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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GPR158
Full Name:
Probable G-protein coupled receptor 158
Alias:
G protein-coupled receptor 158; GP158; G-protein coupled receptor 158; KIAA1136
Type:
Receptor, GPCR
Mass (Da):
135489
Number AA:
1215
UniProt ID:
Q5T848
International Prot ID:
IPI00412541
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004930
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
G
L
G
A
V
G
A
S
R
D
P
Q
G
R
P
Site 2
S34
D
P
Q
G
R
P
D
S
P
R
E
R
T
P
K
Site 3
T39
P
D
S
P
R
E
R
T
P
K
G
K
P
H
A
Site 4
S53
A
Q
Q
P
G
R
A
S
A
S
D
S
S
A
P
Site 5
S55
Q
P
G
R
A
S
A
S
D
S
S
A
P
W
S
Site 6
S57
G
R
A
S
A
S
D
S
S
A
P
W
S
R
S
Site 7
S58
R
A
S
A
S
D
S
S
A
P
W
S
R
S
T
Site 8
S62
S
D
S
S
A
P
W
S
R
S
T
D
G
T
I
Site 9
S64
S
S
A
P
W
S
R
S
T
D
G
T
I
L
A
Site 10
T65
S
A
P
W
S
R
S
T
D
G
T
I
L
A
Q
Site 11
T68
W
S
R
S
T
D
G
T
I
L
A
Q
K
L
A
Site 12
S84
E
V
P
M
D
V
A
S
Y
L
Y
T
G
D
S
Site 13
Y85
V
P
M
D
V
A
S
Y
L
Y
T
G
D
S
H
Site 14
Y87
M
D
V
A
S
Y
L
Y
T
G
D
S
H
Q
L
Site 15
T88
D
V
A
S
Y
L
Y
T
G
D
S
H
Q
L
K
Site 16
S91
S
Y
L
Y
T
G
D
S
H
Q
L
K
R
A
N
Site 17
S100
Q
L
K
R
A
N
C
S
G
R
Y
E
L
A
G
Site 18
Y103
R
A
N
C
S
G
R
Y
E
L
A
G
L
P
G
Site 19
S117
G
K
W
P
A
L
A
S
A
H
P
S
L
H
R
Site 20
S121
A
L
A
S
A
H
P
S
L
H
R
A
L
D
T
Site 21
T128
S
L
H
R
A
L
D
T
L
T
H
A
T
N
F
Site 22
T130
H
R
A
L
D
T
L
T
H
A
T
N
F
L
N
Site 23
S145
V
M
L
Q
S
N
K
S
R
E
Q
N
L
Q
D
Site 24
Y157
L
Q
D
D
L
D
W
Y
Q
A
L
V
W
S
L
Site 25
S172
L
E
G
E
P
S
I
S
R
A
A
I
T
F
S
Site 26
S179
S
R
A
A
I
T
F
S
T
D
S
L
S
A
P
Site 27
S182
A
I
T
F
S
T
D
S
L
S
A
P
A
P
Q
Site 28
S199
L
Q
A
T
R
E
E
S
R
I
L
L
Q
D
L
Site 29
S209
L
L
Q
D
L
S
S
S
A
P
H
L
A
N
A
Site 30
S249
G
P
R
G
L
G
H
S
W
R
R
K
D
G
L
Site 31
S261
D
G
L
G
G
D
K
S
H
F
K
W
S
P
P
Site 32
S266
D
K
S
H
F
K
W
S
P
P
Y
L
E
C
E
Site 33
Y269
H
F
K
W
S
P
P
Y
L
E
C
E
N
G
S
Site 34
Y277
L
E
C
E
N
G
S
Y
K
P
G
W
L
V
T
Site 35
S319
K
V
D
I
D
Q
C
S
S
D
G
W
F
S
G
Site 36
S379
R
G
P
D
Q
H
I
S
G
S
T
K
D
V
S
Site 37
S381
P
D
Q
H
I
S
G
S
T
K
D
V
S
E
E
Site 38
S386
S
G
S
T
K
D
V
S
E
E
A
Y
V
C
L
Site 39
Y390
K
D
V
S
E
E
A
Y
V
C
L
P
C
R
E
Site 40
S446
Y
H
F
R
K
A
K
S
I
R
A
S
G
L
I
Site 41
S512
R
V
L
K
V
F
L
S
R
T
A
Q
R
I
P
Site 42
Y520
R
T
A
Q
R
I
P
Y
M
T
G
G
R
V
M
Site 43
T522
A
Q
R
I
P
Y
M
T
G
G
R
V
M
R
M
Site 44
S557
Q
N
L
E
K
Q
I
S
L
I
G
Q
G
K
T
Site 45
Y612
S
A
F
H
E
P
R
Y
M
A
V
A
V
H
N
Site 46
Y647
S
D
W
M
L
M
L
Y
F
A
H
T
H
L
T
Site 47
S668
L
L
L
I
P
K
F
S
H
S
S
N
N
P
R
Site 48
S670
L
I
P
K
F
S
H
S
S
N
N
P
R
D
D
Site 49
T680
N
P
R
D
D
I
A
T
E
A
Y
E
D
E
L
Site 50
S692
D
E
L
D
M
G
R
S
G
S
Y
L
N
S
S
Site 51
S694
L
D
M
G
R
S
G
S
Y
L
N
S
S
I
N
Site 52
Y695
D
M
G
R
S
G
S
Y
L
N
S
S
I
N
S
Site 53
S698
R
S
G
S
Y
L
N
S
S
I
N
S
A
W
S
Site 54
S699
S
G
S
Y
L
N
S
S
I
N
S
A
W
S
E
Site 55
S702
Y
L
N
S
S
I
N
S
A
W
S
E
H
S
L
Site 56
S705
S
S
I
N
S
A
W
S
E
H
S
L
D
P
E
Site 57
S708
N
S
A
W
S
E
H
S
L
D
P
E
D
I
R
Site 58
Y722
R
D
E
L
K
K
L
Y
A
Q
L
E
I
Y
K
Site 59
Y728
L
Y
A
Q
L
E
I
Y
K
R
K
K
M
I
T
Site 60
T735
Y
K
R
K
K
M
I
T
N
N
P
H
L
Q
K
Site 61
S746
H
L
Q
K
K
R
C
S
K
K
G
L
G
R
S
Site 62
S753
S
K
K
G
L
G
R
S
I
M
R
R
I
T
E
Site 63
T759
R
S
I
M
R
R
I
T
E
I
P
E
T
V
S
Site 64
T764
R
I
T
E
I
P
E
T
V
S
R
Q
C
S
K
Site 65
S770
E
T
V
S
R
Q
C
S
K
E
D
K
E
G
A
Site 66
S795
I
R
K
N
P
P
E
S
S
G
N
T
G
K
S
Site 67
S796
R
K
N
P
P
E
S
S
G
N
T
G
K
S
K
Site 68
S802
S
S
G
N
T
G
K
S
K
E
E
T
L
K
N
Site 69
T806
T
G
K
S
K
E
E
T
L
K
N
R
V
F
S
Site 70
S813
T
L
K
N
R
V
F
S
L
K
K
S
H
S
T
Site 71
S817
R
V
F
S
L
K
K
S
H
S
T
Y
D
H
V
Site 72
S819
F
S
L
K
K
S
H
S
T
Y
D
H
V
R
D
Site 73
Y821
L
K
K
S
H
S
T
Y
D
H
V
R
D
Q
T
Site 74
T828
Y
D
H
V
R
D
Q
T
E
E
S
S
S
L
P
Site 75
S833
D
Q
T
E
E
S
S
S
L
P
T
E
S
Q
E
Site 76
T836
E
E
S
S
S
L
P
T
E
S
Q
E
E
E
T
Site 77
S838
S
S
S
L
P
T
E
S
Q
E
E
E
T
T
E
Site 78
T844
E
S
Q
E
E
E
T
T
E
N
S
T
L
E
S
Site 79
S847
E
E
E
T
T
E
N
S
T
L
E
S
L
S
G
Site 80
S851
T
E
N
S
T
L
E
S
L
S
G
K
K
L
T
Site 81
S853
N
S
T
L
E
S
L
S
G
K
K
L
T
Q
K
Site 82
S865
T
Q
K
L
K
E
D
S
E
A
E
S
T
E
S
Site 83
S869
K
E
D
S
E
A
E
S
T
E
S
V
P
L
V
Site 84
T870
E
D
S
E
A
E
S
T
E
S
V
P
L
V
C
Site 85
S872
S
E
A
E
S
T
E
S
V
P
L
V
C
K
S
Site 86
S879
S
V
P
L
V
C
K
S
A
S
A
H
N
L
S
Site 87
S881
P
L
V
C
K
S
A
S
A
H
N
L
S
S
E
Site 88
S886
S
A
S
A
H
N
L
S
S
E
K
K
T
G
H
Site 89
S887
A
S
A
H
N
L
S
S
E
K
K
T
G
H
P
Site 90
T891
N
L
S
S
E
K
K
T
G
H
P
R
T
S
M
Site 91
S897
K
T
G
H
P
R
T
S
M
L
Q
K
S
L
S
Site 92
S904
S
M
L
Q
K
S
L
S
V
I
A
S
A
K
E
Site 93
S908
K
S
L
S
V
I
A
S
A
K
E
K
T
L
G
Site 94
T929
T
A
G
V
E
E
R
T
K
S
Q
K
P
L
P
Site 95
S931
G
V
E
E
R
T
K
S
Q
K
P
L
P
K
D
Site 96
T941
P
L
P
K
D
K
E
T
N
R
N
H
S
N
S
Site 97
S946
K
E
T
N
R
N
H
S
N
S
D
N
T
E
T
Site 98
S948
T
N
R
N
H
S
N
S
D
N
T
E
T
K
D
Site 99
T951
N
H
S
N
S
D
N
T
E
T
K
D
P
A
P
Site 100
T953
S
N
S
D
N
T
E
T
K
D
P
A
P
Q
N
Site 101
S973
E
P
R
K
P
Q
K
S
G
I
M
K
Q
Q
R
Site 102
T985
Q
Q
R
V
N
P
T
T
A
N
S
D
L
N
P
Site 103
S988
V
N
P
T
T
A
N
S
D
L
N
P
G
T
T
Site 104
Y1012
E
V
C
P
W
E
V
Y
D
L
T
P
G
P
V
Site 105
T1015
P
W
E
V
Y
D
L
T
P
G
P
V
P
S
E
Site 106
S1021
L
T
P
G
P
V
P
S
E
S
K
V
Q
K
H
Site 107
S1023
P
G
P
V
P
S
E
S
K
V
Q
K
H
V
S
Site 108
S1030
S
K
V
Q
K
H
V
S
I
V
A
S
E
M
E
Site 109
S1034
K
H
V
S
I
V
A
S
E
M
E
K
N
P
T
Site 110
T1041
S
E
M
E
K
N
P
T
F
S
L
K
E
K
S
Site 111
S1043
M
E
K
N
P
T
F
S
L
K
E
K
S
H
H
Site 112
S1076
A
E
V
C
L
W
E
S
Q
G
Q
S
I
L
E
Site 113
S1080
L
W
E
S
Q
G
Q
S
I
L
E
D
E
K
L
Site 114
S1090
E
D
E
K
L
L
I
S
K
T
P
V
L
P
E
Site 115
T1092
E
K
L
L
I
S
K
T
P
V
L
P
E
R
A
Site 116
T1129
P
K
A
V
A
S
K
T
E
N
E
N
L
N
Q
Site 117
S1145
G
H
Q
E
K
K
T
S
S
S
E
E
N
V
R
Site 118
S1147
Q
E
K
K
T
S
S
S
E
E
N
V
R
G
S
Site 119
S1154
S
E
E
N
V
R
G
S
Y
N
S
S
N
N
F
Site 120
Y1155
E
E
N
V
R
G
S
Y
N
S
S
N
N
F
Q
Site 121
S1157
N
V
R
G
S
Y
N
S
S
N
N
F
Q
Q
P
Site 122
S1158
V
R
G
S
Y
N
S
S
N
N
F
Q
Q
P
L
Site 123
T1166
N
N
F
Q
Q
P
L
T
S
R
A
E
V
C
P
Site 124
T1178
V
C
P
W
E
F
E
T
P
A
Q
P
N
A
G
Site 125
S1187
A
Q
P
N
A
G
R
S
V
A
L
P
A
S
S
Site 126
S1193
R
S
V
A
L
P
A
S
S
A
L
S
A
N
K
Site 127
S1197
L
P
A
S
S
A
L
S
A
N
K
I
A
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation