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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAGI3
Full Name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Alias:
KIAA1634; MAGI-3; Membrane associated guanylate kinase, WW and PDZ domain containing 3; Membrane-associated guanylate kinase inverted 3; Membrane-associated guanylate kinase-related 3
Type:
Kinase (non-protein); Membrane protein, peripheral
Mass (Da):
165608
Number AA:
1506
UniProt ID:
Q5TCQ9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005634
GO:0005923
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004385
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0044419
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
K
K
K
K
H
W
L
S
K
V
Q
E
C
A
V
Site 2
S21
K
V
Q
E
C
A
V
S
W
A
G
P
P
G
D
Site 3
Y44
A
E
R
G
E
F
P
Y
L
G
R
L
R
E
E
Site 4
T56
R
E
E
P
G
G
G
T
C
C
V
V
S
G
K
Site 5
T83
G
T
P
V
S
G
L
T
N
R
D
T
L
A
V
Site 6
T87
S
G
L
T
N
R
D
T
L
A
V
I
R
H
F
Site 7
T102
R
E
P
I
R
L
K
T
V
K
P
G
K
V
I
Site 8
Y116
I
N
K
D
L
R
H
Y
L
S
L
Q
F
Q
K
Site 9
S118
K
D
L
R
H
Y
L
S
L
Q
F
Q
K
G
S
Site 10
S125
S
L
Q
F
Q
K
G
S
I
D
H
K
L
Q
Q
Site 11
Y139
Q
V
I
R
D
N
L
Y
L
R
T
I
P
C
T
Site 12
T146
Y
L
R
T
I
P
C
T
T
R
A
P
R
D
G
Site 13
T147
L
R
T
I
P
C
T
T
R
A
P
R
D
G
E
Site 14
Y160
G
E
V
P
G
V
D
Y
N
F
I
S
V
E
Q
Site 15
T182
G
A
L
L
E
S
G
T
Y
D
G
N
F
Y
G
Site 16
Y183
A
L
L
E
S
G
T
Y
D
G
N
F
Y
G
T
Site 17
Y188
G
T
Y
D
G
N
F
Y
G
T
P
K
P
P
A
Site 18
T190
Y
D
G
N
F
Y
G
T
P
K
P
P
A
E
P
Site 19
S198
P
K
P
P
A
E
P
S
P
F
Q
P
D
P
V
Site 20
S218
D
N
E
F
D
A
E
S
Q
R
K
R
T
T
S
Site 21
T223
A
E
S
Q
R
K
R
T
T
S
V
S
K
M
E
Site 22
T224
E
S
Q
R
K
R
T
T
S
V
S
K
M
E
R
Site 23
S225
S
Q
R
K
R
T
T
S
V
S
K
M
E
R
M
Site 24
S227
R
K
R
T
T
S
V
S
K
M
E
R
M
D
S
Site 25
S234
S
K
M
E
R
M
D
S
S
L
P
E
E
E
E
Site 26
S235
K
M
E
R
M
D
S
S
L
P
E
E
E
E
D
Site 27
S261
A
E
N
R
E
R
H
S
E
S
S
D
W
M
K
Site 28
S264
R
E
R
H
S
E
S
S
D
W
M
K
T
V
P
Site 29
T269
E
S
S
D
W
M
K
T
V
P
S
Y
N
Q
T
Site 30
Y273
W
M
K
T
V
P
S
Y
N
Q
T
N
S
S
M
Site 31
T276
T
V
P
S
Y
N
Q
T
N
S
S
M
D
F
R
Site 32
Y285
S
S
M
D
F
R
N
Y
M
M
R
D
E
T
L
Site 33
T291
N
Y
M
M
R
D
E
T
L
E
P
L
P
K
N
Site 34
Y310
Y
T
D
T
G
M
I
Y
F
I
D
H
N
T
K
Site 35
T318
F
I
D
H
N
T
K
T
T
T
W
L
D
P
R
Site 36
Y353
E
K
I
E
D
P
Q
Y
G
T
Y
Y
V
D
F
Site 37
Y356
E
D
P
Q
Y
G
T
Y
Y
V
D
F
T
L
V
Site 38
Y357
D
P
Q
Y
G
T
Y
Y
V
D
F
T
L
V
A
Site 39
S375
V
Q
W
H
D
L
G
S
L
Q
P
P
P
P
G
Site 40
S412
L
G
Q
V
E
I
G
S
S
K
P
D
M
E
K
Site 41
S413
G
Q
V
E
I
G
S
S
K
P
D
M
E
K
S
Site 42
S420
S
K
P
D
M
E
K
S
H
F
T
R
D
P
S
Site 43
S427
S
H
F
T
R
D
P
S
Q
L
K
G
V
L
V
Site 44
S437
K
G
V
L
V
R
A
S
L
K
K
S
T
M
G
Site 45
S441
V
R
A
S
L
K
K
S
T
M
G
F
G
F
T
Site 46
Y519
N
L
T
L
C
R
G
Y
P
L
P
D
D
S
E
Site 47
S525
G
Y
P
L
P
D
D
S
E
D
P
V
V
D
I
Site 48
S569
V
L
E
Q
N
G
K
S
G
H
T
L
T
G
D
Site 49
T574
G
K
S
G
H
T
L
T
G
D
G
L
N
G
P
Site 50
S582
G
D
G
L
N
G
P
S
D
A
S
E
Q
R
V
Site 51
S585
L
N
G
P
S
D
A
S
E
Q
R
V
S
M
A
Site 52
S590
D
A
S
E
Q
R
V
S
M
A
S
S
G
S
S
Site 53
S593
E
Q
R
V
S
M
A
S
S
G
S
S
Q
P
E
Site 54
S594
Q
R
V
S
M
A
S
S
G
S
S
Q
P
E
L
Site 55
S596
V
S
M
A
S
S
G
S
S
Q
P
E
L
V
T
Site 56
S597
S
M
A
S
S
G
S
S
Q
P
E
L
V
T
I
Site 57
S620
F
G
F
A
I
A
D
S
P
T
G
Q
K
V
K
Site 58
Y648
G
D
I
I
K
E
I
Y
H
Q
N
V
Q
N
L
Site 59
S684
I
L
R
G
G
P
P
S
P
T
K
T
A
K
M
Site 60
T688
G
P
P
S
P
T
K
T
A
K
M
K
T
D
K
Site 61
S701
D
K
K
E
N
A
G
S
L
E
A
I
N
E
P
Site 62
S718
Q
P
M
P
F
P
P
S
I
I
R
S
G
S
P
Site 63
S722
F
P
P
S
I
I
R
S
G
S
P
K
L
D
P
Site 64
S724
P
S
I
I
R
S
G
S
P
K
L
D
P
S
E
Site 65
S730
G
S
P
K
L
D
P
S
E
V
Y
L
K
S
K
Site 66
Y733
K
L
D
P
S
E
V
Y
L
K
S
K
T
L
Y
Site 67
S736
P
S
E
V
Y
L
K
S
K
T
L
Y
E
D
K
Site 68
Y740
Y
L
K
S
K
T
L
Y
E
D
K
P
P
N
T
Site 69
S810
G
I
P
V
K
G
K
S
H
K
Q
V
L
D
L
Site 70
T830
R
N
G
H
V
L
L
T
V
R
R
K
I
F
Y
Site 71
Y837
T
V
R
R
K
I
F
Y
G
E
K
Q
P
E
D
Site 72
S846
E
K
Q
P
E
D
D
S
S
Q
A
F
I
S
T
Site 73
S847
K
Q
P
E
D
D
S
S
Q
A
F
I
S
T
Q
Site 74
S852
D
S
S
Q
A
F
I
S
T
Q
N
G
S
P
R
Site 75
T853
S
S
Q
A
F
I
S
T
Q
N
G
S
P
R
L
Site 76
S857
F
I
S
T
Q
N
G
S
P
R
L
N
R
A
E
Site 77
Y875
R
P
A
P
Q
E
P
Y
D
V
V
L
Q
R
K
Site 78
T893
G
F
G
F
V
I
L
T
S
K
N
K
P
P
P
Site 79
S894
F
G
F
V
I
L
T
S
K
N
K
P
P
P
G
Site 80
S914
I
G
R
V
I
E
G
S
P
A
D
R
C
G
K
Site 81
S970
E
E
H
H
G
P
P
S
G
T
N
S
A
R
Q
Site 82
S974
G
P
P
S
G
T
N
S
A
R
Q
S
P
A
L
Site 83
S978
G
T
N
S
A
R
Q
S
P
A
L
Q
H
R
P
Site 84
S989
Q
H
R
P
M
G
Q
S
Q
A
N
H
I
P
G
Site 85
S999
N
H
I
P
G
D
R
S
A
L
E
G
E
I
G
Site 86
S1010
G
E
I
G
K
D
V
S
T
S
Y
R
H
S
W
Site 87
T1011
E
I
G
K
D
V
S
T
S
Y
R
H
S
W
S
Site 88
S1012
I
G
K
D
V
S
T
S
Y
R
H
S
W
S
D
Site 89
Y1013
G
K
D
V
S
T
S
Y
R
H
S
W
S
D
H
Site 90
S1016
V
S
T
S
Y
R
H
S
W
S
D
H
K
H
L
Site 91
S1032
Q
P
D
T
A
V
I
S
V
V
G
S
R
H
N
Site 92
S1036
A
V
I
S
V
V
G
S
R
H
N
Q
N
L
G
Site 93
Y1045
H
N
Q
N
L
G
C
Y
P
V
E
L
E
R
G
Site 94
S1059
G
P
R
G
F
G
F
S
L
R
G
G
K
E
Y
Site 95
S1145
D
I
N
N
P
S
S
S
N
V
I
Y
D
E
Q
Site 96
Y1149
P
S
S
S
N
V
I
Y
D
E
Q
S
P
L
P
Site 97
S1153
N
V
I
Y
D
E
Q
S
P
L
P
P
S
S
H
Site 98
S1158
E
Q
S
P
L
P
P
S
S
H
F
A
S
I
F
Site 99
S1159
Q
S
P
L
P
P
S
S
H
F
A
S
I
F
E
Site 100
S1163
P
P
S
S
H
F
A
S
I
F
E
E
S
H
V
Site 101
S1197
D
I
V
P
E
K
K
S
T
L
N
E
N
Q
P
Site 102
T1198
I
V
P
E
K
K
S
T
L
N
E
N
Q
P
E
Site 103
S1217
S
L
L
Q
K
N
V
S
K
R
D
P
P
S
S
Site 104
S1223
V
S
K
R
D
P
P
S
S
H
G
H
S
N
K
Site 105
S1224
S
K
R
D
P
P
S
S
H
G
H
S
N
K
K
Site 106
S1228
P
P
S
S
H
G
H
S
N
K
K
N
L
L
K
Site 107
T1241
L
K
V
E
N
G
V
T
R
R
G
R
S
V
S
Site 108
S1246
G
V
T
R
R
G
R
S
V
S
P
K
K
P
A
Site 109
S1248
T
R
R
G
R
S
V
S
P
K
K
P
A
S
Q
Site 110
S1254
V
S
P
K
K
P
A
S
Q
H
S
E
E
H
L
Site 111
S1266
E
H
L
D
K
I
P
S
P
L
K
N
N
P
K
Site 112
S1280
K
R
R
P
R
D
Q
S
L
S
P
S
K
G
E
Site 113
S1282
R
P
R
D
Q
S
L
S
P
S
K
G
E
N
K
Site 114
S1284
R
D
Q
S
L
S
P
S
K
G
E
N
K
S
C
Site 115
S1290
P
S
K
G
E
N
K
S
C
Q
V
S
T
R
A
Site 116
S1294
E
N
K
S
C
Q
V
S
T
R
A
G
S
G
Q
Site 117
T1295
N
K
S
C
Q
V
S
T
R
A
G
S
G
Q
D
Site 118
S1299
Q
V
S
T
R
A
G
S
G
Q
D
Q
C
R
K
Site 119
S1307
G
Q
D
Q
C
R
K
S
R
G
R
S
A
S
P
Site 120
S1311
C
R
K
S
R
G
R
S
A
S
P
K
K
Q
Q
Site 121
S1313
K
S
R
G
R
S
A
S
P
K
K
Q
Q
K
I
Site 122
S1323
K
Q
Q
K
I
E
G
S
K
A
P
S
N
A
E
Site 123
S1327
I
E
G
S
K
A
P
S
N
A
E
A
K
L
L
Site 124
S1338
A
K
L
L
E
G
K
S
R
R
I
A
G
Y
T
Site 125
T1345
S
R
R
I
A
G
Y
T
G
S
N
A
E
Q
I
Site 126
S1347
R
I
A
G
Y
T
G
S
N
A
E
Q
I
P
D
Site 127
S1359
I
P
D
G
K
E
K
S
D
V
I
R
K
D
A
Site 128
S1374
K
Q
N
Q
L
E
K
S
R
T
R
S
P
E
K
Site 129
T1376
N
Q
L
E
K
S
R
T
R
S
P
E
K
K
I
Site 130
S1378
L
E
K
S
R
T
R
S
P
E
K
K
I
K
R
Site 131
S1390
I
K
R
M
V
E
K
S
L
P
S
K
M
T
N
Site 132
T1399
P
S
K
M
T
N
K
T
T
S
K
E
V
S
E
Site 133
S1401
K
M
T
N
K
T
T
S
K
E
V
S
E
N
E
Site 134
S1405
K
T
T
S
K
E
V
S
E
N
E
K
G
K
K
Site 135
T1415
E
K
G
K
K
V
T
T
G
E
T
S
S
S
N
Site 136
S1421
T
T
G
E
T
S
S
S
N
D
K
I
G
E
N
Site 137
S1432
I
G
E
N
V
Q
L
S
E
K
R
L
K
Q
E
Site 138
S1446
E
P
E
E
K
V
V
S
N
K
T
E
D
H
K
Site 139
S1473
T
G
R
F
K
P
E
S
S
S
P
V
K
K
T
Site 140
S1475
R
F
K
P
E
S
S
S
P
V
K
K
T
L
I
Site 141
T1480
S
S
S
P
V
K
K
T
L
I
T
P
G
P
W
Site 142
T1483
P
V
K
K
T
L
I
T
P
G
P
W
K
V
P
Site 143
S1491
P
G
P
W
K
V
P
S
G
N
K
V
T
G
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation