KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HECTD3
Full Name:
E3 ubiquitin-protein ligase HECTD3
Alias:
HECT domain-containing protein 3
Type:
Mass (Da):
97113
Number AA:
861
UniProt ID:
Q5T447
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
G
P
G
A
V
L
E
S
P
R
Q
L
L
G
R
Site 2
Y52
R
E
V
L
Y
K
L
Y
K
D
P
A
G
P
S
Site 3
T84
A
A
G
P
A
P
G
T
G
S
G
P
L
R
A
Site 4
S86
G
P
A
P
G
T
G
S
G
P
L
R
A
A
R
Site 5
S95
P
L
R
A
A
R
D
S
I
E
L
R
R
G
A
Site 6
T107
R
G
A
C
V
R
T
T
G
E
E
L
C
N
G
Site 7
T122
H
G
L
W
V
K
L
T
K
E
Q
L
A
E
H
Site 8
T157
A
R
L
V
P
I
D
T
P
N
H
L
Q
R
Q
Site 9
Y172
Q
Q
L
F
G
V
D
Y
R
P
V
L
R
W
E
Site 10
T185
W
E
Q
V
V
D
L
T
Y
S
H
R
L
G
S
Site 11
Y186
E
Q
V
V
D
L
T
Y
S
H
R
L
G
S
R
Site 12
S187
Q
V
V
D
L
T
Y
S
H
R
L
G
S
R
P
Site 13
S192
T
Y
S
H
R
L
G
S
R
P
Q
P
A
E
A
Site 14
Y209
E
A
V
Q
R
L
L
Y
V
P
P
T
W
T
Y
Site 15
T213
R
L
L
Y
V
P
P
T
W
T
Y
E
C
D
E
Site 16
Y216
Y
V
P
P
T
W
T
Y
E
C
D
E
D
L
I
Site 17
Y227
E
D
L
I
H
F
L
Y
D
H
L
G
K
E
D
Site 18
S239
K
E
D
E
N
L
G
S
V
K
Q
Y
V
E
S
Site 19
Y243
N
L
G
S
V
K
Q
Y
V
E
S
I
D
V
S
Site 20
S246
S
V
K
Q
Y
V
E
S
I
D
V
S
S
Y
T
Site 21
S250
Y
V
E
S
I
D
V
S
S
Y
T
E
E
F
N
Site 22
S251
V
E
S
I
D
V
S
S
Y
T
E
E
F
N
V
Site 23
T253
S
I
D
V
S
S
Y
T
E
E
F
N
V
S
C
Site 24
S259
Y
T
E
E
F
N
V
S
C
L
T
D
S
N
A
Site 25
T268
L
T
D
S
N
A
D
T
Y
W
E
S
D
G
S
Site 26
Y269
T
D
S
N
A
D
T
Y
W
E
S
D
G
S
Q
Site 27
T297
I
V
K
K
L
L
L
T
V
D
T
T
D
D
N
Site 28
T300
K
L
L
L
T
V
D
T
T
D
D
N
F
M
P
Site 29
T301
L
L
L
T
V
D
T
T
D
D
N
F
M
P
K
Site 30
S324
G
D
N
L
K
K
L
S
D
V
S
I
D
E
T
Site 31
S372
L
R
G
V
K
I
K
S
S
R
Q
R
E
L
G
Site 32
S373
R
G
V
K
I
K
S
S
R
Q
R
E
L
G
L
Site 33
S389
A
D
L
F
Q
P
T
S
L
V
R
Y
P
R
L
Site 34
Y393
Q
P
T
S
L
V
R
Y
P
R
L
E
G
T
D
Site 35
T399
R
Y
P
R
L
E
G
T
D
P
E
V
L
Y
R
Site 36
Y405
G
T
D
P
E
V
L
Y
R
R
A
V
L
L
Q
Site 37
T435
A
W
D
H
T
L
G
T
F
S
E
I
K
Q
V
Site 38
S463
V
A
Q
C
L
R
D
S
E
S
S
K
P
S
F
Site 39
S465
Q
C
L
R
D
S
E
S
S
K
P
S
F
M
P
Site 40
S466
C
L
R
D
S
E
S
S
K
P
S
F
M
P
R
Site 41
S469
D
S
E
S
S
K
P
S
F
M
P
R
L
Y
I
Site 42
Y475
P
S
F
M
P
R
L
Y
I
N
R
R
L
A
M
Site 43
Y503
N
A
V
F
T
Q
V
Y
E
G
L
K
P
S
D
Site 44
Y512
G
L
K
P
S
D
K
Y
E
K
P
L
D
Y
R
Site 45
Y518
K
Y
E
K
P
L
D
Y
R
W
P
M
R
Y
D
Site 46
S547
Q
G
G
G
F
R
D
S
L
A
D
M
S
E
E
Site 47
S552
R
D
S
L
A
D
M
S
E
E
L
C
P
S
S
Site 48
S558
M
S
E
E
L
C
P
S
S
A
D
T
P
V
P
Site 49
S559
S
E
E
L
C
P
S
S
A
D
T
P
V
P
L
Site 50
Y586
T
G
E
A
R
D
M
Y
V
P
N
P
S
C
R
Site 51
Y598
S
C
R
D
F
A
K
Y
E
W
I
G
Q
L
M
Site 52
S628
G
F
V
W
K
Q
L
S
G
E
E
V
S
W
S
Site 53
S635
S
G
E
E
V
S
W
S
K
D
F
P
A
V
D
Site 54
S643
K
D
F
P
A
V
D
S
V
L
V
K
L
L
E
Site 55
T659
M
E
G
M
D
K
E
T
F
E
F
K
F
G
K
Site 56
T671
F
G
K
E
L
T
F
T
T
V
L
S
D
Q
Q
Site 57
S697
V
V
G
Y
G
D
R
S
R
F
I
Q
L
V
Q
Site 58
T735
Q
A
V
L
D
L
L
T
W
Q
E
L
E
K
K
Site 59
T758
V
D
A
L
R
K
L
T
R
F
E
D
F
E
P
Site 60
S766
R
F
E
D
F
E
P
S
D
S
R
V
Q
Y
F
Site 61
S768
E
D
F
E
P
S
D
S
R
V
Q
Y
F
W
E
Site 62
Y772
P
S
D
S
R
V
Q
Y
F
W
E
A
L
N
N
Site 63
T793
S
R
F
L
R
F
V
T
G
R
S
R
L
P
A
Site 64
Y803
S
R
L
P
A
R
I
Y
I
Y
P
D
K
L
G
Site 65
Y805
L
P
A
R
I
Y
I
Y
P
D
K
L
G
Y
E
Site 66
S820
T
T
D
A
L
P
E
S
S
T
C
S
S
T
L
Site 67
S821
T
D
A
L
P
E
S
S
T
C
S
S
T
L
F
Site 68
S824
L
P
E
S
S
T
C
S
S
T
L
F
L
P
H
Site 69
S825
P
E
S
S
T
C
S
S
T
L
F
L
P
H
Y
Site 70
S834
L
F
L
P
H
Y
A
S
A
K
V
C
E
E
K
Site 71
Y847
E
K
L
R
Y
A
A
Y
N
C
V
A
I
D
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation