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Updated November 2019
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Protein Info
Short Name:
SNAPC4
Full Name:
snRNA-activating protein complex subunit 4
Alias:
FLJ13451; Proximal sequence element-binding transcription factor alpha; PSE-binding factor alpha; PTF alpha; PTFalpha; Small nuclear RNA activating complex polypeptide 4 190kDa; Small nuclear RNA activating complex, polypeptide 4, 190kDa; SNAP190; SNAPc 190 kDa; SNPC4; SnRNA-activating protein complex 190 kDa
Type:
Mass (Da):
159433
Number AA:
1469
UniProt ID:
Q5SXM2
International Prot ID:
IPI00158992
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019185
Uniprot
OncoNet
Molecular Function:
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0042795
GO:0042796
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
E
R
I
L
D
P
G
S
S
G
S
H
V
E
I
Site 2
S26
R
I
L
D
P
G
S
S
G
S
H
V
E
I
S
Site 3
S28
L
D
P
G
S
S
G
S
H
V
E
I
S
E
S
Site 4
S33
S
G
S
H
V
E
I
S
E
S
S
L
E
S
D
Site 5
S35
S
H
V
E
I
S
E
S
S
L
E
S
D
S
E
Site 6
S36
H
V
E
I
S
E
S
S
L
E
S
D
S
E
A
Site 7
S39
I
S
E
S
S
L
E
S
D
S
E
A
D
S
L
Site 8
S41
E
S
S
L
E
S
D
S
E
A
D
S
L
P
S
Site 9
S45
E
S
D
S
E
A
D
S
L
P
S
E
D
L
D
Site 10
S59
D
P
A
D
P
P
I
S
E
E
E
R
W
G
E
Site 11
S68
E
E
R
W
G
E
A
S
N
D
E
D
D
P
K
Site 12
T78
E
D
D
P
K
D
K
T
L
P
E
D
P
E
T
Site 13
T85
T
L
P
E
D
P
E
T
C
L
Q
L
N
M
V
Site 14
Y93
C
L
Q
L
N
M
V
Y
Q
E
V
I
Q
E
K
Site 15
S125
L
M
R
D
L
A
G
S
K
G
T
K
V
K
D
Site 16
S135
T
K
V
K
D
G
K
S
L
P
P
S
T
Y
M
Site 17
S139
D
G
K
S
L
P
P
S
T
Y
M
G
H
F
M
Site 18
T140
G
K
S
L
P
P
S
T
Y
M
G
H
F
M
K
Site 19
Y141
K
S
L
P
P
S
T
Y
M
G
H
F
M
K
P
Site 20
Y149
M
G
H
F
M
K
P
Y
F
K
D
K
V
T
G
Site 21
T155
P
Y
F
K
D
K
V
T
G
V
G
P
P
A
N
Site 22
T182
A
F
E
E
L
L
V
T
K
W
K
N
W
E
K
Site 23
S195
E
K
A
L
L
R
K
S
V
V
S
D
R
L
Q
Site 24
S198
L
L
R
K
S
V
V
S
D
R
L
Q
R
L
L
Site 25
Y214
P
K
L
L
K
L
E
Y
L
H
Q
K
Q
S
K
Site 26
S220
E
Y
L
H
Q
K
Q
S
K
V
S
S
E
L
E
Site 27
S224
Q
K
Q
S
K
V
S
S
E
L
E
R
Q
A
L
Site 28
S260
L
L
G
N
R
L
D
S
H
D
W
E
K
I
S
Site 29
S276
I
N
F
E
G
S
R
S
A
E
E
I
R
K
F
Site 30
S298
S
I
N
K
Q
E
W
S
R
E
E
E
E
R
L
Site 31
T326
K
I
A
E
E
L
G
T
S
R
S
A
F
Q
C
Site 32
S329
E
E
L
G
T
S
R
S
A
F
Q
C
L
Q
K
Site 33
T358
E
E
E
D
R
M
L
T
Q
L
V
Q
E
M
R
Site 34
S368
V
Q
E
M
R
V
G
S
H
I
P
Y
R
R
I
Site 35
Y372
R
V
G
S
H
I
P
Y
R
R
I
V
Y
Y
M
Site 36
Y377
I
P
Y
R
R
I
V
Y
Y
M
E
G
R
D
S
Site 37
Y378
P
Y
R
R
I
V
Y
Y
M
E
G
R
D
S
M
Site 38
Y389
R
D
S
M
Q
L
I
Y
R
W
T
K
S
L
D
Site 39
T392
M
Q
L
I
Y
R
W
T
K
S
L
D
P
G
L
Site 40
S394
L
I
Y
R
W
T
K
S
L
D
P
G
L
K
K
Site 41
Y403
D
P
G
L
K
K
G
Y
W
A
P
E
E
D
A
Site 42
Y443
D
A
Q
C
R
D
R
Y
L
R
R
L
H
F
S
Site 43
S450
Y
L
R
R
L
H
F
S
L
K
K
G
R
W
N
Site 44
S481
G
H
W
A
K
I
A
S
E
L
P
H
R
S
G
Site 45
S487
A
S
E
L
P
H
R
S
G
S
Q
C
L
S
K
Site 46
S489
E
L
P
H
R
S
G
S
Q
C
L
S
K
W
K
Site 47
S515
R
R
R
R
A
R
H
S
V
R
W
S
S
T
S
Site 48
S519
A
R
H
S
V
R
W
S
S
T
S
S
S
G
S
Site 49
S520
R
H
S
V
R
W
S
S
T
S
S
S
G
S
S
Site 50
T521
H
S
V
R
W
S
S
T
S
S
S
G
S
S
S
Site 51
S522
S
V
R
W
S
S
T
S
S
S
G
S
S
S
G
Site 52
S523
V
R
W
S
S
T
S
S
S
G
S
S
S
G
S
Site 53
S524
R
W
S
S
T
S
S
S
G
S
S
S
G
S
S
Site 54
S526
S
S
T
S
S
S
G
S
S
S
G
S
S
G
G
Site 55
S527
S
T
S
S
S
G
S
S
S
G
S
S
G
G
S
Site 56
S528
T
S
S
S
G
S
S
S
G
S
S
G
G
S
S
Site 57
S530
S
S
G
S
S
S
G
S
S
G
G
S
S
S
S
Site 58
S531
S
G
S
S
S
G
S
S
G
G
S
S
S
S
S
Site 59
S534
S
S
G
S
S
G
G
S
S
S
S
S
S
S
S
Site 60
S535
S
G
S
S
G
G
S
S
S
S
S
S
S
S
S
Site 61
S536
G
S
S
G
G
S
S
S
S
S
S
S
S
S
E
Site 62
S537
S
S
G
G
S
S
S
S
S
S
S
S
S
E
E
Site 63
S538
S
G
G
S
S
S
S
S
S
S
S
S
E
E
D
Site 64
S539
G
G
S
S
S
S
S
S
S
S
S
E
E
D
E
Site 65
S540
G
S
S
S
S
S
S
S
S
S
E
E
D
E
P
Site 66
S541
S
S
S
S
S
S
S
S
S
E
E
D
E
P
E
Site 67
S542
S
S
S
S
S
S
S
S
E
E
D
E
P
E
Q
Site 68
S561
E
G
D
R
A
L
L
S
P
Q
Y
M
V
P
D
Site 69
Y564
R
A
L
L
S
P
Q
Y
M
V
P
D
M
D
L
Site 70
S578
L
W
V
P
A
R
Q
S
T
S
Q
P
W
R
G
Site 71
T579
W
V
P
A
R
Q
S
T
S
Q
P
W
R
G
G
Site 72
S580
V
P
A
R
Q
S
T
S
Q
P
W
R
G
G
A
Site 73
S597
W
L
G
G
P
A
A
S
L
S
P
P
K
G
S
Site 74
S599
G
G
P
A
A
S
L
S
P
P
K
G
S
S
A
Site 75
S604
S
L
S
P
P
K
G
S
S
A
S
Q
G
G
S
Site 76
S605
L
S
P
P
K
G
S
S
A
S
Q
G
G
S
K
Site 77
S607
P
P
K
G
S
S
A
S
Q
G
G
S
K
E
A
Site 78
S611
S
S
A
S
Q
G
G
S
K
E
A
S
T
T
A
Site 79
S615
Q
G
G
S
K
E
A
S
T
T
A
A
A
P
G
Site 80
T616
G
G
S
K
E
A
S
T
T
A
A
A
P
G
E
Site 81
T617
G
S
K
E
A
S
T
T
A
A
A
P
G
E
E
Site 82
S626
A
A
P
G
E
E
T
S
P
V
Q
V
P
A
R
Site 83
S641
A
H
G
P
V
P
R
S
A
Q
A
S
H
S
A
Site 84
S645
V
P
R
S
A
Q
A
S
H
S
A
D
T
R
P
Site 85
S647
R
S
A
Q
A
S
H
S
A
D
T
R
P
A
G
Site 86
T650
Q
A
S
H
S
A
D
T
R
P
A
G
A
E
K
Site 87
T673
L
L
T
V
P
V
E
T
V
L
R
V
L
R
A
Site 88
T682
L
R
V
L
R
A
N
T
A
A
R
S
C
T
Q
Site 89
T688
N
T
A
A
R
S
C
T
Q
K
E
Q
L
R
Q
Site 90
T700
L
R
Q
P
P
L
P
T
S
S
P
G
V
S
S
Site 91
S701
R
Q
P
P
L
P
T
S
S
P
G
V
S
S
G
Site 92
S702
Q
P
P
L
P
T
S
S
P
G
V
S
S
G
D
Site 93
S706
P
T
S
S
P
G
V
S
S
G
D
S
V
A
R
Site 94
S707
T
S
S
P
G
V
S
S
G
D
S
V
A
R
S
Site 95
S710
P
G
V
S
S
G
D
S
V
A
R
S
H
V
Q
Site 96
S714
S
G
D
S
V
A
R
S
H
V
Q
W
L
R
H
Site 97
T724
Q
W
L
R
H
R
A
T
Q
S
G
Q
R
R
W
Site 98
S726
L
R
H
R
A
T
Q
S
G
Q
R
R
W
R
H
Site 99
T760
G
D
V
V
V
P
C
T
Q
A
S
Q
R
P
A
Site 100
S835
P
V
H
L
L
Q
A
S
S
S
A
Q
S
T
P
Site 101
S836
V
H
L
L
Q
A
S
S
S
A
Q
S
T
P
G
Site 102
S837
H
L
L
Q
A
S
S
S
A
Q
S
T
P
G
H
Site 103
S840
Q
A
S
S
S
A
Q
S
T
P
G
H
L
F
P
Site 104
T841
A
S
S
S
A
Q
S
T
P
G
H
L
F
P
N
Site 105
S855
N
V
P
A
Q
E
A
S
K
S
A
S
H
K
G
Site 106
S857
P
A
Q
E
A
S
K
S
A
S
H
K
G
S
R
Site 107
S859
Q
E
A
S
K
S
A
S
H
K
G
S
R
R
L
Site 108
S863
K
S
A
S
H
K
G
S
R
R
L
A
S
S
R
Site 109
S868
K
G
S
R
R
L
A
S
S
R
V
E
R
T
L
Site 110
S869
G
S
R
R
L
A
S
S
R
V
E
R
T
L
P
Site 111
T874
A
S
S
R
V
E
R
T
L
P
Q
A
S
L
L
Site 112
S879
E
R
T
L
P
Q
A
S
L
L
A
S
T
G
P
Site 113
S883
P
Q
A
S
L
L
A
S
T
G
P
R
P
K
P
Site 114
T892
G
P
R
P
K
P
K
T
V
S
E
L
L
Q
E
Site 115
T911
E
A
R
A
R
E
A
T
R
G
P
V
V
L
P
Site 116
T936
L
Q
P
P
L
P
H
T
P
H
G
R
P
A
P
Site 117
T946
G
R
P
A
P
G
P
T
V
L
N
V
P
L
S
Site 118
S968
A
K
P
G
T
S
G
S
W
Q
E
A
G
T
S
Site 119
S975
S
W
Q
E
A
G
T
S
A
K
D
K
R
L
S
Site 120
S982
S
A
K
D
K
R
L
S
T
M
Q
A
L
P
L
Site 121
T983
A
K
D
K
R
L
S
T
M
Q
A
L
P
L
A
Site 122
T999
V
F
S
E
A
E
G
T
A
P
A
A
S
Q
A
Site 123
S1004
E
G
T
A
P
A
A
S
Q
A
P
A
L
G
P
Site 124
S1017
G
P
G
Q
I
S
V
S
C
P
E
S
G
L
G
Site 125
S1021
I
S
V
S
C
P
E
S
G
L
G
Q
S
Q
A
Site 126
S1026
P
E
S
G
L
G
Q
S
Q
A
P
A
A
S
R
Site 127
T1117
A
T
L
L
P
P
L
T
E
T
R
A
A
Q
G
Site 128
S1131
G
P
R
A
P
A
L
S
S
S
W
Q
P
P
A
Site 129
S1132
P
R
A
P
A
L
S
S
S
W
Q
P
P
A
N
Site 130
S1133
R
A
P
A
L
S
S
S
W
Q
P
P
A
N
M
Site 131
S1147
M
N
R
E
P
E
P
S
C
R
T
D
T
P
A
Site 132
T1150
E
P
E
P
S
C
R
T
D
T
P
A
P
P
T
Site 133
T1152
E
P
S
C
R
T
D
T
P
A
P
P
T
H
A
Site 134
T1157
T
D
T
P
A
P
P
T
H
A
L
S
Q
S
P
Site 135
S1161
A
P
P
T
H
A
L
S
Q
S
P
A
E
A
D
Site 136
S1163
P
T
H
A
L
S
Q
S
P
A
E
A
D
G
S
Site 137
S1170
S
P
A
E
A
D
G
S
V
A
F
V
P
G
E
Site 138
S1190
E
I
P
E
P
R
T
S
S
H
A
D
P
P
E
Site 139
S1191
I
P
E
P
R
T
S
S
H
A
D
P
P
E
A
Site 140
S1203
P
E
A
E
P
P
W
S
G
R
L
P
A
F
G
Site 141
T1216
F
G
G
V
I
P
A
T
E
P
R
G
T
P
G
Site 142
T1221
P
A
T
E
P
R
G
T
P
G
S
P
S
G
T
Site 143
S1224
E
P
R
G
T
P
G
S
P
S
G
T
Q
E
P
Site 144
S1226
R
G
T
P
G
S
P
S
G
T
Q
E
P
R
G
Site 145
T1228
T
P
G
S
P
S
G
T
Q
E
P
R
G
P
L
Site 146
T1329
K
A
L
E
H
K
A
T
S
L
V
V
G
G
E
Site 147
Y1361
Q
L
Q
D
N
P
A
Y
L
L
L
R
A
R
F
Site 148
T1388
L
A
P
Q
G
V
R
T
T
L
S
V
P
S
R
Site 149
T1389
A
P
Q
G
V
R
T
T
L
S
V
P
S
R
V
Site 150
S1391
Q
G
V
R
T
T
L
S
V
P
S
R
V
G
S
Site 151
S1394
R
T
T
L
S
V
P
S
R
V
G
S
E
S
E
Site 152
S1398
S
V
P
S
R
V
G
S
E
S
E
D
E
D
L
Site 153
S1400
P
S
R
V
G
S
E
S
E
D
E
D
L
L
S
Site 154
S1407
S
E
D
E
D
L
L
S
E
L
E
L
A
D
R
Site 155
S1433
P
I
Q
G
A
P
D
S
G
K
C
S
A
S
S
Site 156
S1437
A
P
D
S
G
K
C
S
A
S
S
C
L
D
T
Site 157
S1439
D
S
G
K
C
S
A
S
S
C
L
D
T
S
N
Site 158
S1440
S
G
K
C
S
A
S
S
C
L
D
T
S
N
D
Site 159
T1444
S
A
S
S
C
L
D
T
S
N
D
P
D
D
L
Site 160
S1445
A
S
S
C
L
D
T
S
N
D
P
D
D
L
D
Site 161
T1462
R
T
R
H
A
R
H
T
R
K
R
R
R
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation