 31
Y707
A
K
V
A
M
D
D
Y
L
K
N
V
M
L
E
Site 32
S754
Q
V
C
E
K
E
S
S
P
K
L
V
E
L
L
Site 33
S764
L
V
E
L
L
L
N
S
G
S
R
E
Q
D
V
Site 34
S766
E
L
L
L
N
S
G
S
R
E
Q
D
V
R
K
Site 35
T776
Q
D
V
R
K
A
L
T
I
S
I
G
K
G
D
Site 36
T826
G
P
L
F
P
D
K
T
S
N
L
R
K
Q
T
Site 37
S827
P
L
F
P
D
K
T
S
N
L
R
K
Q
T
N
Site 38
T833
T
S
N
L
R
K
Q
T
N
I
A
S
T
L
A
Site 39
T838
K
Q
T
N
I
A
S
T
L
A
R
M
V
I
R
Site 40
S850
V
I
R
Y
Q
M
K
S
A
V
E
E
G
T
A
Site 41
T856
K
S
A
V
E
E
G
T
A
S
G
S
D
G
N
Site 42
S858
A
V
E
E
G
T
A
S
G
S
D
G
N
F
S
Site 43
S860
E
E
G
T
A
S
G
S
D
G
N
F
S
E
D
Site 44
S865
S
G
S
D
G
N
F
S
E
D
V
L
S
K
F
Site 45
T876
L
S
K
F
D
E
W
T
F
I
P
D
S
S
M
Site 46
S881
E
W
T
F
I
P
D
S
S
M
D
S
V
F
A
Site 47
S885
I
P
D
S
S
M
D
S
V
F
A
Q
S
D
D
Site 48
S890
M
D
S
V
F
A
Q
S
D
D
L
D
S
E
G
Site 49
S895
A
Q
S
D
D
L
D
S
E
G
S
E
G
S
F
Site 50
S898
D
D
L
D
S
E
G
S
E
G
S
F
L
V
K
Site 51
S901
D
S
E
G
S
E
G
S
F
L
V
K
K
K
S
Site 52
S908
S
F
L
V
K
K
K
S
N
S
I
S
V
G
E
Site 53
S910
L
V
K
K
K
S
N
S
I
S
V
G
E
F
Y
Site 54
S912
K
K
K
S
N
S
I
S
V
G
E
F
Y
R
D
Site 55
Y917
S
I
S
V
G
E
F
Y
R
D
A
V
L
Q
R
Site 56
S926
D
A
V
L
Q
R
C
S
P
N
L
Q
R
H
S
Site 57
S933
S
P
N
L
Q
R
H
S
N
S
L
G
P
I
F
Site 58
S935
N
L
Q
R
H
S
N
S
L
G
P
I
F
D
H
Site 59
S954
K
R
K
R
K
I
L
S
S
D
D
S
L
R
S
Site 60
S955
R
K
R
K
I
L
S
S
D
D
S
L
R
S
S
Site 61
S958
K
I
L
S
S
D
D
S
L
R
S
S
K
L
Q
Site 62
S961
S
S
D
D
S
L
R
S
S
K
L
Q
S
H
M
Site 63
S962
S
D
D
S
L
R
S
S
K
L
Q
S
H
M
R
Site 64
S966
L
R
S
S
K
L
Q
S
H
M
R
H
S
D
S
Site 65
S971
L
Q
S
H
M
R
H
S
D
S
I
S
S
L
A
Site 66
S973
S
H
M
R
H
S
D
S
I
S
S
L
A
S
E
Site 67
S975
M
R
H
S
D
S
I
S
S
L
A
S
E
R
E
Site 68
S976
R
H
S
D
S
I
S
S
L
A
S
E
R
E
Y
Site 69
S979
D
S
I
S
S
L
A
S
E
R
E
Y
I
T
S
Site 70
Y983
S
L
A
S
E
R
E
Y
I
T
S
L
D
L
S
Site 71
S986
S
E
R
E
Y
I
T
S
L
D
L
S
A
N
E
Site 72
S990
Y
I
T
S
L
D
L
S
A
N
E
L
R
D
I
Site 73
T1024
E
L
H
Q
N
A
L
T
S
F
P
Q
Q
L
C
Site 74
S1025
L
H
Q
N
A
L
T
S
F
P
Q
Q
L
C
E
Site 75
T1033
F
P
Q
Q
L
C
E
T
L
K
S
L
T
H
L
Site 76
S1036
Q
L
C
E
T
L
K
S
L
T
H
L
D
L
H
Site 77
S1044
L
T
H
L
D
L
H
S
N
K
F
T
S
F
P
Site 78
T1048
D
L
H
S
N
K
F
T
S
F
P
S
Y
L
L
Site 79
S1049
L
H
S
N
K
F
T
S
F
P
S
Y
L
L
K
Site 80
S1058
P
S
Y
L
L
K
M
S
C
I
A
N
L
D
V
Site 81
S1073
S
R
N
D
I
G
P
S
V
V
L
D
P
T
V
Site 82
S1091
T
L
K
Q
F
N
L
S
Y
N
Q
L
S
F
V
Site 83
Y1092
L
K
Q
F
N
L
S
Y
N
Q
L
S
F
V
P
Site 84
S1096
N
L
S
Y
N
Q
L
S
F
V
P
E
N
L
T
Site 85
T1103
S
F
V
P
E
N
L
T
D
V
V
E
K
L
E
Site 86
S1124
N
K
I
S
G
I
C
S
P
L
R
L
K
E
L
Site 87
S1137
E
L
K
I
L
N
L
S
K
N
H
I
S
S
L
Site 88
S1143
L
S
K
N
H
I
S
S
L
S
E
N
F
L
E
Site 89
S1145
K
N
H
I
S
S
L
S
E
N
F
L
E
A
C
Site 90
S1157
E
A
C
P
K
V
E
S
F
S
A
R
M
N
F
Site 91
S1200
L
N
L
P
H
L
R
S
L
D
M
S
S
N
D
Site 92
S1204
H
L
R
S
L
D
M
S
S
N
D
I
Q
Y
L
Site 93
Y1210
M
S
S
N
D
I
Q
Y
L
P
G
P
A
H
W
Site 94
S1219
P
G
P
A
H
W
K
S
L
N
L
R
E
L
L
Site 95
S1228
N
L
R
E
L
L
F
S
H
N
Q
I
S
I
L
Site 96
S1233
L
F
S
H
N
Q
I
S
I
L
D
L
S
E
K
Site 97
Y1242
L
D
L
S
E
K
A
Y
L
W
S
R
V
E
K
Site 98
S1253
R
V
E
K
L
H
L
S
H
N
K
L
K
E
I
Site 99
S1276
N
L
T
S
L
D
V
S
Y
N
L
E
L
R
S
Site 100
Y1277
L
T
S
L
D
V
S
Y
N
L
E
L
R
S
F
Site 101
S1283
S
Y
N
L
E
L
R
S
F
P
N
E
M
G
K
Site 102
S1292
P
N
E
M
G
K
L
S
K
I
W
D
L
P
L
Site 103
Y1332
R
L
K
K
A
V
P
Y
N
R
M
K
L
M
I
Site 104
T1343
K
L
M
I
V
G
N
T
G
S
G
K
T
T
L
Site 105
S1345
M
I
V
G
N
T
G
S
G
K
T
T
L
L
Q
Site 106
T1348
G
N
T
G
S
G
K
T
T
L
L
Q
Q
L
M
Site 107
T1349
N
T
G
S
G
K
T
T
L
L
Q
Q
L
M
K
Site 108
T1357
L
L
Q
Q
L
M
K
T
K
K
S
D
L
G
M
Site 109
S1360
Q
L
M
K
T
K
K
S
D
L
G
M
Q
S
A
Site 110
T1368
D
L
G
M
Q
S
A
T
V
G
I
D
V
K
D
Site 111
Y1402
F
A
G
R
E
E
F
Y
S
T
H
P
H
F
M
Site 112
S1403
A
G
R
E
E
F
Y
S
T
H
P
H
F
M
T
Site 113
T1404
G
R
E
E
F
Y
S
T
H
P
H
F
M
T
Q
Site 114
T1410
S
T
H
P
H
F
M
T
Q
R
A
L
Y
L
A
Site 115
S1443
F
N
I
K
A
R
A
S
S
S
P
V
I
L
V
Site 116
S1444
N
I
K
A
R
A
S
S
S
P
V
I
L
V
G
Site 117
S1445
I
K
A
R
A
S
S
S
P
V
I
L
V
G
T
Site 118
T1452
S
P
V
I
L
V
G
T
H
L
D
V
S
D
E
Site 119
S1457
V
G
T
H
L
D
V
S
D
E
K
Q
R
K
A
Site 120
S1467
K
Q
R
K
A
C
M
S
K
I
T
K
E
L
L
Site 121
T1470
K
A
C
M
S
K
I
T
K
E
L
L
N
K
R
Site 122
Y1485
G
F
P
A
I
R
D
Y
H
F
V
N
A
T
E
Site 123
T1491
D
Y
H
F
V
N
A
T
E
E
S
D
A
L
A
Site 124
T1503
A
L
A
K
L
R
K
T
I
I
N
E
S
L
N
Site 125
S1508
R
K
T
I
I
N
E
S
L
N
F
K
I
R
D
Site 126
S1536
E
L
E
K
I
I
L
S
E
R
K
N
V
P
I
Site 127
S1593
Q
D
P
A
L
Q
L
S
D
L
Y
F
V
E
P
Site 128
T1612
K
I
M
A
Q
I
L
T
V
K
V
E
G
C
P
Site 129
S1627
K
H
P
K
G
I
I
S
R
R
D
V
E
K
F
Site 130
S1636
R
D
V
E
K
F
L
S
K
K
R
K
F
P
K
Site 131
Y1645
K
R
K
F
P
K
N
Y
M
S
Q
Y
F
K
L
Site 132
S1647
K
F
P
K
N
Y
M
S
Q
Y
F
K
L
L
E
Site 133
Y1649
P
K
N
Y
M
S
Q
Y
F
K
L
L
E
K
F
Site 134
S1672
E
Y
L
L
V
P
S
S
L
S
D
H
R
P
V
Site 135
S1716
I
N
R
L
L
E
I
S
P
Y
M
L
S
G
R
Site 136
Y1718
R
L
L
E
I
S
P
Y
M
L
S
G
R
E
R
Site 137
S1721
E
I
S
P
Y
M
L
S
G
R
E
R
A
L
R
Site 138
Y1733
A
L
R
P
N
R
M
Y
W
R
Q
G
I
Y
L
Site 139
Y1739
M
Y
W
R
Q
G
I
Y
L
N
W
S
P
E
A
Site 140
S1761
V
L
D
N
H
P
E
S
F
L
K
I
T
V
P
Site 141
T1766
P
E
S
F
L
K
I
T
V
P
S
C
R
K
G
Site 142
S1815
L
K
K
W
A
L
Y
S
F
N
D
G
E
E
H
Site 143
T1849
N
P
D
Q
P
R
L
T
I
P
I
S
Q
I
A
Site 144
S1853
P
R
L
T
I
P
I
S
Q
I
A
P
D
L
I
Site 145
S1892
L
G
D
G
S
F
G
S
V
Y
R
A
A
Y
E
Site 146
Y1894
D
G
S
F
G
S
V
Y
R
A
A
Y
E
G
E
Site 147
Y1898
G
S
V
Y
R
A
A
Y
E
G
E
E
V
A
V
Site 148
T1912
V
K
I
F
N
K
H
T
S
L
R
L
L
R
Q
Site 149
S1913
K
I
F
N
K
H
T
S
L
R
L
L
R
Q
E
Site 150
S1954
M
E
L
A
S
K
G
S
L
D
R
L
L
Q
Q
Site 151
S1965
L
L
Q
Q
D
K
A
S
L
T
R
T
L
Q
H
Site 152
T1967
Q
Q
D
K
A
S
L
T
R
T
L
Q
H
R
I
Site 153
T1969
D
K
A
S
L
T
R
T
L
Q
H
R
I
A
L
Site 154
Y1992
L
H
S
A
M
I
I
Y
R
D
L
K
P
H
N
Site 155
Y2023
A
D
Y
G
I
A
Q
Y
C
C
R
M
G
I
K
Site 156
T2031
C
C
R
M
G
I
K
T
S
E
G
T
P
G
F
Site 157
S2032
C
R
M
G
I
K
T
S
E
G
T
P
G
F
R
Site 158
T2035
G
I
K
T
S
E
G
T
P
G
F
R
A
P
E
Site 159
Y2050
V
A
R
G
N
V
I
Y
N
Q
Q
A
D
V
Y
Site 160
Y2057
Y
N
Q
Q
A
D
V
Y
S
F
G
L
L
L
Y
Site 161
S2058
N
Q
Q
A
D
V
Y
S
F
G
L
L
L
Y
D
Site 162
T2124
E
N
P
Q
E
R
P
T
S
A
Q
V
F
D
I
Site 163
S2125
N
P
Q
E
R
P
T
S
A
Q
V
F
D
I
L
Site 164
T2174
I
W
L
G
C
G
H
T
D
R
G
Q
L
S
F
Site 165
S2180
H
T
D
R
G
Q
L
S
F
L
D
L
N
T
E
Site 166
T2186
L
S
F
L
D
L
N
T
E
G
Y
T
S
E
E
Site 167
Y2189
L
D
L
N
T
E
G
Y
T
S
E
E
V
A
D
Site 168
S2191
L
N
T
E
G
Y
T
S
E
E
V
A
D
S
R
Site 169
S2217
E
K
E
S
W
I
V
S
G
T
Q
S
G
T
L
Site 170
T2237
E
D
G
K
K
R
H
T
L
E
K
M
T
D
S
Site 171
Y2249
T
D
S
V
T
C
L
Y
C
N
S
F
S
K
Q
Site 172
S2257
C
N
S
F
S
K
Q
S
K
Q
K
N
F
L
L
Site 173
S2304
S
T
P
L
M
C
L
S
E
S
T
N
S
T
E
Site 174
S2309
C
L
S
E
S
T
N
S
T
E
R
N
V
M
W
Site 175
T2310
L
S
E
S
T
N
S
T
E
R
N
V
M
W
G
Site 176
T2331
F
S
F
S
N
D
F
T
I
Q
K
L
I
E
T
Site 177
T2340
Q
K
L
I
E
T
R
T
S
Q
L
F
S
Y
A
Site 178
S2341
K
L
I
E
T
R
T
S
Q
L
F
S
Y
A
A
Site 179
S2345
T
R
T
S
Q
L
F
S
Y
A
A
F
S
D
S
Site 180
Y2346
R
T
S
Q
L
F
S
Y
A
A
F
S
D
S
N
Site 181
S2370
L
Y
I
A
K
Q
N
S
P
V
V
E
V
W
D
Site 182
T2380
V
E
V
W
D
K
K
T
E
K
L
C
G
L
I
Site 183
S2404
M
V
K
E
N
K
E
S
K
H
K
M
S
Y
S
Site 184
S2411
S
K
H
K
M
S
Y
S
G
R
V
K
T
L
C
Site 185
T2416
S
Y
S
G
R
V
K
T
L
C
L
Q
K
N
T
Site 186
Y2449
R
R
L
I
R
V
I
Y
N
F
C
N
S
V
R
Site 187
T2460
N
S
V
R
V
M
M
T
A
Q
L
G
S
L
K
Site 188
Y2475
N
V
M
L
V
L
G
Y
N
R
K
N
T
E
G
Site 189
T2480
L
G
Y
N
R
K
N
T
E
G
T
Q
K
Q
K
Site 190
T2483
N
R
K
N
T
E
G
T
Q
K
Q
K
E
I
Q
Site 191
T2524
L
A
E
K
M
R
R
T
S
V
E
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation