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Updated November 2019
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Protein Info
Short Name:
FRMPD1
Full Name:
FERM and PDZ domain-containing protein 1
Alias:
FERM domain-containing protein 2
Type:
Mass (Da):
173437
Number AA:
1578
UniProt ID:
Q5SYB0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
E
L
E
T
S
L
F
Q
T
R
K
A
Site 2
T11
L
E
T
S
L
F
Q
T
R
K
A
H
R
I
E
Site 3
S28
V
A
R
W
L
R
R
S
R
D
S
S
A
R
A
Site 4
S31
W
L
R
R
S
R
D
S
S
A
R
A
K
V
A
Site 5
S32
L
R
R
S
R
D
S
S
A
R
A
K
V
A
A
Site 6
T48
D
G
P
A
R
N
P
T
Q
T
L
I
P
V
R
Site 7
T50
P
A
R
N
P
T
Q
T
L
I
P
V
R
H
T
Site 8
T57
T
L
I
P
V
R
H
T
V
K
I
D
K
D
T
Site 9
T64
T
V
K
I
D
K
D
T
L
L
Q
D
Y
G
F
Site 10
Y69
K
D
T
L
L
Q
D
Y
G
F
H
I
S
E
S
Site 11
S74
Q
D
Y
G
F
H
I
S
E
S
L
P
L
T
V
Site 12
S112
N
E
P
A
E
D
L
S
W
E
R
A
V
D
I
Site 13
S128
R
E
A
E
D
S
L
S
I
T
V
V
R
C
T
Site 14
S141
C
T
S
G
V
P
K
S
S
F
L
T
E
E
K
Site 15
S142
T
S
G
V
P
K
S
S
F
L
T
E
E
K
R
Site 16
T145
V
P
K
S
S
F
L
T
E
E
K
R
A
R
L
Site 17
T154
E
K
R
A
R
L
K
T
N
P
V
K
V
H
F
Site 18
S168
F
A
E
E
V
L
I
S
G
H
S
Q
G
N
S
Site 19
S175
S
G
H
S
Q
G
N
S
L
L
C
M
P
N
V
Site 20
Y186
M
P
N
V
L
K
L
Y
L
E
N
G
Q
T
K
Site 21
T192
L
Y
L
E
N
G
Q
T
K
A
F
K
F
E
A
Site 22
S215
L
T
V
K
E
K
L
S
I
R
S
I
E
Y
F
Site 23
S253
Q
V
V
E
R
E
E
S
H
D
Y
R
C
L
F
Site 24
Y256
E
R
E
E
S
H
D
Y
R
C
L
F
R
V
C
Site 25
Y282
E
D
P
V
A
F
E
Y
L
Y
L
Q
S
C
S
Site 26
S287
F
E
Y
L
Y
L
Q
S
C
S
D
V
L
Q
E
Site 27
S289
Y
L
Y
L
Q
S
C
S
D
V
L
Q
E
R
F
Site 28
Y318
L
H
I
Q
E
R
I
Y
A
C
A
Q
P
Q
K
Site 29
Y330
P
Q
K
I
S
L
K
Y
I
E
K
D
W
G
I
Site 30
T395
Q
I
L
G
E
L
K
T
Y
G
G
R
I
F
N
Site 31
T404
G
G
R
I
F
N
A
T
L
M
L
Q
D
R
E
Site 32
S453
R
V
E
L
T
E
E
S
E
K
V
S
V
V
K
Site 33
S457
T
E
E
S
E
K
V
S
V
V
K
V
Y
L
Q
Site 34
S513
K
Q
Q
A
H
R
V
S
A
E
E
G
Y
E
S
Site 35
Y518
R
V
S
A
E
E
G
Y
E
S
R
A
C
S
D
Site 36
S520
S
A
E
E
G
Y
E
S
R
A
C
S
D
S
E
Site 37
S524
G
Y
E
S
R
A
C
S
D
S
E
E
S
S
E
Site 38
S526
E
S
R
A
C
S
D
S
E
E
S
S
E
V
D
Site 39
S530
C
S
D
S
E
E
S
S
E
V
D
C
V
L
E
Site 40
S540
D
C
V
L
E
P
L
S
D
R
R
L
V
K
L
Site 41
S552
V
K
L
A
P
C
R
S
L
I
K
E
E
Q
P
Site 42
S563
E
E
Q
P
P
G
N
S
P
T
P
E
V
A
R
Site 43
T565
Q
P
P
G
N
S
P
T
P
E
V
A
R
R
G
Site 44
S574
E
V
A
R
R
G
P
S
T
C
G
A
S
S
T
Site 45
T575
V
A
R
R
G
P
S
T
C
G
A
S
S
T
T
Site 46
S580
P
S
T
C
G
A
S
S
T
T
D
S
A
E
S
Site 47
S584
G
A
S
S
T
T
D
S
A
E
S
E
A
S
D
Site 48
S587
S
T
T
D
S
A
E
S
E
A
S
D
S
A
N
Site 49
S590
D
S
A
E
S
E
A
S
D
S
A
N
T
E
S
Site 50
S592
A
E
S
E
A
S
D
S
A
N
T
E
S
R
G
Site 51
S597
S
D
S
A
N
T
E
S
R
G
Y
R
T
S
G
Site 52
Y600
A
N
T
E
S
R
G
Y
R
T
S
G
S
S
E
Site 53
S603
E
S
R
G
Y
R
T
S
G
S
S
E
S
M
D
Site 54
S605
R
G
Y
R
T
S
G
S
S
E
S
M
D
A
L
Site 55
S606
G
Y
R
T
S
G
S
S
E
S
M
D
A
L
E
Site 56
S608
R
T
S
G
S
S
E
S
M
D
A
L
E
E
D
Site 57
T619
L
E
E
D
D
L
D
T
C
S
S
S
R
S
T
Site 58
S621
E
D
D
L
D
T
C
S
S
S
R
S
T
F
F
Site 59
S622
D
D
L
D
T
C
S
S
S
R
S
T
F
F
H
Site 60
S623
D
L
D
T
C
S
S
S
R
S
T
F
F
H
F
Site 61
S625
D
T
C
S
S
S
R
S
T
F
F
H
F
G
S
Site 62
T626
T
C
S
S
S
R
S
T
F
F
H
F
G
S
P
Site 63
S632
S
T
F
F
H
F
G
S
P
G
L
A
E
S
I
Site 64
S638
G
S
P
G
L
A
E
S
I
D
S
D
S
Q
E
Site 65
S641
G
L
A
E
S
I
D
S
D
S
Q
E
E
R
S
Site 66
S643
A
E
S
I
D
S
D
S
Q
E
E
R
S
G
I
Site 67
S648
S
D
S
Q
E
E
R
S
G
I
E
T
S
G
F
Site 68
T672
A
N
P
Q
C
Q
K
T
E
F
S
E
S
A
A
Site 69
S677
Q
K
T
E
F
S
E
S
A
A
L
E
T
F
G
Site 70
T682
S
E
S
A
A
L
E
T
F
G
W
A
P
E
L
Site 71
S690
F
G
W
A
P
E
L
S
T
V
R
L
D
P
R
Site 72
T691
G
W
A
P
E
L
S
T
V
R
L
D
P
R
L
Site 73
Y699
V
R
L
D
P
R
L
Y
E
G
S
H
A
D
Y
Site 74
S702
D
P
R
L
Y
E
G
S
H
A
D
Y
Y
S
L
Site 75
Y706
Y
E
G
S
H
A
D
Y
Y
S
L
C
S
S
V
Site 76
Y707
E
G
S
H
A
D
Y
Y
S
L
C
S
S
V
S
Site 77
S708
G
S
H
A
D
Y
Y
S
L
C
S
S
V
S
P
Site 78
S711
A
D
Y
Y
S
L
C
S
S
V
S
P
A
S
Y
Site 79
S712
D
Y
Y
S
L
C
S
S
V
S
P
A
S
Y
L
Site 80
S714
Y
S
L
C
S
S
V
S
P
A
S
Y
L
S
D
Site 81
S717
C
S
S
V
S
P
A
S
Y
L
S
D
S
S
E
Site 82
Y718
S
S
V
S
P
A
S
Y
L
S
D
S
S
E
S
Site 83
S720
V
S
P
A
S
Y
L
S
D
S
S
E
S
T
A
Site 84
S722
P
A
S
Y
L
S
D
S
S
E
S
T
A
S
R
Site 85
S723
A
S
Y
L
S
D
S
S
E
S
T
A
S
R
Q
Site 86
T726
L
S
D
S
S
E
S
T
A
S
R
Q
G
G
A
Site 87
S728
D
S
S
E
S
T
A
S
R
Q
G
G
A
P
P
Site 88
S748
G
W
T
E
A
Q
P
S
S
M
L
E
P
L
A
Site 89
S749
W
T
E
A
Q
P
S
S
M
L
E
P
L
A
L
Site 90
S766
P
L
A
F
E
D
G
S
S
D
E
E
Y
Y
D
Site 91
S767
L
A
F
E
D
G
S
S
D
E
E
Y
Y
D
A
Site 92
Y771
D
G
S
S
D
E
E
Y
Y
D
A
A
D
K
L
Site 93
T779
Y
D
A
A
D
K
L
T
P
P
G
P
P
S
G
Site 94
S785
L
T
P
P
G
P
P
S
G
P
R
D
V
S
T
Site 95
S791
P
S
G
P
R
D
V
S
T
A
E
P
S
A
T
Site 96
T792
S
G
P
R
D
V
S
T
A
E
P
S
A
T
S
Site 97
T798
S
T
A
E
P
S
A
T
S
L
Q
N
K
A
S
Site 98
S805
T
S
L
Q
N
K
A
S
T
S
S
P
E
N
S
Site 99
T806
S
L
Q
N
K
A
S
T
S
S
P
E
N
S
L
Site 100
S807
L
Q
N
K
A
S
T
S
S
P
E
N
S
L
P
Site 101
S808
Q
N
K
A
S
T
S
S
P
E
N
S
L
P
C
Site 102
S812
S
T
S
S
P
E
N
S
L
P
C
G
P
D
G
Site 103
S823
G
P
D
G
R
Q
P
S
R
R
G
G
V
K
K
Site 104
Y831
R
R
G
G
V
K
K
Y
A
K
T
L
R
K
R
Site 105
T834
G
V
K
K
Y
A
K
T
L
R
K
R
R
S
F
Site 106
S840
K
T
L
R
K
R
R
S
F
L
Q
T
D
Y
T
Site 107
T844
K
R
R
S
F
L
Q
T
D
Y
T
S
Q
V
S
Site 108
Y846
R
S
F
L
Q
T
D
Y
T
S
Q
V
S
F
P
Site 109
T847
S
F
L
Q
T
D
Y
T
S
Q
V
S
F
P
L
Site 110
S851
T
D
Y
T
S
Q
V
S
F
P
L
V
P
S
A
Site 111
Y868
E
S
V
D
D
V
C
Y
Y
D
R
E
P
Y
L
Site 112
Y869
S
V
D
D
V
C
Y
Y
D
R
E
P
Y
L
A
Site 113
Y874
C
Y
Y
D
R
E
P
Y
L
A
L
G
A
P
S
Site 114
S885
G
A
P
S
P
T
V
S
S
L
Q
D
M
Q
G
Site 115
T911
L
L
A
P
L
R
E
T
K
S
T
N
P
A
S
Site 116
S913
A
P
L
R
E
T
K
S
T
N
P
A
S
R
V
Site 117
T914
P
L
R
E
T
K
S
T
N
P
A
S
R
V
M
Site 118
S918
T
K
S
T
N
P
A
S
R
V
M
E
M
E
P
Site 119
T927
V
M
E
M
E
P
E
T
M
E
T
K
S
V
I
Site 120
T930
M
E
P
E
T
M
E
T
K
S
V
I
D
S
R
Site 121
S932
P
E
T
M
E
T
K
S
V
I
D
S
R
V
S
Site 122
S936
E
T
K
S
V
I
D
S
R
V
S
S
I
S
A
Site 123
S940
V
I
D
S
R
V
S
S
I
S
A
I
R
F
R
Site 124
S942
D
S
R
V
S
S
I
S
A
I
R
F
R
I
D
Site 125
S963
S
G
V
V
P
A
A
S
S
S
A
S
T
P
H
Site 126
S967
P
A
A
S
S
S
A
S
T
P
H
C
S
N
P
Site 127
T968
A
A
S
S
S
A
S
T
P
H
C
S
N
P
G
Site 128
S972
S
A
S
T
P
H
C
S
N
P
G
S
S
G
P
Site 129
S976
P
H
C
S
N
P
G
S
S
G
P
D
T
A
Q
Site 130
T981
P
G
S
S
G
P
D
T
A
Q
A
R
P
S
Q
Site 131
S987
D
T
A
Q
A
R
P
S
Q
I
L
P
L
S
Q
Site 132
S1011
P
T
I
E
H
G
D
S
S
F
S
L
S
S
G
Site 133
S1012
T
I
E
H
G
D
S
S
F
S
L
S
S
G
D
Site 134
S1014
E
H
G
D
S
S
F
S
L
S
S
G
D
P
N
Site 135
S1016
G
D
S
S
F
S
L
S
S
G
D
P
N
P
D
Site 136
S1017
D
S
S
F
S
L
S
S
G
D
P
N
P
D
R
Site 137
S1029
P
D
R
A
C
L
A
S
N
P
G
L
N
N
V
Site 138
S1037
N
P
G
L
N
N
V
S
Q
G
D
T
L
E
L
Site 139
T1041
N
N
V
S
Q
G
D
T
L
E
L
Q
L
E
P
Site 140
Y1071
I
Q
E
T
A
P
K
Y
T
E
P
L
L
S
P
Site 141
S1077
K
Y
T
E
P
L
L
S
P
R
D
E
P
R
S
Site 142
S1084
S
P
R
D
E
P
R
S
D
E
C
G
I
N
P
Site 143
S1097
N
P
G
E
K
I
A
S
I
P
T
K
E
E
P
Site 144
S1109
E
E
P
Q
G
Q
L
S
L
E
R
D
R
E
V
Site 145
T1117
L
E
R
D
R
E
V
T
N
K
N
G
T
N
V
Site 146
S1129
T
N
V
F
Q
E
E
S
R
K
D
S
G
D
S
Site 147
S1133
Q
E
E
S
R
K
D
S
G
D
S
P
G
D
V
Site 148
S1136
S
R
K
D
S
G
D
S
P
G
D
V
S
N
N
Site 149
S1141
G
D
S
P
G
D
V
S
N
N
V
S
Q
T
L
Site 150
S1145
G
D
V
S
N
N
V
S
Q
T
L
D
I
S
S
Site 151
T1147
V
S
N
N
V
S
Q
T
L
D
I
S
S
P
A
Site 152
S1152
S
Q
T
L
D
I
S
S
P
A
G
K
I
V
T
Site 153
T1168
L
S
L
D
A
P
V
T
G
T
E
Q
I
P
P
Site 154
S1185
P
R
D
P
Q
G
Q
S
R
E
P
P
G
Q
G
Site 155
S1218
F
L
G
K
Q
T
V
S
P
A
V
P
P
E
G
Site 156
S1244
Q
D
I
A
P
R
D
S
P
E
W
V
C
F
N
Site 157
S1255
V
C
F
N
P
E
P
S
L
P
E
P
L
P
C
Site 158
S1272
E
D
P
H
L
E
T
S
N
H
C
L
L
S
E
Site 159
S1278
T
S
N
H
C
L
L
S
E
G
K
S
D
S
S
Site 160
S1284
L
S
E
G
K
S
D
S
S
S
I
C
L
S
A
Site 161
S1285
S
E
G
K
S
D
S
S
S
I
C
L
S
A
E
Site 162
S1286
E
G
K
S
D
S
S
S
I
C
L
S
A
E
K
Site 163
S1309
S
H
P
E
V
S
A
S
L
R
V
A
T
S
L
Site 164
T1351
F
R
G
P
Q
P
E
T
E
E
E
D
R
D
L
Site 165
T1367
A
H
P
M
A
P
L
T
S
P
P
S
A
G
S
Site 166
S1368
H
P
M
A
P
L
T
S
P
P
S
A
G
S
P
Site 167
S1374
T
S
P
P
S
A
G
S
P
V
V
L
P
W
R
Site 168
S1387
W
R
P
A
R
A
H
S
C
T
T
A
P
L
S
Site 169
T1389
P
A
R
A
H
S
C
T
T
A
P
L
S
R
K
Site 170
T1390
A
R
A
H
S
C
T
T
A
P
L
S
R
K
S
Site 171
S1394
S
C
T
T
A
P
L
S
R
K
S
H
I
W
P
Site 172
Y1403
K
S
H
I
W
P
E
Y
C
S
R
A
L
R
Q
Site 173
T1414
A
L
R
Q
L
K
A
T
P
A
S
T
P
E
G
Site 174
S1417
Q
L
K
A
T
P
A
S
T
P
E
G
F
I
Q
Site 175
T1456
E
K
C
T
W
H
F
T
E
S
R
S
R
L
C
Site 176
S1466
R
S
R
L
C
M
G
S
Q
K
L
L
S
S
C
Site 177
S1471
M
G
S
Q
K
L
L
S
S
C
R
H
V
I
R
Site 178
S1472
G
S
Q
K
L
L
S
S
C
R
H
V
I
R
M
Site 179
S1482
H
V
I
R
M
D
Q
S
P
E
E
M
Q
G
A
Site 180
T1493
M
Q
G
A
V
R
D
T
F
Q
H
L
V
Q
L
Site 181
S1514
F
T
D
C
S
R
C
S
A
R
H
R
E
A
A
Site 182
Y1529
G
N
L
R
D
V
V
Y
T
Y
H
Q
F
I
E
Site 183
Y1546
K
S
T
C
E
R
G
Y
H
D
L
S
V
K
L
Site 184
S1550
E
R
G
Y
H
D
L
S
V
K
L
L
A
R
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation