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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDKAL1
Full Name:
CDK5 regulatory subunit-associated protein 1-like 1
Alias:
CDK5 regulatory subunit associated protein 1-like 1; CDKAL; FLJ20342
Type:
Enzyme, misc.; Unknown function
Mass (Da):
65110
Number AA:
UniProt ID:
Q5VV42
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0051539
GO:0003824
GO:0005506
PhosphoSite+
KinaseNET
Biological Process:
GO:0009451
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
D
D
I
E
D
I
V
S
Q
E
D
S
K
P
Q
Site 2
S22
D
I
V
S
Q
E
D
S
K
P
Q
D
R
H
F
Site 3
T43
P
K
V
R
R
R
N
T
Q
K
Y
L
Q
E
E
Site 4
Y46
R
R
R
N
T
Q
K
Y
L
Q
E
E
E
N
S
Site 5
S53
Y
L
Q
E
E
E
N
S
P
P
S
D
S
T
I
Site 6
S56
E
E
E
N
S
P
P
S
D
S
T
I
P
G
I
Site 7
S58
E
N
S
P
P
S
D
S
T
I
P
G
I
Q
K
Site 8
T59
N
S
P
P
S
D
S
T
I
P
G
I
Q
K
I
Site 9
Y82
H
N
N
S
D
G
E
Y
M
A
G
Q
L
A
A
Site 10
T110
L
W
L
L
N
S
C
T
V
K
N
P
A
E
D
Site 11
S122
A
E
D
H
F
R
N
S
I
K
K
A
Q
E
E
Site 12
Y148
Q
A
Q
P
R
Q
D
Y
L
K
G
L
S
I
I
Site 13
S175
E
E
T
I
K
G
H
S
V
R
L
L
G
Q
K
Site 14
Y220
G
C
L
N
A
C
T
Y
C
K
T
K
H
A
R
Site 15
S232
H
A
R
G
N
L
A
S
Y
P
I
D
E
L
V
Site 16
Y233
A
R
G
N
L
A
S
Y
P
I
D
E
L
V
D
Site 17
S245
L
V
D
R
A
K
Q
S
F
Q
E
G
V
C
E
Site 18
T256
G
V
C
E
I
W
L
T
S
E
D
T
G
A
Y
Site 19
Y263
T
S
E
D
T
G
A
Y
G
R
D
I
G
T
N
Site 20
T269
A
Y
G
R
D
I
G
T
N
L
P
T
L
L
W
Site 21
Y297
L
G
M
T
N
P
P
Y
I
L
E
H
L
E
E
Site 22
Y315
I
L
N
H
P
R
V
Y
A
F
L
H
I
P
V
Site 23
S328
P
V
Q
S
A
S
D
S
V
L
M
E
M
K
R
Site 24
Y337
L
M
E
M
K
R
E
Y
C
V
A
D
F
K
R
Site 25
Y395
S
L
F
I
N
Q
F
Y
P
R
P
G
T
P
A
Site 26
T400
Q
F
Y
P
R
P
G
T
P
A
A
K
M
E
Q
Site 27
S421
K
Q
R
T
K
D
L
S
R
V
F
H
S
Y
S
Site 28
S426
D
L
S
R
V
F
H
S
Y
S
P
Y
D
H
K
Site 29
Y427
L
S
R
V
F
H
S
Y
S
P
Y
D
H
K
I
Site 30
S428
S
R
V
F
H
S
Y
S
P
Y
D
H
K
I
G
Site 31
Y430
V
F
H
S
Y
S
P
Y
D
H
K
I
G
E
R
Site 32
T443
E
R
Q
Q
V
L
V
T
E
E
S
F
D
S
K
Site 33
S446
Q
V
L
V
T
E
E
S
F
D
S
K
F
Y
V
Site 34
S449
V
T
E
E
S
F
D
S
K
F
Y
V
A
H
N
Site 35
Y452
E
S
F
D
S
K
F
Y
V
A
H
N
Q
F
Y
Site 36
Y459
Y
V
A
H
N
Q
F
Y
E
Q
V
L
V
P
K
Site 37
Y480
K
M
V
E
V
D
I
Y
E
S
G
K
H
F
M
Site 38
S493
F
M
K
G
Q
P
V
S
D
A
K
V
Y
T
P
Site 39
T499
V
S
D
A
K
V
Y
T
P
S
I
S
K
P
L
Site 40
S501
D
A
K
V
Y
T
P
S
I
S
K
P
L
A
K
Site 41
S527
N
G
L
G
N
Q
L
S
S
G
S
H
T
S
A
Site 42
S528
G
L
G
N
Q
L
S
S
G
S
H
T
S
A
A
Site 43
S530
G
N
Q
L
S
S
G
S
H
T
S
A
A
S
Q
Site 44
T532
Q
L
S
S
G
S
H
T
S
A
A
S
Q
C
D
Site 45
S533
L
S
S
G
S
H
T
S
A
A
S
Q
C
D
S
Site 46
S536
G
S
H
T
S
A
A
S
Q
C
D
S
A
S
S
Site 47
S540
S
A
A
S
Q
C
D
S
A
S
S
R
M
V
L
Site 48
S542
A
S
Q
C
D
S
A
S
S
R
M
V
L
P
M
Site 49
S543
S
Q
C
D
S
A
S
S
R
M
V
L
P
M
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation