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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP1R15B
Full Name:
Protein phosphatase 1 regulatory subunit 15B
Alias:
CReP; FLJ14744; protein phosphatase 1 regulatory (inhibitor) subunit 15B; protein phosphatase 1, regulatory (inhibitor) subunit 15B
Type:
Protein phosphatase, regulatory subunit
Mass (Da):
79152
Number AA:
713
UniProt ID:
Q5SWA1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006417
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
P
P
F
F
P
R
R
S
Q
A
G
S
S
K
F
Site 2
S33
P
R
R
S
Q
A
G
S
S
K
F
P
T
P
L
Site 3
S34
R
R
S
Q
A
G
S
S
K
F
P
T
P
L
G
Site 4
T38
A
G
S
S
K
F
P
T
P
L
G
P
E
N
S
Site 5
S45
T
P
L
G
P
E
N
S
G
N
P
T
L
L
S
Site 6
T49
P
E
N
S
G
N
P
T
L
L
S
S
A
Q
P
Site 7
S52
S
G
N
P
T
L
L
S
S
A
Q
P
E
T
R
Site 8
S53
G
N
P
T
L
L
S
S
A
Q
P
E
T
R
V
Site 9
S61
A
Q
P
E
T
R
V
S
Y
W
T
K
L
L
S
Site 10
Y62
Q
P
E
T
R
V
S
Y
W
T
K
L
L
S
Q
Site 11
T64
E
T
R
V
S
Y
W
T
K
L
L
S
Q
L
L
Site 12
T119
R
E
K
P
A
A
P
T
A
Q
K
S
L
S
S
Site 13
S123
A
A
P
T
A
Q
K
S
L
S
S
L
Q
L
D
Site 14
S125
P
T
A
Q
K
S
L
S
S
L
Q
L
D
S
S
Site 15
S126
T
A
Q
K
S
L
S
S
L
Q
L
D
S
S
D
Site 16
S131
L
S
S
L
Q
L
D
S
S
D
P
S
V
T
S
Site 17
S132
S
S
L
Q
L
D
S
S
D
P
S
V
T
S
P
Site 18
S135
Q
L
D
S
S
D
P
S
V
T
S
P
L
D
W
Site 19
S138
S
S
D
P
S
V
T
S
P
L
D
W
L
E
E
Site 20
Y151
E
E
G
I
H
W
Q
Y
S
P
P
D
L
K
L
Site 21
S152
E
G
I
H
W
Q
Y
S
P
P
D
L
K
L
E
Site 22
S188
W
G
V
E
L
L
P
S
S
L
Q
S
R
L
Y
Site 23
S189
G
V
E
L
L
P
S
S
L
Q
S
R
L
Y
S
Site 24
S192
L
L
P
S
S
L
Q
S
R
L
Y
S
N
R
E
Site 25
Y195
S
S
L
Q
S
R
L
Y
S
N
R
E
L
G
S
Site 26
S196
S
L
Q
S
R
L
Y
S
N
R
E
L
G
S
S
Site 27
S202
Y
S
N
R
E
L
G
S
S
P
S
G
P
L
N
Site 28
S203
S
N
R
E
L
G
S
S
P
S
G
P
L
N
I
Site 29
S205
R
E
L
G
S
S
P
S
G
P
L
N
I
Q
R
Site 30
S226
V
S
Y
L
L
N
P
S
Y
L
D
C
F
P
R
Site 31
Y227
S
Y
L
L
N
P
S
Y
L
D
C
F
P
R
L
Site 32
Y238
F
P
R
L
E
V
S
Y
Q
N
S
D
G
N
S
Site 33
S241
L
E
V
S
Y
Q
N
S
D
G
N
S
E
V
V
Site 34
S245
Y
Q
N
S
D
G
N
S
E
V
V
G
F
Q
T
Site 35
T252
S
E
V
V
G
F
Q
T
L
T
P
E
S
S
C
Site 36
S258
Q
T
L
T
P
E
S
S
C
L
R
E
D
H
C
Site 37
S271
H
C
H
P
Q
P
L
S
A
E
L
I
P
A
S
Site 38
S286
W
Q
G
C
P
P
L
S
T
E
G
L
P
E
I
Site 39
T315
N
K
G
Q
D
L
P
T
P
D
Q
D
N
G
Y
Site 40
Y322
T
P
D
Q
D
N
G
Y
H
S
L
E
E
E
H
Site 41
S324
D
Q
D
N
G
Y
H
S
L
E
E
E
H
S
L
Site 42
S330
H
S
L
E
E
E
H
S
L
L
R
M
D
P
K
Site 43
T344
K
H
C
R
D
N
P
T
Q
F
V
P
A
A
G
Site 44
S380
P
L
A
L
E
E
E
S
P
S
E
G
C
P
S
Site 45
S382
A
L
E
E
E
S
P
S
E
G
C
P
S
S
E
Site 46
S387
S
P
S
E
G
C
P
S
S
E
I
P
M
E
K
Site 47
S388
P
S
E
G
C
P
S
S
E
I
P
M
E
K
E
Site 48
S402
E
P
G
E
G
R
I
S
V
V
D
Y
S
Y
L
Site 49
Y406
G
R
I
S
V
V
D
Y
S
Y
L
E
G
D
L
Site 50
S407
R
I
S
V
V
D
Y
S
Y
L
E
G
D
L
P
Site 51
S416
L
E
G
D
L
P
I
S
A
R
P
A
C
S
N
Site 52
S435
Y
I
L
G
G
A
S
S
D
L
E
T
S
S
D
Site 53
T439
G
A
S
S
D
L
E
T
S
S
D
P
E
G
E
Site 54
S440
A
S
S
D
L
E
T
S
S
D
P
E
G
E
D
Site 55
S441
S
S
D
L
E
T
S
S
D
P
E
G
E
D
W
Site 56
S459
A
E
D
D
G
F
D
S
D
S
S
L
S
D
S
Site 57
S461
D
D
G
F
D
S
D
S
S
L
S
D
S
D
L
Site 58
S462
D
G
F
D
S
D
S
S
L
S
D
S
D
L
E
Site 59
S464
F
D
S
D
S
S
L
S
D
S
D
L
E
Q
D
Site 60
S466
S
D
S
S
L
S
D
S
D
L
E
Q
D
P
E
Site 61
Y487
S
F
C
S
V
D
P
Y
N
P
Q
N
F
T
A
Site 62
S508
R
I
V
P
E
E
P
S
D
S
E
K
D
L
S
Site 63
S510
V
P
E
E
P
S
D
S
E
K
D
L
S
G
K
Site 64
S515
S
D
S
E
K
D
L
S
G
K
S
D
L
E
N
Site 65
S518
E
K
D
L
S
G
K
S
D
L
E
N
S
S
Q
Site 66
S523
G
K
S
D
L
E
N
S
S
Q
S
G
S
L
P
Site 67
S524
K
S
D
L
E
N
S
S
Q
S
G
S
L
P
E
Site 68
S528
E
N
S
S
Q
S
G
S
L
P
E
T
P
E
H
Site 69
T532
Q
S
G
S
L
P
E
T
P
E
H
S
S
G
E
Site 70
S552
S
S
A
D
E
A
E
S
L
K
L
W
N
S
F
Site 71
S558
E
S
L
K
L
W
N
S
F
C
N
S
D
D
P
Site 72
Y566
F
C
N
S
D
D
P
Y
N
P
L
N
F
K
A
Site 73
S588
N
E
K
G
C
R
D
S
K
T
P
S
E
S
I
Site 74
T590
K
G
C
R
D
S
K
T
P
S
E
S
I
V
A
Site 75
S592
C
R
D
S
K
T
P
S
E
S
I
V
A
I
S
Site 76
S594
D
S
K
T
P
S
E
S
I
V
A
I
S
E
C
Site 77
S614
C
K
V
Q
L
L
G
S
Q
E
S
E
C
P
D
Site 78
S617
Q
L
L
G
S
Q
E
S
E
C
P
D
S
V
Q
Site 79
S622
Q
E
S
E
C
P
D
S
V
Q
R
D
V
L
S
Site 80
S629
S
V
Q
R
D
V
L
S
G
G
R
H
T
H
V
Site 81
T634
V
L
S
G
G
R
H
T
H
V
K
R
K
K
V
Site 82
Y650
F
L
E
E
V
T
E
Y
Y
I
S
G
D
E
D
Site 83
Y651
L
E
E
V
T
E
Y
Y
I
S
G
D
E
D
R
Site 84
S653
E
V
T
E
Y
Y
I
S
G
D
E
D
R
K
G
Site 85
Y685
E
T
E
D
A
I
G
Y
C
L
T
F
E
H
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation