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Updated November 2019
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Protein Info
Short Name:
TTBK1
Full Name:
Tau-tubulin kinase 1
Alias:
Brain-derived tau kinase
Type:
Mass (Da):
142737
Number AA:
1321
UniProt ID:
Q5TCY1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
A
A
A
L
K
D
E
T
N
M
S
G
G
G
E
Site 2
S15
L
K
D
E
T
N
M
S
G
G
G
E
Q
A
D
Site 3
Y28
A
D
I
L
P
A
N
Y
V
V
K
D
R
W
K
Site 4
Y104
G
R
N
E
K
F
N
Y
V
V
M
Q
L
Q
G
Site 5
S120
N
L
A
D
L
R
R
S
Q
P
R
G
T
F
T
Site 6
T125
R
R
S
Q
P
R
G
T
F
T
L
S
T
T
L
Site 7
T127
S
Q
P
R
G
T
F
T
L
S
T
T
L
R
L
Site 8
S129
P
R
G
T
F
T
L
S
T
T
L
R
L
G
K
Site 9
T130
R
G
T
F
T
L
S
T
T
L
R
L
G
K
Q
Site 10
S147
E
S
I
E
A
I
H
S
V
G
F
L
H
R
D
Site 11
S158
L
H
R
D
I
K
P
S
N
F
A
M
G
R
L
Site 12
T168
A
M
G
R
L
P
S
T
Y
R
K
C
Y
M
L
Site 13
Y169
M
G
R
L
P
S
T
Y
R
K
C
Y
M
L
D
Site 14
Y173
P
S
T
Y
R
K
C
Y
M
L
D
F
G
L
A
Site 15
Y183
D
F
G
L
A
R
Q
Y
T
N
T
T
G
D
V
Site 16
T184
F
G
L
A
R
Q
Y
T
N
T
T
G
D
V
R
Site 17
T186
L
A
R
Q
Y
T
N
T
T
G
D
V
R
P
P
Site 18
T202
N
V
A
G
F
R
G
T
V
R
Y
A
S
V
N
Site 19
Y205
G
F
R
G
T
V
R
Y
A
S
V
N
A
H
K
Site 20
S207
R
G
T
V
R
Y
A
S
V
N
A
H
K
N
R
Site 21
Y255
V
G
M
I
K
E
K
Y
E
H
R
M
L
L
K
Site 22
Y280
D
H
I
A
S
L
D
Y
F
T
K
P
D
Y
Q
Site 23
Y286
D
Y
F
T
K
P
D
Y
Q
L
I
M
S
V
F
Site 24
T315
F
D
W
E
K
A
G
T
D
A
L
L
S
T
S
Site 25
S320
A
G
T
D
A
L
L
S
T
S
T
S
T
P
P
Site 26
S322
T
D
A
L
L
S
T
S
T
S
T
P
P
Q
Q
Site 27
S324
A
L
L
S
T
S
T
S
T
P
P
Q
Q
N
T
Site 28
T325
L
L
S
T
S
T
S
T
P
P
Q
Q
N
T
R
Site 29
T334
P
Q
Q
N
T
R
Q
T
A
A
M
F
G
V
V
Site 30
T355
G
D
L
L
R
E
N
T
E
D
V
L
Q
G
E
Site 31
S365
V
L
Q
G
E
H
L
S
D
Q
E
N
A
P
P
Site 32
S379
P
I
L
P
G
R
P
S
E
G
L
G
P
S
P
Site 33
S385
P
S
E
G
L
G
P
S
P
H
L
V
P
H
P
Site 34
S417
L
R
I
N
I
G
K
S
P
C
V
E
E
E
Q
Site 35
S432
S
R
G
M
G
V
P
S
S
P
V
R
A
P
P
Site 36
S433
R
G
M
G
V
P
S
S
P
V
R
A
P
P
D
Site 37
S441
P
V
R
A
P
P
D
S
P
T
T
P
V
R
S
Site 38
T443
R
A
P
P
D
S
P
T
T
P
V
R
S
L
R
Site 39
T444
A
P
P
D
S
P
T
T
P
V
R
S
L
R
Y
Site 40
S448
S
P
T
T
P
V
R
S
L
R
Y
R
R
V
N
Site 41
Y451
T
P
V
R
S
L
R
Y
R
R
V
N
S
P
E
Site 42
S456
L
R
Y
R
R
V
N
S
P
E
S
E
R
L
S
Site 43
S459
R
R
V
N
S
P
E
S
E
R
L
S
T
A
D
Site 44
S463
S
P
E
S
E
R
L
S
T
A
D
G
R
V
E
Site 45
T464
P
E
S
E
R
L
S
T
A
D
G
R
V
E
L
Site 46
S476
V
E
L
P
E
R
R
S
R
M
D
L
P
G
S
Site 47
S483
S
R
M
D
L
P
G
S
P
S
R
Q
A
C
S
Site 48
S485
M
D
L
P
G
S
P
S
R
Q
A
C
S
S
Q
Site 49
S491
P
S
R
Q
A
C
S
S
Q
P
A
Q
M
L
S
Site 50
S498
S
Q
P
A
Q
M
L
S
V
D
T
G
H
A
D
Site 51
S509
G
H
A
D
R
Q
A
S
G
R
M
D
V
S
A
Site 52
S515
A
S
G
R
M
D
V
S
A
S
V
E
Q
E
A
Site 53
S517
G
R
M
D
V
S
A
S
V
E
Q
E
A
L
S
Site 54
S524
S
V
E
Q
E
A
L
S
N
A
F
R
S
V
P
Site 55
S540
A
E
E
E
D
F
D
S
K
E
W
V
I
I
D
Site 56
S562
F
P
P
G
A
E
P
S
T
S
G
T
T
D
E
Site 57
S564
P
G
A
E
P
S
T
S
G
T
T
D
E
E
P
Site 58
T566
A
E
P
S
T
S
G
T
T
D
E
E
P
E
E
Site 59
T592
R
R
L
G
A
E
P
T
V
R
P
R
G
R
S
Site 60
S599
T
V
R
P
R
G
R
S
M
Q
A
L
A
E
E
Site 61
S621
Q
P
L
P
P
Q
L
S
Q
G
D
G
R
S
E
Site 62
S627
L
S
Q
G
D
G
R
S
E
T
S
Q
P
P
T
Site 63
T629
Q
G
D
G
R
S
E
T
S
Q
P
P
T
P
G
Site 64
S630
G
D
G
R
S
E
T
S
Q
P
P
T
P
G
S
Site 65
T634
S
E
T
S
Q
P
P
T
P
G
S
P
S
H
S
Site 66
S637
S
Q
P
P
T
P
G
S
P
S
H
S
P
L
H
Site 67
S639
P
P
T
P
G
S
P
S
H
S
P
L
H
S
G
Site 68
S641
T
P
G
S
P
S
H
S
P
L
H
S
G
P
R
Site 69
S645
P
S
H
S
P
L
H
S
G
P
R
P
R
R
R
Site 70
S654
P
R
P
R
R
R
E
S
D
P
T
G
P
Q
R
Site 71
T657
R
R
R
E
S
D
P
T
G
P
Q
R
Q
V
F
Site 72
S682
L
P
R
A
V
P
L
S
L
P
Y
Q
D
F
K
Site 73
S693
Q
D
F
K
R
D
L
S
D
Y
R
E
R
A
R
Site 74
Y695
F
K
R
D
L
S
D
Y
R
E
R
A
R
L
L
Site 75
S711
R
V
R
R
V
G
F
S
H
M
L
L
T
T
P
Site 76
S786
G
E
V
L
G
P
R
S
G
S
S
S
E
G
S
Site 77
S788
V
L
G
P
R
S
G
S
S
S
E
G
S
E
R
Site 78
S789
L
G
P
R
S
G
S
S
S
E
G
S
E
R
S
Site 79
S790
G
P
R
S
G
S
S
S
E
G
S
E
R
S
T
Site 80
S793
S
G
S
S
S
E
G
S
E
R
S
T
D
R
S
Site 81
S796
S
S
E
G
S
E
R
S
T
D
R
S
Q
E
G
Site 82
T797
S
E
G
S
E
R
S
T
D
R
S
Q
E
G
A
Site 83
S800
S
E
R
S
T
D
R
S
Q
E
G
A
P
S
T
Site 84
S806
R
S
Q
E
G
A
P
S
T
L
L
A
D
D
Q
Site 85
S816
L
A
D
D
Q
K
E
S
R
G
R
A
S
M
A
Site 86
S821
K
E
S
R
G
R
A
S
M
A
D
G
D
L
E
Site 87
T835
E
P
E
E
G
S
K
T
L
V
L
V
S
P
G
Site 88
S840
S
K
T
L
V
L
V
S
P
G
D
M
K
K
S
Site 89
S847
S
P
G
D
M
K
K
S
P
V
T
A
E
L
A
Site 90
T861
A
P
D
P
D
L
G
T
L
A
A
L
T
P
Q
Site 91
T866
L
G
T
L
A
A
L
T
P
Q
H
E
R
P
Q
Site 92
S877
E
R
P
Q
P
T
G
S
Q
L
D
V
S
E
P
Site 93
S882
T
G
S
Q
L
D
V
S
E
P
G
T
L
S
S
Site 94
T886
L
D
V
S
E
P
G
T
L
S
S
V
L
K
S
Site 95
S888
V
S
E
P
G
T
L
S
S
V
L
K
S
E
P
Site 96
S889
S
E
P
G
T
L
S
S
V
L
K
S
E
P
K
Site 97
S893
T
L
S
S
V
L
K
S
E
P
K
P
P
G
P
Site 98
S921
G
G
V
A
V
T
S
S
P
F
T
K
V
E
R
Site 99
T929
P
F
T
K
V
E
R
T
F
V
H
I
A
E
K
Site 100
S944
T
H
L
N
V
M
S
S
G
G
Q
A
L
R
S
Site 101
S951
S
G
G
Q
A
L
R
S
E
E
F
S
A
G
G
Site 102
S955
A
L
R
S
E
E
F
S
A
G
G
E
L
G
L
Site 103
S996
N
G
A
E
I
E
G
S
A
L
S
G
A
P
R
Site 104
S999
E
I
E
G
S
A
L
S
G
A
P
R
E
T
P
Site 105
T1005
L
S
G
A
P
R
E
T
P
S
E
M
A
T
N
Site 106
S1007
G
A
P
R
E
T
P
S
E
M
A
T
N
S
L
Site 107
T1011
E
T
P
S
E
M
A
T
N
S
L
P
N
G
P
Site 108
S1013
P
S
E
M
A
T
N
S
L
P
N
G
P
A
L
Site 109
S1028
A
D
G
P
A
P
V
S
P
L
E
P
S
P
E
Site 110
S1033
P
V
S
P
L
E
P
S
P
E
K
V
A
T
I
Site 111
T1039
P
S
P
E
K
V
A
T
I
S
P
R
R
H
A
Site 112
S1041
P
E
K
V
A
T
I
S
P
R
R
H
A
M
P
Site 113
S1050
R
R
H
A
M
P
G
S
R
P
R
S
R
I
P
Site 114
S1054
M
P
G
S
R
P
R
S
R
I
P
V
L
L
S
Site 115
S1061
S
R
I
P
V
L
L
S
E
E
D
T
G
S
E
Site 116
T1065
V
L
L
S
E
E
D
T
G
S
E
P
S
G
S
Site 117
S1067
L
S
E
E
D
T
G
S
E
P
S
G
S
L
S
Site 118
S1070
E
D
T
G
S
E
P
S
G
S
L
S
A
K
E
Site 119
S1072
T
G
S
E
P
S
G
S
L
S
A
K
E
R
W
Site 120
S1074
S
E
P
S
G
S
L
S
A
K
E
R
W
S
K
Site 121
S1080
L
S
A
K
E
R
W
S
K
R
A
R
P
Q
Q
Site 122
S1107
R
L
L
L
R
L
A
S
G
A
S
S
S
S
S
Site 123
S1110
L
R
L
A
S
G
A
S
S
S
S
S
E
E
Q
Site 124
S1111
R
L
A
S
G
A
S
S
S
S
S
E
E
Q
R
Site 125
S1112
L
A
S
G
A
S
S
S
S
S
E
E
Q
R
R
Site 126
S1114
S
G
A
S
S
S
S
S
E
E
Q
R
R
A
S
Site 127
S1121
S
E
E
Q
R
R
A
S
E
T
L
S
G
T
G
Site 128
T1123
E
Q
R
R
A
S
E
T
L
S
G
T
G
S
E
Site 129
S1125
R
R
A
S
E
T
L
S
G
T
G
S
E
E
D
Site 130
S1129
E
T
L
S
G
T
G
S
E
E
D
T
P
A
S
Site 131
T1133
G
T
G
S
E
E
D
T
P
A
S
E
P
A
A
Site 132
S1136
S
E
E
D
T
P
A
S
E
P
A
A
A
L
P
Site 133
S1146
A
A
A
L
P
R
K
S
G
R
A
A
A
T
R
Site 134
T1152
K
S
G
R
A
A
A
T
R
S
R
I
P
R
P
Site 135
S1154
G
R
A
A
A
T
R
S
R
I
P
R
P
I
G
Site 136
S1175
V
A
A
Q
Q
P
A
S
R
S
H
G
A
A
P
Site 137
T1189
P
A
L
D
T
A
I
T
S
R
L
Q
L
Q
T
Site 138
T1196
T
S
R
L
Q
L
Q
T
P
P
G
S
A
T
A
Site 139
S1200
Q
L
Q
T
P
P
G
S
A
T
A
A
D
L
R
Site 140
T1202
Q
T
P
P
G
S
A
T
A
A
D
L
R
P
K
Site 141
S1232
A
R
P
P
A
P
R
S
P
R
L
P
A
S
T
Site 142
S1238
R
S
P
R
L
P
A
S
T
S
A
A
R
N
A
Site 143
T1239
S
P
R
L
P
A
S
T
S
A
A
R
N
A
S
Site 144
S1240
P
R
L
P
A
S
T
S
A
A
R
N
A
S
A
Site 145
S1246
T
S
A
A
R
N
A
S
A
S
P
R
S
Q
S
Site 146
S1248
A
A
R
N
A
S
A
S
P
R
S
Q
S
L
S
Site 147
S1251
N
A
S
A
S
P
R
S
Q
S
L
S
R
R
E
Site 148
S1253
S
A
S
P
R
S
Q
S
L
S
R
R
E
S
P
Site 149
S1255
S
P
R
S
Q
S
L
S
R
R
E
S
P
S
P
Site 150
S1259
Q
S
L
S
R
R
E
S
P
S
P
S
H
Q
A
Site 151
S1261
L
S
R
R
E
S
P
S
P
S
H
Q
A
R
P
Site 152
S1263
R
R
E
S
P
S
P
S
H
Q
A
R
P
G
V
Site 153
T1286
A
R
A
Q
P
D
G
T
P
S
P
G
G
S
K
Site 154
S1288
A
Q
P
D
G
T
P
S
P
G
G
S
K
K
G
Site 155
S1292
G
T
P
S
P
G
G
S
K
K
G
P
R
G
K
Site 156
T1306
K
L
Q
A
Q
R
A
T
T
K
G
R
A
G
G
Site 157
T1307
L
Q
A
Q
R
A
T
T
K
G
R
A
G
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation