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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RC3H1
Full Name:
Roquin
Alias:
KIAA2025; KIAA2025 protein; RING finger and C3H zinc finger 1; RING finger and C3H zinc finger protein 1; Ring finger and CCCH-type zinc finger domains 1; RING finger protein 198; RNF198; RP5-1198E17.5
Type:
Ubiquitin conjugating system
Mass (Da):
125736
Number AA:
1133
UniProt ID:
Q5TC82
International Prot ID:
IPI00216992
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
S
C
P
I
C
T
Q
T
F
D
E
T
I
R
K
Site 2
T24
C
T
Q
T
F
D
E
T
I
R
K
P
I
S
L
Site 3
S30
E
T
I
R
K
P
I
S
L
G
C
G
H
T
V
Site 4
T85
V
P
E
Q
Q
P
I
T
L
C
S
G
V
E
D
Site 5
S115
L
Y
L
K
P
L
S
S
A
R
G
V
G
L
N
Site 6
S123
A
R
G
V
G
L
N
S
T
T
Q
S
V
L
S
Site 7
T124
R
G
V
G
L
N
S
T
T
Q
S
V
L
S
R
Site 8
T125
G
V
G
L
N
S
T
T
Q
S
V
L
S
R
P
Site 9
S127
G
L
N
S
T
T
Q
S
V
L
S
R
P
M
Q
Site 10
S130
S
T
T
Q
S
V
L
S
R
P
M
Q
R
K
L
Site 11
T167
S
L
G
E
R
T
V
T
E
L
I
L
Q
H
Q
Site 12
S238
E
P
R
F
P
Q
A
S
K
T
S
I
G
H
V
Site 13
T240
R
F
P
Q
A
S
K
T
S
I
G
H
V
V
Q
Site 14
S253
V
Q
L
L
Y
R
A
S
C
F
K
V
T
K
R
Site 15
S264
V
T
K
R
D
E
D
S
S
L
M
Q
L
K
E
Site 16
S265
T
K
R
D
E
D
S
S
L
M
Q
L
K
E
E
Site 17
T275
Q
L
K
E
E
F
R
T
Y
E
A
L
R
R
E
Site 18
Y276
L
K
E
E
F
R
T
Y
E
A
L
R
R
E
H
Site 19
S285
A
L
R
R
E
H
D
S
Q
I
V
Q
I
A
M
Site 20
S305
I
A
P
D
Q
W
S
S
L
L
Y
G
D
Q
S
Site 21
Y308
D
Q
W
S
S
L
L
Y
G
D
Q
S
H
K
S
Site 22
S312
S
L
L
Y
G
D
Q
S
H
K
S
H
M
Q
S
Site 23
S319
S
H
K
S
H
M
Q
S
I
I
D
K
L
Q
T
Site 24
T326
S
I
I
D
K
L
Q
T
P
A
S
F
A
Q
S
Site 25
S329
D
K
L
Q
T
P
A
S
F
A
Q
S
V
Q
E
Site 26
S366
L
L
A
N
I
D
P
S
P
D
A
P
P
P
T
Site 27
T373
S
P
D
A
P
P
P
T
W
E
Q
L
E
N
G
Site 28
Y394
V
V
H
G
L
V
D
Y
I
Q
N
H
S
K
K
Site 29
Y414
Q
P
P
Q
H
S
K
Y
K
T
Y
M
C
R
D
Site 30
Y417
Q
H
S
K
Y
K
T
Y
M
C
R
D
M
K
Q
Site 31
S433
G
G
C
P
R
G
A
S
C
T
F
A
H
S
Q
Site 32
T435
C
P
R
G
A
S
C
T
F
A
H
S
Q
E
E
Site 33
S439
A
S
C
T
F
A
H
S
Q
E
E
L
E
K
F
Site 34
S460
L
V
P
R
R
P
L
S
A
S
L
G
Q
L
N
Site 35
S462
P
R
R
P
L
S
A
S
L
G
Q
L
N
E
V
Site 36
S487
E
G
A
V
D
L
P
S
R
K
P
P
A
L
P
Site 37
T512
T
Q
L
I
P
R
G
T
D
P
S
Y
D
S
S
Site 38
S515
I
P
R
G
T
D
P
S
Y
D
S
S
L
K
P
Site 39
Y516
P
R
G
T
D
P
S
Y
D
S
S
L
K
P
G
Site 40
S518
G
T
D
P
S
Y
D
S
S
L
K
P
G
K
I
Site 41
S519
T
D
P
S
Y
D
S
S
L
K
P
G
K
I
D
Site 42
S529
P
G
K
I
D
H
L
S
S
S
A
P
G
S
P
Site 43
S530
G
K
I
D
H
L
S
S
S
A
P
G
S
P
P
Site 44
S531
K
I
D
H
L
S
S
S
A
P
G
S
P
P
D
Site 45
S535
L
S
S
S
A
P
G
S
P
P
D
L
L
E
S
Site 46
S542
S
P
P
D
L
L
E
S
V
P
K
S
I
S
A
Site 47
S548
E
S
V
P
K
S
I
S
A
L
P
V
N
P
H
Site 48
S556
A
L
P
V
N
P
H
S
I
P
P
R
G
P
A
Site 49
S581
L
Q
M
V
P
R
G
S
Q
L
Y
P
A
Q
Q
Site 50
Y584
V
P
R
G
S
Q
L
Y
P
A
Q
Q
T
D
V
Site 51
Y592
P
A
Q
Q
T
D
V
Y
Y
Q
D
P
R
G
A
Site 52
Y593
A
Q
Q
T
D
V
Y
Y
Q
D
P
R
G
A
A
Site 53
Y608
P
P
F
E
P
A
P
Y
Q
Q
G
M
Y
Y
T
Site 54
Y613
A
P
Y
Q
Q
G
M
Y
Y
T
P
P
P
Q
C
Site 55
Y614
P
Y
Q
Q
G
M
Y
Y
T
P
P
P
Q
C
V
Site 56
S622
T
P
P
P
Q
C
V
S
R
F
V
R
P
P
P
Site 57
S630
R
F
V
R
P
P
P
S
A
P
E
P
A
P
P
Site 58
Y638
A
P
E
P
A
P
P
Y
L
D
H
Y
P
P
Y
Site 59
Y642
A
P
P
Y
L
D
H
Y
P
P
Y
L
Q
E
R
Site 60
Y645
Y
L
D
H
Y
P
P
Y
L
Q
E
R
V
V
N
Site 61
S653
L
Q
E
R
V
V
N
S
Q
Y
G
T
Q
P
Q
Site 62
T657
V
V
N
S
Q
Y
G
T
Q
P
Q
Q
Y
P
P
Site 63
Y662
Y
G
T
Q
P
Q
Q
Y
P
P
I
Y
P
S
H
Site 64
Y666
P
Q
Q
Y
P
P
I
Y
P
S
H
Y
D
G
R
Site 65
Y670
P
P
I
Y
P
S
H
Y
D
G
R
R
V
Y
P
Site 66
Y676
H
Y
D
G
R
R
V
Y
P
A
P
S
Y
T
R
Site 67
S680
R
R
V
Y
P
A
P
S
Y
T
R
E
E
I
F
Site 68
Y681
R
V
Y
P
A
P
S
Y
T
R
E
E
I
F
R
Site 69
S690
R
E
E
I
F
R
E
S
P
I
P
I
E
I
P
Site 70
S703
I
P
P
A
A
V
P
S
Y
V
P
E
S
R
E
Site 71
Y704
P
P
A
A
V
P
S
Y
V
P
E
S
R
E
R
Site 72
S708
V
P
S
Y
V
P
E
S
R
E
R
Y
Q
Q
I
Site 73
Y712
V
P
E
S
R
E
R
Y
Q
Q
I
E
S
Y
Y
Site 74
S717
E
R
Y
Q
Q
I
E
S
Y
Y
P
V
A
P
H
Site 75
Y718
R
Y
Q
Q
I
E
S
Y
Y
P
V
A
P
H
P
Site 76
Y719
Y
Q
Q
I
E
S
Y
Y
P
V
A
P
H
P
T
Site 77
S731
H
P
T
Q
I
R
P
S
Y
L
R
E
P
P
Y
Site 78
Y732
P
T
Q
I
R
P
S
Y
L
R
E
P
P
Y
S
Site 79
Y738
S
Y
L
R
E
P
P
Y
S
R
L
P
P
P
P
Site 80
S739
Y
L
R
E
P
P
Y
S
R
L
P
P
P
P
Q
Site 81
S750
P
P
P
Q
P
H
P
S
L
D
E
L
H
R
R
Site 82
S772
L
E
E
R
K
V
I
S
P
P
P
F
A
P
S
Site 83
S779
S
P
P
P
F
A
P
S
P
T
L
P
P
T
F
Site 84
T781
P
P
F
A
P
S
P
T
L
P
P
T
F
H
P
Site 85
T785
P
S
P
T
L
P
P
T
F
H
P
E
E
F
L
Site 86
Y807
G
K
Y
K
G
N
D
Y
S
Q
Y
S
P
W
S
Site 87
S808
K
Y
K
G
N
D
Y
S
Q
Y
S
P
W
S
C
Site 88
Y810
K
G
N
D
Y
S
Q
Y
S
P
W
S
C
D
T
Site 89
S811
G
N
D
Y
S
Q
Y
S
P
W
S
C
D
T
I
Site 90
T824
T
I
G
S
Y
I
G
T
K
D
A
K
P
K
D
Site 91
S863
Q
R
R
A
A
E
T
S
D
D
D
L
I
P
F
Site 92
S877
F
G
D
R
P
T
V
S
R
F
G
A
I
S
R
Site 93
S883
V
S
R
F
G
A
I
S
R
T
S
K
T
I
Y
Site 94
S886
F
G
A
I
S
R
T
S
K
T
I
Y
Q
G
A
Site 95
T888
A
I
S
R
T
S
K
T
I
Y
Q
G
A
G
P
Site 96
Y890
S
R
T
S
K
T
I
Y
Q
G
A
G
P
M
Q
Site 97
S908
P
Q
G
A
P
T
K
S
I
N
I
S
D
Y
S
Site 98
S912
P
T
K
S
I
N
I
S
D
Y
S
P
Y
G
T
Site 99
Y914
K
S
I
N
I
S
D
Y
S
P
Y
G
T
H
G
Site 100
S915
S
I
N
I
S
D
Y
S
P
Y
G
T
H
G
G
Site 101
Y917
N
I
S
D
Y
S
P
Y
G
T
H
G
G
W
G
Site 102
T919
S
D
Y
S
P
Y
G
T
H
G
G
W
G
A
S
Site 103
S926
T
H
G
G
W
G
A
S
P
Y
S
P
H
Q
N
Site 104
Y928
G
G
W
G
A
S
P
Y
S
P
H
Q
N
I
P
Site 105
S929
G
W
G
A
S
P
Y
S
P
H
Q
N
I
P
S
Site 106
S936
S
P
H
Q
N
I
P
S
Q
G
H
F
S
E
R
Site 107
S941
I
P
S
Q
G
H
F
S
E
R
E
R
I
S
M
Site 108
S947
F
S
E
R
E
R
I
S
M
S
E
V
A
S
H
Site 109
S949
E
R
E
R
I
S
M
S
E
V
A
S
H
G
K
Site 110
S953
I
S
M
S
E
V
A
S
H
G
K
P
L
P
S
Site 111
S960
S
H
G
K
P
L
P
S
A
E
R
E
Q
L
R
Site 112
S978
Q
Q
L
N
H
Q
I
S
Q
Q
T
Q
L
R
G
Site 113
S990
L
R
G
L
E
A
V
S
N
R
L
V
L
Q
R
Site 114
T1001
V
L
Q
R
E
A
N
T
L
A
G
Q
S
Q
P
Site 115
S1006
A
N
T
L
A
G
Q
S
Q
P
P
P
P
P
P
Site 116
S1021
P
K
W
P
G
M
I
S
S
E
Q
L
S
L
E
Site 117
S1022
K
W
P
G
M
I
S
S
E
Q
L
S
L
E
L
Site 118
S1026
M
I
S
S
E
Q
L
S
L
E
L
H
Q
V
E
Site 119
T1040
E
R
E
I
G
K
R
T
R
E
L
S
M
E
N
Site 120
S1044
G
K
R
T
R
E
L
S
M
E
N
Q
C
S
L
Site 121
S1050
L
S
M
E
N
Q
C
S
L
D
M
K
S
K
L
Site 122
S1055
Q
C
S
L
D
M
K
S
K
L
N
T
S
K
Q
Site 123
T1080
K
V
P
A
E
D
L
T
L
T
F
S
D
V
P
Site 124
T1082
P
A
E
D
L
T
L
T
F
S
D
V
P
N
G
Site 125
S1084
E
D
L
T
L
T
F
S
D
V
P
N
G
S
A
Site 126
S1101
Q
E
N
I
S
L
L
S
N
K
T
S
S
L
N
Site 127
T1104
I
S
L
L
S
N
K
T
S
S
L
N
L
S
E
Site 128
S1105
S
L
L
S
N
K
T
S
S
L
N
L
S
E
D
Site 129
S1106
L
L
S
N
K
T
S
S
L
N
L
S
E
D
P
Site 130
S1110
K
T
S
S
L
N
L
S
E
D
P
E
G
G
G
Site 131
S1122
G
G
G
D
N
N
D
S
Q
R
S
G
V
T
P
Site 132
S1125
D
N
N
D
S
Q
R
S
G
V
T
P
S
S
A
Site 133
T1128
D
S
Q
R
S
G
V
T
P
S
S
A
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation