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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MANEA
Full Name:
Glycoprotein endo-alpha-1,2-mannosidase
Alias:
Mandaselin
Type:
Mass (Da):
53671
Number AA:
462
UniProt ID:
Q5SRI9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S64
K
N
F
D
F
Q
K
S
D
R
I
N
S
E
T
Site 2
S69
Q
K
S
D
R
I
N
S
E
T
N
T
K
N
L
Site 3
T71
S
D
R
I
N
S
E
T
N
T
K
N
L
K
S
Site 4
T73
R
I
N
S
E
T
N
T
K
N
L
K
S
V
E
Site 5
S78
T
N
T
K
N
L
K
S
V
E
I
T
M
K
P
Site 6
T82
N
L
K
S
V
E
I
T
M
K
P
S
K
A
S
Site 7
S86
V
E
I
T
M
K
P
S
K
A
S
E
L
N
L
Site 8
Y102
E
L
P
P
L
N
N
Y
L
H
V
F
Y
Y
S
Site 9
Y139
D
P
R
I
A
K
N
Y
P
Q
G
R
H
N
P
Site 10
S152
N
P
P
D
D
I
G
S
S
F
Y
P
E
L
G
Site 11
S153
P
P
D
D
I
G
S
S
F
Y
P
E
L
G
S
Site 12
Y155
D
D
I
G
S
S
F
Y
P
E
L
G
S
Y
S
Site 13
S160
S
F
Y
P
E
L
G
S
Y
S
S
R
D
P
S
Site 14
Y161
F
Y
P
E
L
G
S
Y
S
S
R
D
P
S
V
Site 15
S162
Y
P
E
L
G
S
Y
S
S
R
D
P
S
V
I
Site 16
S163
P
E
L
G
S
Y
S
S
R
D
P
S
V
I
E
Site 17
S167
S
Y
S
S
R
D
P
S
V
I
E
T
H
M
R
Site 18
T171
R
D
P
S
V
I
E
T
H
M
R
Q
M
R
S
Site 19
Y189
G
V
L
A
L
S
W
Y
P
P
D
V
N
D
E
Site 20
Y215
I
L
D
K
A
H
K
Y
N
L
K
V
T
F
H
Site 21
Y235
N
R
D
D
Q
N
M
Y
K
N
V
K
Y
I
I
Site 22
Y240
N
M
Y
K
N
V
K
Y
I
I
D
K
Y
G
N
Site 23
Y245
V
K
Y
I
I
D
K
Y
G
N
H
P
A
F
Y
Site 24
Y252
Y
G
N
H
P
A
F
Y
R
Y
K
T
K
T
G
Site 25
T256
P
A
F
Y
R
Y
K
T
K
T
G
N
A
L
P
Site 26
T258
F
Y
R
Y
K
T
K
T
G
N
A
L
P
M
F
Site 27
Y271
M
F
Y
V
Y
D
S
Y
I
T
K
P
E
K
W
Site 28
T283
E
K
W
A
N
L
L
T
T
S
G
S
R
S
I
Site 29
S285
W
A
N
L
L
T
T
S
G
S
R
S
I
R
N
Site 30
S287
N
L
L
T
T
S
G
S
R
S
I
R
N
S
P
Site 31
S289
L
T
T
S
G
S
R
S
I
R
N
S
P
Y
D
Site 32
S293
G
S
R
S
I
R
N
S
P
Y
D
G
L
F
I
Site 33
Y295
R
S
I
R
N
S
P
Y
D
G
L
F
I
A
L
Site 34
Y310
L
V
E
E
K
H
K
Y
D
I
L
Q
S
G
F
Site 35
Y321
Q
S
G
F
D
G
I
Y
T
Y
F
A
T
N
G
Site 36
Y323
G
F
D
G
I
Y
T
Y
F
A
T
N
G
F
T
Site 37
Y331
F
A
T
N
G
F
T
Y
G
S
S
H
Q
N
W
Site 38
Y360
I
P
S
V
G
P
G
Y
I
D
T
S
I
R
P
Site 39
T363
V
G
P
G
Y
I
D
T
S
I
R
P
W
N
T
Site 40
Y381
R
N
R
I
N
G
K
Y
Y
E
I
G
L
S
A
Site 41
Y382
N
R
I
N
G
K
Y
Y
E
I
G
L
S
A
A
Site 42
S387
K
Y
Y
E
I
G
L
S
A
A
L
Q
T
R
P
Site 43
S398
Q
T
R
P
S
L
I
S
I
T
S
F
N
E
W
Site 44
S401
P
S
L
I
S
I
T
S
F
N
E
W
H
E
G
Site 45
S420
K
A
V
P
K
R
T
S
N
T
V
Y
L
D
Y
Site 46
Y424
K
R
T
S
N
T
V
Y
L
D
Y
R
P
H
K
Site 47
Y427
S
N
T
V
Y
L
D
Y
R
P
H
K
P
G
L
Site 48
Y435
R
P
H
K
P
G
L
Y
L
E
L
T
R
K
W
Site 49
T439
P
G
L
Y
L
E
L
T
R
K
W
S
E
K
Y
Site 50
S443
L
E
L
T
R
K
W
S
E
K
Y
S
K
E
R
Site 51
S447
R
K
W
S
E
K
Y
S
K
E
R
A
T
Y
A
Site 52
T452
K
Y
S
K
E
R
A
T
Y
A
L
D
R
Q
L
Site 53
Y453
Y
S
K
E
R
A
T
Y
A
L
D
R
Q
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation