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Updated November 2019
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Protein Info
Short Name:
NHSL1
Full Name:
NHS-like protein 1
Alias:
Type:
Mass (Da):
170650
Number AA:
1610
UniProt ID:
Q5SYE7
International Prot ID:
IPI00455733
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
K
K
E
G
S
S
G
S
F
R
L
Q
P
N
T
Site 2
T16
S
F
R
L
Q
P
N
T
G
S
L
S
R
A
V
Site 3
S18
R
L
Q
P
N
T
G
S
L
S
R
A
V
S
W
Site 4
S20
Q
P
N
T
G
S
L
S
R
A
V
S
W
I
N
Site 5
S24
G
S
L
S
R
A
V
S
W
I
N
F
S
S
L
Site 6
S30
V
S
W
I
N
F
S
S
L
S
R
Q
T
K
R
Site 7
T35
F
S
S
L
S
R
Q
T
K
R
L
F
R
S
D
Site 8
S41
Q
T
K
R
L
F
R
S
D
G
E
L
S
V
C
Site 9
S46
F
R
S
D
G
E
L
S
V
C
G
Q
Q
V
E
Site 10
Y61
V
D
D
E
N
W
I
Y
R
A
Q
P
R
K
A
Site 11
T97
E
N
V
F
L
P
T
T
R
P
P
C
V
E
D
Site 12
S115
Q
A
K
L
N
L
K
S
V
L
R
E
C
D
K
Site 13
Y128
D
K
L
R
H
D
G
Y
R
S
S
Q
Y
Y
S
Site 14
S130
L
R
H
D
G
Y
R
S
S
Q
Y
Y
S
Q
G
Site 15
S131
R
H
D
G
Y
R
S
S
Q
Y
Y
S
Q
G
P
Site 16
Y133
D
G
Y
R
S
S
Q
Y
Y
S
Q
G
P
T
F
Site 17
Y134
G
Y
R
S
S
Q
Y
Y
S
Q
G
P
T
F
A
Site 18
S135
Y
R
S
S
Q
Y
Y
S
Q
G
P
T
F
A
A
Site 19
T139
Q
Y
Y
S
Q
G
P
T
F
A
A
N
A
S
P
Site 20
S145
P
T
F
A
A
N
A
S
P
F
C
D
D
Y
Q
Site 21
Y151
A
S
P
F
C
D
D
Y
Q
D
E
D
E
E
T
Site 22
T158
Y
Q
D
E
D
E
E
T
D
Q
K
C
S
L
S
Site 23
S163
E
E
T
D
Q
K
C
S
L
S
S
S
E
E
E
Site 24
S165
T
D
Q
K
C
S
L
S
S
S
E
E
E
R
F
Site 25
S166
D
Q
K
C
S
L
S
S
S
E
E
E
R
F
I
Site 26
S167
Q
K
C
S
L
S
S
S
E
E
E
R
F
I
S
Site 27
S174
S
E
E
E
R
F
I
S
I
R
R
P
K
T
P
Site 28
T180
I
S
I
R
R
P
K
T
P
A
S
S
D
F
S
Site 29
S183
R
R
P
K
T
P
A
S
S
D
F
S
D
L
N
Site 30
S184
R
P
K
T
P
A
S
S
D
F
S
D
L
N
T
Site 31
S187
T
P
A
S
S
D
F
S
D
L
N
T
Q
T
N
Site 32
T191
S
D
F
S
D
L
N
T
Q
T
N
W
T
K
S
Site 33
S198
T
Q
T
N
W
T
K
S
L
P
L
P
T
P
E
Site 34
T203
T
K
S
L
P
L
P
T
P
E
E
K
M
R
Q
Site 35
T214
K
M
R
Q
Q
A
Q
T
V
Q
A
D
V
V
P
Site 36
S227
V
P
I
N
I
T
A
S
G
T
G
Q
D
D
A
Site 37
Y240
D
A
D
G
H
S
V
Y
T
P
D
H
Y
S
T
Site 38
T241
A
D
G
H
S
V
Y
T
P
D
H
Y
S
T
L
Site 39
Y245
S
V
Y
T
P
D
H
Y
S
T
L
G
R
F
N
Site 40
S246
V
Y
T
P
D
H
Y
S
T
L
G
R
F
N
S
Site 41
T247
Y
T
P
D
H
Y
S
T
L
G
R
F
N
S
C
Site 42
S253
S
T
L
G
R
F
N
S
C
R
S
A
G
Q
R
Site 43
S261
C
R
S
A
G
Q
R
S
E
T
R
D
S
S
C
Site 44
T263
S
A
G
Q
R
S
E
T
R
D
S
S
C
Q
T
Site 45
S266
Q
R
S
E
T
R
D
S
S
C
Q
T
E
D
V
Site 46
S267
R
S
E
T
R
D
S
S
C
Q
T
E
D
V
K
Site 47
T270
T
R
D
S
S
C
Q
T
E
D
V
K
V
V
P
Site 48
S279
D
V
K
V
V
P
P
S
M
R
R
I
R
A
Q
Site 49
S299
A
A
Q
M
G
H
F
S
G
S
S
G
N
M
S
Site 50
S301
Q
M
G
H
F
S
G
S
S
G
N
M
S
V
L
Site 51
S302
M
G
H
F
S
G
S
S
G
N
M
S
V
L
S
Site 52
S306
S
G
S
S
G
N
M
S
V
L
S
D
S
A
G
Site 53
S318
S
A
G
I
V
F
P
S
R
L
D
S
D
A
G
Site 54
S322
V
F
P
S
R
L
D
S
D
A
G
F
H
S
L
Site 55
S328
D
S
D
A
G
F
H
S
L
P
R
S
G
A
R
Site 56
S332
G
F
H
S
L
P
R
S
G
A
R
A
N
I
Q
Site 57
S340
G
A
R
A
N
I
Q
S
L
E
P
R
L
G
A
Site 58
Y360
D
M
N
G
T
F
L
Y
Q
R
G
H
P
Q
A
Site 59
T382
G
G
A
S
G
T
G
T
L
L
R
P
K
S
Q
Site 60
S388
G
T
L
L
R
P
K
S
Q
E
L
R
H
F
E
Site 61
S396
Q
E
L
R
H
F
E
S
E
N
I
M
S
P
A
Site 62
S413
V
S
P
H
A
T
Y
S
T
S
I
I
P
N
A
Site 63
S442
Q
S
A
G
Q
R
E
S
K
S
S
G
S
S
H
Site 64
S444
A
G
Q
R
E
S
K
S
S
G
S
S
H
A
R
Site 65
S445
G
Q
R
E
S
K
S
S
G
S
S
H
A
R
I
Site 66
S448
E
S
K
S
S
G
S
S
H
A
R
I
K
S
R
Site 67
S454
S
S
H
A
R
I
K
S
R
D
H
L
I
S
R
Site 68
S460
K
S
R
D
H
L
I
S
R
H
A
V
K
G
D
Site 69
S470
A
V
K
G
D
P
Q
S
P
G
R
H
W
N
E
Site 70
S484
E
G
H
A
T
I
L
S
Q
D
L
D
P
H
S
Site 71
S491
S
Q
D
L
D
P
H
S
P
G
E
P
A
L
L
Site 72
S517
P
A
N
R
E
N
G
S
Q
A
M
P
Y
N
C
Site 73
Y522
N
G
S
Q
A
M
P
Y
N
C
R
N
N
L
A
Site 74
S541
P
Q
D
V
D
G
K
S
E
S
S
Y
S
G
G
Site 75
S543
D
V
D
G
K
S
E
S
S
Y
S
G
G
G
G
Site 76
S544
V
D
G
K
S
E
S
S
Y
S
G
G
G
G
H
Site 77
Y545
D
G
K
S
E
S
S
Y
S
G
G
G
G
H
S
Site 78
S546
G
K
S
E
S
S
Y
S
G
G
G
G
H
S
S
Site 79
S552
Y
S
G
G
G
G
H
S
S
S
E
P
W
E
Y
Site 80
S553
S
G
G
G
G
H
S
S
S
E
P
W
E
Y
K
Site 81
S554
G
G
G
G
H
S
S
S
E
P
W
E
Y
K
S
Site 82
Y559
S
S
S
E
P
W
E
Y
K
S
S
G
N
G
R
Site 83
S561
S
E
P
W
E
Y
K
S
S
G
N
G
R
A
S
Site 84
S562
E
P
W
E
Y
K
S
S
G
N
G
R
A
S
P
Site 85
S568
S
S
G
N
G
R
A
S
P
L
K
P
H
L
A
Site 86
T576
P
L
K
P
H
L
A
T
P
G
Y
S
T
P
T
Site 87
Y579
P
H
L
A
T
P
G
Y
S
T
P
T
S
N
M
Site 88
S580
H
L
A
T
P
G
Y
S
T
P
T
S
N
M
S
Site 89
T581
L
A
T
P
G
Y
S
T
P
T
S
N
M
S
S
Site 90
T583
T
P
G
Y
S
T
P
T
S
N
M
S
S
C
S
Site 91
S584
P
G
Y
S
T
P
T
S
N
M
S
S
C
S
L
Site 92
S587
S
T
P
T
S
N
M
S
S
C
S
L
D
Q
T
Site 93
S588
T
P
T
S
N
M
S
S
C
S
L
D
Q
T
S
Site 94
S590
T
S
N
M
S
S
C
S
L
D
Q
T
S
N
K
Site 95
T594
S
S
C
S
L
D
Q
T
S
N
K
E
D
A
G
Site 96
S602
S
N
K
E
D
A
G
S
L
Y
S
E
D
H
D
Site 97
Y604
K
E
D
A
G
S
L
Y
S
E
D
H
D
G
Y
Site 98
Y611
Y
S
E
D
H
D
G
Y
C
A
S
V
H
T
D
Site 99
S619
C
A
S
V
H
T
D
S
G
H
G
S
G
N
L
Site 100
S623
H
T
D
S
G
H
G
S
G
N
L
C
N
S
S
Site 101
S629
G
S
G
N
L
C
N
S
S
D
G
F
G
N
P
Site 102
S630
S
G
N
L
C
N
S
S
D
G
F
G
N
P
R
Site 103
S639
G
F
G
N
P
R
H
S
V
I
N
V
F
V
G
Site 104
Y658
N
Q
G
D
R
S
N
Y
Q
D
K
S
L
S
R
Site 105
S662
R
S
N
Y
Q
D
K
S
L
S
R
N
I
S
L
Site 106
S664
N
Y
Q
D
K
S
L
S
R
N
I
S
L
K
K
Site 107
S668
K
S
L
S
R
N
I
S
L
K
K
A
K
K
P
Site 108
S680
K
K
P
P
L
P
P
S
R
T
D
S
L
R
R
Site 109
T682
P
P
L
P
P
S
R
T
D
S
L
R
R
I
P
Site 110
S684
L
P
P
S
R
T
D
S
L
R
R
I
P
K
K
Site 111
S692
L
R
R
I
P
K
K
S
S
Q
C
N
G
Q
V
Site 112
S693
R
R
I
P
K
K
S
S
Q
C
N
G
Q
V
L
Site 113
S703
N
G
Q
V
L
N
E
S
L
I
A
T
L
Q
H
Site 114
S715
L
Q
H
S
L
Q
L
S
L
P
G
K
S
G
S
Site 115
S720
Q
L
S
L
P
G
K
S
G
S
S
P
S
Q
S
Site 116
S722
S
L
P
G
K
S
G
S
S
P
S
Q
S
P
C
Site 117
S723
L
P
G
K
S
G
S
S
P
S
Q
S
P
C
S
Site 118
S725
G
K
S
G
S
S
P
S
Q
S
P
C
S
D
L
Site 119
S727
S
G
S
S
P
S
Q
S
P
C
S
D
L
E
E
Site 120
S730
S
P
S
Q
S
P
C
S
D
L
E
E
P
W
L
Site 121
S740
E
E
P
W
L
P
R
S
R
S
Q
S
T
V
S
Site 122
S742
P
W
L
P
R
S
R
S
Q
S
T
V
S
A
G
Site 123
S744
L
P
R
S
R
S
Q
S
T
V
S
A
G
S
S
Site 124
T745
P
R
S
R
S
Q
S
T
V
S
A
G
S
S
M
Site 125
S747
S
R
S
Q
S
T
V
S
A
G
S
S
M
T
S
Site 126
S751
S
T
V
S
A
G
S
S
M
T
S
A
T
T
P
Site 127
S754
S
A
G
S
S
M
T
S
A
T
T
P
N
V
Y
Site 128
T757
S
S
M
T
S
A
T
T
P
N
V
Y
S
L
C
Site 129
S762
A
T
T
P
N
V
Y
S
L
C
G
A
T
P
S
Site 130
T767
V
Y
S
L
C
G
A
T
P
S
Q
S
D
T
S
Site 131
S769
S
L
C
G
A
T
P
S
Q
S
D
T
S
S
V
Site 132
S771
C
G
A
T
P
S
Q
S
D
T
S
S
V
K
S
Site 133
T773
A
T
P
S
Q
S
D
T
S
S
V
K
S
E
Y
Site 134
S774
T
P
S
Q
S
D
T
S
S
V
K
S
E
Y
T
Site 135
S775
P
S
Q
S
D
T
S
S
V
K
S
E
Y
T
D
Site 136
S778
S
D
T
S
S
V
K
S
E
Y
T
D
P
W
G
Site 137
Y780
T
S
S
V
K
S
E
Y
T
D
P
W
G
Y
Y
Site 138
Y790
P
W
G
Y
Y
I
D
Y
T
G
M
Q
E
D
P
Site 139
S805
G
N
P
A
G
G
C
S
T
S
S
G
V
P
T
Site 140
S807
P
A
G
G
C
S
T
S
S
G
V
P
T
G
N
Site 141
S808
A
G
G
C
S
T
S
S
G
V
P
T
G
N
G
Site 142
T812
S
T
S
S
G
V
P
T
G
N
G
P
V
R
H
Site 143
T827
V
Q
E
G
S
R
A
T
M
P
Q
V
P
G
G
Site 144
S835
M
P
Q
V
P
G
G
S
V
K
P
K
I
M
S
Site 145
S842
S
V
K
P
K
I
M
S
P
E
K
S
H
R
V
Site 146
S846
K
I
M
S
P
E
K
S
H
R
V
I
S
P
S
Site 147
S851
E
K
S
H
R
V
I
S
P
S
S
G
Y
S
S
Site 148
S853
S
H
R
V
I
S
P
S
S
G
Y
S
S
Q
S
Site 149
S854
H
R
V
I
S
P
S
S
G
Y
S
S
Q
S
N
Site 150
S857
I
S
P
S
S
G
Y
S
S
Q
S
N
T
P
T
Site 151
S858
S
P
S
S
G
Y
S
S
Q
S
N
T
P
T
A
Site 152
S860
S
S
G
Y
S
S
Q
S
N
T
P
T
A
L
T
Site 153
T862
G
Y
S
S
Q
S
N
T
P
T
A
L
T
P
V
Site 154
T864
S
S
Q
S
N
T
P
T
A
L
T
P
V
P
V
Site 155
S877
P
V
F
L
K
S
V
S
P
A
N
G
K
G
K
Site 156
S894
P
K
V
P
E
R
K
S
S
L
I
S
S
V
S
Site 157
S895
K
V
P
E
R
K
S
S
L
I
S
S
V
S
I
Site 158
S898
E
R
K
S
S
L
I
S
S
V
S
I
S
S
S
Site 159
S899
R
K
S
S
L
I
S
S
V
S
I
S
S
S
S
Site 160
S901
S
S
L
I
S
S
V
S
I
S
S
S
S
T
S
Site 161
S904
I
S
S
V
S
I
S
S
S
S
T
S
L
S
S
Site 162
S905
S
S
V
S
I
S
S
S
S
T
S
L
S
S
S
Site 163
S906
S
V
S
I
S
S
S
S
T
S
L
S
S
S
T
Site 164
T907
V
S
I
S
S
S
S
T
S
L
S
S
S
T
S
Site 165
S908
S
I
S
S
S
S
T
S
L
S
S
S
T
S
T
Site 166
S910
S
S
S
S
T
S
L
S
S
S
T
S
T
E
G
Site 167
S911
S
S
S
T
S
L
S
S
S
T
S
T
E
G
S
Site 168
S912
S
S
T
S
L
S
S
S
T
S
T
E
G
S
G
Site 169
S914
T
S
L
S
S
S
T
S
T
E
G
S
G
T
M
Site 170
T915
S
L
S
S
S
T
S
T
E
G
S
G
T
M
K
Site 171
S918
S
S
T
S
T
E
G
S
G
T
M
K
K
L
D
Site 172
S930
K
L
D
P
A
V
G
S
P
P
A
P
P
P
P
Site 173
S941
P
P
P
P
P
V
P
S
P
P
F
P
C
P
A
Site 174
S951
F
P
C
P
A
D
R
S
P
F
L
P
P
P
P
Site 175
T961
L
P
P
P
P
P
V
T
D
C
S
Q
G
S
P
Site 176
S964
P
P
P
V
T
D
C
S
Q
G
S
P
L
P
H
Site 177
S967
V
T
D
C
S
Q
G
S
P
L
P
H
S
P
V
Site 178
S972
Q
G
S
P
L
P
H
S
P
V
F
P
P
P
P
Site 179
S995
S
P
P
D
W
C
L
S
P
P
R
P
A
L
S
Site 180
S1002
S
P
P
R
P
A
L
S
P
I
L
P
D
S
P
Site 181
S1021
L
P
P
P
L
L
P
S
S
E
P
P
P
A
P
Site 182
S1022
P
P
P
L
L
P
S
S
E
P
P
P
A
P
P
Site 183
T1038
D
P
K
F
M
K
D
T
R
P
P
F
T
N
S
Site 184
T1043
K
D
T
R
P
P
F
T
N
S
G
Q
P
E
S
Site 185
S1045
T
R
P
P
F
T
N
S
G
Q
P
E
S
S
R
Site 186
S1050
T
N
S
G
Q
P
E
S
S
R
G
S
L
R
P
Site 187
S1054
Q
P
E
S
S
R
G
S
L
R
P
P
S
T
K
Site 188
S1059
R
G
S
L
R
P
P
S
T
K
E
E
T
S
R
Site 189
T1060
G
S
L
R
P
P
S
T
K
E
E
T
S
R
P
Site 190
T1064
P
P
S
T
K
E
E
T
S
R
P
P
M
P
L
Site 191
S1065
P
S
T
K
E
E
T
S
R
P
P
M
P
L
I
Site 192
S1089
L
R
P
V
R
K
N
S
G
A
E
A
A
Q
L
Site 193
S1097
G
A
E
A
A
Q
L
S
E
R
T
A
Q
E
Q
Site 194
T1106
R
T
A
Q
E
Q
R
T
P
V
A
P
Q
Y
H
Site 195
Y1112
R
T
P
V
A
P
Q
Y
H
L
K
P
S
A
F
Site 196
S1117
P
Q
Y
H
L
K
P
S
A
F
L
K
S
R
N
Site 197
S1122
K
P
S
A
F
L
K
S
R
N
S
T
N
E
M
Site 198
S1125
A
F
L
K
S
R
N
S
T
N
E
M
E
S
E
Site 199
T1126
F
L
K
S
R
N
S
T
N
E
M
E
S
E
S
Site 200
S1131
N
S
T
N
E
M
E
S
E
S
Q
P
A
S
V
Site 201
S1133
T
N
E
M
E
S
E
S
Q
P
A
S
V
T
S
Site 202
S1137
E
S
E
S
Q
P
A
S
V
T
S
S
L
P
T
Site 203
S1140
S
Q
P
A
S
V
T
S
S
L
P
T
P
A
K
Site 204
S1141
Q
P
A
S
V
T
S
S
L
P
T
P
A
K
S
Site 205
T1144
S
V
T
S
S
L
P
T
P
A
K
S
S
S
Q
Site 206
S1148
S
L
P
T
P
A
K
S
S
S
Q
G
D
H
G
Site 207
S1150
P
T
P
A
K
S
S
S
Q
G
D
H
G
S
A
Site 208
S1156
S
S
Q
G
D
H
G
S
A
A
E
R
G
G
P
Site 209
S1165
A
E
R
G
G
P
V
S
R
S
P
G
A
P
S
Site 210
S1167
R
G
G
P
V
S
R
S
P
G
A
P
S
A
G
Site 211
S1181
G
E
A
E
A
R
P
S
P
S
T
T
P
L
P
Site 212
S1183
A
E
A
R
P
S
P
S
T
T
P
L
P
D
S
Site 213
T1184
E
A
R
P
S
P
S
T
T
P
L
P
D
S
S
Site 214
T1185
A
R
P
S
P
S
T
T
P
L
P
D
S
S
P
Site 215
S1190
S
T
T
P
L
P
D
S
S
P
S
R
K
P
P
Site 216
S1191
T
T
P
L
P
D
S
S
P
S
R
K
P
P
P
Site 217
S1193
P
L
P
D
S
S
P
S
R
K
P
P
P
I
S
Site 218
S1200
S
R
K
P
P
P
I
S
K
K
P
K
L
F
L
Site 219
S1233
E
A
L
R
A
V
P
S
P
T
T
G
E
E
G
Site 220
S1241
P
T
T
G
E
E
G
S
V
H
S
R
E
A
K
Site 221
S1250
H
S
R
E
A
K
E
S
S
A
A
Q
A
G
S
Site 222
S1251
S
R
E
A
K
E
S
S
A
A
Q
A
G
S
H
Site 223
S1265
H
A
T
H
P
G
T
S
V
L
E
G
G
A
A
Site 224
S1274
L
E
G
G
A
A
G
S
M
S
P
S
R
V
E
Site 225
S1276
G
G
A
A
G
S
M
S
P
S
R
V
E
A
N
Site 226
S1278
A
A
G
S
M
S
P
S
R
V
E
A
N
V
P
Site 227
S1292
P
M
V
Q
P
D
V
S
P
A
P
K
Q
E
E
Site 228
T1307
P
A
E
N
S
A
D
T
G
G
D
G
E
S
C
Site 229
S1313
D
T
G
G
D
G
E
S
C
L
S
Q
Q
D
G
Site 230
S1316
G
D
G
E
S
C
L
S
Q
Q
D
G
A
A
G
Site 231
T1327
G
A
A
G
V
P
E
T
N
A
A
G
S
S
S
Site 232
S1333
E
T
N
A
A
G
S
S
S
E
A
C
D
F
L
Site 233
S1334
T
N
A
A
G
S
S
S
E
A
C
D
F
L
K
Site 234
T1350
D
G
N
D
E
V
M
T
P
S
R
P
R
T
T
Site 235
S1352
N
D
E
V
M
T
P
S
R
P
R
T
T
E
D
Site 236
T1356
M
T
P
S
R
P
R
T
T
E
D
L
F
A
A
Site 237
T1357
T
P
S
R
P
R
T
T
E
D
L
F
A
A
I
Site 238
S1367
L
F
A
A
I
H
R
S
K
R
K
V
L
G
R
Site 239
S1377
K
V
L
G
R
R
D
S
D
D
D
H
S
R
N
Site 240
S1382
R
D
S
D
D
D
H
S
R
N
H
S
P
S
P
Site 241
S1386
D
D
H
S
R
N
H
S
P
S
P
P
V
T
P
Site 242
S1388
H
S
R
N
H
S
P
S
P
P
V
T
P
T
G
Site 243
T1392
H
S
P
S
P
P
V
T
P
T
G
A
A
P
S
Site 244
S1399
T
P
T
G
A
A
P
S
L
A
S
P
K
Q
V
Site 245
S1408
A
S
P
K
Q
V
G
S
I
Q
R
S
I
R
K
Site 246
S1412
Q
V
G
S
I
Q
R
S
I
R
K
S
S
T
S
Site 247
S1416
I
Q
R
S
I
R
K
S
S
T
S
S
D
N
F
Site 248
S1417
Q
R
S
I
R
K
S
S
T
S
S
D
N
F
K
Site 249
S1419
S
I
R
K
S
S
T
S
S
D
N
F
K
A
L
Site 250
S1420
I
R
K
S
S
T
S
S
D
N
F
K
A
L
L
Site 251
S1432
A
L
L
L
K
K
G
S
R
S
D
T
S
A
R
Site 252
T1436
K
K
G
S
R
S
D
T
S
A
R
M
S
A
A
Site 253
S1437
K
G
S
R
S
D
T
S
A
R
M
S
A
A
E
Site 254
S1441
S
D
T
S
A
R
M
S
A
A
E
M
L
K
N
Site 255
S1456
T
D
P
R
F
Q
R
S
R
S
E
P
S
P
D
Site 256
S1458
P
R
F
Q
R
S
R
S
E
P
S
P
D
A
P
Site 257
S1461
Q
R
S
R
S
E
P
S
P
D
A
P
E
S
P
Site 258
S1467
P
S
P
D
A
P
E
S
P
S
S
C
S
P
S
Site 259
S1469
P
D
A
P
E
S
P
S
S
C
S
P
S
K
N
Site 260
S1470
D
A
P
E
S
P
S
S
C
S
P
S
K
N
R
Site 261
S1472
P
E
S
P
S
S
C
S
P
S
K
N
R
R
A
Site 262
S1474
S
P
S
S
C
S
P
S
K
N
R
R
A
Q
E
Site 263
S1493
N
E
G
L
M
P
R
S
L
S
F
S
G
P
R
Site 264
S1495
G
L
M
P
R
S
L
S
F
S
G
P
R
Y
G
Site 265
S1497
M
P
R
S
L
S
F
S
G
P
R
Y
G
R
S
Site 266
Y1501
L
S
F
S
G
P
R
Y
G
R
S
R
T
P
P
Site 267
S1504
S
G
P
R
Y
G
R
S
R
T
P
P
S
A
A
Site 268
T1506
P
R
Y
G
R
S
R
T
P
P
S
A
A
S
S
Site 269
S1509
G
R
S
R
T
P
P
S
A
A
S
S
R
Y
S
Site 270
S1512
R
T
P
P
S
A
A
S
S
R
Y
S
M
R
N
Site 271
S1513
T
P
P
S
A
A
S
S
R
Y
S
M
R
N
R
Site 272
S1516
S
A
A
S
S
R
Y
S
M
R
N
R
I
Q
S
Site 273
S1523
S
M
R
N
R
I
Q
S
S
P
M
T
V
I
S
Site 274
S1524
M
R
N
R
I
Q
S
S
P
M
T
V
I
S
E
Site 275
T1527
R
I
Q
S
S
P
M
T
V
I
S
E
G
E
G
Site 276
S1530
S
S
P
M
T
V
I
S
E
G
E
G
E
A
V
Site 277
S1555
L
G
A
A
E
G
C
S
L
D
G
L
A
R
E
Site 278
S1578
C
G
E
G
P
A
A
S
L
Q
P
Q
A
P
G
Site 279
T1590
A
P
G
P
V
D
G
T
A
S
A
E
G
R
E
Site 280
S1599
S
A
E
G
R
E
P
S
P
Q
C
G
G
S
L
Site 281
S1605
P
S
P
Q
C
G
G
S
L
S
E
E
S
_
_
Site 282
S1607
P
Q
C
G
G
S
L
S
E
E
S
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation