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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FREM2
Full Name:
FRAS1-related extracellular matrix protein 2
Alias:
DKFZp686J0811; ECM3; FRAS1 related extracellular matrix protein 2; FRAS1-related extracellular matrix 2
Type:
Extracellular matrix
Mass (Da):
351160
Number AA:
UniProt ID:
Q5SZK8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0007156
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
H
S
A
G
T
P
G
L
S
S
R
R
Site 2
S10
S
A
G
T
P
G
L
S
S
R
R
T
G
N
S
Site 3
S11
A
G
T
P
G
L
S
S
R
R
T
G
N
S
T
Site 4
T14
P
G
L
S
S
R
R
T
G
N
S
T
S
F
Q
Site 5
S17
S
S
R
R
T
G
N
S
T
S
F
Q
P
G
P
Site 6
T18
S
R
R
T
G
N
S
T
S
F
Q
P
G
P
P
Site 7
S19
R
R
T
G
N
S
T
S
F
Q
P
G
P
P
P
Site 8
S39
L
L
L
L
L
L
L
S
L
V
S
R
V
P
A
Site 9
S295
S
R
G
A
P
V
G
S
P
A
L
K
R
E
H
Site 10
Y786
I
N
H
H
K
I
A
Y
R
P
P
G
Q
E
L
Site 11
T797
G
Q
E
L
G
V
A
T
R
V
A
Q
F
Q
F
Site 12
S1134
S
R
A
G
I
A
I
S
A
F
N
L
K
D
L
Site 13
T1319
L
E
I
E
I
G
D
T
K
I
I
N
N
K
I
Site 14
S1525
V
F
R
T
F
R
I
S
I
S
D
V
D
N
K
Site 15
S1527
R
T
F
R
I
S
I
S
D
V
D
N
K
K
P
Site 16
T1537
D
N
K
K
P
V
V
T
I
H
K
L
V
V
S
Site 17
T1800
R
R
G
Y
L
G
E
T
S
F
I
S
I
G
T
Site 18
S1804
L
G
E
T
S
F
I
S
I
G
T
R
D
R
T
Site 19
T2050
V
T
V
R
S
R
K
T
D
P
P
S
A
D
A
Site 20
T2059
P
P
S
A
D
A
G
T
D
Y
V
G
I
S
R
Site 21
Y2061
S
A
D
A
G
T
D
Y
V
G
I
S
R
N
L
Site 22
S2065
G
T
D
Y
V
G
I
S
R
N
L
D
F
A
P
Site 23
Y2137
M
Q
F
K
E
R
I
Y
T
G
S
E
S
D
G
Site 24
T2138
Q
F
K
E
R
I
Y
T
G
S
E
S
D
G
Q
Site 25
Y2158
H
R
T
G
D
V
Q
Y
R
S
S
V
R
C
Y
Site 26
Y2433
I
N
D
T
L
T
R
Y
R
W
L
I
S
A
P
Site 27
Y2614
G
E
T
Y
P
Y
Q
Y
S
L
S
I
R
G
S
Site 28
S2766
H
P
A
S
F
T
S
S
V
I
M
S
A
D
H
Site 29
T3058
K
K
R
E
I
R
S
T
P
S
L
A
W
E
I
Site 30
S3140
L
M
C
R
G
K
E
S
F
R
G
K
D
A
P
Site 31
S3150
G
K
D
A
P
K
G
S
S
S
S
E
P
M
V
Site 32
S3152
D
A
P
K
G
S
S
S
S
E
P
M
V
P
P
Site 33
S3153
A
P
K
G
S
S
S
S
E
P
M
V
P
P
Q
Site 34
S3161
E
P
M
V
P
P
Q
S
H
H
N
D
S
S
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation