KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ZNF658
Full Name:
Zinc finger protein 658
Alias:
Type:
Mass (Da):
122274
Number AA:
1059
UniProt ID:
Q5TYW1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
N
M
S
Q
A
S
V
S
F
Q
D
V
T
V
E
Site 2
T14
S
V
S
F
Q
D
V
T
V
E
F
T
R
E
E
Site 3
Y33
G
P
V
E
R
T
L
Y
R
D
V
M
L
E
N
Site 4
Y41
R
D
V
M
L
E
N
Y
S
H
L
I
S
V
G
Site 5
S68
E
K
G
E
E
P
W
S
L
E
D
E
F
L
N
Site 6
Y78
D
E
F
L
N
Q
R
Y
P
G
Y
F
K
V
D
Site 7
Y81
L
N
Q
R
Y
P
G
Y
F
K
V
D
H
I
K
Site 8
S105
L
W
Q
E
I
F
I
S
D
A
D
K
T
L
S
Site 9
T110
F
I
S
D
A
D
K
T
L
S
K
E
G
Q
K
Site 10
S112
S
D
A
D
K
T
L
S
K
E
G
Q
K
V
L
Site 11
S132
L
E
I
A
P
E
L
S
E
K
I
S
C
K
C
Site 12
S136
P
E
L
S
E
K
I
S
C
K
C
D
S
H
R
Site 13
S150
R
M
N
L
P
V
A
S
Q
L
I
I
S
E
R
Site 14
S155
V
A
S
Q
L
I
I
S
E
R
K
Y
S
R
K
Site 15
Y159
L
I
I
S
E
R
K
Y
S
R
K
K
T
E
Y
Site 16
S160
I
I
S
E
R
K
Y
S
R
K
K
T
E
Y
M
Site 17
T164
R
K
Y
S
R
K
K
T
E
Y
M
N
V
C
E
Site 18
Y166
Y
S
R
K
K
T
E
Y
M
N
V
C
E
K
L
Site 19
S188
K
A
H
A
E
E
K
S
Y
E
H
G
E
N
A
Site 20
Y189
A
H
A
E
E
K
S
Y
E
H
G
E
N
A
K
Site 21
T210
D
Q
H
W
K
F
Q
T
L
E
E
S
F
E
C
Site 22
S214
K
F
Q
T
L
E
E
S
F
E
C
D
G
S
G
Site 23
S220
E
S
F
E
C
D
G
S
G
Q
G
L
Y
D
K
Site 24
Y225
D
G
S
G
Q
G
L
Y
D
K
T
I
C
I
T
Site 25
T228
G
Q
G
L
Y
D
K
T
I
C
I
T
P
Q
S
Site 26
T232
Y
D
K
T
I
C
I
T
P
Q
S
F
L
T
G
Site 27
S235
T
I
C
I
T
P
Q
S
F
L
T
G
E
K
S
Site 28
T238
I
T
P
Q
S
F
L
T
G
E
K
S
C
K
D
Site 29
S242
S
F
L
T
G
E
K
S
C
K
D
D
E
F
R
Site 30
T265
F
N
H
M
R
T
D
T
R
G
K
C
S
D
L
Site 31
Y275
K
C
S
D
L
N
E
Y
G
T
S
C
D
K
T
Site 32
T277
S
D
L
N
E
Y
G
T
S
C
D
K
T
T
A
Site 33
S278
D
L
N
E
Y
G
T
S
C
D
K
T
T
A
V
Site 34
T282
Y
G
T
S
C
D
K
T
T
A
V
E
Y
N
K
Site 35
Y297
V
H
M
A
M
T
H
Y
E
C
N
E
R
G
I
Site 36
S307
N
E
R
G
I
N
F
S
R
K
S
P
L
T
Q
Site 37
S310
G
I
N
F
S
R
K
S
P
L
T
Q
S
Q
R
Site 38
T313
F
S
R
K
S
P
L
T
Q
S
Q
R
T
I
T
Site 39
S315
R
K
S
P
L
T
Q
S
Q
R
T
I
T
G
W
Site 40
T320
T
Q
S
Q
R
T
I
T
G
W
S
A
F
E
S
Site 41
S335
N
K
C
E
E
N
F
S
Q
S
S
A
H
I
V
Site 42
T346
A
H
I
V
H
Q
K
T
Q
A
G
D
K
F
G
Site 43
Y363
N
E
C
T
D
A
L
Y
Q
K
L
D
F
T
A
Site 44
T376
T
A
H
Q
R
I
H
T
E
D
K
F
Y
L
S
Site 45
Y381
I
H
T
E
D
K
F
Y
L
S
D
E
H
G
K
Site 46
S383
T
E
D
K
F
Y
L
S
D
E
H
G
K
C
R
Site 47
S392
E
H
G
K
C
R
K
S
F
Y
R
K
A
H
L
Site 48
S407
I
Q
H
Q
R
P
H
S
G
E
K
T
Y
Q
Y
Site 49
T411
R
P
H
S
G
E
K
T
Y
Q
Y
E
E
C
A
Site 50
Y414
S
G
E
K
T
Y
Q
Y
E
E
C
A
K
S
F
Site 51
S420
Q
Y
E
E
C
A
K
S
F
C
S
S
S
H
P
Site 52
S424
C
A
K
S
F
C
S
S
S
H
P
I
Q
H
P
Site 53
S425
A
K
S
F
C
S
S
S
H
P
I
Q
H
P
G
Site 54
T433
H
P
I
Q
H
P
G
T
Y
V
G
F
K
L
Y
Site 55
Y434
P
I
Q
H
P
G
T
Y
V
G
F
K
L
Y
E
Site 56
Y440
T
Y
V
G
F
K
L
Y
E
C
N
E
C
G
K
Site 57
S453
G
K
A
F
C
Q
N
S
N
L
S
K
H
L
R
Site 58
T463
S
K
H
L
R
I
H
T
K
E
K
P
C
D
N
Site 59
S476
D
N
N
G
C
G
R
S
Y
K
S
P
L
I
G
Site 60
Y477
N
N
G
C
G
R
S
Y
K
S
P
L
I
G
H
Site 61
S479
G
C
G
R
S
Y
K
S
P
L
I
G
H
Q
K
Site 62
T487
P
L
I
G
H
Q
K
T
D
A
E
M
E
L
C
Site 63
Y499
E
L
C
G
G
S
E
Y
G
K
T
S
H
L
K
Site 64
T502
G
G
S
E
Y
G
K
T
S
H
L
K
G
H
Q
Site 65
S503
G
S
E
Y
G
K
T
S
H
L
K
G
H
Q
R
Site 66
Y518
I
L
M
G
E
K
P
Y
E
C
I
E
C
G
K
Site 67
T526
E
C
I
E
C
G
K
T
F
S
K
T
S
H
L
Site 68
S528
I
E
C
G
K
T
F
S
K
T
S
H
L
R
A
Site 69
T530
C
G
K
T
F
S
K
T
S
H
L
R
A
H
Q
Site 70
S531
G
K
T
F
S
K
T
S
H
L
R
A
H
Q
R
Site 71
T541
R
A
H
Q
R
I
H
T
G
E
K
P
Y
E
C
Site 72
Y546
I
H
T
G
E
K
P
Y
E
C
V
E
C
E
K
Site 73
S556
V
E
C
E
K
T
F
S
H
K
T
H
L
S
V
Site 74
T559
E
K
T
F
S
H
K
T
H
L
S
V
H
Q
R
Site 75
T569
S
V
H
Q
R
V
H
T
G
E
K
P
Y
E
C
Site 76
Y574
V
H
T
G
E
K
P
Y
E
C
N
D
C
G
K
Site 77
S587
G
K
S
F
T
Y
N
S
A
L
R
A
H
Q
R
Site 78
S605
G
E
K
P
Y
E
C
S
D
C
E
K
T
F
A
Site 79
T610
E
C
S
D
C
E
K
T
F
A
H
N
S
A
L
Site 80
S615
E
K
T
F
A
H
N
S
A
L
R
A
H
H
R
Site 81
T625
R
A
H
H
R
I
H
T
G
E
K
P
Y
E
C
Site 82
Y630
I
H
T
G
E
K
P
Y
E
C
N
E
C
G
R
Site 83
S643
G
R
S
F
A
H
I
S
V
L
K
A
H
Q
R
Site 84
T653
K
A
H
Q
R
I
H
T
G
E
K
P
Y
E
C
Site 85
T668
N
E
C
G
R
S
F
T
Y
N
S
A
L
R
A
Site 86
S671
G
R
S
F
T
Y
N
S
A
L
R
A
H
Q
R
Site 87
T681
R
A
H
Q
R
I
H
T
G
R
K
P
Y
E
C
Site 88
Y686
I
H
T
G
R
K
P
Y
E
C
S
D
C
E
K
Site 89
S689
G
R
K
P
Y
E
C
S
D
C
E
K
T
F
A
Site 90
S699
E
K
T
F
A
H
N
S
A
L
K
I
H
Q
R
Site 91
T709
K
I
H
Q
R
I
H
T
G
E
K
P
Y
E
C
Site 92
Y714
I
H
T
G
E
K
P
Y
E
C
N
E
C
E
K
Site 93
S727
E
K
T
F
A
H
N
S
A
L
R
A
H
Q
N
Site 94
Y742
I
H
T
G
E
K
L
Y
E
C
S
E
C
G
K
Site 95
T750
E
C
S
E
C
G
K
T
F
F
Q
K
T
R
L
Site 96
T755
G
K
T
F
F
Q
K
T
R
L
S
T
H
R
R
Site 97
S758
F
F
Q
K
T
R
L
S
T
H
R
R
I
H
T
Site 98
T759
F
Q
K
T
R
L
S
T
H
R
R
I
H
T
G
Site 99
T765
S
T
H
R
R
I
H
T
G
E
K
P
Y
E
C
Site 100
Y770
I
H
T
G
E
K
P
Y
E
C
S
K
C
G
K
Site 101
S773
G
E
K
P
Y
E
C
S
K
C
G
K
T
F
S
Site 102
T778
E
C
S
K
C
G
K
T
F
S
Q
K
S
Y
L
Site 103
S780
S
K
C
G
K
T
F
S
Q
K
S
Y
L
S
G
Site 104
S783
G
K
T
F
S
Q
K
S
Y
L
S
G
H
E
R
Site 105
Y784
K
T
F
S
Q
K
S
Y
L
S
G
H
E
R
I
Site 106
S786
F
S
Q
K
S
Y
L
S
G
H
E
R
I
H
T
Site 107
T793
S
G
H
E
R
I
H
T
G
E
K
P
Y
E
C
Site 108
Y798
I
H
T
G
E
K
P
Y
E
C
N
V
C
G
K
Site 109
T821
I
V
H
Q
R
I
H
T
G
E
K
P
Y
E
C
Site 110
Y826
I
H
T
G
E
K
P
Y
E
C
N
Q
C
G
K
Site 111
T849
C
A
H
Q
R
I
H
T
G
E
K
P
Y
E
C
Site 112
Y854
I
H
T
G
E
K
P
Y
E
C
N
E
C
G
K
Site 113
T862
E
C
N
E
C
G
K
T
F
A
D
N
S
A
L
Site 114
S867
G
K
T
F
A
D
N
S
A
L
R
A
H
H
R
Site 115
Y882
I
H
T
G
E
K
P
Y
E
C
N
D
C
G
K
Site 116
T890
E
C
N
D
C
G
K
T
F
S
K
T
S
H
L
Site 117
S892
N
D
C
G
K
T
F
S
K
T
S
H
L
R
A
Site 118
T894
C
G
K
T
F
S
K
T
S
H
L
R
A
H
L
Site 119
S895
G
K
T
F
S
K
T
S
H
L
R
A
H
L
R
Site 120
T903
H
L
R
A
H
L
R
T
R
S
G
E
K
P
Y
Site 121
S905
R
A
H
L
R
T
R
S
G
E
K
P
Y
E
C
Site 122
Y910
T
R
S
G
E
K
P
Y
E
C
S
E
C
G
K
Site 123
S913
G
E
K
P
Y
E
C
S
E
C
G
K
T
F
S
Site 124
T918
E
C
S
E
C
G
K
T
F
S
E
K
S
Y
V
Site 125
S920
S
E
C
G
K
T
F
S
E
K
S
Y
V
S
A
Site 126
S923
G
K
T
F
S
E
K
S
Y
V
S
A
H
Q
R
Site 127
Y924
K
T
F
S
E
K
S
Y
V
S
A
H
Q
R
V
Site 128
T933
S
A
H
Q
R
V
H
T
G
E
K
P
Y
E
C
Site 129
Y938
V
H
T
G
E
K
P
Y
E
C
N
V
C
G
K
Site 130
S951
G
K
P
F
A
H
N
S
T
L
R
V
H
Q
R
Site 131
T952
K
P
F
A
H
N
S
T
L
R
V
H
Q
R
I
Site 132
T961
R
V
H
Q
R
I
H
T
G
E
K
S
Y
E
C
Site 133
Y966
I
H
T
G
E
K
S
Y
E
C
N
D
C
G
K
Site 134
T974
E
C
N
D
C
G
K
T
F
S
Q
K
S
H
L
Site 135
S976
N
D
C
G
K
T
F
S
Q
K
S
H
L
S
A
Site 136
S979
G
K
T
F
S
Q
K
S
H
L
S
A
H
Q
R
Site 137
S982
F
S
Q
K
S
H
L
S
A
H
Q
R
I
H
T
Site 138
T989
S
A
H
Q
R
I
H
T
G
E
K
P
Y
E
C
Site 139
S1007
G
K
A
F
A
Q
N
S
T
L
R
V
H
Q
R
Site 140
T1008
K
A
F
A
Q
N
S
T
L
R
V
H
Q
R
I
Site 141
T1017
R
V
H
Q
R
I
H
T
G
E
K
P
Y
E
C
Site 142
Y1022
I
H
T
G
E
K
P
Y
E
C
D
E
C
G
K
Site 143
T1030
E
C
D
E
C
G
K
T
F
V
R
K
A
A
L
Site 144
T1046
V
H
H
T
R
M
H
T
R
E
K
T
L
A
C
Site 145
T1050
R
M
H
T
R
E
K
T
L
A
C
N
G
F
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation