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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX59
Full Name:
Probable ATP-dependent RNA helicase DDX59
Alias:
ATP-dependent RNA helicase DDX59; DEAD (Asp-Glu-Ala-Asp) box polypeptide 59; DEAD box 59; DEAD box protein 59; DKFZP564B1023; Zinc finger HIT domain-containing protein 5; ZNHIT5
Type:
Hydrolase; EC 3.6.1.-
Mass (Da):
68810
Number AA:
619
UniProt ID:
Q5T1V6
International Prot ID:
IPI00217157
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0044464
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
N
A
N
D
D
G
K
S
C
V
A
K
I
I
K
Site 2
S37
E
D
L
Q
L
D
K
S
R
D
V
P
V
D
A
Site 3
S57
A
T
I
D
R
H
I
S
E
S
C
P
F
P
S
Site 4
S59
I
D
R
H
I
S
E
S
C
P
F
P
S
P
G
Site 5
S64
S
E
S
C
P
F
P
S
P
G
G
Q
L
A
E
Site 6
S74
G
Q
L
A
E
V
H
S
V
S
P
E
Q
G
A
Site 7
S76
L
A
E
V
H
S
V
S
P
E
Q
G
A
K
D
Site 8
S84
P
E
Q
G
A
K
D
S
H
P
S
E
E
P
V
Site 9
S87
G
A
K
D
S
H
P
S
E
E
P
V
K
S
F
Site 10
S93
P
S
E
E
P
V
K
S
F
S
K
T
Q
R
W
Site 11
S95
E
E
P
V
K
S
F
S
K
T
Q
R
W
A
E
Site 12
T97
P
V
K
S
F
S
K
T
Q
R
W
A
E
P
G
Site 13
Y117
V
C
G
R
Y
G
E
Y
I
C
D
K
T
D
E
Site 14
T122
G
E
Y
I
C
D
K
T
D
E
D
V
C
S
L
Site 15
S128
K
T
D
E
D
V
C
S
L
E
C
K
A
K
H
Site 16
S146
V
K
E
K
E
E
K
S
K
L
S
N
P
Q
K
Site 17
S149
K
E
E
K
S
K
L
S
N
P
Q
K
A
D
S
Site 18
S156
S
N
P
Q
K
A
D
S
E
P
E
S
P
L
N
Site 19
S160
K
A
D
S
E
P
E
S
P
L
N
A
S
Y
V
Site 20
S165
P
E
S
P
L
N
A
S
Y
V
Y
K
E
H
P
Site 21
Y166
E
S
P
L
N
A
S
Y
V
Y
K
E
H
P
F
Site 22
S221
L
N
H
N
L
K
K
S
G
Y
E
V
P
T
P
Site 23
Y223
H
N
L
K
K
S
G
Y
E
V
P
T
P
I
Q
Site 24
T227
K
S
G
Y
E
V
P
T
P
I
Q
M
Q
M
I
Site 25
S246
L
G
R
D
I
L
A
S
A
D
T
G
S
G
K
Site 26
T249
D
I
L
A
S
A
D
T
G
S
G
K
T
A
A
Site 27
T303
S
G
L
P
R
M
K
T
V
L
L
V
G
G
L
Site 28
Y317
L
P
L
P
P
Q
L
Y
R
L
Q
Q
H
V
K
Site 29
S390
V
S
A
T
I
P
T
S
I
E
Q
L
A
S
Q
Site 30
S396
T
S
I
E
Q
L
A
S
Q
L
L
H
N
P
V
Site 31
T407
H
N
P
V
R
I
I
T
G
E
K
N
L
P
C
Site 32
S472
Q
K
I
T
G
L
K
S
I
S
I
H
S
E
K
Site 33
S474
I
T
G
L
K
S
I
S
I
H
S
E
K
S
Q
Site 34
S480
I
S
I
H
S
E
K
S
Q
I
E
R
K
N
I
Site 35
Y529
M
P
S
S
M
D
E
Y
V
H
Q
I
G
R
V
Site 36
T547
G
Q
N
G
T
A
I
T
F
I
N
N
N
S
K
Site 37
S569
K
R
V
K
P
T
G
S
I
L
P
P
Q
L
L
Site 38
S578
L
P
P
Q
L
L
N
S
P
Y
L
H
D
Q
K
Site 39
Y580
P
Q
L
L
N
S
P
Y
L
H
D
Q
K
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation