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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THEM4
Full Name:
Thioesterase superfamily member 4
Alias:
Carboxyl-terminal modulator protein; C-terminal modulator protein; CTMP
Type:
Mass (Da):
27130
Number AA:
240
UniProt ID:
Q5T1C6
International Prot ID:
IPI00064739
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
GO:0016020
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
V
G
R
R
L
P
G
S
E
P
R
P
E
L
R
Site 2
S35
E
P
R
P
E
L
R
S
F
S
S
E
E
V
I
Site 3
S37
R
P
E
L
R
S
F
S
S
E
E
V
I
L
K
Site 4
S38
P
E
L
R
S
F
S
S
E
E
V
I
L
K
D
Site 5
S47
E
V
I
L
K
D
C
S
V
P
N
P
S
W
N
Site 6
S52
D
C
S
V
P
N
P
S
W
N
K
D
L
R
L
Site 7
S72
M
K
K
C
E
D
G
S
W
K
R
L
P
S
Y
Site 8
S78
G
S
W
K
R
L
P
S
Y
K
R
T
P
T
E
Site 9
Y79
S
W
K
R
L
P
S
Y
K
R
T
P
T
E
W
Site 10
T82
R
L
P
S
Y
K
R
T
P
T
E
W
I
Q
D
Site 11
T84
P
S
Y
K
R
T
P
T
E
W
I
Q
D
F
K
Site 12
T92
E
W
I
Q
D
F
K
T
H
F
L
D
P
K
L
Site 13
S106
L
M
K
E
E
Q
M
S
Q
A
Q
L
F
T
R
Site 14
S114
Q
A
Q
L
F
T
R
S
F
D
D
G
L
G
F
Site 15
Y123
D
D
G
L
G
F
E
Y
V
M
F
Y
N
D
I
Site 16
Y127
G
F
E
Y
V
M
F
Y
N
D
I
E
K
R
M
Site 17
Y184
T
A
N
L
N
I
N
Y
K
R
P
I
P
L
C
Site 18
S192
K
R
P
I
P
L
C
S
V
V
M
I
N
S
Q
Site 19
S198
C
S
V
V
M
I
N
S
Q
L
D
K
V
E
G
Site 20
S211
E
G
R
K
F
F
V
S
C
N
V
Q
S
V
D
Site 21
S216
F
V
S
C
N
V
Q
S
V
D
E
K
T
L
Y
Site 22
T221
V
Q
S
V
D
E
K
T
L
Y
S
E
A
T
S
Site 23
Y223
S
V
D
E
K
T
L
Y
S
E
A
T
S
L
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation