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Updated November 2019
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Protein Info
Short Name:
CEP350
Full Name:
Centrosome-associated protein 350
Alias:
CAP350; CE350; Centrosomal protein 350kDa; Centrosome associated protein 350; Centrosome-associated protein of 350 kDa; FLJ38282; FLJ44058; Gm133; KIAA0480
Type:
Cell cycle regulation
Mass (Da):
350930
Number AA:
3117
UniProt ID:
Q5VT06
International Prot ID:
IPI00103595
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005634
GO:0005819
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
R
S
S
K
S
K
E
V
P
L
P
N
Site 2
S17
P
L
P
N
P
R
N
S
Q
S
K
D
T
V
Q
Site 3
T22
R
N
S
Q
S
K
D
T
V
Q
A
D
I
T
T
Site 4
T28
D
T
V
Q
A
D
I
T
T
S
W
D
A
L
S
Site 5
S30
V
Q
A
D
I
T
T
S
W
D
A
L
S
Q
T
Site 6
S35
T
T
S
W
D
A
L
S
Q
T
K
A
A
L
R
Site 7
T53
N
K
L
E
V
A
P
T
S
T
A
V
C
D
S
Site 8
S60
T
S
T
A
V
C
D
S
V
M
D
T
K
K
S
Site 9
T64
V
C
D
S
V
M
D
T
K
K
S
S
T
S
A
Site 10
S67
S
V
M
D
T
K
K
S
S
T
S
A
T
R
K
Site 11
S70
D
T
K
K
S
S
T
S
A
T
R
K
I
S
R
Site 12
T72
K
K
S
S
T
S
A
T
R
K
I
S
R
K
D
Site 13
S76
T
S
A
T
R
K
I
S
R
K
D
G
R
Y
L
Site 14
Y82
I
S
R
K
D
G
R
Y
L
D
D
S
W
V
N
Site 15
S86
D
G
R
Y
L
D
D
S
W
V
N
A
P
I
S
Site 16
S93
S
W
V
N
A
P
I
S
K
S
T
K
S
R
K
Site 17
S95
V
N
A
P
I
S
K
S
T
K
S
R
K
E
K
Site 18
S98
P
I
S
K
S
T
K
S
R
K
E
K
S
R
S
Site 19
S103
T
K
S
R
K
E
K
S
R
S
P
L
R
A
T
Site 20
S105
S
R
K
E
K
S
R
S
P
L
R
A
T
T
L
Site 21
T110
S
R
S
P
L
R
A
T
T
L
E
S
N
V
K
Site 22
T111
R
S
P
L
R
A
T
T
L
E
S
N
V
K
K
Site 23
S130
E
F
R
E
P
L
V
S
Y
R
E
I
H
G
A
Site 24
S139
R
E
I
H
G
A
P
S
N
F
S
S
S
H
L
Site 25
S142
H
G
A
P
S
N
F
S
S
S
H
L
E
S
K
Site 26
S143
G
A
P
S
N
F
S
S
S
H
L
E
S
K
H
Site 27
S144
A
P
S
N
F
S
S
S
H
L
E
S
K
H
V
Site 28
S148
F
S
S
S
H
L
E
S
K
H
V
Y
C
V
D
Site 29
Y152
H
L
E
S
K
H
V
Y
C
V
D
V
N
E
E
Site 30
S163
V
N
E
E
K
T
E
S
G
N
W
M
I
G
S
Site 31
S170
S
G
N
W
M
I
G
S
R
E
E
R
N
I
R
Site 32
S178
R
E
E
R
N
I
R
S
C
D
F
E
S
S
Q
Site 33
S183
I
R
S
C
D
F
E
S
S
Q
S
S
V
I
N
Site 34
S184
R
S
C
D
F
E
S
S
Q
S
S
V
I
N
D
Site 35
S187
D
F
E
S
S
Q
S
S
V
I
N
D
T
V
V
Site 36
T192
Q
S
S
V
I
N
D
T
V
V
R
F
L
N
D
Site 37
S218
C
L
I
R
M
G
A
S
M
R
T
E
E
E
M
Site 38
S239
S
E
N
N
L
K
L
S
V
N
N
M
A
H
D
Site 39
T247
V
N
N
M
A
H
D
T
D
P
K
A
L
R
L
Site 40
T255
D
P
K
A
L
R
L
T
D
S
S
P
S
S
T
Site 41
S257
K
A
L
R
L
T
D
S
S
P
S
S
T
S
T
Site 42
S258
A
L
R
L
T
D
S
S
P
S
S
T
S
T
S
Site 43
S260
R
L
T
D
S
S
P
S
S
T
S
T
S
N
S
Site 44
S261
L
T
D
S
S
P
S
S
T
S
T
S
N
S
Q
Site 45
T262
T
D
S
S
P
S
S
T
S
T
S
N
S
Q
R
Site 46
S263
D
S
S
P
S
S
T
S
T
S
N
S
Q
R
L
Site 47
T264
S
S
P
S
S
T
S
T
S
N
S
Q
R
L
D
Site 48
S265
S
P
S
S
T
S
T
S
N
S
Q
R
L
D
I
Site 49
S267
S
S
T
S
T
S
N
S
Q
R
L
D
I
L
K
Site 50
S296
I
R
K
Q
W
E
H
S
E
E
T
N
G
R
G
Site 51
S321
M
V
V
N
V
D
N
S
V
T
A
K
V
R
K
Site 52
T331
A
K
V
R
K
V
A
T
A
P
P
A
P
A
Y
Site 53
Y338
T
A
P
P
A
P
A
Y
K
G
F
N
P
S
E
Site 54
S344
A
Y
K
G
F
N
P
S
E
T
K
I
R
T
P
Site 55
T346
K
G
F
N
P
S
E
T
K
I
R
T
P
D
G
Site 56
T350
P
S
E
T
K
I
R
T
P
D
G
K
V
W
Q
Site 57
Y369
Q
N
M
S
R
E
L
Y
R
D
L
A
L
H
F
Site 58
S381
L
H
F
A
D
D
I
S
I
K
E
K
P
A
E
Site 59
S410
Q
K
V
A
Q
L
S
S
T
E
C
R
T
G
S
Site 60
T411
K
V
A
Q
L
S
S
T
E
C
R
T
G
S
S
Site 61
T415
L
S
S
T
E
C
R
T
G
S
S
H
L
I
S
Site 62
S417
S
T
E
C
R
T
G
S
S
H
L
I
S
T
S
Site 63
S418
T
E
C
R
T
G
S
S
H
L
I
S
T
S
S
Site 64
S422
T
G
S
S
H
L
I
S
T
S
S
W
R
D
G
Site 65
S424
S
S
H
L
I
S
T
S
S
W
R
D
G
Q
K
Site 66
S425
S
H
L
I
S
T
S
S
W
R
D
G
Q
K
L
Site 67
S452
P
K
E
Q
R
T
A
S
S
D
R
G
G
R
E
Site 68
S453
K
E
Q
R
T
A
S
S
D
R
G
G
R
E
R
Site 69
T461
D
R
G
G
R
E
R
T
A
K
S
G
G
H
I
Site 70
S464
G
R
E
R
T
A
K
S
G
G
H
I
G
R
A
Site 71
S473
G
H
I
G
R
A
E
S
D
P
R
L
D
V
L
Site 72
S488
H
R
H
L
Q
R
N
S
E
R
S
R
S
K
S
Site 73
S491
L
Q
R
N
S
E
R
S
R
S
K
S
R
S
E
Site 74
S493
R
N
S
E
R
S
R
S
K
S
R
S
E
N
N
Site 75
S495
S
E
R
S
R
S
K
S
R
S
E
N
N
I
K
Site 76
S497
R
S
R
S
K
S
R
S
E
N
N
I
K
K
L
Site 77
S539
L
D
D
L
Q
L
D
S
T
A
H
T
A
K
Q
Site 78
T540
D
D
L
Q
L
D
S
T
A
H
T
A
K
Q
D
Site 79
T548
A
H
T
A
K
Q
D
T
V
E
L
Q
N
Q
K
Site 80
S556
V
E
L
Q
N
Q
K
S
S
A
P
V
H
A
P
Site 81
S557
E
L
Q
N
Q
K
S
S
A
P
V
H
A
P
R
Site 82
S565
A
P
V
H
A
P
R
S
H
S
P
V
K
R
K
Site 83
S567
V
H
A
P
R
S
H
S
P
V
K
R
K
P
D
Site 84
T577
K
R
K
P
D
K
I
T
A
N
E
D
P
P
V
Site 85
S586
N
E
D
P
P
V
I
S
K
R
R
H
Y
D
T
Site 86
Y591
V
I
S
K
R
R
H
Y
D
T
D
E
V
R
Q
Site 87
T593
S
K
R
R
H
Y
D
T
D
E
V
R
Q
Y
I
Site 88
Y599
D
T
D
E
V
R
Q
Y
I
V
R
Q
Q
E
E
Site 89
Y633
N
K
R
L
Q
E
L
Y
R
K
Q
K
E
A
F
Site 90
S649
K
V
K
N
V
P
P
S
E
P
S
A
T
R
R
Site 91
S652
N
V
P
P
S
E
P
S
A
T
R
R
L
Q
E
Site 92
T654
P
P
S
E
P
S
A
T
R
R
L
Q
E
T
Y
Site 93
T660
A
T
R
R
L
Q
E
T
Y
S
K
L
L
L
E
Site 94
Y661
T
R
R
L
Q
E
T
Y
S
K
L
L
L
E
K
Site 95
S662
R
R
L
Q
E
T
Y
S
K
L
L
L
E
K
T
Site 96
T669
S
K
L
L
L
E
K
T
L
L
E
E
P
S
H
Site 97
S675
K
T
L
L
E
E
P
S
H
Q
H
V
T
Q
E
Site 98
Y689
E
T
Q
A
K
P
G
Y
Q
P
S
G
E
S
D
Site 99
S692
A
K
P
G
Y
Q
P
S
G
E
S
D
K
E
N
Site 100
S707
K
V
Q
E
R
P
P
S
A
S
S
S
S
D
M
Site 101
S709
Q
E
R
P
P
S
A
S
S
S
S
D
M
S
L
Site 102
S710
E
R
P
P
S
A
S
S
S
S
D
M
S
L
S
Site 103
S711
R
P
P
S
A
S
S
S
S
D
M
S
L
S
E
Site 104
S712
P
P
S
A
S
S
S
S
D
M
S
L
S
E
P
Site 105
S715
A
S
S
S
S
D
M
S
L
S
E
P
P
Q
P
Site 106
S717
S
S
S
D
M
S
L
S
E
P
P
Q
P
L
A
Site 107
S740
W
M
Q
P
E
R
L
S
P
Q
V
H
H
S
Q
Site 108
S746
L
S
P
Q
V
H
H
S
Q
P
Q
P
F
A
G
Site 109
T793
N
M
A
S
R
P
L
T
F
T
P
Q
P
Y
V
Site 110
T795
A
S
R
P
L
T
F
T
P
Q
P
Y
V
T
S
Site 111
Y799
L
T
F
T
P
Q
P
Y
V
T
S
P
A
A
Y
Site 112
S802
T
P
Q
P
Y
V
T
S
P
A
A
Y
T
D
A
Site 113
S816
A
L
L
K
P
S
A
S
Q
Y
K
S
K
L
D
Site 114
Y818
L
K
P
S
A
S
Q
Y
K
S
K
L
D
R
I
Site 115
S820
P
S
A
S
Q
Y
K
S
K
L
D
R
I
E
A
Site 116
T831
R
I
E
A
L
K
A
T
A
A
S
L
S
S
R
Site 117
S834
A
L
K
A
T
A
A
S
L
S
S
R
I
E
S
Site 118
S836
K
A
T
A
A
S
L
S
S
R
I
E
S
E
A
Site 119
S841
S
L
S
S
R
I
E
S
E
A
K
K
L
A
G
Site 120
S850
A
K
K
L
A
G
A
S
I
N
Y
G
S
A
W
Site 121
Y861
G
S
A
W
N
T
E
Y
D
V
Q
Q
A
P
Q
Site 122
T874
P
Q
E
D
G
P
W
T
K
A
V
T
P
P
V
Site 123
T878
G
P
W
T
K
A
V
T
P
P
V
K
D
D
N
Site 124
S890
D
D
N
E
D
V
F
S
A
R
I
Q
K
M
L
Site 125
S902
K
M
L
G
S
C
V
S
H
A
T
F
D
D
D
Site 126
T905
G
S
C
V
S
H
A
T
F
D
D
D
L
P
G
Site 127
S917
L
P
G
V
G
N
L
S
E
F
K
K
L
P
E
Site 128
S930
P
E
M
I
R
P
Q
S
A
I
S
S
F
R
V
Site 129
S933
I
R
P
Q
S
A
I
S
S
F
R
V
R
S
P
Site 130
S934
R
P
Q
S
A
I
S
S
F
R
V
R
S
P
G
Site 131
S939
I
S
S
F
R
V
R
S
P
G
P
K
P
E
G
Site 132
T956
A
Q
L
C
K
R
Q
T
D
S
S
S
S
D
M
Site 133
S958
L
C
K
R
Q
T
D
S
S
S
S
D
M
Q
A
Site 134
S959
C
K
R
Q
T
D
S
S
S
S
D
M
Q
A
C
Site 135
S960
K
R
Q
T
D
S
S
S
S
D
M
Q
A
C
S
Site 136
S961
R
Q
T
D
S
S
S
S
D
M
Q
A
C
S
Q
Site 137
S967
S
S
D
M
Q
A
C
S
Q
D
K
A
K
I
S
Site 138
S974
S
Q
D
K
A
K
I
S
L
G
S
S
I
D
S
Site 139
S977
K
A
K
I
S
L
G
S
S
I
D
S
V
S
E
Site 140
S978
A
K
I
S
L
G
S
S
I
D
S
V
S
E
G
Site 141
S983
G
S
S
I
D
S
V
S
E
G
P
L
L
S
E
Site 142
S989
V
S
E
G
P
L
L
S
E
G
S
L
S
E
E
Site 143
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S
L
N
E
E
K
K
S
Site 447
S2744
S
L
N
E
E
K
K
S
K
Q
Q
L
E
K
I
Site 448
S2752
K
Q
Q
L
E
K
I
S
L
L
T
D
S
L
L
Site 449
S2784
R
D
E
K
I
Q
L
S
N
Q
E
L
L
G
D
Site 450
T2797
G
D
D
Q
K
K
V
T
P
Q
D
L
S
Q
N
Site 451
S2802
K
V
T
P
Q
D
L
S
Q
N
V
E
E
Q
S
Site 452
S2809
S
Q
N
V
E
E
Q
S
P
S
I
S
G
C
F
Site 453
S2811
N
V
E
E
Q
S
P
S
I
S
G
C
F
L
S
Site 454
S2813
E
E
Q
S
P
S
I
S
G
C
F
L
S
S
E
Site 455
S2818
S
I
S
G
C
F
L
S
S
E
L
E
D
E
K
Site 456
S2830
D
E
K
E
E
I
S
S
P
D
M
C
P
R
P
Site 457
S2839
D
M
C
P
R
P
E
S
P
V
F
G
A
S
G
Site 458
S2845
E
S
P
V
F
G
A
S
G
Q
E
E
L
A
K
Site 459
S2881
F
D
E
D
F
G
L
S
S
S
H
K
I
Q
K
Site 460
S2883
E
D
F
G
L
S
S
S
H
K
I
Q
K
N
K
Site 461
T2906
M
A
E
P
K
R
V
T
Q
Q
P
C
E
T
L
Site 462
S2946
E
L
G
H
D
L
H
S
I
S
I
P
T
K
L
Site 463
S2948
G
H
D
L
H
S
I
S
I
P
T
K
L
L
G
Site 464
S2958
T
K
L
L
G
C
A
S
K
G
L
D
I
E
S
Site 465
S2965
S
K
G
L
D
I
E
S
T
S
K
R
V
Y
K
Site 466
T2966
K
G
L
D
I
E
S
T
S
K
R
V
Y
K
Q
Site 467
S2967
G
L
D
I
E
S
T
S
K
R
V
Y
K
Q
A
Site 468
Y2971
E
S
T
S
K
R
V
Y
K
Q
A
V
F
D
L
Site 469
T2979
K
Q
A
V
F
D
L
T
K
E
I
F
E
E
I
Site 470
S3006
M
K
P
C
R
I
N
S
S
Y
F
R
R
V
K
Site 471
S3007
K
P
C
R
I
N
S
S
Y
F
R
R
V
K
N
Site 472
Y3008
P
C
R
I
N
S
S
Y
F
R
R
V
K
N
P
Site 473
S3034
S
E
V
L
K
L
F
S
L
K
K
E
P
N
H
Site 474
Y3077
E
E
A
Q
W
V
N
Y
D
E
D
E
L
C
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation