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Updated November 2019
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Protein Info
Short Name:
KIAA0649
Full Name:
Protein KIAA0649
Alias:
Type:
Mass (Da):
127351
Number AA:
1209
UniProt ID:
Q5T8A7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
S
P
V
V
A
L
Q
S
K
W
E
A
F
G
P
Site 2
S24
E
A
F
G
P
P
G
S
C
R
F
P
R
C
F
Site 3
S32
C
R
F
P
R
C
F
S
E
A
D
E
G
V
E
Site 4
S40
E
A
D
E
G
V
E
S
A
S
V
S
A
R
V
Site 5
S42
D
E
G
V
E
S
A
S
V
S
A
R
V
Q
M
Site 6
T63
R
D
G
A
A
R
G
T
S
D
E
R
A
A
Q
Site 7
S64
D
G
A
A
R
G
T
S
D
E
R
A
A
Q
R
Site 8
T88
A
R
P
A
A
K
P
T
V
H
K
E
P
P
A
Site 9
T114
P
M
G
E
E
E
T
T
D
F
G
P
L
V
L
Site 10
S123
F
G
P
L
V
L
D
S
D
S
D
D
S
V
D
Site 11
S125
P
L
V
L
D
S
D
S
D
D
S
V
D
R
D
Site 12
S128
L
D
S
D
S
D
D
S
V
D
R
D
I
E
E
Site 13
Y140
I
E
E
A
I
Q
E
Y
L
K
A
K
S
G
A
Site 14
S163
Q
P
G
A
A
Q
P
S
R
A
A
G
G
G
S
Site 15
S194
P
P
K
L
V
P
G
S
G
G
G
P
G
S
Q
Site 16
S200
G
S
G
G
G
P
G
S
Q
V
G
S
S
K
D
Site 17
S204
G
P
G
S
Q
V
G
S
S
K
D
Q
G
S
A
Site 18
S205
P
G
S
Q
V
G
S
S
K
D
Q
G
S
A
S
Site 19
S210
G
S
S
K
D
Q
G
S
A
S
P
V
S
V
S
Site 20
S212
S
K
D
Q
G
S
A
S
P
V
S
V
S
S
D
Site 21
S215
Q
G
S
A
S
P
V
S
V
S
S
D
D
S
F
Site 22
S217
S
A
S
P
V
S
V
S
S
D
D
S
F
E
Q
Site 23
S218
A
S
P
V
S
V
S
S
D
D
S
F
E
Q
S
Site 24
S221
V
S
V
S
S
D
D
S
F
E
Q
S
I
R
A
Site 25
S225
S
D
D
S
F
E
Q
S
I
R
A
E
I
E
Q
Site 26
S248
E
T
Q
K
C
D
G
S
V
E
K
K
P
D
T
Site 27
T255
S
V
E
K
K
P
D
T
N
E
N
S
A
K
S
Site 28
S259
K
P
D
T
N
E
N
S
A
K
S
L
L
K
S
Site 29
S262
T
N
E
N
S
A
K
S
L
L
K
S
H
Q
E
Site 30
S266
S
A
K
S
L
L
K
S
H
Q
E
P
P
T
K
Site 31
T272
K
S
H
Q
E
P
P
T
K
V
V
H
R
Q
G
Site 32
S304
K
M
N
V
Q
P
R
S
L
R
S
K
V
T
T
Site 33
T311
S
L
R
S
K
V
T
T
T
Q
E
N
E
G
S
Site 34
S318
T
T
Q
E
N
E
G
S
T
K
P
A
T
P
C
Site 35
T323
E
G
S
T
K
P
A
T
P
C
R
P
S
E
A
Site 36
S328
P
A
T
P
C
R
P
S
E
A
A
Q
N
K
G
Site 37
S340
N
K
G
G
I
K
R
S
A
S
A
A
R
R
G
Site 38
S342
G
G
I
K
R
S
A
S
A
A
R
R
G
K
R
Site 39
S352
R
R
G
K
R
V
M
S
A
A
Q
A
S
E
A
Site 40
S357
V
M
S
A
A
Q
A
S
E
A
S
D
S
S
S
Site 41
S360
A
A
Q
A
S
E
A
S
D
S
S
S
D
D
G
Site 42
S362
Q
A
S
E
A
S
D
S
S
S
D
D
G
I
E
Site 43
S364
S
E
A
S
D
S
S
S
D
D
G
I
E
E
A
Site 44
Y375
I
E
E
A
I
Q
L
Y
Q
L
Q
K
T
R
K
Site 45
S406
A
P
D
P
P
A
H
S
T
S
S
A
T
K
S
Site 46
S408
D
P
P
A
H
S
T
S
S
A
T
K
S
A
L
Site 47
S409
P
P
A
H
S
T
S
S
A
T
K
S
A
L
P
Site 48
S413
S
T
S
S
A
T
K
S
A
L
P
E
T
H
R
Site 49
T418
T
K
S
A
L
P
E
T
H
R
K
T
P
S
K
Site 50
T422
L
P
E
T
H
R
K
T
P
S
K
K
K
L
V
Site 51
S424
E
T
H
R
K
T
P
S
K
K
K
L
V
A
T
Site 52
T433
K
K
L
V
A
T
K
T
M
D
P
G
P
G
G
Site 53
T443
P
G
P
G
G
L
D
T
D
H
A
P
K
L
L
Site 54
T453
A
P
K
L
L
K
E
T
K
A
P
P
P
A
S
Site 55
S460
T
K
A
P
P
P
A
S
P
A
S
R
S
E
F
Site 56
S463
P
P
P
A
S
P
A
S
R
S
E
F
V
E
R
Site 57
S465
P
A
S
P
A
S
R
S
E
F
V
E
R
S
S
Site 58
S471
R
S
E
F
V
E
R
S
S
C
R
A
D
T
S
Site 59
S472
S
E
F
V
E
R
S
S
C
R
A
D
T
S
A
Site 60
T477
R
S
S
C
R
A
D
T
S
A
E
L
M
C
A
Site 61
S478
S
S
C
R
A
D
T
S
A
E
L
M
C
A
E
Site 62
S502
L
P
A
P
V
E
G
S
D
G
S
L
S
A
S
Site 63
S505
P
V
E
G
S
D
G
S
L
S
A
S
P
L
F
Site 64
S507
E
G
S
D
G
S
L
S
A
S
P
L
F
Y
S
Site 65
S509
S
D
G
S
L
S
A
S
P
L
F
Y
S
P
N
Site 66
Y513
L
S
A
S
P
L
F
Y
S
P
N
V
P
S
R
Site 67
S514
S
A
S
P
L
F
Y
S
P
N
V
P
S
R
S
Site 68
S519
F
Y
S
P
N
V
P
S
R
S
D
G
D
S
S
Site 69
S521
S
P
N
V
P
S
R
S
D
G
D
S
S
S
V
Site 70
S525
P
S
R
S
D
G
D
S
S
S
V
D
S
D
D
Site 71
S526
S
R
S
D
G
D
S
S
S
V
D
S
D
D
S
Site 72
S527
R
S
D
G
D
S
S
S
V
D
S
D
D
S
I
Site 73
S530
G
D
S
S
S
V
D
S
D
D
S
I
E
Q
E
Site 74
S533
S
S
V
D
S
D
D
S
I
E
Q
E
I
R
T
Site 75
T540
S
I
E
Q
E
I
R
T
F
L
A
L
K
A
Q
Site 76
S550
A
L
K
A
Q
S
G
S
L
L
A
R
G
E
S
Site 77
S557
S
L
L
A
R
G
E
S
C
P
Q
A
A
Q
G
Site 78
S573
L
L
P
P
G
L
N
S
Q
T
G
G
H
K
T
Site 79
T580
S
Q
T
G
G
H
K
T
P
L
S
K
T
P
D
Site 80
S583
G
G
H
K
T
P
L
S
K
T
P
D
P
L
L
Site 81
T585
H
K
T
P
L
S
K
T
P
D
P
L
L
G
C
Site 82
S605
G
G
G
H
V
R
P
S
T
P
K
K
M
Q
E
Site 83
T606
G
G
H
V
R
P
S
T
P
K
K
M
Q
E
V
Site 84
S618
Q
E
V
V
K
D
G
S
Q
D
A
D
H
S
Q
Site 85
S624
G
S
Q
D
A
D
H
S
Q
G
R
A
E
P
G
Site 86
S644
L
P
I
Q
G
K
A
S
E
A
L
G
G
E
G
Site 87
T652
E
A
L
G
G
E
G
T
A
R
G
P
G
D
T
Site 88
T659
T
A
R
G
P
G
D
T
R
M
S
Q
G
Q
G
Site 89
S662
G
P
G
D
T
R
M
S
Q
G
Q
G
K
T
D
Site 90
S679
R
R
L
D
E
K
E
S
S
E
D
K
S
S
S
Site 91
S680
R
L
D
E
K
E
S
S
E
D
K
S
S
S
L
Site 92
S684
K
E
S
S
E
D
K
S
S
S
L
D
S
D
E
Site 93
S685
E
S
S
E
D
K
S
S
S
L
D
S
D
E
D
Site 94
S686
S
S
E
D
K
S
S
S
L
D
S
D
E
D
L
Site 95
S689
D
K
S
S
S
L
D
S
D
E
D
L
D
T
A
Site 96
T695
D
S
D
E
D
L
D
T
A
I
K
D
L
L
R
Site 97
S703
A
I
K
D
L
L
R
S
K
R
K
L
K
K
R
Site 98
S725
C
R
K
K
V
R
F
S
T
A
Q
T
H
F
L
Site 99
T726
R
K
K
V
R
F
S
T
A
Q
T
H
F
L
E
Site 100
S752
R
G
P
P
V
L
K
S
C
L
S
K
S
K
R
Site 101
S755
P
V
L
K
S
C
L
S
K
S
K
R
D
S
G
Site 102
S757
L
K
S
C
L
S
K
S
K
R
D
S
G
E
G
Site 103
S761
L
S
K
S
K
R
D
S
G
E
G
P
G
K
K
Site 104
S771
G
P
G
K
K
P
P
S
V
F
G
S
T
A
E
Site 105
S775
K
P
P
S
V
F
G
S
T
A
E
R
M
R
Q
Site 106
S787
M
R
Q
E
G
A
A
S
Q
D
A
A
L
A
F
Site 107
S801
F
R
V
R
R
P
A
S
A
S
A
S
E
G
N
Site 108
S803
V
R
R
P
A
S
A
S
A
S
E
G
N
P
F
Site 109
S805
R
P
A
S
A
S
A
S
E
G
N
P
F
P
R
Site 110
S814
G
N
P
F
P
R
E
S
Q
G
P
A
P
S
P
Site 111
S820
E
S
Q
G
P
A
P
S
P
G
S
L
S
D
D
Site 112
S823
G
P
A
P
S
P
G
S
L
S
D
D
S
S
S
Site 113
S825
A
P
S
P
G
S
L
S
D
D
S
S
S
V
D
Site 114
S828
P
G
S
L
S
D
D
S
S
S
V
D
S
N
D
Site 115
S829
G
S
L
S
D
D
S
S
S
V
D
S
N
D
S
Site 116
S830
S
L
S
D
D
S
S
S
V
D
S
N
D
S
I
Site 117
S833
D
D
S
S
S
V
D
S
N
D
S
I
E
L
E
Site 118
S836
S
S
V
D
S
N
D
S
I
E
L
E
I
R
K
Site 119
S852
L
A
E
K
A
K
E
S
V
S
S
S
E
V
Q
Site 120
S854
E
K
A
K
E
S
V
S
S
S
E
V
Q
A
E
Site 121
S855
K
A
K
E
S
V
S
S
S
E
V
Q
A
E
G
Site 122
S856
A
K
E
S
V
S
S
S
E
V
Q
A
E
G
P
Site 123
T868
E
G
P
T
A
L
G
T
G
G
P
A
R
P
E
Site 124
S892
P
P
G
V
C
T
R
S
Q
R
A
R
G
V
P
Site 125
T908
L
A
E
G
L
R
G
T
E
S
A
G
A
Q
G
Site 126
S910
E
G
L
R
G
T
E
S
A
G
A
Q
G
T
A
Site 127
S921
Q
G
T
A
G
L
F
S
Q
G
G
K
G
L
P
Site 128
S941
G
D
P
V
P
P
R
S
T
S
G
G
V
S
A
Site 129
T942
D
P
V
P
P
R
S
T
S
G
G
V
S
A
K
Site 130
S943
P
V
P
P
R
S
T
S
G
G
V
S
A
K
G
Site 131
S947
R
S
T
S
G
G
V
S
A
K
G
L
S
V
S
Site 132
S952
G
V
S
A
K
G
L
S
V
S
R
R
N
V
Y
Site 133
S954
S
A
K
G
L
S
V
S
R
R
N
V
Y
V
H
Site 134
Y959
S
V
S
R
R
N
V
Y
V
H
K
D
Q
S
P
Site 135
S965
V
Y
V
H
K
D
Q
S
P
R
G
A
E
P
A
Site 136
S975
G
A
E
P
A
A
K
S
A
F
G
Q
L
P
S
Site 137
S982
S
A
F
G
Q
L
P
S
C
A
T
A
G
T
E
Site 138
T996
E
A
G
G
A
R
G
T
F
H
M
G
C
G
S
Site 139
S1003
T
F
H
M
G
C
G
S
P
S
F
L
T
P
S
Site 140
S1005
H
M
G
C
G
S
P
S
F
L
T
P
S
P
G
Site 141
T1008
C
G
S
P
S
F
L
T
P
S
P
G
A
E
R
Site 142
S1010
S
P
S
F
L
T
P
S
P
G
A
E
R
D
A
Site 143
T1024
A
G
A
Q
A
D
R
T
P
P
W
S
D
F
A
Site 144
S1028
A
D
R
T
P
P
W
S
D
F
A
H
Q
S
R
Site 145
S1038
A
H
Q
S
R
L
P
S
P
W
V
L
R
S
E
Site 146
S1044
P
S
P
W
V
L
R
S
E
G
R
D
A
V
W
Site 147
S1057
V
W
R
G
G
V
G
S
E
R
D
K
G
S
E
Site 148
S1063
G
S
E
R
D
K
G
S
E
G
P
A
R
G
L
Site 149
S1094
F
H
F
G
K
G
V
S
W
G
G
R
Q
A
G
Site 150
S1115
G
L
P
L
Q
G
P
S
F
S
A
F
R
E
A
Site 151
S1117
P
L
Q
G
P
S
F
S
A
F
R
E
A
Q
A
Site 152
S1127
R
E
A
Q
A
G
P
S
P
V
F
G
S
P
H
Site 153
S1132
G
P
S
P
V
F
G
S
P
H
L
L
A
K
K
Site 154
S1154
R
K
A
Q
A
G
L
S
L
H
D
R
R
S
S
Site 155
S1160
L
S
L
H
D
R
R
S
S
G
S
E
E
S
I
Site 156
S1161
S
L
H
D
R
R
S
S
G
S
E
E
S
I
L
Site 157
S1163
H
D
R
R
S
S
G
S
E
E
S
I
L
D
L
Site 158
S1166
R
S
S
G
S
E
E
S
I
L
D
L
R
Y
R
Site 159
Y1172
E
S
I
L
D
L
R
Y
R
R
R
V
N
R
D
Site 160
S1188
Q
E
Q
D
A
L
G
S
D
A
S
D
F
S
D
Site 161
S1191
D
A
L
G
S
D
A
S
D
F
S
D
T
S
T
Site 162
S1194
G
S
D
A
S
D
F
S
D
T
S
T
E
D
S
Site 163
S1197
A
S
D
F
S
D
T
S
T
E
D
S
G
G
S
Site 164
T1198
S
D
F
S
D
T
S
T
E
D
S
G
G
S
S
Site 165
S1201
S
D
T
S
T
E
D
S
G
G
S
S
V
V
K
Site 166
S1205
T
E
D
S
G
G
S
S
V
V
K
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation