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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VWA5B1
Full Name:
von Willebrand factor A domain-containing protein 5B1
Alias:
Type:
Mass (Da):
133802
Number AA:
1220
UniProt ID:
Q5TIE3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S89
E
S
G
H
F
D
A
S
H
V
R
S
P
T
V
Site 2
S93
F
D
A
S
H
V
R
S
P
T
V
T
G
N
I
Site 3
T95
A
S
H
V
R
S
P
T
V
T
G
N
I
L
Q
Site 4
T97
H
V
R
S
P
T
V
T
G
N
I
L
Q
D
G
Site 5
T113
S
I
A
P
H
S
C
T
P
G
K
V
T
L
D
Site 6
T153
S
T
S
S
E
L
P
T
L
P
S
G
A
V
R
Site 7
S178
V
P
Q
F
C
T
K
S
T
G
T
S
N
Q
Q
Site 8
S182
C
T
K
S
T
G
T
S
N
Q
Q
A
Q
G
K
Site 9
S216
T
L
L
N
T
E
V
S
N
P
M
E
Y
E
F
Site 10
Y221
E
V
S
N
P
M
E
Y
E
F
N
F
Q
L
E
Site 11
S252
I
R
A
D
A
A
P
S
A
R
S
A
K
S
I
Site 12
T268
I
T
L
A
N
K
H
T
F
D
R
P
V
E
I
Site 13
S280
V
E
I
L
I
H
P
S
E
P
H
M
P
H
V
Site 14
T295
L
I
E
K
G
D
M
T
L
G
E
F
D
Q
H
Site 15
S317
I
K
G
M
K
K
K
S
R
A
E
R
K
T
E
Site 16
T323
K
S
R
A
E
R
K
T
E
I
I
R
K
R
L
Site 17
S369
F
I
F
L
I
D
R
S
S
S
M
S
G
I
S
Site 18
S371
F
L
I
D
R
S
S
S
M
S
G
I
S
M
H
Site 19
S373
I
D
R
S
S
S
M
S
G
I
S
M
H
R
V
Site 20
S376
S
S
S
M
S
G
I
S
M
H
R
V
K
D
A
Site 21
S408
G
F
G
S
T
F
K
S
L
F
P
S
S
Q
T
Site 22
S412
T
F
K
S
L
F
P
S
S
Q
T
Y
S
E
D
Site 23
S413
F
K
S
L
F
P
S
S
Q
T
Y
S
E
D
S
Site 24
Y416
L
F
P
S
S
Q
T
Y
S
E
D
S
L
A
M
Site 25
S417
F
P
S
S
Q
T
Y
S
E
D
S
L
A
M
A
Site 26
S420
S
Q
T
Y
S
E
D
S
L
A
M
A
C
D
D
Site 27
Y488
H
A
F
S
T
R
C
Y
S
F
G
I
G
P
N
Site 28
S506
R
L
V
K
G
L
A
S
V
S
E
G
S
A
E
Site 29
S528
L
Q
P
K
M
V
K
S
L
K
K
A
M
A
P
Site 30
S578
Y
G
I
V
C
D
A
S
L
H
I
S
N
P
R
Site 31
S582
C
D
A
S
L
H
I
S
N
P
R
S
D
K
R
Site 32
S586
L
H
I
S
N
P
R
S
D
K
R
R
R
Y
S
Site 33
Y592
R
S
D
K
R
R
R
Y
S
M
L
H
S
Q
E
Site 34
S593
S
D
K
R
R
R
Y
S
M
L
H
S
Q
E
S
Site 35
S597
R
R
Y
S
M
L
H
S
Q
E
S
G
S
S
V
Site 36
S600
S
M
L
H
S
Q
E
S
G
S
S
V
F
Y
H
Site 37
S603
H
S
Q
E
S
G
S
S
V
F
Y
H
S
Q
D
Site 38
Y606
E
S
G
S
S
V
F
Y
H
S
Q
D
D
G
P
Site 39
S608
G
S
S
V
F
Y
H
S
Q
D
D
G
P
G
L
Site 40
S640
A
K
N
A
R
L
A
S
G
D
S
T
T
K
H
Site 41
T644
R
L
A
S
G
D
S
T
T
K
H
D
L
N
L
Site 42
S652
T
K
H
D
L
N
L
S
Q
R
R
R
A
Y
S
Site 43
Y658
L
S
Q
R
R
R
A
Y
S
T
N
Q
I
T
N
Site 44
S659
S
Q
R
R
R
A
Y
S
T
N
Q
I
T
N
H
Site 45
T660
Q
R
R
R
A
Y
S
T
N
Q
I
T
N
H
K
Site 46
T673
H
K
P
L
P
R
A
T
M
A
S
D
P
M
P
Site 47
S676
L
P
R
A
T
M
A
S
D
P
M
P
A
A
K
Site 48
Y685
P
M
P
A
A
K
R
Y
P
L
R
K
A
R
L
Site 49
T696
K
A
R
L
Q
D
L
T
N
Q
T
S
L
D
V
Site 50
S700
Q
D
L
T
N
Q
T
S
L
D
V
Q
R
W
Q
Site 51
S735
G
P
G
A
R
R
P
S
L
L
P
Q
G
C
Q
Site 52
T751
F
L
P
W
G
Q
E
T
Q
A
W
S
P
V
R
Site 53
S755
G
Q
E
T
Q
A
W
S
P
V
R
E
R
T
S
Site 54
T761
W
S
P
V
R
E
R
T
S
D
S
R
S
P
G
Site 55
S762
S
P
V
R
E
R
T
S
D
S
R
S
P
G
D
Site 56
S764
V
R
E
R
T
S
D
S
R
S
P
G
D
L
E
Site 57
S766
E
R
T
S
D
S
R
S
P
G
D
L
E
P
S
Site 58
S773
S
P
G
D
L
E
P
S
H
H
P
S
A
F
E
Site 59
S777
L
E
P
S
H
H
P
S
A
F
E
T
E
T
S
Site 60
T781
H
H
P
S
A
F
E
T
E
T
S
S
D
W
D
Site 61
S784
S
A
F
E
T
E
T
S
S
D
W
D
P
P
A
Site 62
S785
A
F
E
T
E
T
S
S
D
W
D
P
P
A
E
Site 63
S793
D
W
D
P
P
A
E
S
Q
E
R
A
S
P
S
Site 64
S798
A
E
S
Q
E
R
A
S
P
S
R
P
A
T
P
Site 65
S800
S
Q
E
R
A
S
P
S
R
P
A
T
P
A
P
Site 66
T804
A
S
P
S
R
P
A
T
P
A
P
V
L
G
K
Site 67
S820
L
V
K
G
L
H
D
S
Q
R
L
Q
W
E
V
Site 68
S828
Q
R
L
Q
W
E
V
S
F
E
L
G
T
P
G
Site 69
T833
E
V
S
F
E
L
G
T
P
G
P
E
R
G
G
Site 70
S848
A
Q
D
A
D
L
W
S
E
T
F
H
H
L
A
Site 71
T850
D
A
D
L
W
S
E
T
F
H
H
L
A
A
R
Site 72
S877
E
G
E
I
E
Q
G
S
N
R
R
Y
Q
V
S
Site 73
Y881
E
Q
G
S
N
R
R
Y
Q
V
S
A
L
H
T
Site 74
S884
S
N
R
R
Y
Q
V
S
A
L
H
T
S
K
A
Site 75
Y911
V
D
V
S
K
S
R
Y
L
P
T
V
V
E
Y
Site 76
T914
S
K
S
R
Y
L
P
T
V
V
E
Y
P
N
S
Site 77
T939
L
A
Q
Q
W
R
G
T
S
S
G
F
G
R
P
Site 78
S940
A
Q
Q
W
R
G
T
S
S
G
F
G
R
P
Q
Site 79
S941
Q
Q
W
R
G
T
S
S
G
F
G
R
P
Q
T
Site 80
T948
S
G
F
G
R
P
Q
T
M
L
G
E
D
S
A
Site 81
S954
Q
T
M
L
G
E
D
S
A
P
G
N
G
K
F
Site 82
S969
Q
A
L
N
M
E
A
S
P
T
A
L
F
S
E
Site 83
T971
L
N
M
E
A
S
P
T
A
L
F
S
E
A
R
Site 84
S975
A
S
P
T
A
L
F
S
E
A
R
S
P
G
R
Site 85
S979
A
L
F
S
E
A
R
S
P
G
R
E
K
H
G
Site 86
S988
G
R
E
K
H
G
A
S
E
G
P
Q
R
S
L
Site 87
S994
A
S
E
G
P
Q
R
S
L
A
T
N
T
L
S
Site 88
T997
G
P
Q
R
S
L
A
T
N
T
L
S
S
M
K
Site 89
T999
Q
R
S
L
A
T
N
T
L
S
S
M
K
A
S
Site 90
S1001
S
L
A
T
N
T
L
S
S
M
K
A
S
E
N
Site 91
S1002
L
A
T
N
T
L
S
S
M
K
A
S
E
N
L
Site 92
S1006
T
L
S
S
M
K
A
S
E
N
L
F
G
S
W
Site 93
S1012
A
S
E
N
L
F
G
S
W
L
N
L
N
K
S
Site 94
S1019
S
W
L
N
L
N
K
S
R
L
L
T
R
A
A
Site 95
T1023
L
N
K
S
R
L
L
T
R
A
A
K
G
F
L
Site 96
S1040
P
L
I
K
A
V
E
S
T
S
G
N
Q
S
F
Site 97
S1042
I
K
A
V
E
S
T
S
G
N
Q
S
F
D
Y
Site 98
S1046
E
S
T
S
G
N
Q
S
F
D
Y
I
P
L
V
Site 99
Y1049
S
G
N
Q
S
F
D
Y
I
P
L
V
S
L
Q
Site 100
T1086
L
K
W
T
S
P
F
T
C
H
R
V
S
L
T
Site 101
S1091
P
F
T
C
H
R
V
S
L
T
T
R
P
S
E
Site 102
T1093
T
C
H
R
V
S
L
T
T
R
P
S
E
S
K
Site 103
T1094
C
H
R
V
S
L
T
T
R
P
S
E
S
K
T
Site 104
S1097
V
S
L
T
T
R
P
S
E
S
K
T
P
S
P
Site 105
S1099
L
T
T
R
P
S
E
S
K
T
P
S
P
Q
L
Site 106
T1101
T
R
P
S
E
S
K
T
P
S
P
Q
L
C
T
Site 107
S1103
P
S
E
S
K
T
P
S
P
Q
L
C
T
S
S
Site 108
T1108
T
P
S
P
Q
L
C
T
S
S
P
P
R
H
P
Site 109
S1109
P
S
P
Q
L
C
T
S
S
P
P
R
H
P
S
Site 110
S1110
S
P
Q
L
C
T
S
S
P
P
R
H
P
S
C
Site 111
S1116
S
S
P
P
R
H
P
S
C
D
S
F
S
L
E
Site 112
S1119
P
R
H
P
S
C
D
S
F
S
L
E
P
L
A
Site 113
S1121
H
P
S
C
D
S
F
S
L
E
P
L
A
K
G
Site 114
Y1161
L
E
H
S
S
A
S
Y
F
T
E
W
E
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation