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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMTC4
Full Name:
Transmembrane and TPR repeat-containing protein 4
Alias:
FLJ14624; FLJ22153; Transmembrane and tetratricopeptide repeat containing 4
Type:
Unknown function
Mass (Da):
82991
Number AA:
741
UniProt ID:
Q5T4D3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
D
L
D
H
I
L
P
S
S
V
L
P
P
F
W
Site 2
S47
G
D
F
V
F
D
D
S
E
A
I
V
N
N
K
Site 3
T60
N
K
D
L
Q
A
E
T
P
L
G
D
L
W
H
Site 4
S76
D
F
W
G
S
R
L
S
S
N
T
S
H
K
S
Site 5
S77
F
W
G
S
R
L
S
S
N
T
S
H
K
S
Y
Site 6
T79
G
S
R
L
S
S
N
T
S
H
K
S
Y
R
P
Site 7
S80
S
R
L
S
S
N
T
S
H
K
S
Y
R
P
L
Site 8
S83
S
S
N
T
S
H
K
S
Y
R
P
L
T
V
L
Site 9
T88
H
K
S
Y
R
P
L
T
V
L
T
F
R
I
N
Site 10
Y97
L
T
F
R
I
N
Y
Y
L
S
G
G
F
H
P
Site 11
Y135
V
L
F
G
G
L
Q
Y
T
S
K
G
R
R
L
Site 12
S137
F
G
G
L
Q
Y
T
S
K
G
R
R
L
H
L
Site 13
S195
Y
C
K
A
F
R
E
S
N
K
E
G
A
H
S
Site 14
S202
S
N
K
E
G
A
H
S
S
T
F
W
V
L
L
Site 15
S203
N
K
E
G
A
H
S
S
T
F
W
V
L
L
S
Site 16
S257
K
V
L
H
K
D
K
S
L
E
N
L
G
M
L
Site 17
T277
L
F
R
M
T
L
L
T
S
G
G
A
G
M
L
Site 18
T299
G
T
G
P
P
A
F
T
E
V
D
N
P
A
S
Site 19
Y320
V
R
A
V
N
Y
N
Y
Y
Y
S
L
N
A
W
Site 20
Y321
R
A
V
N
Y
N
Y
Y
Y
S
L
N
A
W
L
Site 21
Y322
A
V
N
Y
N
Y
Y
Y
S
L
N
A
W
L
L
Site 22
S433
T
F
G
F
G
A
L
S
K
H
T
K
K
K
K
Site 23
S461
T
L
R
C
V
L
R
S
G
E
W
R
S
E
E
Site 24
S466
L
R
S
G
E
W
R
S
E
E
Q
L
F
R
S
Site 25
Y505
Q
T
A
A
I
R
Y
Y
R
E
A
V
R
L
N
Site 26
Y515
A
V
R
L
N
P
K
Y
V
H
A
M
N
N
L
Site 27
S540
Q
E
A
E
E
L
L
S
L
A
V
Q
I
Q
P
Site 28
S562
N
L
G
I
V
Q
N
S
L
K
R
F
E
A
A
Site 29
S572
R
F
E
A
A
E
Q
S
Y
R
T
A
I
K
H
Site 30
Y583
A
I
K
H
R
R
K
Y
P
D
C
Y
Y
N
L
Site 31
Y587
R
R
K
Y
P
D
C
Y
Y
N
L
G
R
L
Y
Site 32
Y588
R
K
Y
P
D
C
Y
Y
N
L
G
R
L
Y
A
Site 33
Y594
Y
Y
N
L
G
R
L
Y
A
D
L
N
R
H
V
Site 34
T611
L
N
A
W
R
N
A
T
V
L
K
P
E
H
S
Site 35
S653
E
L
I
P
N
D
H
S
L
M
F
S
L
A
N
Site 36
S665
L
A
N
V
L
G
K
S
Q
K
Y
K
E
S
E
Site 37
S671
K
S
Q
K
Y
K
E
S
E
A
L
F
L
K
A
Site 38
Y696
H
G
N
L
A
V
L
Y
H
R
W
G
H
L
D
Site 39
Y709
L
D
L
A
K
K
H
Y
E
I
S
L
Q
L
D
Site 40
T718
I
S
L
Q
L
D
P
T
A
S
G
T
K
E
N
Site 41
S720
L
Q
L
D
P
T
A
S
G
T
K
E
N
Y
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation