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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VPS53
Full Name:
Vacuolar protein sorting-associated protein 53 homolog
Alias:
FLJ10979; HCCS1; Pp13624; Vacuolar protein sorting 53
Type:
Mass (Da):
79653
Number AA:
699
UniProt ID:
Q5VIR6
International Prot ID:
IPI00656021
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005768
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
GO:0015031
GO:0045184
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
A
I
E
Q
V
F
P
S
Q
D
P
L
D
R
A
Site 2
T50
N
A
V
E
Y
I
N
T
L
F
P
T
E
Q
S
Site 3
T81
R
L
D
D
N
I
R
T
V
V
R
G
Q
T
N
Site 4
T87
R
T
V
V
R
G
Q
T
N
V
G
Q
D
G
R
Site 5
S121
I
K
D
K
A
E
K
S
E
Q
M
V
K
E
I
Site 6
T143
D
H
A
K
R
H
L
T
T
S
I
T
T
L
N
Site 7
S145
A
K
R
H
L
T
T
S
I
T
T
L
N
H
L
Site 8
T147
R
H
L
T
T
S
I
T
T
L
N
H
L
H
M
Site 9
S161
M
L
A
G
G
V
D
S
L
E
A
M
T
R
R
Site 10
Y171
A
M
T
R
R
R
Q
Y
G
E
V
A
N
L
L
Site 11
Y191
V
L
E
H
F
H
K
Y
M
G
I
P
Q
I
R
Site 12
S201
I
P
Q
I
R
Q
L
S
E
R
V
K
A
A
Q
Site 13
S225
D
F
E
E
A
F
P
S
Q
G
T
K
R
P
G
Site 14
T228
E
A
F
P
S
Q
G
T
K
R
P
G
G
P
S
Site 15
S235
T
K
R
P
G
G
P
S
N
V
L
R
D
A
C
Site 16
Y268
I
K
Q
H
L
S
E
Y
L
V
L
F
Q
E
N
Site 17
Y288
L
D
K
I
D
R
R
Y
A
W
I
K
R
Q
L
Site 18
Y298
I
K
R
Q
L
V
D
Y
E
E
K
Y
G
R
M
Site 19
Y302
L
V
D
Y
E
E
K
Y
G
R
M
F
P
R
E
Site 20
T366
A
K
R
F
S
G
C
T
L
T
D
G
T
L
K
Site 21
T371
G
C
T
L
T
D
G
T
L
K
K
L
E
S
P
Site 22
S377
G
T
L
K
K
L
E
S
P
P
P
S
T
N
P
Site 23
S381
K
L
E
S
P
P
P
S
T
N
P
F
L
E
D
Site 24
T391
P
F
L
E
D
E
P
T
P
E
M
E
E
L
A
Site 25
T399
P
E
M
E
E
L
A
T
E
K
G
D
L
D
Q
Site 26
Y430
K
C
F
E
P
H
L
Y
V
Y
I
E
S
Q
D
Site 27
Y432
F
E
P
H
L
Y
V
Y
I
E
S
Q
D
K
N
Site 28
S435
H
L
Y
V
Y
I
E
S
Q
D
K
N
L
G
E
Site 29
T461
Q
G
P
P
K
P
N
T
D
E
G
G
A
V
L
Site 30
Y477
S
C
A
D
L
F
V
Y
Y
K
K
C
M
V
Q
Site 31
Y478
C
A
D
L
F
V
Y
Y
K
K
C
M
V
Q
C
Site 32
S486
K
K
C
M
V
Q
C
S
Q
L
S
T
G
E
P
Site 33
Y504
L
T
T
I
F
Q
K
Y
L
R
E
Y
A
W
K
Site 34
Y508
F
Q
K
Y
L
R
E
Y
A
W
K
I
L
S
G
Site 35
S514
E
Y
A
W
K
I
L
S
G
N
L
P
K
T
T
Site 36
T520
L
S
G
N
L
P
K
T
T
T
S
S
G
G
L
Site 37
T521
S
G
N
L
P
K
T
T
T
S
S
G
G
L
T
Site 38
T522
G
N
L
P
K
T
T
T
S
S
G
G
L
T
I
Site 39
S524
L
P
K
T
T
T
S
S
G
G
L
T
I
S
S
Site 40
T528
T
T
S
S
G
G
L
T
I
S
S
L
L
K
E
Site 41
S530
S
S
G
G
L
T
I
S
S
L
L
K
E
K
E
Site 42
S531
S
G
G
L
T
I
S
S
L
L
K
E
K
E
G
Site 43
S539
L
L
K
E
K
E
G
S
E
V
A
K
F
T
L
Site 44
Y561
N
I
L
S
T
A
E
Y
C
L
A
T
T
Q
Q
Site 45
S580
L
K
E
K
V
D
V
S
L
I
E
R
I
N
L
Site 46
T593
N
L
T
G
E
M
D
T
F
S
T
V
I
S
S
Site 47
T596
G
E
M
D
T
F
S
T
V
I
S
S
S
I
Q
Site 48
S635
V
E
H
V
G
D
Q
S
P
Y
V
T
S
V
I
Site 49
Y637
H
V
G
D
Q
S
P
Y
V
T
S
V
I
L
H
Site 50
T639
G
D
Q
S
P
Y
V
T
S
V
I
L
H
I
K
Site 51
S658
I
I
R
D
N
L
A
S
T
R
K
Y
F
T
Q
Site 52
Y662
N
L
A
S
T
R
K
Y
F
T
Q
F
C
V
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation