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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDZK1
Full Name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF3
Alias:
CAP70; CFTR associated protein of 70 kDa; CFTR-associated protein of 70 kDa; Na /H exchanger regulatory factor 3; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein; NaPi-Cap1; NHERF3; PDZ domain containing 1; PDZ domain containing protein 1; PDZ domain-containing protein 1; PDZD1; Sodium-hydrogen exchanger regulatory factor 3
Type:
Adapter/scaffold protein
Mass (Da):
57129
Number AA:
519
UniProt ID:
Q5T2W1
International Prot ID:
IPI00298067
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031526
GO:0019898
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0030165
GO:0008022
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0015879
GO:0008283
GO:0015893
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
S
T
F
N
P
R
E
Site 2
S13
N
P
R
E
C
K
L
S
K
Q
E
G
Q
N
Y
Site 3
Y20
S
K
Q
E
G
Q
N
Y
G
F
F
L
R
I
E
Site 4
T30
F
L
R
I
E
K
D
T
E
G
H
L
V
R
V
Site 5
S42
V
R
V
V
E
K
C
S
P
A
E
K
A
G
L
Site 6
T83
R
K
S
G
N
S
V
T
L
L
V
L
D
G
D
Site 7
S91
L
L
V
L
D
G
D
S
Y
E
K
A
V
K
T
Site 8
Y92
L
V
L
D
G
D
S
Y
E
K
A
V
K
T
R
Site 9
S108
D
L
K
E
L
G
Q
S
Q
K
E
Q
G
L
S
Site 10
S115
S
Q
K
E
Q
G
L
S
D
N
I
L
S
P
V
Site 11
Y137
W
T
Q
P
R
L
C
Y
L
V
K
E
G
G
S
Site 12
S144
Y
L
V
K
E
G
G
S
Y
G
F
S
L
K
T
Site 13
S148
E
G
G
S
Y
G
F
S
L
K
T
V
Q
G
K
Site 14
T151
S
Y
G
F
S
L
K
T
V
Q
G
K
K
G
V
Site 15
S192
G
E
N
V
E
D
A
S
H
E
E
V
V
E
K
Site 16
T216
F
L
L
V
D
K
E
T
D
K
R
H
V
E
Q
Site 17
T231
K
I
Q
F
K
R
E
T
A
S
L
K
L
L
P
Site 18
S233
Q
F
K
R
E
T
A
S
L
K
L
L
P
H
Q
Site 19
S250
I
V
E
M
K
K
G
S
N
G
Y
G
F
Y
L
Site 20
Y253
M
K
K
G
S
N
G
Y
G
F
Y
L
R
A
G
Site 21
Y256
G
S
N
G
Y
G
F
Y
L
R
A
G
S
E
Q
Site 22
S261
G
F
Y
L
R
A
G
S
E
Q
K
G
Q
I
I
Site 23
S273
Q
I
I
K
D
I
D
S
G
S
P
A
E
E
A
Site 24
S275
I
K
D
I
D
S
G
S
P
A
E
E
A
G
L
Site 25
S295
V
V
A
V
N
G
E
S
V
E
T
L
D
H
D
Site 26
T298
V
N
G
E
S
V
E
T
L
D
H
D
S
V
V
Site 27
S303
V
E
T
L
D
H
D
S
V
V
E
M
I
R
K
Site 28
S316
R
K
G
G
D
Q
T
S
L
L
V
V
D
K
E
Site 29
Y328
D
K
E
T
D
N
M
Y
R
L
A
H
F
S
P
Site 30
S334
M
Y
R
L
A
H
F
S
P
F
L
Y
Y
Q
S
Site 31
Y338
A
H
F
S
P
F
L
Y
Y
Q
S
Q
E
L
P
Site 32
Y339
H
F
S
P
F
L
Y
Y
Q
S
Q
E
L
P
N
Site 33
S341
S
P
F
L
Y
Y
Q
S
Q
E
L
P
N
G
S
Site 34
S348
S
Q
E
L
P
N
G
S
V
K
E
A
P
A
P
Site 35
T356
V
K
E
A
P
A
P
T
P
T
S
L
E
V
S
Site 36
S359
A
P
A
P
T
P
T
S
L
E
V
S
S
P
P
Site 37
S363
T
P
T
S
L
E
V
S
S
P
P
D
T
T
E
Site 38
S364
P
T
S
L
E
V
S
S
P
P
D
T
T
E
E
Site 39
T368
E
V
S
S
P
P
D
T
T
E
E
V
D
H
K
Site 40
T369
V
S
S
P
P
D
T
T
E
E
V
D
H
K
P
Site 41
S401
A
I
R
G
L
P
G
S
F
I
K
E
V
Q
K
Site 42
Y436
V
N
V
L
D
E
P
Y
E
K
V
V
D
R
I
Site 43
S445
K
V
V
D
R
I
Q
S
S
G
K
N
V
T
L
Site 44
T451
Q
S
S
G
K
N
V
T
L
L
V
C
G
K
K
Site 45
Y462
C
G
K
K
A
Y
D
Y
F
Q
A
K
K
I
P
Site 46
T480
S
L
A
D
P
L
D
T
P
P
D
S
K
E
G
Site 47
S484
P
L
D
T
P
P
D
S
K
E
G
I
V
V
E
Site 48
S492
K
E
G
I
V
V
E
S
N
H
D
S
H
M
A
Site 49
S496
V
V
E
S
N
H
D
S
H
M
A
K
E
R
A
Site 50
S505
M
A
K
E
R
A
H
S
T
A
S
H
S
S
S
Site 51
T506
A
K
E
R
A
H
S
T
A
S
H
S
S
S
N
Site 52
S508
E
R
A
H
S
T
A
S
H
S
S
S
N
S
E
Site 53
S510
A
H
S
T
A
S
H
S
S
S
N
S
E
D
T
Site 54
S511
H
S
T
A
S
H
S
S
S
N
S
E
D
T
E
Site 55
S512
S
T
A
S
H
S
S
S
N
S
E
D
T
E
M
Site 56
S514
A
S
H
S
S
S
N
S
E
D
T
E
M
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation