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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRCH2
Full Name:
Leucine-rich repeat and calponin homology domain-containing protein 2
Alias:
KIAA1495; Leucine-rich repeats and calponiny (CH) domain containing 2
Type:
Unknown function
Mass (Da):
84590
Number AA:
UniProt ID:
Q5VUJ6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
S
Q
G
G
G
G
N
S
G
G
G
G
C
G
G
Site 2
S21
G
G
C
G
G
G
G
S
S
G
G
C
G
T
A
Site 3
S22
G
C
G
G
G
G
S
S
G
G
C
G
T
A
G
Site 4
S70
G
P
P
W
N
P
G
S
L
Q
P
Q
H
T
V
Site 5
T76
G
S
L
Q
P
Q
H
T
V
R
S
L
D
R
A
Site 6
S79
Q
P
Q
H
T
V
R
S
L
D
R
A
L
E
E
Site 7
S94
A
G
S
S
G
I
L
S
L
S
G
R
K
L
R
Site 8
S96
S
S
G
I
L
S
L
S
G
R
K
L
R
D
F
Site 9
S106
K
L
R
D
F
P
G
S
G
Y
D
L
T
D
T
Site 10
T111
P
G
S
G
Y
D
L
T
D
T
T
Q
A
D
L
Site 11
T113
S
G
Y
D
L
T
D
T
T
Q
A
D
L
S
R
Site 12
T114
G
Y
D
L
T
D
T
T
Q
A
D
L
S
R
N
Site 13
S119
D
T
T
Q
A
D
L
S
R
N
R
F
T
E
I
Site 14
T124
D
L
S
R
N
R
F
T
E
I
P
S
D
V
W
Site 15
S128
N
R
F
T
E
I
P
S
D
V
W
L
F
A
P
Site 16
T160
I
K
N
L
Q
M
L
T
Y
L
N
I
S
R
N
Site 17
Y161
K
N
L
Q
M
L
T
Y
L
N
I
S
R
N
L
Site 18
S170
N
I
S
R
N
L
L
S
T
L
P
K
Y
L
F
Site 19
T171
I
S
R
N
L
L
S
T
L
P
K
Y
L
F
D
Site 20
S193
V
S
N
N
K
L
V
S
I
P
E
E
I
G
K
Site 21
S226
Q
Q
M
G
K
L
H
S
L
R
E
L
N
I
R
Site 22
S315
R
M
D
K
K
P
D
S
L
D
L
P
S
L
S
Site 23
S320
P
D
S
L
D
L
P
S
L
S
K
R
M
P
S
Site 24
S322
S
L
D
L
P
S
L
S
K
R
M
P
S
Q
P
Site 25
S327
S
L
S
K
R
M
P
S
Q
P
L
T
D
S
M
Site 26
T331
R
M
P
S
Q
P
L
T
D
S
M
E
D
F
Y
Site 27
S333
P
S
Q
P
L
T
D
S
M
E
D
F
Y
P
N
Site 28
Y338
T
D
S
M
E
D
F
Y
P
N
K
N
H
G
P
Site 29
S347
N
K
N
H
G
P
D
S
G
I
G
S
D
N
G
Site 30
S351
G
P
D
S
G
I
G
S
D
N
G
E
K
R
L
Site 31
S359
D
N
G
E
K
R
L
S
T
T
E
P
S
D
D
Site 32
T360
N
G
E
K
R
L
S
T
T
E
P
S
D
D
D
Site 33
T361
G
E
K
R
L
S
T
T
E
P
S
D
D
D
T
Site 34
S364
R
L
S
T
T
E
P
S
D
D
D
T
V
S
L
Site 35
T368
T
E
P
S
D
D
D
T
V
S
L
H
S
Q
V
Site 36
S370
P
S
D
D
D
T
V
S
L
H
S
Q
V
S
E
Site 37
S373
D
D
T
V
S
L
H
S
Q
V
S
E
S
N
R
Site 38
S376
V
S
L
H
S
Q
V
S
E
S
N
R
E
Q
T
Site 39
S378
L
H
S
Q
V
S
E
S
N
R
E
Q
T
S
R
Site 40
T383
S
E
S
N
R
E
Q
T
S
R
N
D
S
H
I
Site 41
S384
E
S
N
R
E
Q
T
S
R
N
D
S
H
I
I
Site 42
S388
E
Q
T
S
R
N
D
S
H
I
I
G
S
K
T
Site 43
S393
N
D
S
H
I
I
G
S
K
T
D
S
Q
K
D
Site 44
T395
S
H
I
I
G
S
K
T
D
S
Q
K
D
Q
E
Site 45
S397
I
I
G
S
K
T
D
S
Q
K
D
Q
E
V
Y
Site 46
Y404
S
Q
K
D
Q
E
V
Y
D
F
V
D
P
N
T
Site 47
T411
Y
D
F
V
D
P
N
T
E
D
V
A
V
P
E
Site 48
S426
Q
G
N
A
H
I
G
S
F
V
S
F
F
K
G
Site 49
S429
A
H
I
G
S
F
V
S
F
F
K
G
K
E
K
Site 50
S441
K
E
K
C
S
E
K
S
R
K
N
E
E
L
G
Site 51
S493
K
N
R
I
L
N
H
S
T
S
V
M
R
N
K
Site 52
S495
R
I
L
N
H
S
T
S
V
M
R
N
K
P
K
Site 53
S510
Q
T
V
E
C
E
K
S
V
S
A
D
E
V
N
Site 54
S512
V
E
C
E
K
S
V
S
A
D
E
V
N
S
P
Site 55
S518
V
S
A
D
E
V
N
S
P
L
S
P
L
T
W
Site 56
S521
D
E
V
N
S
P
L
S
P
L
T
W
Q
P
L
Site 57
T524
N
S
P
L
S
P
L
T
W
Q
P
L
E
N
Q
Site 58
S550
S
H
P
I
I
W
Q
S
E
E
R
R
R
S
K
Site 59
S556
Q
S
E
E
R
R
R
S
K
Q
I
R
K
E
Y
Site 60
Y563
S
K
Q
I
R
K
E
Y
F
K
Y
K
S
M
R
Site 61
Y566
I
R
K
E
Y
F
K
Y
K
S
M
R
K
S
S
Site 62
S568
K
E
Y
F
K
Y
K
S
M
R
K
S
S
S
G
Site 63
S572
K
Y
K
S
M
R
K
S
S
S
G
N
E
N
D
Site 64
S573
Y
K
S
M
R
K
S
S
S
G
N
E
N
D
E
Site 65
S574
K
S
M
R
K
S
S
S
G
N
E
N
D
E
Q
Site 66
S583
N
E
N
D
E
Q
D
S
D
N
A
N
M
S
T
Site 67
S589
D
S
D
N
A
N
M
S
T
Q
S
P
V
S
S
Site 68
T590
S
D
N
A
N
M
S
T
Q
S
P
V
S
S
E
Site 69
S592
N
A
N
M
S
T
Q
S
P
V
S
S
E
E
Y
Site 70
S596
S
T
Q
S
P
V
S
S
E
E
Y
D
R
T
D
Site 71
Y599
S
P
V
S
S
E
E
Y
D
R
T
D
G
F
S
Site 72
T602
S
S
E
E
Y
D
R
T
D
G
F
S
H
S
P
Site 73
S606
Y
D
R
T
D
G
F
S
H
S
P
F
G
L
K
Site 74
S608
R
T
D
G
F
S
H
S
P
F
G
L
K
P
R
Site 75
S616
P
F
G
L
K
P
R
S
A
F
S
R
S
S
R
Site 76
S619
L
K
P
R
S
A
F
S
R
S
S
R
Q
E
Y
Site 77
S621
P
R
S
A
F
S
R
S
S
R
Q
E
Y
G
A
Site 78
S622
R
S
A
F
S
R
S
S
R
Q
E
Y
G
A
A
Site 79
Y626
S
R
S
S
R
Q
E
Y
G
A
A
D
P
G
F
Site 80
T634
G
A
A
D
P
G
F
T
M
R
R
K
M
E
H
Site 81
S658
Q
L
R
N
N
L
E
S
R
L
K
V
I
L
P
Site 82
S689
A
N
H
I
R
P
R
S
V
A
S
I
H
V
P
Site 83
S704
S
P
A
V
P
K
L
S
M
A
K
C
R
R
N
Site 84
S725
A
C
K
K
L
G
V
S
Q
E
R
L
C
L
P
Site 85
S760
E
L
P
T
T
K
A
S
Q
L
S
V
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation