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Updated November 2019
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Protein Info
Short Name:
FAM21B
Full Name:
WASH complex subunit FAM21B
Alias:
bA98I6.1; family with sequence similarity 21, member B; FLJ10824
Type:
Phosphoprotein
Mass (Da):
136969
Number AA:
1253
UniProt ID:
Q5SNT6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
P
R
L
S
G
K
S
V
R
V
Y
D
E
E
Site 2
Y12
S
G
K
S
V
R
V
Y
D
E
E
V
E
E
P
Site 3
T28
L
K
A
E
A
E
K
T
E
Q
E
K
T
R
E
Site 4
T33
E
K
T
E
Q
E
K
T
R
E
Q
K
E
V
D
Site 5
Y51
K
V
Q
E
A
V
N
Y
G
L
Q
V
L
D
S
Site 6
S70
L
D
I
K
A
G
N
S
D
S
E
E
D
D
A
Site 7
S72
I
K
A
G
N
S
D
S
E
E
D
D
A
N
G
Site 8
Y91
I
L
E
P
K
D
L
Y
I
D
R
P
L
P
Y
Site 9
S117
D
V
G
L
G
E
L
S
S
E
E
G
S
V
G
Site 10
S118
V
G
L
G
E
L
S
S
E
E
G
S
V
G
S
Site 11
S122
E
L
S
S
E
E
G
S
V
G
S
D
R
G
S
Site 12
S125
S
E
E
G
S
V
G
S
D
R
G
S
I
V
D
Site 13
S129
S
V
G
S
D
R
G
S
I
V
D
T
E
E
E
Site 14
T133
D
R
G
S
I
V
D
T
E
E
E
K
E
E
E
Site 15
S142
E
E
K
E
E
E
E
S
D
E
D
F
A
H
H
Site 16
S150
D
E
D
F
A
H
H
S
D
N
E
Q
N
R
H
Site 17
T158
D
N
E
Q
N
R
H
T
T
Q
M
S
D
E
E
Site 18
T159
N
E
Q
N
R
H
T
T
Q
M
S
D
E
E
E
Site 19
S162
N
R
H
T
T
Q
M
S
D
E
E
E
D
D
D
Site 20
S177
G
C
D
L
F
A
D
S
E
K
E
E
E
D
I
Site 21
S196
E
N
T
R
P
K
R
S
R
P
T
S
F
A
D
Site 22
T199
R
P
K
R
S
R
P
T
S
F
A
D
E
L
A
Site 23
S200
P
K
R
S
R
P
T
S
F
A
D
E
L
A
A
Site 24
T222
G
R
V
D
E
E
P
T
T
L
P
S
G
E
A
Site 25
T223
R
V
D
E
E
P
T
T
L
P
S
G
E
A
K
Site 26
S226
E
E
P
T
T
L
P
S
G
E
A
K
P
R
K
Site 27
T234
G
E
A
K
P
R
K
T
L
K
E
K
K
E
R
Site 28
T243
K
E
K
K
E
R
R
T
P
S
D
D
E
E
D
Site 29
S245
K
K
E
R
R
T
P
S
D
D
E
E
D
N
L
Site 30
T254
D
E
E
D
N
L
F
T
P
P
K
L
T
D
E
Site 31
T259
L
F
T
P
P
K
L
T
D
E
D
F
S
P
F
Site 32
S264
K
L
T
D
E
D
F
S
P
F
G
S
G
G
G
Site 33
S268
E
D
F
S
P
F
G
S
G
G
G
L
F
S
G
Site 34
S274
G
S
G
G
G
L
F
S
G
G
K
G
L
F
D
Site 35
S287
F
D
D
E
D
E
E
S
D
L
F
T
E
A
P
Site 36
T291
D
E
E
S
D
L
F
T
E
A
P
Q
D
R
Q
Site 37
S302
Q
D
R
Q
A
G
A
S
V
K
E
E
S
S
S
Site 38
S307
G
A
S
V
K
E
E
S
S
S
S
K
P
G
K
Site 39
S308
A
S
V
K
E
E
S
S
S
S
K
P
G
K
K
Site 40
S309
S
V
K
E
E
S
S
S
S
K
P
G
K
K
I
Site 41
S310
V
K
E
E
S
S
S
S
K
P
G
K
K
I
P
Site 42
S335
T
D
V
F
G
A
A
S
V
P
S
M
K
E
P
Site 43
T349
P
Q
K
P
E
Q
P
T
P
R
K
S
P
Y
G
Site 44
S353
E
Q
P
T
P
R
K
S
P
Y
G
P
P
P
T
Site 45
Y355
P
T
P
R
K
S
P
Y
G
P
P
P
T
G
L
Site 46
T360
S
P
Y
G
P
P
P
T
G
L
F
D
D
D
D
Site 47
S376
D
D
D
D
D
F
F
S
A
P
H
S
K
P
S
Site 48
S380
D
F
F
S
A
P
H
S
K
P
S
K
T
G
K
Site 49
S383
S
A
P
H
S
K
P
S
K
T
G
K
V
Q
S
Site 50
T385
P
H
S
K
P
S
K
T
G
K
V
Q
S
T
A
Site 51
S390
S
K
T
G
K
V
Q
S
T
A
D
I
F
G
D
Site 52
S410
F
K
E
K
A
V
A
S
P
E
A
T
V
S
Q
Site 53
T414
A
V
A
S
P
E
A
T
V
S
Q
T
D
E
N
Site 54
S416
A
S
P
E
A
T
V
S
Q
T
D
E
N
K
A
Site 55
T430
A
R
A
E
K
K
V
T
L
S
S
S
K
N
L
Site 56
S432
A
E
K
K
V
T
L
S
S
S
K
N
L
K
P
Site 57
S434
K
K
V
T
L
S
S
S
K
N
L
K
P
S
S
Site 58
S441
S
K
N
L
K
P
S
S
E
T
K
T
Q
K
G
Site 59
T445
K
P
S
S
E
T
K
T
Q
K
G
L
F
S
D
Site 60
S451
K
T
Q
K
G
L
F
S
D
E
E
D
S
E
D
Site 61
S456
L
F
S
D
E
E
D
S
E
D
L
F
S
S
Q
Site 62
S461
E
D
S
E
D
L
F
S
S
Q
S
A
S
K
L
Site 63
S462
D
S
E
D
L
F
S
S
Q
S
A
S
K
L
K
Site 64
S464
E
D
L
F
S
S
Q
S
A
S
K
L
K
G
A
Site 65
S466
L
F
S
S
Q
S
A
S
K
L
K
G
A
S
L
Site 66
S481
L
P
G
K
L
P
T
S
V
S
L
F
D
D
E
Site 67
S483
G
K
L
P
T
S
V
S
L
F
D
D
E
D
E
Site 68
T504
G
T
A
A
K
K
Q
T
L
C
L
Q
A
Q
R
Site 69
S531
K
A
S
A
L
L
F
S
S
D
E
E
D
Q
W
Site 70
S532
A
S
A
L
L
F
S
S
D
E
E
D
Q
W
N
Site 71
S543
D
Q
W
N
I
P
A
S
Q
T
H
L
A
S
D
Site 72
S549
A
S
Q
T
H
L
A
S
D
S
R
S
K
G
E
Site 73
S551
Q
T
H
L
A
S
D
S
R
S
K
G
E
P
R
Site 74
S553
H
L
A
S
D
S
R
S
K
G
E
P
R
D
S
Site 75
S560
S
K
G
E
P
R
D
S
G
T
L
Q
S
Q
E
Site 76
T562
G
E
P
R
D
S
G
T
L
Q
S
Q
E
A
K
Site 77
S565
R
D
S
G
T
L
Q
S
Q
E
A
K
A
V
K
Site 78
S575
A
K
A
V
K
K
T
S
L
F
E
E
D
E
E
Site 79
S592
L
F
A
I
A
K
D
S
Q
K
K
T
Q
R
V
Site 80
T596
A
K
D
S
Q
K
K
T
Q
R
V
S
L
L
F
Site 81
S600
Q
K
K
T
Q
R
V
S
L
L
F
E
D
D
V
Site 82
S609
L
F
E
D
D
V
D
S
R
G
S
L
F
G
S
Site 83
S612
D
D
V
D
S
R
G
S
L
F
G
S
P
P
T
Site 84
S616
S
R
G
S
L
F
G
S
P
P
T
S
V
P
P
Site 85
T619
S
L
F
G
S
P
P
T
S
V
P
P
A
T
K
Site 86
S620
L
F
G
S
P
P
T
S
V
P
P
A
T
K
K
Site 87
T630
P
A
T
K
K
K
E
T
V
S
E
A
P
P
L
Site 88
S632
T
K
K
K
E
T
V
S
E
A
P
P
L
L
F
Site 89
S640
E
A
P
P
L
L
F
S
D
E
E
E
K
E
A
Site 90
S653
E
A
Q
L
G
V
K
S
V
D
K
K
V
E
S
Site 91
S660
S
V
D
K
K
V
E
S
A
K
E
S
L
K
F
Site 92
S664
K
V
E
S
A
K
E
S
L
K
F
G
R
T
D
Site 93
T670
E
S
L
K
F
G
R
T
D
V
A
E
S
E
K
Site 94
T682
S
E
K
E
G
L
L
T
R
S
A
Q
E
T
V
Site 95
S684
K
E
G
L
L
T
R
S
A
Q
E
T
V
K
H
Site 96
T688
L
T
R
S
A
Q
E
T
V
K
H
S
D
L
F
Site 97
S692
A
Q
E
T
V
K
H
S
D
L
F
S
S
S
S
Site 98
S696
V
K
H
S
D
L
F
S
S
S
S
P
W
D
K
Site 99
S697
K
H
S
D
L
F
S
S
S
S
P
W
D
K
G
Site 100
S698
H
S
D
L
F
S
S
S
S
P
W
D
K
G
T
Site 101
S699
S
D
L
F
S
S
S
S
P
W
D
K
G
T
K
Site 102
T705
S
S
P
W
D
K
G
T
K
P
R
T
K
T
V
Site 103
T709
D
K
G
T
K
P
R
T
K
T
V
L
S
L
F
Site 104
T711
G
T
K
P
R
T
K
T
V
L
S
L
F
D
E
Site 105
S714
P
R
T
K
T
V
L
S
L
F
D
E
E
E
D
Site 106
S748
D
P
D
A
H
P
K
S
T
G
V
F
Q
D
E
Site 107
S789
L
L
E
P
S
V
G
S
L
F
G
D
D
E
D
Site 108
S801
D
E
D
D
D
L
F
S
S
A
K
S
Q
P
L
Site 109
S802
E
D
D
D
L
F
S
S
A
K
S
Q
P
L
V
Site 110
S805
D
L
F
S
S
A
K
S
Q
P
L
V
Q
E
K
Site 111
S821
R
V
V
K
K
D
H
S
V
D
S
F
K
N
Q
Site 112
S824
K
K
D
H
S
V
D
S
F
K
N
Q
K
H
P
Site 113
S833
K
N
Q
K
H
P
E
S
I
Q
G
S
K
E
K
Site 114
S837
H
P
E
S
I
Q
G
S
K
E
K
G
I
W
K
Site 115
T847
K
G
I
W
K
P
E
T
P
Q
D
S
S
G
L
Site 116
T859
S
G
L
A
P
F
K
T
K
E
P
S
T
R
I
Site 117
S863
P
F
K
T
K
E
P
S
T
R
I
G
K
I
Q
Site 118
S903
P
E
L
A
F
P
S
S
E
H
R
R
S
H
G
Site 119
S908
P
S
S
E
H
R
R
S
H
G
L
E
S
V
P
Site 120
S913
R
R
S
H
G
L
E
S
V
P
V
L
P
G
S
Site 121
S920
S
V
P
V
L
P
G
S
G
E
A
G
V
S
F
Site 122
S926
G
S
G
E
A
G
V
S
F
D
L
P
A
Q
A
Site 123
T935
D
L
P
A
Q
A
D
T
L
H
S
A
N
K
S
Site 124
S938
A
Q
A
D
T
L
H
S
A
N
K
S
R
V
K
Site 125
S942
T
L
H
S
A
N
K
S
R
V
K
M
R
G
K
Site 126
T954
R
G
K
R
R
P
Q
T
R
A
A
R
R
L
A
Site 127
S965
R
R
L
A
A
Q
E
S
S
E
T
E
D
M
S
Site 128
S966
R
L
A
A
Q
E
S
S
E
T
E
D
M
S
V
Site 129
T968
A
A
Q
E
S
S
E
T
E
D
M
S
V
P
R
Site 130
S972
S
S
E
T
E
D
M
S
V
P
R
G
P
I
A
Site 131
S987
Q
W
A
D
G
A
I
S
P
N
G
H
R
P
Q
Site 132
S999
R
P
Q
L
R
A
A
S
G
E
D
S
T
E
E
Site 133
S1003
R
A
A
S
G
E
D
S
T
E
E
A
L
A
A
Site 134
T1004
A
A
S
G
E
D
S
T
E
E
A
L
A
A
A
Site 135
S1026
P
V
P
G
V
D
R
S
P
F
A
K
S
L
G
Site 136
S1031
D
R
S
P
F
A
K
S
L
G
H
S
R
G
E
Site 137
S1035
F
A
K
S
L
G
H
S
R
G
E
A
D
L
F
Site 138
S1044
G
E
A
D
L
F
D
S
G
D
I
F
S
T
G
Site 139
S1049
F
D
S
G
D
I
F
S
T
G
T
G
S
Q
S
Site 140
T1050
D
S
G
D
I
F
S
T
G
T
G
S
Q
S
V
Site 141
T1052
G
D
I
F
S
T
G
T
G
S
Q
S
V
E
R
Site 142
S1054
I
F
S
T
G
T
G
S
Q
S
V
E
R
T
K
Site 143
S1056
S
T
G
T
G
S
Q
S
V
E
R
T
K
P
K
Site 144
T1060
G
S
Q
S
V
E
R
T
K
P
K
A
K
I
A
Site 145
S1081
P
V
G
G
K
A
K
S
P
M
F
P
A
L
G
Site 146
S1091
F
P
A
L
G
E
A
S
S
D
D
D
L
F
Q
Site 147
S1092
P
A
L
G
E
A
S
S
D
D
D
L
F
Q
S
Site 148
S1099
S
D
D
D
L
F
Q
S
A
K
P
K
P
A
K
Site 149
T1110
K
P
A
K
K
T
N
T
F
P
L
L
E
D
E
Site 150
T1131
Q
K
V
K
K
N
E
T
K
S
N
S
Q
Q
D
Site 151
S1133
V
K
K
N
E
T
K
S
N
S
Q
Q
D
V
I
Site 152
S1135
K
N
E
T
K
S
N
S
Q
Q
D
V
I
L
T
Site 153
T1169
K
T
R
E
K
E
K
T
L
E
S
N
L
F
D
Site 154
T1186
I
D
I
F
A
D
L
T
V
K
P
K
E
K
S
Site 155
S1201
K
K
K
V
E
A
K
S
I
F
D
D
D
M
D
Site 156
T1219
S
S
G
I
Q
A
K
T
T
K
P
K
S
R
S
Site 157
T1220
S
G
I
Q
A
K
T
T
K
P
K
S
R
S
A
Site 158
S1224
A
K
T
T
K
P
K
S
R
S
A
Q
A
A
P
Site 159
S1240
P
R
F
E
H
K
V
S
N
I
F
D
D
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation