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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SH2D4B
Full Name:
SH2 domain-containing protein 4B
Alias:
SH2 domain containing 4b; Sh24b
Type:
Uncharacterized protein
Mass (Da):
51232
Number AA:
431
UniProt ID:
Q5SQS7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
Q
Q
I
L
H
D
M
Y
I
D
P
E
L
L
A
Site 2
T44
R
R
W
K
E
R
E
T
W
E
A
L
A
Q
D
Site 3
T59
E
G
L
R
P
P
K
T
K
R
A
S
D
K
H
Site 4
S63
P
P
K
T
K
R
A
S
D
K
H
I
Q
W
L
Site 5
Y91
E
G
P
G
D
K
P
Y
E
E
I
S
E
E
L
Site 6
T123
R
Q
K
E
A
E
I
T
K
K
F
R
D
A
L
Site 7
Y190
E
Q
R
A
K
E
L
Y
W
T
L
K
Q
A
Q
Site 8
T192
R
A
K
E
L
Y
W
T
L
K
Q
A
Q
L
H
Site 9
S203
A
Q
L
H
C
Q
A
S
E
K
E
E
R
E
W
Site 10
S217
W
E
E
Q
L
R
R
S
K
A
A
D
E
E
R
Site 11
S225
K
A
A
D
E
E
R
S
R
R
A
Q
R
A
R
Site 12
Y235
A
Q
R
A
R
D
E
Y
R
H
H
S
L
R
A
Site 13
S239
R
D
E
Y
R
H
H
S
L
R
A
I
Q
K
G
Site 14
T247
L
R
A
I
Q
K
G
T
V
A
G
L
S
S
M
Site 15
S252
K
G
T
V
A
G
L
S
S
M
F
R
E
L
G
Site 16
S261
M
F
R
E
L
G
Q
S
H
E
Q
E
A
R
L
Site 17
Y269
H
E
Q
E
A
R
L
Y
H
H
L
P
D
P
G
Site 18
S296
E
R
P
L
R
P
V
S
R
D
V
I
V
R
W
Site 19
S331
P
W
F
H
G
I
I
S
R
E
D
A
E
A
L
Site 20
T359
S
E
K
I
W
G
Y
T
L
S
Y
R
L
Q
K
Site 21
S381
D
A
S
G
D
F
Y
S
F
L
G
V
D
P
N
Site 22
T392
V
D
P
N
R
H
A
T
L
T
D
L
V
D
F
Site 23
T394
P
N
R
H
A
T
L
T
D
L
V
D
F
H
K
Site 24
S422
E
P
C
G
Q
R
D
S
P
P
D
Y
H
L
L
Site 25
Y426
Q
R
D
S
P
P
D
Y
H
L
L
F
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation