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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHDC7A
Full Name:
Kelch domain-containing protein 7A
Alias:
FLJ38753; Kelch domain containing 7A; KLD7A
Type:
Membrane protein
Mass (Da):
84479
Number AA:
777
UniProt ID:
Q5VTJ3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y38
V
T
V
A
Y
R
L
Y
K
S
R
P
A
P
A
Site 2
S63
A
K
E
E
A
E
G
S
G
Q
P
A
V
Q
E
Site 3
S72
Q
P
A
V
Q
E
A
S
P
G
V
L
L
R
G
Site 4
S85
R
G
P
R
R
R
R
S
S
K
R
A
E
A
P
Site 5
S86
G
P
R
R
R
R
S
S
K
R
A
E
A
P
Q
Site 6
Y104
C
E
N
P
R
G
P
Y
V
L
V
T
G
A
T
Site 7
T108
R
G
P
Y
V
L
V
T
G
A
T
S
T
D
R
Site 8
T113
L
V
T
G
A
T
S
T
D
R
K
P
Q
R
K
Site 9
S122
R
K
P
Q
R
K
G
S
G
E
E
R
G
G
Q
Site 10
S131
E
E
R
G
G
Q
G
S
D
S
E
Q
V
P
P
Site 11
S133
R
G
G
Q
G
S
D
S
E
Q
V
P
P
C
C
Site 12
S142
Q
V
P
P
C
C
P
S
Q
E
T
R
T
A
V
Site 13
T147
C
P
S
Q
E
T
R
T
A
V
G
S
N
P
D
Site 14
S151
E
T
R
T
A
V
G
S
N
P
D
P
P
H
F
Site 15
S163
P
H
F
P
R
L
G
S
E
P
K
S
S
P
A
Site 16
S167
R
L
G
S
E
P
K
S
S
P
A
G
L
I
A
Site 17
S186
S
C
A
G
G
E
P
S
P
W
Q
D
S
K
P
Site 18
S191
E
P
S
P
W
Q
D
S
K
P
R
E
H
P
G
Site 19
Y209
L
E
P
P
H
C
H
Y
V
A
P
L
Q
G
S
Site 20
S217
V
A
P
L
Q
G
S
S
D
M
N
Q
S
W
V
Site 21
T248
A
A
S
D
V
D
L
T
L
H
Q
Q
E
G
A
Site 22
S258
Q
Q
E
G
A
P
N
S
S
Y
T
F
S
S
I
Site 23
S259
Q
E
G
A
P
N
S
S
Y
T
F
S
S
I
A
Site 24
Y260
E
G
A
P
N
S
S
Y
T
F
S
S
I
A
R
Site 25
T261
G
A
P
N
S
S
Y
T
F
S
S
I
A
R
V
Site 26
S263
P
N
S
S
Y
T
F
S
S
I
A
R
V
R
M
Site 27
S264
N
S
S
Y
T
F
S
S
I
A
R
V
R
M
E
Site 28
Y290
P
R
L
K
G
K
V
Y
D
Y
Y
V
E
S
T
Site 29
Y292
L
K
G
K
V
Y
D
Y
Y
V
E
S
T
S
Q
Site 30
Y293
K
G
K
V
Y
D
Y
Y
V
E
S
T
S
Q
A
Site 31
S298
D
Y
Y
V
E
S
T
S
Q
A
I
F
Q
G
R
Site 32
T310
Q
G
R
L
A
P
R
T
A
A
L
T
E
V
P
Site 33
T314
A
P
R
T
A
A
L
T
E
V
P
S
P
R
P
Site 34
S318
A
A
L
T
E
V
P
S
P
R
P
P
P
G
S
Site 35
S325
S
P
R
P
P
P
G
S
L
G
T
G
A
A
S
Site 36
T328
P
P
P
G
S
L
G
T
G
A
A
S
G
G
Q
Site 37
T339
S
G
G
Q
A
G
D
T
K
G
A
A
E
R
A
Site 38
S348
G
A
A
E
R
A
A
S
P
Q
T
G
P
W
P
Site 39
S356
P
Q
T
G
P
W
P
S
T
R
G
F
S
R
K
Site 40
T357
Q
T
G
P
W
P
S
T
R
G
F
S
R
K
E
Site 41
S361
W
P
S
T
R
G
F
S
R
K
E
S
L
L
Q
Site 42
S365
R
G
F
S
R
K
E
S
L
L
Q
I
A
E
N
Site 43
S401
A
L
P
G
L
G
R
S
S
R
E
P
H
V
Q
Site 44
S402
L
P
G
L
G
R
S
S
R
E
P
H
V
Q
P
Site 45
S424
H
I
P
L
T
P
A
S
A
P
Q
V
R
L
D
Site 46
T440
G
N
C
Y
E
V
L
T
L
A
K
R
Q
N
L
Site 47
Y455
E
A
L
K
E
A
A
Y
K
V
M
S
E
N
Y
Site 48
Y493
R
R
L
R
G
R
Q
Y
L
V
V
A
D
V
C
Site 49
Y511
D
S
G
G
L
C
C
Y
D
D
E
Q
D
V
W
Site 50
S557
G
P
G
H
Q
P
S
S
R
V
F
C
Y
N
P
Site 51
Y562
P
S
S
R
V
F
C
Y
N
P
L
T
G
I
W
Site 52
S601
I
G
G
E
C
L
N
S
V
E
R
Y
D
P
R
Site 53
Y605
C
L
N
S
V
E
R
Y
D
P
R
L
D
R
W
Site 54
T669
T
G
G
S
K
D
R
T
A
E
M
V
A
V
N
Site 55
Y693
R
S
L
G
I
A
V
Y
R
C
S
A
S
T
R
Site 56
Y703
S
A
S
T
R
L
W
Y
E
C
A
T
Y
R
T
Site 57
Y708
L
W
Y
E
C
A
T
Y
R
T
P
Y
P
D
A
Site 58
Y712
C
A
T
Y
R
T
P
Y
P
D
A
F
Q
C
A
Site 59
S742
C
F
L
A
D
S
V
S
P
R
F
V
P
K
E
Site 60
S752
F
V
P
K
E
L
R
S
F
P
A
P
Q
G
T
Site 61
T769
P
T
V
L
T
L
P
T
P
D
L
P
Q
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation