KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
THEMIS2
Full Name:
Protein THEMIS2
Alias:
Induced by contact to basement membrane 1 protein; Thymocyte-expressed molecule involved in selection protein 2
Type:
Mass (Da):
72030
Number AA:
643
UniProt ID:
Q5TEJ8
International Prot ID:
IPI00003922
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
S
G
V
Y
F
E
G
S
I
Y
E
I
S
G
N
Site 2
Y35
V
Y
F
E
G
S
I
Y
E
I
S
G
N
E
C
Site 3
S38
E
G
S
I
Y
E
I
S
G
N
E
C
C
L
S
Site 4
T53
T
G
D
L
I
K
V
T
Q
V
R
L
Q
K
V
Site 5
T67
V
V
C
E
N
P
K
T
S
Q
T
M
E
L
A
Site 6
S68
V
C
E
N
P
K
T
S
Q
T
M
E
L
A
P
Site 7
T70
E
N
P
K
T
S
Q
T
M
E
L
A
P
N
F
Site 8
Y80
L
A
P
N
F
Q
G
Y
F
T
P
L
N
T
P
Site 9
T82
P
N
F
Q
G
Y
F
T
P
L
N
T
P
Q
S
Site 10
T86
G
Y
F
T
P
L
N
T
P
Q
S
Y
E
T
L
Site 11
S89
T
P
L
N
T
P
Q
S
Y
E
T
L
E
E
L
Site 12
S98
E
T
L
E
E
L
V
S
A
T
T
Q
S
S
K
Site 13
T109
Q
S
S
K
Q
L
P
T
C
F
M
S
T
H
R
Site 14
T119
M
S
T
H
R
I
V
T
E
G
R
V
V
T
E
Site 15
T169
S
Q
K
G
P
F
W
T
W
E
P
S
A
P
R
Site 16
S173
P
F
W
T
W
E
P
S
A
P
R
T
L
L
Q
Site 17
T177
W
E
P
S
A
P
R
T
L
L
Q
V
L
Q
D
Site 18
T235
E
V
D
V
E
D
V
T
A
S
S
R
H
V
H
Site 19
S237
D
V
E
D
V
T
A
S
S
R
H
V
H
F
I
Site 20
S277
E
G
R
P
I
F
L
S
P
W
V
G
S
L
Q
Site 21
Y292
K
G
Q
R
L
C
V
Y
G
L
A
S
P
P
W
Site 22
S305
P
W
R
V
L
A
S
S
K
G
R
K
V
P
R
Site 23
S317
V
P
R
H
F
L
V
S
G
G
Y
Q
G
K
L
Site 24
Y335
P
R
E
F
P
T
A
Y
D
L
L
G
A
F
Q
Site 25
T366
R
E
E
N
P
E
F
T
S
L
A
V
G
D
R
Site 26
S367
E
E
N
P
E
F
T
S
L
A
V
G
D
R
L
Site 27
S399
V
L
V
C
Q
R
L
S
D
Q
A
G
E
D
E
Site 28
S416
E
C
K
E
E
A
E
S
P
E
R
V
L
L
P
Site 29
S429
L
P
F
H
F
P
G
S
F
V
E
E
M
S
D
Site 30
S435
G
S
F
V
E
E
M
S
D
S
R
R
Y
S
L
Site 31
S437
F
V
E
E
M
S
D
S
R
R
Y
S
L
A
D
Site 32
S441
M
S
D
S
R
R
Y
S
L
A
D
L
T
A
Q
Site 33
T462
V
K
V
V
A
K
D
T
S
H
P
T
D
P
L
Site 34
T470
S
H
P
T
D
P
L
T
S
F
L
G
L
R
L
Site 35
S471
H
P
T
D
P
L
T
S
F
L
G
L
R
L
E
Site 36
T508
P
P
R
W
L
D
L
T
V
V
K
A
K
G
Q
Site 37
S522
Q
P
D
L
P
E
G
S
L
P
I
A
T
V
E
Site 38
T527
E
G
S
L
P
I
A
T
V
E
E
L
T
D
T
Site 39
T534
T
V
E
E
L
T
D
T
F
Y
Y
R
L
R
K
Site 40
Y536
E
E
L
T
D
T
F
Y
Y
R
L
R
K
L
P
Site 41
S561
P
P
K
N
Q
G
L
S
K
Q
R
R
H
S
S
Site 42
S567
L
S
K
Q
R
R
H
S
S
E
G
G
V
K
S
Site 43
S568
S
K
Q
R
R
H
S
S
E
G
G
V
K
S
S
Site 44
S574
S
S
E
G
G
V
K
S
S
Q
V
L
G
L
Q
Site 45
S575
S
E
G
G
V
K
S
S
Q
V
L
G
L
Q
Q
Site 46
T593
L
P
K
P
K
A
K
T
L
P
E
F
I
K
D
Site 47
S602
P
E
F
I
K
D
G
S
S
T
Y
S
K
I
P
Site 48
S603
E
F
I
K
D
G
S
S
T
Y
S
K
I
P
A
Site 49
T604
F
I
K
D
G
S
S
T
Y
S
K
I
P
A
H
Site 50
S606
K
D
G
S
S
T
Y
S
K
I
P
A
H
R
K
Site 51
Y632
L
D
D
D
E
H
D
Y
E
E
I
L
E
Q
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation