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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MARCH-VIII
Full Name:
E3 ubiquitin-protein ligase MARCH8
Alias:
Cellular modulator of immune recognition;Membrane-associated RING finger protein 8;Membrane-associated RING-CH protein VIII;RING finger protein 178
Type:
Mass (Da):
32965
Number AA:
291
UniProt ID:
Q5T0T0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
M
P
L
H
Q
I
S
A
I
P
S
Q
D
A
Site 2
S13
H
Q
I
S
A
I
P
S
Q
D
A
I
S
A
R
Site 3
S18
I
P
S
Q
D
A
I
S
A
R
V
Y
R
S
K
Site 4
Y22
D
A
I
S
A
R
V
Y
R
S
K
T
K
E
K
Site 5
T26
A
R
V
Y
R
S
K
T
K
E
K
E
R
E
E
Site 6
T38
R
E
E
Q
N
E
K
T
L
G
H
F
M
S
H
Site 7
S44
K
T
L
G
H
F
M
S
H
S
S
N
I
S
K
Site 8
S46
L
G
H
F
M
S
H
S
S
N
I
S
K
A
G
Site 9
S47
G
H
F
M
S
H
S
S
N
I
S
K
A
G
S
Site 10
S50
M
S
H
S
S
N
I
S
K
A
G
S
P
P
S
Site 11
S54
S
N
I
S
K
A
G
S
P
P
S
A
S
A
P
Site 12
S57
S
K
A
G
S
P
P
S
A
S
A
P
A
P
V
Site 13
S59
A
G
S
P
P
S
A
S
A
P
A
P
V
S
S
Site 14
S65
A
S
A
P
A
P
V
S
S
F
S
R
T
S
I
Site 15
S66
S
A
P
A
P
V
S
S
F
S
R
T
S
I
T
Site 16
S68
P
A
P
V
S
S
F
S
R
T
S
I
T
P
S
Site 17
T70
P
V
S
S
F
S
R
T
S
I
T
P
S
S
Q
Site 18
S71
V
S
S
F
S
R
T
S
I
T
P
S
S
Q
D
Site 19
T73
S
F
S
R
T
S
I
T
P
S
S
Q
D
I
C
Site 20
S75
S
R
T
S
I
T
P
S
S
Q
D
I
C
R
I
Site 21
S76
R
T
S
I
T
P
S
S
Q
D
I
C
R
I
C
Site 22
S91
H
C
E
G
D
D
E
S
P
L
I
T
P
C
H
Site 23
T95
D
D
E
S
P
L
I
T
P
C
H
C
T
G
S
Site 24
Y128
R
C
C
E
L
C
K
Y
E
F
I
M
E
T
K
Site 25
S150
E
K
L
Q
M
T
S
S
E
R
R
K
I
M
C
Site 26
Y232
L
W
K
R
L
K
A
Y
N
R
V
I
Y
V
Q
Site 27
Y237
K
A
Y
N
R
V
I
Y
V
Q
N
C
P
E
T
Site 28
S253
K
K
N
I
F
E
K
S
P
L
T
E
P
N
F
Site 29
T256
I
F
E
K
S
P
L
T
E
P
N
F
E
N
K
Site 30
T279
D
T
N
S
S
C
C
T
E
P
E
D
T
G
A
Site 31
T284
C
C
T
E
P
E
D
T
G
A
E
I
I
H
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation