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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMCO4
Full Name:
Transmembrane and coiled-coil domain-containing protein 4
Alias:
Type:
Mass (Da):
67910
Number AA:
634
UniProt ID:
Q5TGY1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
Q
P
L
V
A
E
P
T
A
E
G
E
P
H
L
Site 2
T30
E
G
E
P
H
L
P
T
G
R
E
L
T
E
A
Site 3
T35
L
P
T
G
R
E
L
T
E
A
N
R
F
A
Y
Site 4
S124
T
Q
D
L
L
S
F
S
L
K
D
G
H
Y
D
Site 5
Y130
F
S
L
K
D
G
H
Y
D
A
R
A
R
V
L
Site 6
Y190
N
R
R
K
W
K
R
Y
L
L
I
G
L
A
T
Site 7
Y254
A
G
A
G
L
T
G
Y
K
M
K
K
R
V
G
Site 8
T272
E
F
T
F
L
P
L
T
E
G
R
Q
L
H
I
Site 9
S289
A
V
T
G
W
L
A
S
G
K
Y
R
T
F
S
Site 10
Y292
G
W
L
A
S
G
K
Y
R
T
F
S
A
P
W
Site 11
T294
L
A
S
G
K
Y
R
T
F
S
A
P
W
A
A
Site 12
S296
S
G
K
Y
R
T
F
S
A
P
W
A
A
L
A
Site 13
Y309
L
A
H
S
R
E
Q
Y
C
L
A
W
E
A
K
Site 14
T399
Q
Q
G
R
R
P
V
T
L
I
G
F
S
L
G
Site 15
S452
E
P
F
R
K
V
V
S
G
R
I
I
N
G
Y
Site 16
Y459
S
G
R
I
I
N
G
Y
C
R
G
D
W
L
L
Site 17
S467
C
R
G
D
W
L
L
S
F
V
Y
R
T
S
S
Site 18
S540
L
A
P
G
C
L
P
S
E
E
P
R
Q
A
A
Site 19
T555
A
A
A
S
S
G
E
T
P
H
Q
V
G
Q
T
Site 20
T562
T
P
H
Q
V
G
Q
T
Q
G
P
I
S
G
D
Site 21
S567
G
Q
T
Q
G
P
I
S
G
D
T
S
K
L
A
Site 22
S571
G
P
I
S
G
D
T
S
K
L
A
M
S
T
D
Site 23
S576
D
T
S
K
L
A
M
S
T
D
P
S
Q
A
Q
Site 24
S580
L
A
M
S
T
D
P
S
Q
A
Q
V
P
V
G
Site 25
S595
L
D
Q
S
E
G
A
S
L
P
A
A
A
S
P
Site 26
S601
A
S
L
P
A
A
A
S
P
E
R
P
P
I
C
Site 27
S609
P
E
R
P
P
I
C
S
H
G
M
D
P
N
P
Site 28
T626
C
P
D
C
A
C
K
T
Q
G
P
S
T
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation