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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DEPDC1A
Full Name:
DEP domain-containing protein 1A
Alias:
DEP domain containing 1; DEP.8; DEP1A; DEPDC1-V2; FLJ20354; SDP35
Type:
Mass (Da):
89358
Number AA:
784
UniProt ID:
Q5TB30
International Prot ID:
IPI00016922
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
Q
G
V
P
P
G
P
Y
R
A
T
K
L
W
N
Site 2
T14
P
P
G
P
Y
R
A
T
K
L
W
N
E
V
T
Site 3
Y40
H
R
Q
H
F
K
K
Y
G
N
C
F
T
A
G
Site 4
Y54
G
E
A
V
D
W
L
Y
D
L
L
R
N
N
S
Site 5
S61
Y
D
L
L
R
N
N
S
N
F
G
P
E
V
T
Site 6
T72
P
E
V
T
R
Q
Q
T
I
Q
L
L
R
K
F
Site 7
S94
D
I
K
G
R
W
G
S
E
N
V
D
D
N
N
Site 8
T109
Q
L
F
R
F
P
A
T
S
P
L
K
T
L
P
Site 9
S110
L
F
R
F
P
A
T
S
P
L
K
T
L
P
R
Site 10
T114
P
A
T
S
P
L
K
T
L
P
R
R
Y
P
E
Site 11
Y119
L
K
T
L
P
R
R
Y
P
E
L
R
K
N
N
Site 12
S131
K
N
N
I
E
N
F
S
K
D
K
D
S
I
F
Site 13
S136
N
F
S
K
D
K
D
S
I
F
K
L
R
N
L
Site 14
S144
I
F
K
L
R
N
L
S
R
R
T
P
K
R
H
Site 15
T147
L
R
N
L
S
R
R
T
P
K
R
H
G
L
H
Site 16
S156
K
R
H
G
L
H
L
S
Q
E
N
G
E
K
I
Site 17
S182
A
I
D
N
R
E
L
S
Q
E
D
V
E
E
V
Site 18
Y220
P
K
Q
V
I
P
Q
Y
I
M
Y
N
M
A
N
Site 19
Y223
V
I
P
Q
Y
I
M
Y
N
M
A
N
T
S
K
Site 20
Y268
N
D
M
N
N
P
T
Y
V
G
F
E
R
D
V
Site 21
T278
F
E
R
D
V
F
R
T
I
A
D
Y
F
L
D
Site 22
T292
D
L
P
E
P
L
L
T
F
E
Y
Y
E
L
F
Site 23
S316
I
T
V
S
D
R
S
S
G
I
H
K
I
Q
D
Site 24
S327
K
I
Q
D
D
P
Q
S
S
K
F
L
H
L
N
Site 25
S338
L
H
L
N
N
L
N
S
F
K
S
T
E
C
L
Site 26
S341
N
N
L
N
S
F
K
S
T
E
C
L
L
L
S
Site 27
S348
S
T
E
C
L
L
L
S
L
L
H
R
E
K
N
Site 28
S359
R
E
K
N
K
E
E
S
D
S
T
E
R
L
Q
Site 29
S361
K
N
K
E
E
S
D
S
T
E
R
L
Q
I
S
Site 30
T362
N
K
E
E
S
D
S
T
E
R
L
Q
I
S
N
Site 31
S368
S
T
E
R
L
Q
I
S
N
P
G
F
Q
E
R
Site 32
S391
N
L
R
N
R
R
V
S
A
N
D
I
M
G
G
Site 33
S413
L
S
N
M
H
D
L
S
S
N
S
K
P
R
C
Site 34
S414
S
N
M
H
D
L
S
S
N
S
K
P
R
C
C
Site 35
S416
M
H
D
L
S
S
N
S
K
P
R
C
C
S
L
Site 36
S422
N
S
K
P
R
C
C
S
L
E
G
I
V
D
V
Site 37
S434
V
D
V
P
G
N
S
S
K
E
A
S
S
V
F
Site 38
S438
G
N
S
S
K
E
A
S
S
V
F
H
Q
S
F
Site 39
S439
N
S
S
K
E
A
S
S
V
F
H
Q
S
F
P
Site 40
S444
A
S
S
V
F
H
Q
S
F
P
N
I
E
G
Q
Site 41
S471
E
F
L
L
N
L
H
S
E
E
N
I
Q
K
P
Site 42
S480
E
N
I
Q
K
P
F
S
A
G
F
K
R
T
S
Site 43
S487
S
A
G
F
K
R
T
S
T
L
T
V
Q
D
Q
Site 44
T488
A
G
F
K
R
T
S
T
L
T
V
Q
D
Q
E
Site 45
T490
F
K
R
T
S
T
L
T
V
Q
D
Q
E
E
L
Site 46
S510
K
S
K
Q
L
C
R
S
Q
S
L
L
L
R
S
Site 47
S512
K
Q
L
C
R
S
Q
S
L
L
L
R
S
S
T
Site 48
S517
S
Q
S
L
L
L
R
S
S
T
R
R
N
S
Y
Site 49
S518
Q
S
L
L
L
R
S
S
T
R
R
N
S
Y
I
Site 50
T519
S
L
L
L
R
S
S
T
R
R
N
S
Y
I
N
Site 51
S523
R
S
S
T
R
R
N
S
Y
I
N
T
P
V
A
Site 52
Y524
S
S
T
R
R
N
S
Y
I
N
T
P
V
A
E
Site 53
T527
R
R
N
S
Y
I
N
T
P
V
A
E
I
I
M
Site 54
S544
N
V
G
Q
G
S
T
S
V
Q
T
A
M
E
S
Site 55
S551
S
V
Q
T
A
M
E
S
E
L
G
E
S
S
A
Site 56
S556
M
E
S
E
L
G
E
S
S
A
T
I
N
K
R
Site 57
T559
E
L
G
E
S
S
A
T
I
N
K
R
L
C
K
Site 58
S567
I
N
K
R
L
C
K
S
T
I
E
L
S
E
N
Site 59
T568
N
K
R
L
C
K
S
T
I
E
L
S
E
N
S
Site 60
S572
C
K
S
T
I
E
L
S
E
N
S
L
L
P
A
Site 61
S575
T
I
E
L
S
E
N
S
L
L
P
A
S
S
M
Site 62
S580
E
N
S
L
L
P
A
S
S
M
L
T
G
T
Q
Site 63
S581
N
S
L
L
P
A
S
S
M
L
T
G
T
Q
S
Site 64
S588
S
M
L
T
G
T
Q
S
L
L
Q
P
H
L
E
Site 65
S625
Q
L
L
M
R
M
I
S
R
M
S
Q
N
V
D
Site 66
Y688
E
I
L
Q
V
P
S
Y
L
Q
T
A
V
E
K
Site 67
T691
Q
V
P
S
Y
L
Q
T
A
V
E
K
H
L
D
Site 68
Y699
A
V
E
K
H
L
D
Y
L
K
K
G
H
V
S
Site 69
S723
S
Q
L
Q
V
A
N
S
S
Q
N
S
L
I
K
Site 70
S724
Q
L
Q
V
A
N
S
S
Q
N
S
L
I
K
K
Site 71
S727
V
A
N
S
S
Q
N
S
L
I
K
K
G
D
F
Site 72
S736
I
K
K
G
D
F
I
S
S
H
K
Q
P
L
K
Site 73
S755
D
R
I
W
D
S
N
S
Y
M
T
L
S
I
P
Site 74
Y756
R
I
W
D
S
N
S
Y
M
T
L
S
I
P
P
Site 75
T758
W
D
S
N
S
Y
M
T
L
S
I
P
P
S
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation