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Updated November 2019
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Protein Info
Short Name:
FAM75A1
Full Name:
Protein FAM75A1
Alias:
Type:
Mass (Da):
148561
Number AA:
1347
UniProt ID:
Q5TZJ5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
L
K
L
L
S
A
S
S
L
N
A
P
S
S
Site 2
S20
A
S
S
L
N
A
P
S
S
T
P
W
V
L
D
Site 3
S21
S
S
L
N
A
P
S
S
T
P
W
V
L
D
I
Site 4
Y48
L
L
L
P
Y
L
S
Y
F
R
C
D
D
P
P
Site 5
S56
F
R
C
D
D
P
P
S
P
S
P
G
K
R
K
Site 6
S58
C
D
D
P
P
S
P
S
P
G
K
R
K
C
P
Site 7
S80
R
G
R
M
K
N
H
S
L
R
A
G
R
E
C
Site 8
T94
C
P
R
G
L
Q
E
T
S
D
L
L
S
Q
L
Site 9
S95
P
R
G
L
Q
E
T
S
D
L
L
S
Q
L
Q
Site 10
S99
Q
E
T
S
D
L
L
S
Q
L
Q
S
L
L
G
Site 11
S103
D
L
L
S
Q
L
Q
S
L
L
G
P
H
L
D
Site 12
S118
K
G
D
F
G
Q
L
S
G
P
D
P
P
G
E
Site 13
S135
E
R
A
P
D
G
A
S
Q
S
S
H
E
P
M
Site 14
S137
A
P
D
G
A
S
Q
S
S
H
E
P
M
E
D
Site 15
S150
E
D
A
A
P
I
L
S
P
L
A
S
P
D
P
Site 16
S154
P
I
L
S
P
L
A
S
P
D
P
Q
A
K
H
Site 17
S167
K
H
P
Q
D
L
A
S
T
P
S
P
G
P
M
Site 18
T168
H
P
Q
D
L
A
S
T
P
S
P
G
P
M
T
Site 19
S170
Q
D
L
A
S
T
P
S
P
G
P
M
T
T
S
Site 20
T175
T
P
S
P
G
P
M
T
T
S
V
S
S
L
S
Site 21
T176
P
S
P
G
P
M
T
T
S
V
S
S
L
S
A
Site 22
S177
S
P
G
P
M
T
T
S
V
S
S
L
S
A
S
Site 23
S179
G
P
M
T
T
S
V
S
S
L
S
A
S
Q
P
Site 24
S180
P
M
T
T
S
V
S
S
L
S
A
S
Q
P
P
Site 25
S182
T
T
S
V
S
S
L
S
A
S
Q
P
P
E
P
Site 26
S184
S
V
S
S
L
S
A
S
Q
P
P
E
P
S
L
Site 27
S190
A
S
Q
P
P
E
P
S
L
P
L
E
H
P
S
Site 28
S197
S
L
P
L
E
H
P
S
P
E
P
P
A
L
F
Site 29
T210
L
F
P
H
P
P
H
T
P
D
P
L
A
C
S
Site 30
S217
T
P
D
P
L
A
C
S
P
P
P
P
K
G
F
Site 31
T225
P
P
P
P
K
G
F
T
A
P
P
L
R
D
S
Site 32
S232
T
A
P
P
L
R
D
S
T
L
I
T
P
S
H
Site 33
T233
A
P
P
L
R
D
S
T
L
I
T
P
S
H
C
Site 34
T236
L
R
D
S
T
L
I
T
P
S
H
C
D
S
V
Site 35
S253
P
L
G
T
V
P
Q
S
L
S
P
H
E
D
L
Site 36
S255
G
T
V
P
Q
S
L
S
P
H
E
D
L
V
A
Site 37
S273
A
I
S
G
L
G
G
S
N
S
H
V
S
A
S
Site 38
S275
S
G
L
G
G
S
N
S
H
V
S
A
S
S
R
Site 39
S278
G
G
S
N
S
H
V
S
A
S
S
R
W
Q
E
Site 40
S280
S
N
S
H
V
S
A
S
S
R
W
Q
E
T
A
Site 41
T286
A
S
S
R
W
Q
E
T
A
R
T
S
C
A
F
Site 42
T289
R
W
Q
E
T
A
R
T
S
C
A
F
N
S
S
Site 43
S290
W
Q
E
T
A
R
T
S
C
A
F
N
S
S
V
Site 44
S295
R
T
S
C
A
F
N
S
S
V
Q
Q
D
H
L
Site 45
S296
T
S
C
A
F
N
S
S
V
Q
Q
D
H
L
S
Site 46
S303
S
V
Q
Q
D
H
L
S
R
H
P
P
E
T
Y
Site 47
T309
L
S
R
H
P
P
E
T
Y
Q
M
E
A
G
S
Site 48
Y310
S
R
H
P
P
E
T
Y
Q
M
E
A
G
S
L
Site 49
S316
T
Y
Q
M
E
A
G
S
L
F
L
L
S
S
D
Site 50
S349
E
E
K
E
N
V
G
S
F
T
D
R
M
T
P
Site 51
T351
K
E
N
V
G
S
F
T
D
R
M
T
P
E
K
Site 52
T355
G
S
F
T
D
R
M
T
P
E
K
H
L
N
S
Site 53
S362
T
P
E
K
H
L
N
S
L
R
N
L
A
K
S
Site 54
S369
S
L
R
N
L
A
K
S
L
D
A
E
Q
D
T
Site 55
T376
S
L
D
A
E
Q
D
T
T
N
P
K
P
F
W
Site 56
T377
L
D
A
E
Q
D
T
T
N
P
K
P
F
W
N
Site 57
S399
L
P
G
P
Q
K
L
S
D
P
R
L
W
Q
E
Site 58
T434
L
V
A
N
A
W
V
T
D
R
S
Y
T
L
Q
Site 59
S437
N
A
W
V
T
D
R
S
Y
T
L
Q
S
P
P
Site 60
Y438
A
W
V
T
D
R
S
Y
T
L
Q
S
P
P
F
Site 61
T439
W
V
T
D
R
S
Y
T
L
Q
S
P
P
F
L
Site 62
S442
D
R
S
Y
T
L
Q
S
P
P
F
L
F
N
E
Site 63
T461
C
P
I
Q
R
E
T
T
M
S
P
L
L
F
Q
Site 64
S463
I
Q
R
E
T
T
M
S
P
L
L
F
Q
A
Q
Site 65
S473
L
F
Q
A
Q
P
P
S
H
L
G
P
E
C
Q
Site 66
S485
E
C
Q
P
F
I
S
S
T
P
Q
F
R
P
T
Site 67
T486
C
Q
P
F
I
S
S
T
P
Q
F
R
P
T
P
Site 68
T492
S
T
P
Q
F
R
P
T
P
M
A
Q
A
E
A
Site 69
S505
E
A
Q
A
H
L
Q
S
S
F
P
V
L
S
P
Site 70
S536
Q
N
K
V
Q
A
L
S
L
P
E
T
Q
H
P
Site 71
T540
Q
A
L
S
L
P
E
T
Q
H
P
E
W
P
L
Site 72
S560
E
G
R
L
A
L
P
S
R
V
Q
K
S
Q
D
Site 73
S565
L
P
S
R
V
Q
K
S
Q
D
V
F
S
V
S
Site 74
S570
Q
K
S
Q
D
V
F
S
V
S
T
P
N
L
P
Site 75
S572
S
Q
D
V
F
S
V
S
T
P
N
L
P
Q
E
Site 76
T573
Q
D
V
F
S
V
S
T
P
N
L
P
Q
E
S
Site 77
S580
T
P
N
L
P
Q
E
S
L
T
S
I
L
P
E
Site 78
S583
L
P
Q
E
S
L
T
S
I
L
P
E
N
F
P
Site 79
S592
L
P
E
N
F
P
V
S
P
E
L
R
R
Q
L
Site 80
S630
L
M
Q
L
R
D
E
S
P
G
T
S
Q
A
K
Site 81
T633
L
R
D
E
S
P
G
T
S
Q
A
K
G
K
P
Site 82
S634
R
D
E
S
P
G
T
S
Q
A
K
G
K
P
S
Site 83
S641
S
Q
A
K
G
K
P
S
P
W
Q
S
S
M
S
Site 84
S645
G
K
P
S
P
W
Q
S
S
M
S
T
G
E
S
Site 85
S646
K
P
S
P
W
Q
S
S
M
S
T
G
E
S
S
Site 86
S648
S
P
W
Q
S
S
M
S
T
G
E
S
S
K
E
Site 87
T649
P
W
Q
S
S
M
S
T
G
E
S
S
K
E
A
Site 88
S652
S
S
M
S
T
G
E
S
S
K
E
A
Q
K
V
Site 89
S653
S
M
S
T
G
E
S
S
K
E
A
Q
K
V
K
Site 90
T678
L
G
Q
I
L
G
E
T
P
Q
N
L
S
R
D
Site 91
S683
G
E
T
P
Q
N
L
S
R
D
M
K
S
F
P
Site 92
S688
N
L
S
R
D
M
K
S
F
P
R
K
V
L
G
Site 93
S698
R
K
V
L
G
V
T
S
E
E
S
E
R
N
L
Site 94
S701
L
G
V
T
S
E
E
S
E
R
N
L
R
K
P
Site 95
S711
N
L
R
K
P
L
R
S
D
S
G
S
D
L
L
Site 96
S713
R
K
P
L
R
S
D
S
G
S
D
L
L
R
C
Site 97
S715
P
L
R
S
D
S
G
S
D
L
L
R
C
T
E
Site 98
T721
G
S
D
L
L
R
C
T
E
R
T
H
I
E
N
Site 99
T724
L
L
R
C
T
E
R
T
H
I
E
N
I
L
K
Site 100
T741
M
G
R
N
L
G
Q
T
N
E
G
L
I
P
V
Site 101
S753
I
P
V
R
V
R
R
S
W
L
A
V
N
Q
A
Site 102
S764
V
N
Q
A
L
P
V
S
N
T
H
V
K
T
S
Site 103
T766
Q
A
L
P
V
S
N
T
H
V
K
T
S
N
L
Site 104
S778
S
N
L
A
A
P
K
S
G
K
A
C
V
N
T
Site 105
T796
L
S
F
L
E
P
C
T
Q
Q
G
L
G
A
H
Site 106
T837
K
V
S
S
L
S
L
T
Q
L
A
G
P
S
S
Site 107
S844
T
Q
L
A
G
P
S
S
A
T
C
E
S
G
A
Site 108
S849
P
S
S
A
T
C
E
S
G
A
G
S
E
V
E
Site 109
S853
T
C
E
S
G
A
G
S
E
V
E
V
D
M
F
Site 110
S868
L
R
K
P
P
M
A
S
L
R
K
Q
V
L
T
Site 111
T875
S
L
R
K
Q
V
L
T
K
A
S
D
H
M
P
Site 112
S884
A
S
D
H
M
P
E
S
L
L
A
S
S
P
A
Site 113
S888
M
P
E
S
L
L
A
S
S
P
A
W
K
Q
F
Site 114
S889
P
E
S
L
L
A
S
S
P
A
W
K
Q
F
Q
Site 115
S904
R
A
P
R
G
I
P
S
W
N
D
H
G
P
L
Site 116
S924
G
Q
E
G
R
W
P
S
K
P
L
T
Y
S
L
Site 117
T928
R
W
P
S
K
P
L
T
Y
S
L
T
G
S
T
Site 118
S930
P
S
K
P
L
T
Y
S
L
T
G
S
T
Q
Q
Site 119
T932
K
P
L
T
Y
S
L
T
G
S
T
Q
Q
S
R
Site 120
S934
L
T
Y
S
L
T
G
S
T
Q
Q
S
R
S
L
Site 121
S938
L
T
G
S
T
Q
Q
S
R
S
L
G
A
Q
S
Site 122
S940
G
S
T
Q
Q
S
R
S
L
G
A
Q
S
S
K
Site 123
S946
R
S
L
G
A
Q
S
S
K
A
G
E
T
R
E
Site 124
T985
H
G
F
E
A
P
G
T
S
K
S
S
L
H
P
Site 125
S986
G
F
E
A
P
G
T
S
K
S
S
L
H
P
R
Site 126
S988
E
A
P
G
T
S
K
S
S
L
H
P
R
V
S
Site 127
S989
A
P
G
T
S
K
S
S
L
H
P
R
V
S
V
Site 128
S995
S
S
L
H
P
R
V
S
V
S
Q
D
P
R
K
Site 129
S997
L
H
P
R
V
S
V
S
Q
D
P
R
K
L
C
Site 130
S1021
E
P
G
M
A
T
K
S
E
T
Q
P
Q
V
C
Site 131
S1040
L
L
P
D
G
Q
A
S
V
V
P
H
A
S
E
Site 132
S1051
H
A
S
E
N
L
V
S
Q
V
P
Q
G
H
L
Site 133
S1060
V
P
Q
G
H
L
Q
S
M
P
A
G
N
M
R
Site 134
S1069
P
A
G
N
M
R
A
S
Q
E
L
H
D
L
M
Site 135
S1081
D
L
M
A
A
R
R
S
K
L
V
H
E
E
P
Site 136
S1110
M
F
P
P
I
H
K
S
E
K
S
R
K
P
N
Site 137
S1113
P
I
H
K
S
E
K
S
R
K
P
N
L
E
K
Site 138
T1130
E
R
L
E
G
L
R
T
P
Q
L
T
P
V
R
Site 139
T1134
G
L
R
T
P
Q
L
T
P
V
R
K
T
E
D
Site 140
T1139
Q
L
T
P
V
R
K
T
E
D
T
H
Q
D
E
Site 141
T1142
P
V
R
K
T
E
D
T
H
Q
D
E
G
V
Q
Site 142
S1153
E
G
V
Q
L
L
P
S
K
K
Q
P
P
S
V
Site 143
S1159
P
S
K
K
Q
P
P
S
V
S
H
F
G
G
N
Site 144
S1161
K
K
Q
P
P
S
V
S
H
F
G
G
N
I
K
Site 145
S1180
W
I
F
S
K
K
K
S
K
P
A
P
V
T
A
Site 146
S1189
P
A
P
V
T
A
E
S
Q
K
T
V
K
N
R
Site 147
T1192
V
T
A
E
S
Q
K
T
V
K
N
R
S
C
V
Site 148
S1197
Q
K
T
V
K
N
R
S
C
V
Y
S
S
S
A
Site 149
S1201
K
N
R
S
C
V
Y
S
S
S
A
E
A
Q
G
Site 150
S1203
R
S
C
V
Y
S
S
S
A
E
A
Q
G
L
M
Site 151
S1256
N
H
R
H
L
F
Y
S
E
H
G
R
I
L
S
Site 152
S1263
S
E
H
G
R
I
L
S
Y
A
A
S
S
Q
Q
Site 153
Y1264
E
H
G
R
I
L
S
Y
A
A
S
S
Q
Q
A
Site 154
S1267
R
I
L
S
Y
A
A
S
S
Q
Q
A
T
L
K
Site 155
S1268
I
L
S
Y
A
A
S
S
Q
Q
A
T
L
K
S
Site 156
T1272
A
A
S
S
Q
Q
A
T
L
K
S
Q
G
C
P
Site 157
S1275
S
Q
Q
A
T
L
K
S
Q
G
C
P
N
R
D
Site 158
S1293
R
N
Q
Q
P
L
K
S
V
R
C
N
N
E
Q
Site 159
S1316
L
H
P
K
K
A
V
S
P
V
S
P
L
Q
H
Site 160
S1319
K
K
A
V
S
P
V
S
P
L
Q
H
W
P
K
Site 161
T1327
P
L
Q
H
W
P
K
T
S
G
A
S
S
H
H
Site 162
S1332
P
K
T
S
G
A
S
S
H
H
H
H
C
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation