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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CROCC
Full Name:
Rootletin
Alias:
Ciliary rootlet coiled-coil, rootletin; ROLT; Rootletin; Rootletin, ciliary rootlet protein
Type:
Mass (Da):
228523
Number AA:
2017
UniProt ID:
Q5TZA2
International Prot ID:
IPI00456492
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005814
GO:0035253
Uniprot
OncoNet
Molecular Function:
GO:0019894
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0030030
GO:0051297
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
R
A
Q
E
V
E
L
T
L
E
T
V
I
Q
T
Site 2
S46
A
Q
D
A
Q
I
T
S
L
P
A
L
I
R
E
Site 3
S60
E
I
V
T
R
N
L
S
Q
P
E
S
P
V
L
Site 4
S64
R
N
L
S
Q
P
E
S
P
V
L
L
P
A
T
Site 5
S78
T
E
M
A
S
L
L
S
L
Q
E
E
N
Q
L
Site 6
S91
Q
L
L
Q
Q
E
L
S
R
V
E
D
L
L
A
Site 7
Y111
R
D
E
L
A
I
K
Y
N
A
V
S
E
R
L
Site 8
S115
A
I
K
Y
N
A
V
S
E
R
L
E
Q
A
L
Site 9
T131
L
E
P
G
E
L
E
T
Q
E
P
R
G
L
V
Site 10
S141
P
R
G
L
V
R
Q
S
V
E
L
R
R
Q
L
Site 11
S154
Q
L
Q
E
E
Q
A
S
Y
R
R
K
L
Q
A
Site 12
Y155
L
Q
E
E
Q
A
S
Y
R
R
K
L
Q
A
Y
Site 13
Y162
Y
R
R
K
L
Q
A
Y
Q
E
G
Q
Q
R
Q
Site 14
Y183
L
Q
G
K
I
L
Q
Y
K
K
R
C
S
E
L
Site 15
S188
L
Q
Y
K
K
R
C
S
E
L
E
Q
Q
L
L
Site 16
T209
E
Q
Q
R
L
R
D
T
E
H
S
Q
D
L
E
Site 17
S212
R
L
R
D
T
E
H
S
Q
D
L
E
S
A
L
Site 18
S231
E
E
Q
Q
R
S
A
S
L
A
Q
V
N
A
M
Site 19
S248
E
Q
L
D
Q
A
G
S
A
N
Q
A
L
S
E
Site 20
T261
S
E
D
I
R
K
V
T
N
D
W
T
R
C
R
Site 21
T265
R
K
V
T
N
D
W
T
R
C
R
K
E
L
E
Site 22
S284
A
W
R
R
E
E
E
S
F
N
A
Y
F
S
N
Site 23
Y288
E
E
E
S
F
N
A
Y
F
S
N
E
H
S
R
Site 24
S290
E
S
F
N
A
Y
F
S
N
E
H
S
R
L
L
Site 25
S294
A
Y
F
S
N
E
H
S
R
L
L
L
L
W
R
Site 26
T317
V
S
E
V
K
M
F
T
E
R
D
L
L
Q
L
Site 27
T331
L
G
G
E
L
A
R
T
S
R
A
V
Q
E
A
Site 28
S332
G
G
E
L
A
R
T
S
R
A
V
Q
E
A
G
Site 29
S396
D
L
D
K
A
D
L
S
A
R
V
T
E
L
G
Site 30
T400
A
D
L
S
A
R
V
T
E
L
G
L
A
V
K
Site 31
T424
D
Q
V
N
K
D
L
T
E
K
L
E
A
L
E
Site 32
S432
E
K
L
E
A
L
E
S
L
R
L
Q
E
Q
A
Site 33
T452
D
G
E
G
L
Q
Q
T
L
R
D
L
A
Q
A
Site 34
S462
D
L
A
Q
A
V
L
S
D
S
E
S
G
V
Q
Site 35
S464
A
Q
A
V
L
S
D
S
E
S
G
V
Q
L
S
Site 36
S466
A
V
L
S
D
S
E
S
G
V
Q
L
S
G
S
Site 37
S471
S
E
S
G
V
Q
L
S
G
S
E
R
T
A
D
Site 38
S473
S
G
V
Q
L
S
G
S
E
R
T
A
D
A
S
Site 39
S480
S
E
R
T
A
D
A
S
N
G
S
L
R
G
L
Site 40
S483
T
A
D
A
S
N
G
S
L
R
G
L
S
G
Q
Site 41
S488
N
G
S
L
R
G
L
S
G
Q
R
T
P
S
P
Site 42
T492
R
G
L
S
G
Q
R
T
P
S
P
P
R
R
S
Site 43
S494
L
S
G
Q
R
T
P
S
P
P
R
R
S
S
P
Site 44
S499
T
P
S
P
P
R
R
S
S
P
G
R
G
R
S
Site 45
S500
P
S
P
P
R
R
S
S
P
G
R
G
R
S
P
Site 46
S506
S
S
P
G
R
G
R
S
P
R
R
G
P
S
P
Site 47
S512
R
S
P
R
R
G
P
S
P
A
C
S
D
S
S
Site 48
S516
R
G
P
S
P
A
C
S
D
S
S
T
L
A
L
Site 49
Y542
V
Q
D
M
R
G
R
Y
E
A
S
Q
D
L
L
Site 50
S545
M
R
G
R
Y
E
A
S
Q
D
L
L
G
T
L
Site 51
T551
A
S
Q
D
L
L
G
T
L
R
K
Q
L
S
D
Site 52
S557
G
T
L
R
K
Q
L
S
D
S
E
S
E
R
R
Site 53
S559
L
R
K
Q
L
S
D
S
E
S
E
R
R
A
L
Site 54
S561
K
Q
L
S
D
S
E
S
E
R
R
A
L
E
E
Site 55
T577
L
Q
R
L
R
D
K
T
D
G
A
M
Q
A
H
Site 56
S596
R
E
V
Q
R
L
R
S
A
N
E
L
L
S
R
Site 57
S602
R
S
A
N
E
L
L
S
R
E
K
S
N
L
A
Site 58
S606
E
L
L
S
R
E
K
S
N
L
A
H
S
L
Q
Site 59
S664
V
R
R
E
L
E
R
S
H
R
Q
L
E
Q
L
Site 60
S676
E
Q
L
E
G
K
R
S
V
L
A
K
E
L
V
Site 61
T693
R
E
A
L
S
R
A
T
L
Q
R
D
M
L
Q
Site 62
S723
G
R
V
E
L
E
L
S
M
T
K
L
R
A
E
Site 63
T725
V
E
L
E
L
S
M
T
K
L
R
A
E
E
A
Site 64
S733
K
L
R
A
E
E
A
S
L
Q
D
S
L
S
K
Site 65
S737
E
E
A
S
L
Q
D
S
L
S
K
L
S
A
L
Site 66
S739
A
S
L
Q
D
S
L
S
K
L
S
A
L
N
E
Site 67
S767
A
Q
L
E
E
E
K
S
A
L
Q
G
R
Q
R
Site 68
T781
R
Q
A
E
Q
E
A
T
V
A
R
E
E
Q
E
Site 69
S807
A
R
Q
G
L
E
G
S
L
R
V
A
E
Q
A
Site 70
S830
P
T
L
R
H
E
R
S
Q
L
Q
E
Q
L
A
Site 71
S840
Q
E
Q
L
A
Q
L
S
R
Q
L
S
G
R
E
Site 72
S844
A
Q
L
S
R
Q
L
S
G
R
E
Q
E
L
E
Site 73
S896
E
R
E
G
R
T
L
S
E
E
A
T
R
L
R
Site 74
T900
R
T
L
S
E
E
A
T
R
L
R
L
E
K
E
Site 75
S983
A
E
R
E
A
Q
A
S
L
R
E
Q
R
A
A
Site 76
S1018
A
E
R
A
Q
L
Q
S
Q
L
Q
R
E
Q
E
Site 77
S1039
E
A
E
K
E
E
L
S
E
E
I
A
A
L
Q
Site 78
S1058
E
G
L
L
L
A
E
S
E
K
Q
Q
A
L
S
Site 79
S1065
S
E
K
Q
Q
A
L
S
L
K
E
S
E
K
T
Site 80
S1069
Q
A
L
S
L
K
E
S
E
K
T
A
L
S
E
Site 81
T1072
S
L
K
E
S
E
K
T
A
L
S
E
K
L
M
Site 82
S1075
E
S
E
K
T
A
L
S
E
K
L
M
G
T
R
Site 83
S1084
K
L
M
G
T
R
H
S
L
A
T
I
S
L
E
Site 84
T1087
G
T
R
H
S
L
A
T
I
S
L
E
M
E
R
Site 85
S1108
S
R
Q
E
Q
D
R
S
T
V
N
A
L
T
S
Site 86
T1109
R
Q
E
Q
D
R
S
T
V
N
A
L
T
S
E
Site 87
S1151
D
L
G
K
Q
R
D
S
C
L
R
E
A
E
E
Site 88
T1161
R
E
A
E
E
L
R
T
Q
L
R
L
L
E
D
Site 89
S1187
A
Q
R
K
L
R
E
S
Q
E
G
R
E
V
Q
Site 90
S1204
E
A
G
E
L
R
R
S
L
G
E
G
A
K
E
Site 91
S1218
E
R
E
A
L
R
R
S
N
E
E
L
R
S
A
Site 92
S1224
R
S
N
E
E
L
R
S
A
V
K
K
A
E
S
Site 93
S1231
S
A
V
K
K
A
E
S
E
R
I
S
L
K
L
Site 94
S1235
K
A
E
S
E
R
I
S
L
K
L
A
N
E
D
Site 95
T1255
A
L
L
E
E
A
R
T
A
V
G
K
E
A
G
Site 96
S1274
G
L
Q
E
V
E
R
S
R
L
E
A
R
R
E
Site 97
S1294
R
Q
M
K
M
L
D
S
E
N
T
R
L
G
R
Site 98
S1320
G
E
R
A
E
K
E
S
R
R
E
T
L
G
L
Site 99
T1324
E
K
E
S
R
R
E
T
L
G
L
R
Q
R
L
Site 100
S1337
R
L
L
K
G
E
A
S
L
E
V
M
R
Q
E
Site 101
S1369
R
E
R
R
L
L
G
S
L
E
E
A
R
G
T
Site 102
T1376
S
L
E
E
A
R
G
T
E
K
Q
Q
L
D
H
Site 103
S1406
A
E
L
G
L
R
L
S
A
A
E
G
R
A
Q
Site 104
S1438
A
Q
L
G
G
L
R
S
A
L
R
R
G
L
G
Site 105
S1451
L
G
L
G
R
A
P
S
P
A
P
R
P
V
P
Site 106
S1460
A
P
R
P
V
P
G
S
P
A
R
D
A
P
A
Site 107
S1470
R
D
A
P
A
E
G
S
G
E
G
L
N
S
P
Site 108
S1476
G
S
G
E
G
L
N
S
P
S
T
L
E
C
S
Site 109
S1478
G
E
G
L
N
S
P
S
T
L
E
C
S
P
G
Site 110
T1479
E
G
L
N
S
P
S
T
L
E
C
S
P
G
S
Site 111
S1483
S
P
S
T
L
E
C
S
P
G
S
Q
P
P
S
Site 112
S1486
T
L
E
C
S
P
G
S
Q
P
P
S
P
G
P
Site 113
S1490
S
P
G
S
Q
P
P
S
P
G
P
A
T
S
P
Site 114
T1495
P
P
S
P
G
P
A
T
S
P
A
S
P
D
L
Site 115
S1496
P
S
P
G
P
A
T
S
P
A
S
P
D
L
D
Site 116
S1499
G
P
A
T
S
P
A
S
P
D
L
D
P
E
A
Site 117
S1520
E
F
L
Q
E
L
R
S
A
Q
R
E
R
D
E
Site 118
T1530
R
E
R
D
E
L
R
T
Q
T
S
A
L
N
R
Site 119
T1532
R
D
E
L
R
T
Q
T
S
A
L
N
R
Q
L
Site 120
S1548
E
M
E
A
E
R
D
S
A
T
S
R
A
R
Q
Site 121
T1550
E
A
E
R
D
S
A
T
S
R
A
R
Q
L
Q
Site 122
S1551
A
E
R
D
S
A
T
S
R
A
R
Q
L
Q
K
Site 123
S1569
E
S
E
E
A
R
R
S
V
D
G
R
L
S
G
Site 124
S1575
R
S
V
D
G
R
L
S
G
V
Q
A
E
L
A
Site 125
S1587
E
L
A
L
Q
E
E
S
V
R
R
S
E
R
E
Site 126
S1591
Q
E
E
S
V
R
R
S
E
R
E
R
R
A
T
Site 127
T1598
S
E
R
E
R
R
A
T
L
D
Q
V
A
T
L
Site 128
T1604
A
T
L
D
Q
V
A
T
L
E
R
S
L
Q
A
Site 129
T1612
L
E
R
S
L
Q
A
T
E
S
E
L
R
A
S
Site 130
S1614
R
S
L
Q
A
T
E
S
E
L
R
A
S
Q
E
Site 131
S1619
T
E
S
E
L
R
A
S
Q
E
K
I
S
K
M
Site 132
S1647
L
K
E
V
L
D
A
S
E
S
R
T
V
K
L
Site 133
S1649
E
V
L
D
A
S
E
S
R
T
V
K
L
E
L
Site 134
T1651
L
D
A
S
E
S
R
T
V
K
L
E
L
Q
R
Site 135
S1660
K
L
E
L
Q
R
R
S
L
E
G
E
L
Q
R
Site 136
S1668
L
E
G
E
L
Q
R
S
R
L
G
L
S
D
R
Site 137
S1673
Q
R
S
R
L
G
L
S
D
R
E
A
Q
A
Q
Site 138
S1688
A
L
Q
D
R
V
D
S
L
Q
R
Q
V
A
D
Site 139
S1696
L
Q
R
Q
V
A
D
S
E
V
K
A
G
T
L
Site 140
T1706
K
A
G
T
L
Q
L
T
V
E
R
L
N
G
A
Site 141
T1732
R
D
K
V
R
G
L
T
E
A
L
A
Q
S
S
Site 142
S1741
A
L
A
Q
S
S
A
S
L
N
S
T
R
D
K
Site 143
S1744
Q
S
S
A
S
L
N
S
T
R
D
K
N
L
H
Site 144
T1745
S
S
A
S
L
N
S
T
R
D
K
N
L
H
L
Site 145
T1757
L
H
L
Q
K
A
L
T
A
C
E
H
D
R
Q
Site 146
S1778
D
A
A
R
Q
A
L
S
E
A
R
K
Q
S
S
Site 147
S1784
L
S
E
A
R
K
Q
S
S
S
L
G
E
Q
V
Site 148
S1786
E
A
R
K
Q
S
S
S
L
G
E
Q
V
Q
T
Site 149
T1793
S
L
G
E
Q
V
Q
T
L
R
G
E
V
A
D
Site 150
T1832
G
E
A
A
A
L
N
T
V
Q
K
L
Q
D
E
Site 151
S1849
L
L
Q
E
R
L
G
S
L
Q
R
A
L
A
Q
Site 152
S1867
E
K
R
E
V
E
R
S
A
L
R
L
E
K
D
Site 153
T1881
D
R
V
A
L
R
R
T
L
D
K
V
E
R
E
Site 154
S1892
V
E
R
E
K
L
R
S
H
E
D
T
V
R
L
Site 155
T1896
K
L
R
S
H
E
D
T
V
R
L
S
A
E
K
Site 156
S1900
H
E
D
T
V
R
L
S
A
E
K
G
R
L
D
Site 157
T1909
E
K
G
R
L
D
R
T
L
T
G
A
E
L
E
Site 158
T1911
G
R
L
D
R
T
L
T
G
A
E
L
E
L
A
Site 159
S1939
V
V
L
E
Q
S
H
S
P
A
Q
L
E
V
D
Site 160
S1963
Q
E
V
E
R
L
R
S
A
Q
A
Q
T
E
R
Site 161
S1991
R
G
L
E
E
Q
V
S
T
L
K
G
Q
L
Q
Site 162
T1992
G
L
E
E
Q
V
S
T
L
K
G
Q
L
Q
Q
Site 163
S2004
L
Q
Q
E
L
R
R
S
S
A
P
F
S
P
P
Site 164
S2005
Q
Q
E
L
R
R
S
S
A
P
F
S
P
P
S
Site 165
S2009
R
R
S
S
A
P
F
S
P
P
S
G
P
P
E
Site 166
S2012
S
A
P
F
S
P
P
S
G
P
P
E
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation